| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Koike, K Fehsel, J Zielasek, H Kolb, V Burkar. Gangliosides protect from TNF alpha-induced apoptosis. Immunology letters. vol 35. issue 3. 1993-07-22. PMID:8514331. |
gangliosides protect from tnf alpha-induced apoptosis. |
1993-07-22 |
2023-08-12 |
cattle |
| T Koike, K Fehsel, J Zielasek, H Kolb, V Burkar. Gangliosides protect from TNF alpha-induced apoptosis. Immunology letters. vol 35. issue 3. 1993-07-22. PMID:8514331. |
in situ nick translation revealed that bbg (2 mg/ml) significantly reduces the number of cells with tnf alpha-induced dna-strand breaks from 71.2% to 6.6% (p < 0.0001), indicating a protection against tnf alpha-mediated apoptosis. |
1993-07-22 |
2023-08-12 |
cattle |
| J E Belizario, J L Tilly, S W Sherwoo. Caffeine potentiates the lethality of tumour necrosis factor in cancer cells. British journal of cancer. vol 67. issue 6. 1993-07-21. PMID:8512808. |
l929 cells stimulated with tnf died via apoptosis, as judged by both morphological criteria and the occurrence of internucleosomal dna cleavage. |
1993-07-21 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
we investigated the effect of bcl-2 expression on cellular sensitivity to lysis by tumor necrosis factor (tnf), a cytokine capable of inducing apoptosis in several tumor cell lines. |
1993-04-20 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
bcl-2-overexpressing derivatives of these cell lines did not acquire reduced tnf sensitivity and still exhibited the characteristic pattern of internucleosomal dna fragmentation of tnf-induced apoptosis. |
1993-04-20 |
2023-08-12 |
mouse |
| B Vanhaesebroeck, J C Reed, D De Valck, J Grooten, T Miyashita, S Tanaka, R Beyaert, F Van Roy, W Fier. Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene. vol 8. issue 4. 1993-04-20. PMID:8455935. |
moreover, bcl-2 expression in the interleukin 3 (il-3)-dependent myeloid cell line 32d protected these cells from apoptosis resulting from growth factor deprivation, but not from apoptosis induced by tnf. |
1993-04-20 |
2023-08-12 |
mouse |
| K M Manchester, W D Heston, D B Donne. Tumour necrosis factor-induced cytotoxicity is accompanied by intracellular mitogenic signals in ME-180 human cervical carcinoma cells. The Biochemical journal. vol 290 ( Pt 1). 1993-03-23. PMID:8439287. |
tnf induced dna fragmentation in sensitive cells, suggesting that cytotoxicity occurred via apoptosis. |
1993-03-23 |
2023-08-12 |
human |
| R Munker, L Greither, M Darsow, S Pander, W Wilmann. TNF induces cytoplasmic vesicles in actinomycin D-treated K 562 cells. Annals of hematology. vol 65. issue 1. 1992-09-10. PMID:1643161. |
the formation of these vesicles is characteristic for the combination of actinomycin d with tnf and precedes the changes of apoptosis and cellular disintegration. |
1992-09-10 |
2023-08-11 |
human |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
morphological, biochemical, and kinetic criteria established that tnf activates apoptosis as opposed to necrosis. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
within 2-3 h of exposure to tnf, u937 underwent the morphological alterations characteristic of apoptosis. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
the percentage of cells undergoing apoptosis depended on the concentration of tnf and was augmented by the addition of cycloheximide. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
a tnf-resistant variant derived from u937 did not undergo apoptosis in response to tnf, even in the presence of cycloheximide. |
1992-06-05 |
2023-08-11 |
Not clear |
| S C Wright, P Kumar, A W Tam, N Shen, M Varma, J W Larric. Apoptosis and DNA fragmentation precede TNF-induced cytolysis in U937 cells. Journal of cellular biochemistry. vol 48. issue 4. 1992-06-05. PMID:1577874. |
taken altogether, these data support the hypothesis that activation of apoptosis is at least one essential step in the tnf lytic pathway in the u937 model system. |
1992-06-05 |
2023-08-11 |
Not clear |
| T W Salcedo, H B Flei. Detection of tumor necrosis factor induced nuclear damage with p-phenylenediamine. Journal of immunological methods. vol 148. issue 1-2. 1992-05-19. PMID:1373426. |
using the intercalating dye p-phenylenediamine to stain nuclei, we detected tnf alpha-induced nuclear alterations which characteristically occur during apoptosis in the tnf alpha sensitive u937 cell line. |
1992-05-19 |
2023-08-11 |
Not clear |
| L B Owen-Schaub, S Yonehara, W L Crump, E A Grim. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cellular immunology. vol 140. issue 1. 1992-03-20. PMID:1371242. |
previous studies demonstrated that the anti-fas antibody mediated apoptosis in those cells sensitive to tumor necrosis factor (tnf) and, further, triggered the co-downregulation of tumor necrosis factor receptors (tnf-rs). |
1992-03-20 |
2023-08-11 |
mouse |
| J G Sinkovic. Viral oncolysates as human tumor vaccines. International reviews of immunology. vol 7. issue 4. 1992-03-09. PMID:1663989. |
in contrast, immune t cells (including some til) are mhc-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (tnf beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell dna fragmentation. |
1992-03-09 |
2023-08-11 |
human |
| T Shinagawa, K Yoshioka, S Kakumu, T Wakita, T Ishikawa, Y Itoh, M Takayanag. Apoptosis in cultured rat hepatocytes: the effects of tumour necrosis factor alpha and interferon gamma. The Journal of pathology. vol 165. issue 3. 1992-02-07. PMID:1762032. |
tnf alpha killed cultured rat hepatocytes by increasing apoptosis, and this effect was potentiated by the addition of ifn gamma, which by itself was also weakly cytotoxic. |
1992-02-07 |
2023-08-11 |
rat |
| P Golstein, D M Ojcius, J D Youn. Cell death mechanisms and the immune system. Immunological reviews. vol 121. 1991-12-13. PMID:1937533. |
cell death is strikingly polymorphic: it can proceed via necrosis (as in complement-mediated cell death) or apoptosis, but the latter displays different patterns (in the receptor-mediated death of some thymocytes, in cell death mediated by tnf alpha or by cytotoxic t cells), perhaps reflecting different pathways of control of a common core mechanism. |
1991-12-13 |
2023-08-11 |
Not clear |
| D M Ojcius, A Zychlinsky, L M Zheng, J D Youn. Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Experimental cell research. vol 197. issue 1. 1991-11-21. PMID:1915662. |
two ionophores specific for k+, valinomycin and beauvericin, induce a type of cell death very similar to apoptosis due to tumor necrosis factor (tnf alpha). |
1991-11-21 |
2023-08-11 |
Not clear |
| K Fehsel, V Kolb-Bachofen, H Kol. Analysis of TNF alpha-induced DNA strand breaks at the single cell level. The American journal of pathology. vol 139. issue 2. 1991-09-06. PMID:1867316. |
treatment of l929 cells with tnf alpha initiates apoptosis and subsequent cell death. |
1991-09-06 |
2023-08-11 |
Not clear |