| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshinaga Ito, Deng Pan, Wubing Zhang, Xixi Zhang, Tiffany Y Juan, Jason W Pyrdol, Oleksandr Kyrysyuk, John G Doench, X Shirley Liu, Kai W Wucherpfenni. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. Cancer discovery. 2023-02-22. PMID:36811466. |
autophagy and tnf signaling emerged as top pathways, and inactivation of rnf31 (tnf signaling) and atg5 (autophagy) sensitized mhc-i deficient tumor cells to apoptosis by t cell-derived cytokines. |
2023-02-22 |
2023-08-14 |
Not clear |
| Dinesh Parshuram Satpute, Urjita Shirwadkar, Anil Kumar Tharalla, Sangita Dattatray Shinde, Gargi Nikhil Vaidya, Swarali Joshi, Priyanka Patel Vatsa, Alok Jain, Abhishek A Singh, Rachana Garg, Amit Mandoli, Dinesh Kuma. Discovery of fluorinated 2‑Styryl 4(3H)-quinazolinone as potential therapeutic hit for oral cancer. Bioorganic & medicinal chemistry. vol 81. 2023-02-16. PMID:36796126. |
subsequent rna-seq analysis revealed that the compound induces the activation of molecular pathways involved in apoptosis (such as tnf signalling through nf-κb, p53 pathways) and cell differentiation and suppresses the pathways of cellular growth and development (such as kras signaling) in cal-27 cancer cells. |
2023-02-16 |
2023-08-14 |
Not clear |
| Min Fei, Zheng Li, Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Che. MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 9. 2023-02-12. PMID:36775547. |
it was also observed that mir-182 overexpression reduced apoptosis and attenuated the inflammatory response in spinal cord tissue, as evidenced by the reduction of tumor necrosis factor (tnf)-α, interleukin (il)-6, and il-1β, and the induction of il-10. |
2023-02-12 |
2023-08-14 |
mouse |
| Hongting Yan, Yingjie Li, Bing Yang, Fengxi Long, Zhu Yang, Dongxin Tan. Exploring the mechanism of action of Yiyi Fuzi Baijiang powder in colorectal cancer based on network pharmacology and molecular docking studies. Biotechnology & genetic engineering reviews. 2023-02-03. PMID:36735641. |
yiyi fuzi baijiang powder may influence the pi3k-akt signaling pathway, tnf signaling route, and il-17 signaling pathway, which are involved in transcription, gene expression, apoptosis and proliferation regulation, among other biological processes, according to go and kegg enrichment analyses. |
2023-02-03 |
2023-08-14 |
Not clear |
| Piaoyi Guo, Liang Jin, Huifen Zhou, Yida Bao, Jiehong Yang, Jing Chen, Yu He, Daojun Yu, Haitong Wa. Glycyrrhetinic acid protects against Multidrug-resistant Acinetobacter baumannii-induced lung epithelial cells injury by regulating inflammation and oxidative stress. BMC pharmacology & toxicology. vol 24. issue 1. 2023-01-31. PMID:36717837. |
notwithstanding, ga could reverse mdr-ab-induced cell apoptosis, hampered adhesion and invasion of mdr-ab to cells, and inhibit pro-inflammatory cytokines expression of il-1β, il-6, and tnf. |
2023-01-31 |
2023-08-14 |
human |
| Jingmiao Yang, Shuai Yang, Yongshan Liao, Yuewen Deng, Yu Jia. Histone deacetylase inhibitor butyrate inhibits the cellular immunity and increases the serum immunity of pearl oyster Pinctada fucata martensii. Fish & shellfish immunology. 2023-01-12. PMID:36632915. |
meanwhile, butyrate inhibited the up-regulation of 31.54%-54.96% of the genes induced by lps, and these genes were mainly enriched in "notch signaling pathway", "cell proliferation", "nf-kappa b signaling pathway", "tnf signaling pathway", "apoptosis", "nod-like receptor signaling pathway", "rig-i-like receptor signaling pathway" and "cytosolic dna-sensing pathway". |
2023-01-12 |
2023-08-14 |
Not clear |
| Xuesong Wang, Yan Chai, Zhe Guo, Ziyi Wang, Haiyan Liao, Ziwen Wang, Zhong Wan. A new perspective on the potential application of RIPK1 in the treatment of sepsis. Immunotherapy. 2023-01-04. PMID:36597707. |
