| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramesh M Ray, Shi Jin, Mitulkumar N Bavaria, Leonard R Johnso. Regulation of JNK activity in the apoptotic response of intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 5. 2011-06-28. PMID:21350193. |
tnf + cpt caused apoptosis by activating jnk, p38, and caspases-8, -9, and -3. |
2011-06-28 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Shi Jin, Mitulkumar N Bavaria, Leonard R Johnso. Regulation of JNK activity in the apoptotic response of intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 5. 2011-06-28. PMID:21350193. |
when administered with tnf + cpt, sp-600125, a specific inhibitor of mekk4/7, completely inhibited jnk1/2 and decreased apoptosis. |
2011-06-28 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Shi Jin, Mitulkumar N Bavaria, Leonard R Johnso. Regulation of JNK activity in the apoptotic response of intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 5. 2011-06-28. PMID:21350193. |
however, administration of sp-600125 at 1 h after tnf + cpt failed to prevent jnk1/2 phosphorylation, and the protective effect of sp-600125 on apoptosis was abolished. |
2011-06-28 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Shi Jin, Mitulkumar N Bavaria, Leonard R Johnso. Regulation of JNK activity in the apoptotic response of intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 5. 2011-06-28. PMID:21350193. |
taken together, these results suggest that mkp1 activity determines the duration of jnk1/2 and p38 activation and, thereby, apoptosis in response to tnf + cpt. |
2011-06-28 |
2023-08-12 |
Not clear |
| Xin Li, Jian-Ning Wang, Jun-Ming Huang, Xi-Kun Xiong, Mei-Fen Chen, Choon-Nam Ong, Han-Ming Shen, Xing-Fen Yan. Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 3. 2011-06-23. PMID:21195158. |
chrysin promotes tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induced apoptosis in human cancer cell lines. |
2011-06-23 |
2023-08-12 |
human |
| Pauline G Knox, Clare C Davies, Marina Ioannou, Aristides G Eliopoulo. The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. The Journal of cell biology. vol 192. issue 3. 2011-06-22. PMID:21282461. |
this two-step mechanism of apoptosis induction expands our appreciation of commonalities in apoptosis regulatory pathways across the tnf receptor superfamily and provides a telling example of how tnf family receptors usurp alternative programs to fulfill distinct cellular functions. |
2011-06-22 |
2023-08-12 |
Not clear |
| Annalisa Facchini, Ivana Stanic, Silvia Cetrullo, Rosa Maria Borzì, Giuseppe Filardo, Flavio Flamign. Sulforaphane protects human chondrocytes against cell death induced by various stimuli. Journal of cellular physiology. vol 226. issue 7. 2011-06-17. PMID:21506109. |
however it decreased cell death in c-28/i2 chondrocytes exposed to stimuli previously reported to promptly trigger apoptosis, that is, the cytokine tumor necrosis factor-α (tnf) plus cycloheximide (chx) or the polyamine analogue n(1),n(11)-diethylnorspermine (denspm) plus chx. |
2011-06-17 |
2023-08-12 |
human |
| Wen-Juan Li, Yi Chen, Shao-Ping Nie, Ming-Yong Xie, Ming He, Shen-Shen Zhang, Ke-Xue Zh. Ganoderma atrum polysaccharide induces anti-tumor activity via the mitochondrial apoptotic pathway related to activation of host immune response. Journal of cellular biochemistry. vol 112. issue 3. 2011-06-10. PMID:21328459. |
elevation of immune function was also shown during psg-1-induced tumor apoptosis, as evidenced by increase of spleen and thymus indexes, lymphocyte proliferation, concentrations of tumor necrosis factor (tnf)-α, and interleukin-2 in serum. |
2011-06-10 |
2023-08-12 |
mouse |
| Manolis Roulis, Maria Armaka, Menelaos Manoloukos, Maria Apostolaki, George Kollia. Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 13. 2011-06-10. PMID:21402942. |
by contrast, restricted tnfri expression on iec although sufficient to confer iec apoptosis after acute exogenous tnf administration, fails to induce pathology following chronic specific targeting of iec by endogenous tnf in tnf(Δare/+) mice. |
2011-06-10 |
2023-08-12 |
mouse |
| Mathivadhani Panneerselvam, Piyush M Patel, David M Roth, Michael W Kidd, Blake Chin-Lee, Brian P Head, Ingrid R Niesman, Satoki Inoue, Hemal H Patel, Daniel P Davi. Role of decoy molecules in neuronal ischemic preconditioning. Life sciences. vol 88. issue 15-16. 2011-05-31. PMID:21315738. |
decoy receptors bind with tnf related apoptosis inducing ligands (trail) but do not contain the cytoplasmic domains necessary to transduce apoptotic signals. |
2011-05-31 |
2023-08-12 |
Not clear |
