| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
inhibition of transcription with actinomycin d or translation with cycloheximide also resulted in apoptosis, which reached a maximum value of approximately 35 to 40% of cells after 24 h. tnf alpha induction of apoptosis was either potentiated or abrogated by cycloheximide, depending on the timing of tnf alpha exposure in relation to inhibition of protein synthesis. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
when cycloheximide was added concomitantly with midrange concentrations of tnf alpha, there was both a dramatic acceleration and a synergistic increase in the observed apoptotic response, with all endothelial cells dying within 24 h. when cycloheximide was added as a function of time after termination of tnf alpha exposure, the synergistic induction of apoptosis was maintained at > 70% of its maximum value for 1 h, declining monotonically in a time-dependent fashion to baseline values after 6 h. in contrast, when tnf alpha was added after protein synthesis was inhibited, no additional increase in apoptosis above that observed with inhibition of protein synthesis alone was observed. |
1994-11-04 |
2023-08-12 |
cattle |
| V A Polunovsky, C H Wendt, D H Ingbar, M S Peterson, P B Bitterma. Induction of endothelial cell apoptosis by TNF alpha: modulation by inhibitors of protein synthesis. Experimental cell research. vol 214. issue 2. 1994-11-04. PMID:7925652. |
our results are consistent with the concept that endothelial cell viability depends on an interaction of inducers and suppressors of apoptosis, which are susceptible to modulation by tnf alpha. |
1994-11-04 |
2023-08-12 |
cattle |
| M Weller, K Frei, P Groscurth, P H Krammer, Y Yonekawa, A Fontan. Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines. The Journal of clinical investigation. vol 94. issue 3. 1994-10-13. PMID:7521890. |
further, pretreatment with tgf beta 2, il1 and il8 enhanced fas/apo-1 antibody-induced glioma cell apoptosis whereas other cytokines including tnf beta, il6, macrophage colony-stimulating factor, il10 and il13 had no such effect. |
1994-10-13 |
2023-08-12 |
human |
| A Zychlinsky, C Fitting, J M Cavaillon, P J Sansonett. Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. The Journal of clinical investigation. vol 94. issue 3. 1994-10-13. PMID:8083373. |
peritoneal macrophages undergoing apoptosis induced by shigella flexneri infection release the inflammatory cytokine interleukin 1 (il-1), but not il-6 or tumor necrosis factor alpha (tnf alpha). |
1994-10-13 |
2023-08-12 |
Not clear |
| H Albrecht, J Tschopp, C V Jongenee. Bcl-2 protects from oxidative damage and apoptotic cell death without interfering with activation of NF-kappa B by TNF. FEBS letters. vol 351. issue 1. 1994-10-03. PMID:8076691. |
however, bcl-2 had no effect on the activation of nf-kappa b by tnf, even though it protected cells from tnf-induced apoptosis. |
1994-10-03 |
2023-08-12 |
mouse |
| M Grell, G Zimmermann, D Hülser, K Pfizenmaier, P Scheuric. TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways. Journal of immunology (Baltimore, Md. : 1950). vol 153. issue 5. 1994-09-06. PMID:8051401. |
tnf receptors tr60 and tr80 can mediate apoptosis via induction of distinct signal pathways. |
1994-09-06 |
2023-08-12 |
human |
| A Haimovitz-Friedman, C C Kan, D Ehleiter, R S Persaud, M McLoughlin, Z Fuks, R N Kolesnic. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. The Journal of experimental medicine. vol 180. issue 2. 1994-08-30. PMID:8046331. |
the present studies show that ionizing radiation, like tnf, induces rapid sphingomyelin hydrolysis to ceramide and apoptosis in bovine aortic endothelial cells. |
1994-08-30 |
2023-08-12 |
cattle |
| A Fernandez, M C Marin, T McDonnell, H N Ananthaswam. Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells. Oncogene. vol 9. issue 7. 1994-07-14. PMID:8208546. |
these results suggest that tnf-induced cytotoxicity involves apoptosis and that tnf-induced over-expression of bcl-2, c-myc, and mnsod genes is associated with tnf resistance in c3h mouse embryo fibroblasts. |
1994-07-14 |
2023-08-12 |
mouse |
| T Okazaki, S Ozaki, K Naka. CD4+ T cells require adhesion via LFA-1/ICAM-1 to induce target apoptosis in TNF-independent pathway. Cellular immunology. vol 156. issue 1. 1994-07-01. PMID:7911073. |
