| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joerg Ebmeyer, Anke Leichtle, Michelle Hernandez, Umay Ebmeyer, Jacob Husseman, Kwang Pak, Holger Sudhoff, David Broide, Stephen I Wasserman, Allen F Rya. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC immunology. vol 12. 2011-04-20. PMID:21269505. |
tumor necrosis factor (tnfa) is the canonical member of the tnf superfamily, which plays a major role in both inflammation and apoptosis. |
2011-04-20 |
2023-08-12 |
mouse |
| Joerg Ebmeyer, Anke Leichtle, Michelle Hernandez, Umay Ebmeyer, Jacob Husseman, Kwang Pak, Holger Sudhoff, David Broide, Stephen I Wasserman, Allen F Rya. TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media. BMC immunology. vol 12. 2011-04-20. PMID:21269505. |
to evaluate the role of tnfs in otitis media (om), the most common disease of childhood, we evaluated middle ear (me) expression of genes encoding the tnf and tnf receptor superfamilies during bacterial om in the mouse, characterized om in tnfa-deficient mice, and assessed apoptosis during om in normal versus tnf-deficient mes. |
2011-04-20 |
2023-08-12 |
mouse |
| Helen L Wright, Batsi Chikura, Roger C Bucknall, Robert J Moots, Steven W Edward. Changes in expression of membrane TNF, NF-{kappa}B activation and neutrophil apoptosis during active and resolved inflammation. Annals of the rheumatic diseases. vol 70. issue 3. 2011-04-15. PMID:21109521. |
changes in expression of membrane tnf, nf-{kappa}b activation and neutrophil apoptosis during active and resolved inflammation. |
2011-04-15 |
2023-08-12 |
Not clear |
| Ken Kobayashi, Kazuo Umezawa, Masato Yasu. Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biology of reproduction. vol 84. issue 2. 2011-04-12. PMID:20926808. |
apoptosis in mouse amniotic epithelium is induced by activated macrophages through the tnf receptor type 1/tnf pathway. |
2011-04-12 |
2023-08-12 |
mouse |
| Ken Kobayashi, Kazuo Umezawa, Masato Yasu. Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biology of reproduction. vol 84. issue 2. 2011-04-12. PMID:20926808. |
furthermore, dehydroxymethylepoxyquinomicin, a specific nuclear factor-kappa b inhibitor, was found to inhibit tnf production in macrophages and amniotic apoptosis in vivo. |
2011-04-12 |
2023-08-12 |
mouse |
| Ken Kobayashi, Kazuo Umezawa, Masato Yasu. Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biology of reproduction. vol 84. issue 2. 2011-04-12. PMID:20926808. |
finally, we showed that injection of tnf into the amniotic cavity induces early onset of apoptosis. |
2011-04-12 |
2023-08-12 |
mouse |
| Ken Kobayashi, Kazuo Umezawa, Masato Yasu. Apoptosis in mouse amniotic epithelium is induced by activated macrophages through the TNF receptor type 1/TNF pathway. Biology of reproduction. vol 84. issue 2. 2011-04-12. PMID:20926808. |
these results indicate that amniotic apoptosis is induced by the tnf pathway via tnfr1 expressed in the amniotic epithelial cells and that activation of macrophages may trigger amniotic apoptosis. |
2011-04-12 |
2023-08-12 |
mouse |
| Haja N Kadarmideen, Nathan S Watson-Haigh, Nicholas M Andronico. Systems biology of ovine intestinal parasite resistance: disease gene modules and biomarkers. Molecular bioSystems. vol 7. issue 1. 2011-03-24. PMID:21072409. |
in tc networks, biomarkers were significantly associated with functions such as protein catabolic process, heat shock protein binding, protein targeting and localization, cytokine receptor binding, tnf receptor binding, apoptosis and igf binding. |
2011-03-24 |
2023-08-12 |
cat |
| Rui-Xue Leng, Hai-Feng Pan, Wei-Zi Qin, Chao Wang, Li-Li Chen, Jin-Hui Tao, Dong-Qing Y. TWEAK as a target for therapy in systemic lupus erythematosus. Molecular biology reports. vol 38. issue 1. 2011-03-21. PMID:20358293. |
tumor necrosis factor (tnf)-like weak inducer of apoptosis (tweak) is a recently identified proinflammatory cytokine of the tnf superfamily. |
2011-03-21 |
2023-08-12 |
Not clear |
| M Won, K A Park, H S Byun, K-C Sohn, Y-R Kim, J Jeon, J H Hong, J Park, J H Seok, J M Kim, W-H Yoon, I-S Jang, H M Shen, Z G Liu, G M Hu. Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation. Cell death and differentiation. vol 17. issue 12. 2011-03-10. PMID:20448643. |
the zinc-finger protein a20 has crucial physiological functions as a dual inhibitor of nuclear factor-κb (nf-κb) activation and apoptosis in tumor necrosis factor (tnf) receptor 1 signaling pathway. |
2011-03-10 |
2023-08-12 |
Not clear |
| M Won, K A Park, H S Byun, K-C Sohn, Y-R Kim, J Jeon, J H Hong, J Park, J H Seok, J M Kim, W-H Yoon, I-S Jang, H M Shen, Z G Liu, G M Hu. Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation. Cell death and differentiation. vol 17. issue 12. 2011-03-10. PMID:20448643. |