| Antonio M Galvao, David W Ramilo, Dariusz J Skarzynski, Karolina Lukasik, Angela Tramontano, Antonio Mollo, Luisa M Mateus, Graca Maria L Ferreira-Dia. Is FAS/Fas ligand system involved in equine corpus luteum functional regression? Biology of reproduction. vol 83. issue 6. 2011-05-27. PMID:20720169. |
the aim of the present work was to determine (i) the presence of the cytokine fasl and its receptor fas in the mare's corpus luteum (cl) throughout the luteal phase, as well as (ii) the influence of fasl alone, or together with the cytokines tumor necrosis factor alpha (tnf) and interferon gamma (ifng), on equine luteal cell production of luteotrophic and luteolytic factors, cell viability, and apoptosis. |
2011-05-27 |
2023-08-12 |
Not clear |
| Amanda M Marchiando, Le Shen, W Vallen Graham, Karen L Edelblum, Carrie A Duckworth, Yanfang Guan, Marshall H Montrose, Jerrold R Turner, Alastair J M Watso. The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. Gastroenterology. vol 140. issue 4. 2011-05-26. PMID:21237166. |
tumor necrosis factor (tnf) increases intestinal epithelial cell shedding and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and internal tissues. |
2011-05-26 |
2023-08-12 |
Not clear |
| Jianqiang Wu, Jawed Siddiqui, Minakshi Nihal, Eric C Vonderheid, Gary S Woo. Structural alterations of the FAS gene in cutaneous T-cell lymphoma (CTCL). Archives of biochemistry and biophysics. vol 508. issue 2. 2011-05-18. PMID:21036138. |
fas (tnf receptor superfamily member 6, also known as cd95) plays a major role in t-cell apoptosis and is often dysregulated in ctcl. |
2011-05-18 |
2023-08-12 |
Not clear |
| Freda Wai-San Lam, Szu-Yin Wu, Shih-Jie Lin, Chin-Chou Lin, Yi-Ming Chen, Han-Ching Wang, Tzong-Yueh Chen, Han-Tso Lin, John Han-You Li. The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae. Fish & shellfish immunology. vol 30. issue 2. 2011-05-18. PMID:21195186. |
the tumour necrosis factor (tnf) super-family is a group of important cytokines involved in inflammation, apoptosis, cell proliferation, and the general stimulation of the immune system. |
2011-05-18 |
2023-08-12 |
Not clear |
| Bo Zhang, Hong Shan, Dan Li, Zheng-Ran Li, Kang-Shun Zhu, Zai-Bo Jiang, Ming-Sheng Huan. Cisplatin sensitizes human hepatocellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152876. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf family of cytokines and has been shown to induce cell apoptosis in many types of tumors, but not in normal cells. |
2011-05-09 |
2023-08-12 |
human |
| Harald Wajant, Peter Scheuric. TNFR1-induced activation of the classical NF-κB pathway. The FEBS journal. vol 278. issue 6. 2011-05-09. PMID:21232017. |
there is evidence that protein modification-independent assembly of a core tnfr1 signaling complex containing tnfr1-associated death domain, receptor interacting kinase 1, tnf receptor-associated factor 2 and cellular inhibitor of apoptosis protein 1 and 2 starts a chain of nondegrading ubiquitination events that culminate in the recruitment and activation of ikk complex-stimulating kinases and the ikk complex itself. |
2011-05-09 |
2023-08-12 |
Not clear |
| David Moquin, Francis Ka-Ming Cha. The molecular regulation of programmed necrotic cell injury. Trends in biochemical sciences. vol 35. issue 8. 2011-05-05. PMID:20346680. |
recent evidence indicates that an elaborate biochemical network emanating from receptors in the tnf superfamily can induce apoptosis as well as necrotic cell death. |
2011-05-05 |
2023-08-12 |
Not clear |
| Olivia M Merkel, Andrea Beyerle, Benedikt M Beckmann, Mengyao Zheng, Roland K Hartmann, Tobias Stöger, Thomas H Kisse. Polymer-related off-target effects in non-viral siRNA delivery. Biomaterials. vol 32. issue 9. 2011-04-28. PMID:21183213. |
gene expression profiling confirmed that h1299/luc cells underwent apoptosis via thousand-fold activation of tnf receptor-associated factors. |
2011-04-28 |
2023-08-12 |
Not clear |
| Elizabeth H Humphreys, Kevin T Williams, David H Adams, Simon C Affor. Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand. PloS one. vol 5. issue 11. 2011-04-27. PMID:21103345. |
functional deficiency of cd154, the ligand for cd40, leads to a failure of clearance of biliary tract infections and a predisposition to cholangiocarcinoma implying a direct link between tnf receptor-mediated apoptosis and the development of cholangiocarcinoma. |
2011-04-27 |
2023-08-12 |
human |
| K Puszynski, R Bertolusso, T Lipniack. Crosstalk between p53 and nuclear factor-B systems: pro- and anti-apoptotic functions of NF-B. IET systems biology. vol 3. issue 5. 2011-04-21. PMID:21028926. |
tnf stimulation, preceding dna damaging irradiation, makes cells more resistant to irradiation-induced apoptosis, whereas the same tnf stimulation, when preceded by irradiation, increases the apoptotic cell fraction. |
2011-04-21 |
2023-08-12 |
Not clear |