generally, ripk1 can induce cell apoptosis and necroptosis through tnf, fas and lipopolysaccharide stimulation, while its scaffold function can sense the fluctuation of cellular energy and promote cell survival. |
2023-01-04 |
2023-08-14 |
human |
| John J Krolewski, Shalini Singh, Kai Sha, Neha Jaiswal, Steven G Turowski, Chunliu Pan, Laurie J Rich, Mukund Seshadri, Kent L Nastiu. TNF Signaling Is Required for Castration-Induced Vascular Damage Preceding Prostate Cancer Regression. Cancers. vol 14. issue 24. 2022-12-23. PMID:36551505. |
these results demonstrate that tnf signaling is required for vascular regression, most likely by inducing endothelial cell apoptosis and increasing vessel permeability. |
2022-12-23 |
2023-08-14 |
mouse |
| Jon Huyghe, Dario Priem, Lisette Van Hove, Barbara Gilbert, Jürgen Fritsch, Yasuo Uchiyama, Esther Hoste, Geert van Loo, Mathieu J M Bertran. ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway. Science (New York, N.Y.). vol 378. issue 6625. 2022-12-15. PMID:36520901. |
here, we describe a checkpoint that prevents apoptosis through the detoxification of the cytotoxic complex iia that forms upon tnf sensing. |
2022-12-15 |
2023-08-14 |
mouse |
| Hua Huang, Haochuan Yu, Xuanguang Li, Yongwen Li, Guangsheng Zhu, Lianchun Su, Mingbiao Li, Chen Chen, Min Gao, Di Wu, Ruihao Zhang, Peijun Cao, Hongyu Liu, Jun Che. Genomic analysis of TNF-related genes with prognosis and characterization of the tumor immune microenvironment in lung adenocarcinoma. Frontiers in immunology. vol 13. 2022-12-12. PMID:36505472. |
the tumor necrosis factor (tnf) family plays a role in modulating cellular functions that regulate cellular differentiation, survival, apoptosis, and especially cellular immune functions. |
2022-12-12 |
2023-08-14 |
Not clear |
| Kang-Wei Wang, Qin-Qin Liu, Jian Zhu, Xin Deng, Li Luo, Shi-Mei Lin, Chuan-Jie Qin, Yong-Jun Che. Transcriptome analysis provides insights into the molecular mechanism of liver inflammation and apoptosis in juvenile largemouth bass Micropterus salmoides fed low protein high starch diets. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 45. 2022-12-12. PMID:36508948. |
besides mediating inflammation and immune response, tnf-α signal transduction participated in mediating apoptosis through the receptor of tnf (tnf-r1) pathway by up-regulating the expression of caspase 8 and cytochrome c. in conclusion, our results demonstrated that feeding low protein and high starch diets induced hepatocytes inflammation and apoptosis in lmb through the pi3k/akt/nf-κb signaling pathway. |
2022-12-12 |
2023-08-14 |
Not clear |
| Manjari Kundu, Yoshimi Endo Greer, Jennifer L Dine, Stanley Lipkowit. Targeting TRAIL Death Receptors in Triple-Negative Breast Cancers: Challenges and Strategies for Cancer Therapy. Cells. vol 11. issue 23. 2022-12-11. PMID:36496977. |
the tumor necrosis factor (tnf) superfamily member tnf-related apoptosis-inducing ligand (trail) induces apoptosis in cancer cells via death receptor (dr) activation with little toxicity to normal cells or tissues. |
2022-12-11 |
2023-08-14 |
Not clear |
| David E Lee, Lauren K McKay, Akshay Bareja, Yongwu Li, Alastair Khodabukus, Nenad Bursac, Gregory A Taylor, Gurpreet S Baht, James P Whit. Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling. Nature communications. vol 13. issue 1. 2022-12-09. PMID:36494364. |
using ex vivo media exchange and in vivo tnf inhibition, we demonstrate a mechanism of metrnl action during regeneration, showing it counteracts a pro-fibrotic gene program by triggering tnfα-induced apoptosis of fibro/adipogenic progenitor cells. |
2022-12-09 |
2023-08-14 |
Not clear |
| Sherif A El-Kafrawy, Mai M El-Daly, Leena H Bajrai, Thamir A Alandijany, Arwa A Faizo, Mohammad Mobashir, Sunbul S Ahmed, Sarfraz Ahmed, Shoaib Alam, Raja Jeet, Mohammad Amjad Kamal, Syed Tauqeer Anwer, Bushra Khan, Manal Tashkandi, Moshahid A Rizvi, Esam Ibraheem Azha. Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma. Frontiers in genetics. vol 13. 2022-12-08. PMID:36479247. |