taken together, the results from this study reveal a novel anti-apoptotic mechanism of a20 in tnf signaling pathway: a20 binds to ask1 and mediates ask1 degradation, leading to suppression of jnk activation and eventually blockage of apoptosis. |
2011-03-10 |
2023-08-12 |
Not clear |
| Jeremy A Goettel, Dongchun Liang, Valda C Hilliard, Karen L Edelblum, Matthew R Broadus, Kathleen L Gould, Steven K Hanks, D Brent Pol. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Experimental cell research. vol 317. issue 4. 2011-03-08. PMID:21144847. |
we found that +vector and +d683a/d700a cells underwent apoptosis when treated with tnf, whereas +ksr1 cells were resistant. |
2011-03-08 |
2023-08-12 |
Not clear |
| Subhan Dudekula, Ming-Hui Lee, Li-Jin Hsu, Shean-Jen Chen, Nan-Shan Chan. Zfra is a small wizard in the mitochondrial apoptosis. Aging. vol 2. issue 12. 2011-03-04. PMID:21212468. |
zfra (zinc finger-like protein that regulates apoptosis) is a naturally occurring short peptide consisting of 31 amino acids, which regulates tumor necrosis factor (tnf)-mediated cell death by interacting with receptor adaptor protein tradd (tnf receptorassociated death domain protein) and downstream jnk (c-jun n-terminal kinase), nf-κb (nuclear factor kappa b) and wwox/wox1 (ww domain-containing oxidoreductase). |
2011-03-04 |
2023-08-12 |
Not clear |
| Chung Soo Lee, Eun-Ra Jang, Yun Jeong Kim, Seong Jun Seo, Sun Eun Choi, Min Won Le. Polyphenol acertannin prevents TRAIL-induced apoptosis in human keratinocytes by suppressing apoptosis-related protein activation. Chemico-biological interactions. vol 189. issue 1-2. 2011-03-01. PMID:20971099. |
the tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has been implicated in the inflammatory and immune responses, and apoptosis in skin diseases, such as atopic dermatitis. |
2011-03-01 |
2023-08-12 |
human |
| Yunquan Zheng, Yanwen Xin, Xianai Shi, Yanghao Gu. Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Applied microbiology and biotechnology. vol 88. issue 5. 2011-02-28. PMID:20730532. |
tnf was considered as a major mediator of apoptosis induced by rubropunctatin. |
2011-02-28 |
2023-08-12 |
mouse |
| Bärbel Edelmann, Uwe Bertsch, Vladimir Tchikov, Supandi Winoto-Morbach, Cristiana Perrotta, Marten Jakob, Sabine Adam-Klages, Dieter Kabelitz, Stefan Schütz. Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. The EMBO journal. vol 30. issue 2. 2011-02-22. PMID:21157428. |
we previously demonstrated that tumour necrosis factor (tnf)-induced ceramide production by endosomal acid sphingomyelinase (a-smase) couples to apoptosis signalling via activation of cathepsin d and cleavage of bid, resulting in caspase-9 and caspase-3 activation. |
2011-02-22 |
2023-08-12 |
Not clear |
| Jana Luetzkendorf, Lutz P Mueller, Thomas Mueller, Henrike Caysa, Katrin Nerger, Hans-Joachim Schmol. Growth inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence. Journal of cellular and molecular medicine. vol 14. issue 9. 2011-02-17. PMID:19508388. |
tumour necrosis factor (tnf)-related apoptosis inducing ligand (trail) which promises apoptosis induction preferentially in tumour cells represents such a factor. |
2011-02-17 |
2023-08-12 |
human |
| Vincent M Paulino, Zhongbo Yang, Jean Kloss, Matthew J Ennis, Brock A Armstrong, Joseph C Loftus, Nhan L Tra. TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling. Molecular cancer research : MCR. vol 8. issue 11. 2011-02-17. PMID:20881009. |
members of the tumor necrosis factor (tnf) ligand superfamily and their cognate receptors regulate various cellular responses including proliferation, migration, differentiation, and apoptosis. |
2011-02-17 |
2023-08-12 |
Not clear |
| Jesper B Andersen, Valentina M Factor, Jens U Marquardt, Chiara Raggi, Yun-Han Lee, Daekwan Seo, Elizabeth A Conner, Snorri S Thorgeirsso. An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer. Science translational medicine. vol 2. issue 54. 2011-02-01. PMID:20962331. |
in drug-sensitive cell lines, zebularine caused inhibition of proliferation coupled with increased apoptosis, whereas drug-resistant cell lines showed up-regulation of oncogenic networks (for example, e2f1, myc, and tnf) that drive liver cancer growth in vitro and in preclinical mouse models. |
2011-02-01 |
2023-08-12 |
mouse |
| Dinesh Kumar Agrawal, Pushpesh Kumar Mishr. Curcumin and its analogues: potential anticancer agents. Medicinal research reviews. vol 30. issue 5. 2011-01-27. PMID:20027668. |
it has been shown to interfere with multiple cell signaling pathways, including apoptosis (activation of caspases and downregulation of antiapoptotic gene products), proliferation (her-2, egfr, and ap-1), angiogenesis (vegf), and inflammation (nf-kappab, tnf, il-6, il-1, cox-2, and 5-lox). |
2011-01-27 |
2023-08-12 |
Not clear |