these results suggest that tnf is the only soluble cytolytic factor involved in cd4+ t cell-mediated cytotoxicity, and that tnf-independent apoptosis occurs through cell-to-cell contact via a lfa-1/icam-1 system. |
1994-07-01 |
2023-08-12 |
Not clear |
| J Wang, S A Stohlman, G Denner. TCR cross-linking induces CTL death via internal action of TNF. Journal of immunology (Baltimore, Md. : 1950). vol 152. issue 8. 1994-05-05. PMID:8144951. |
here we demonstrate that microinjection of ab specific for tnf inhibits activation-induced cell death, implicating tnf in anti-cd3-induced apoptosis. |
1994-05-05 |
2023-08-12 |
Not clear |
| M A Wride, E J Sander. Expression of tumor necrosis factor-alpha (TNF alpha)-cross-reactive proteins during early chick embryo development. Developmental dynamics : an official publication of the American Association of Anatomists. vol 198. issue 3. 1994-04-25. PMID:8136526. |
we hypothesize that the expression of tnf alpha-cross-reactive proteins in early development could be indicative of a role for them in programmed cell death (apoptosis) during differentiation of the notochord, the lens, and the nervous system, and in tissue remodeling. |
1994-04-25 |
2023-08-12 |
mouse |
| G H Wong, D V Goedde. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. Journal of immunology (Baltimore, Md. : 1950). vol 152. issue 4. 1994-04-07. PMID:7509828. |
fas antigen and p55 tnf receptor signal apoptosis through distinct pathways. |
1994-04-07 |
2023-08-12 |
Not clear |
| G H Wong, D V Goedde. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. Journal of immunology (Baltimore, Md. : 1950). vol 152. issue 4. 1994-04-07. PMID:7509828. |
the fas ag and the p55 tnf receptor (tnf-r1) are related molecules that can signal apoptosis. |
1994-04-07 |
2023-08-12 |
Not clear |
| D Couez, F Pagès, M Ragueneau, J Nunès, S Klasen, C Mawas, A Truneh, D Oliv. Functional expression of human CD28 in murine T cell hybridomas. Molecular immunology. vol 31. issue 1. 1994-03-04. PMID:8302298. |
in these transfectants, cd28 mabs, similarly to cd3 mabs, were able to induce ca2+ mobilization, il-2 promoter induction (measured as beta-galactosidase activity in t cells hybridomas pre-transfected with the il-2-lac z reporter gene), il-2 secretion, tnf alpha production and apoptosis (observed as growth arrest and genome fragmentation). |
1994-03-04 |
2023-08-12 |
human |
| R Munker, L Greither, M Darsow, J W Ellwart, R Mailhammer, W Wilmann. Effects of tumor necrosis-factor on primary human leukemia cells: ultrastructural changes. Acta haematologica. vol 90. issue 2. 1994-02-17. PMID:8285022. |
when the dna of leukemic cells treated with tnf was separated on agarose, no fragments characteristic of apoptosis were visible. |
1994-02-17 |
2023-08-12 |
human |
| R Munker, L Greither, M Darsow, J W Ellwart, R Mailhammer, W Wilmann. Effects of tumor necrosis-factor on primary human leukemia cells: ultrastructural changes. Acta haematologica. vol 90. issue 2. 1994-02-17. PMID:8285022. |
our results demonstrate that tnf does not induce direct cytotoxicity or apoptosis in acute or chronic myeloid leukemias and are compatible with the notion that some leukemic cells may be activated or stimulated by tnf. |
1994-02-17 |
2023-08-12 |
human |
| S C Wright, H Zheng, J Zhong, F M Torti, J W Larric. Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants. Journal of cellular biochemistry. vol 53. issue 3. 1994-01-25. PMID:8263039. |
role of protein phosphorylation in tnf-induced apoptosis: phosphatase inhibitors synergize with tnf to activate dna fragmentation in normal as well as tnf-resistant u937 variants. |
1994-01-25 |
2023-08-12 |
Not clear |
| S C Wright, H Zheng, J Zhong, F M Torti, J W Larric. Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants. Journal of cellular biochemistry. vol 53. issue 3. 1994-01-25. PMID:8263039. |
this study examined the role of protein phosphorylation in tnf induction of apoptosis in several tumor cell lines by testing the effects of agents that either stimulate or inhibit protein phosphorylation. |
1994-01-25 |
2023-08-12 |
Not clear |
| T Suda, T Takahashi, P Golstein, S Nagat. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. vol 75. issue 6. 1994-01-21. PMID:7505205. |
the fas antigen (fas) belongs to the tumor necrosis factor (tnf)/nerve growth factor receptor family, and it mediates apoptosis. |
1994-01-21 |
2023-08-12 |
mouse |