pi3k, camp, tgf, tnf, rap1, nf-kb, apoptosis, longevity regulating pathway, signaling pathways regulating pluripotency of stem cells, cytokine-cytokine receptor interaction, p53 signaling, wnt signaling, toll-like receptor signaling, and hippo signaling pathways are just a few of the most commonly enriched pathways. |
2022-12-08 |
2023-08-14 |
human |
| Naoki Yamamoto, Himeno Takeuchi, Manami Yamaoka, Tomoya Nakanishi, Shingo Tonai, Ryo Nishimura, Takehito Morita, Masashi Nagano, Shingo Kameda, Kaori Genda, Jun Kawase, Yasuhisa Yamashit. Lipopolysaccharide (LPS) suppresses follicle development marker expression and enhances cytokine expressions, which results in fail to granulosa cell proliferation in developing follicle in cows. Reproductive biology. vol 23. issue 1. 2022-12-05. PMID:36470010. |
ce contraction significantly increased cytokine expressions (tnf, il-1a, and il-1b) in granulosa cells and suppressed apoptosis of granulosa cells compared to normal cows. |
2022-12-05 |
2023-08-14 |
Not clear |
| Yudong Yin, Li Sun, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Weibin Mo, Quande Wang, Keguang Chen. (4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7. Chemico-biological interactions. 2022-12-02. PMID:36460128. |
besides, the human apoptosis array assay demonstrated the expression level of death receptor trail r2/dr5 was upregulated obviously while the expression of tnf r1, iaps and hsp27/60/70 were downregulated. |
2022-12-02 |
2023-08-14 |
human |
| Yusuke Sakamoto, Katsuhiro Sasaki, Mayuki Omatsu, Kensuke Hamada, Yuki Nakanishi, Yoshiro Itatani, Kenji Kawada, Kazutaka Obama, Hiroshi Seno, Kazuhiro Iwa. Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation. The Journal of pathology. 2022-12-01. PMID:36454102. |
iec death was rescued by an anti-tnf antibody, and tnf (but not lps) induced apoptosis of organoids derived from lubac-defective iecs. |
2022-12-01 |
2023-08-14 |
mouse |
| Woo-Gyun Choi, Na Ri Choi, Eun-Jung Park, Byung Joo Ki. A study of the therapeutic mechanism of Jakyakgamcho-Tang about functional dyspepsia through network pharmacology research. International journal of medical sciences. vol 19. issue 13. 2022-11-28. PMID:36438925. |
and the target is enriched in variety fd-related signaling as follows: mapk, toll-like receptor, nod-like receptor, pi3k-akt, apoptosis and tnf signaling pathway. |
2022-11-28 |
2023-08-14 |
Not clear |
| Zimin Yang, Wei Luo, Zhihong Huang, Min Guo, Xiaochuan He, Zihan Fan, Qing Wang, Qiwei Qin, Min Yang, Xuezhu Le. Genome-Wide Analysis of Differentially Expressed mRNAs and lncRNAs in Koi Carp Infected with Koi Herpesvirus. Viruses. vol 14. issue 11. 2022-11-24. PMID:36423164. |
the kegg analysis showed that degs were significantly enriched in many important immune pathways, such as apoptosis, nod-like receptor signaling pathway, jak-stat signaling pathway, tnf signaling pathway, il-17 signaling pathway, nf-kappa b signaling pathway, and so on. |
2022-11-24 |
2023-08-14 |
Not clear |
| Yanlu Liu, Shiting Gong, Kejian Li, Gong Wu, Xiaohong Zheng, Jingna Zheng, Xiaowei Lu, Luyao Zhang, Jincan Li, Ziren Su, Yuhong Liu, Jianhui Xie, Jiannan Chen, Yucui L. Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 156. 2022-11-22. PMID:36411660. |
meanwhile, coptisine treatment significantly suppressed hyperuricemia induced oxidant stress, inflammatory injury and apoptosis through promoting superoxide dismutase (sod) activity, restraining reactive oxygen species (ros), malondialdehyde (mda), tumor necrosis factor (tnf)-α, interleukin (il)- 1β, il-18 levels, down-regulating protein expressions of cleaved-caspase 3, apoptosis-inducing factor (aif), cyto-cytc, cleaved poly adp-ribose polymerase (parp) and bcl-2-associated x protein (bax), and up-regulating protein expressions of bcl-2 and p-bad. |
2022-11-22 |
2023-08-14 |
mouse |