| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Liu, Lei Wang, Takashi Kikuiri, Kentaro Akiyama, Chider Chen, Xingtian Xu, Ruili Yang, Wanjun Chen, Songlin Wang, Songtao Sh. Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α. Nature medicine. vol 17. issue 12. 2012-02-02. PMID:22101767. |
we also found that, through inhibition of nuclear factor κb (nf-κb), tnf-α converts the signaling of the ifn-γ-activated, nonapoptotic form of tnf receptor superfamily member 6 (fas) in bmmscs to a caspase 3- and caspase 8-associated proapoptotic cascade, resulting in the apoptosis of these cells. |
2012-02-02 |
2023-08-12 |
mouse |
| Nives Pustisek, Mirna Situ. UV-radiation, apoptosis and skin. Collegium antropologicum. vol 35 Suppl 2. 2012-01-31. PMID:22220467. |
the extrinsic pathway through death receptors such as fibroblast-associated, tumour necrosis factor receptor and tnf related apoptosis inducing ligand receptor activate caspase cascade. |
2012-01-31 |
2023-08-12 |
Not clear |
| Marie Anne O'Donnell, Eva Perez-Jimenez, Andrew Oberst, Aylwin Ng, Ramin Massoumi, Ramnik Xavier, Douglas R Green, Adrian T Tin. Caspase 8 inhibits programmed necrosis by processing CYLD. Nature cell biology. vol 13. issue 12. 2012-01-26. PMID:22037414. |
caspase 8 initiates apoptosis downstream of tnf death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. |
2012-01-26 |
2023-08-12 |
Not clear |
| Florian R Grete. TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma. Journal of hepatology. vol 55. issue 3. 2012-01-23. PMID:21601601. |
tak1-mediated cancer suppression is exerted through activating nf-kappab in response to tumor necrosis factor (tnf) and through preventing caspase-3-dependent hepatocyte and cholangiocyte apoptosis. |
2012-01-23 |
2023-08-12 |
Not clear |
| Jing Zhao, Yixin Lu, Han-Ming She. Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells. Cancer letters. vol 314. issue 1. 2012-01-18. PMID:22030255. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) has been intensively studied as a cancer therapeutic agent due to its unique ability to induce apoptosis in malignant cells but not in normal cells. |
2012-01-18 |
2023-08-12 |
human |
| Chung S Lee, Yun J Kim, Wonyong Kim, Soon C Myun. Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins. Basic & clinical pharmacology & toxicology. vol 109. issue 4. 2012-01-12. PMID:21554547. |
to assess the ability of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (yc-1) to promote apoptosis, we investigated the effect of yc-1 on tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis in the human epithelial ovarian carcinoma cell lines. |
2012-01-12 |
2023-08-12 |
human |
| Miho Nagai, Kouichi Hirayama, Itaru Ebihara, Takashi Higuchi, Masahiro Imaizumi, Hiroshi Maruyama, Yasunori Miyamoto, Tomoko Kakita, Yujiro Ogawa, Shogo Fujita, Homare Shimohata, Masaki Kobayash. Serum TNF-related and weak inducer of apoptosis levels in septic shock patients. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. vol 15. issue 4. 2012-01-12. PMID:21884467. |
we have previously reported elevated levels of angiopoietin-2 in patients with septic shock, and have investigated tumor necrosis factor (tnf)-related and weak inducer of apoptosis (tweak), which mediates both angiogenesis and inflammation, in those patients. |
2012-01-12 |
2023-08-12 |
Not clear |
| Jennifer S Michaelson, Aldo Amatucci, Rebecca Kelly, Lihe Su, Ellen Garber, Eric S Day, Lisa Berquist, Sandy Cho, You Li, Michael Parr, Laure Wille, Pascal Schneider, Kathleen Wortham, Linda C Burkly, Yen-Ming Hsu, Ingrid B J K Josep. Development of an Fn14 agonistic antibody as an anti-tumor agent. mAbs. vol 3. issue 4. 2012-01-11. PMID:21697654. |
studies described herein show that biib036 binds specifically to fn14 but not other members of the tnf receptor family, induces fn14 signaling, and promotes tumor cell apoptosis in vitro. |
2012-01-11 |
2023-08-12 |
human |
| You-Jin Lee, Jae-Won Seol, Jae-Kyo Jeong, Myung-Hee Moon, Sang-Youel Par. Inhibition of the ubiquitin-proteasome system sensitizes TRAIL-resistant prostate cancer cells by up-regulation of death receptor 5. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21850375. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a type ii transmembrane cytokine and a potent inducer of apoptosis in cancer cells. |
2012-01-09 |
2023-08-12 |
Not clear |
| Parameswaran Ramakrishnan, David Baltimor. Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor. Molecular cell. vol 43. issue 2. 2012-01-03. PMID:21620750. |
sam68 is required for both nf-κb activation and apoptosis signaling by the tnf receptor. |
2012-01-03 |
2023-08-12 |
Not clear |
| Parameswaran Ramakrishnan, David Baltimor. Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor. Molecular cell. vol 43. issue 2. 2012-01-03. PMID:21620750. |
these findings delineate previously unknown functions for sam68 in the tnf signaling pathway, where it acts as a signaling adaptor both in the membrane-associated complex i and in the cytoplasmic complex ii, regulating both nf-κb activation and apoptosis. |
2012-01-03 |
2023-08-12 |
Not clear |
| S Herman, N Zurgil, S Machlav, A Shinberg, P Langevitz, M Ehrenfeld, M Deutsc. Distinct effects of anti-tumor necrosis factor combined therapy on TH1/TH2 balance in rheumatoid arthritis patients. Clinical and vaccine immunology : CVI. vol 18. issue 7. 2011-12-27. PMID:21593236. |
the therapeutic effect of mtx and tnf blockers may be due to apoptosis induction in lymphocytes infiltrating from the inflammation site and restoring the th1/th2 balance. |
2011-12-27 |
2023-08-12 |
Not clear |
| Sumit K Sood, Sabapathy Balasubramanian, Sue Higham, Malee Fernando, Barney Harriso. Osteoprotegerin (OPG) and related proteins (RANK, RANKL and TRAIL) in thyroid disease. World journal of surgery. vol 35. issue 9. 2011-12-23. PMID:21748518. |
osteoprotegerin (opg), receptor activator of nuclear factor kappab (rank), rank ligand (rankl), and tnf related apoptosis inducing ligand (trail) are the key proteins in the development of bone metastases. |
2011-12-23 |
2023-08-12 |
Not clear |
| Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoor. Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. PloS one. vol 6. issue 8. 2011-12-19. PMID:21853060. |
the cytokines tnf (tnfsf2) and ifnγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions. |
2011-12-19 |
2023-08-12 |
Not clear |
| Kati Juuti-Uusitalo, Leon J Klunder, Klaas A Sjollema, Katarina Mackovicova, Ryuichi Ohgaki, Dick Hoekstra, Jan Dekker, Sven C D van Ijzendoor. Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. PloS one. vol 6. issue 8. 2011-12-19. PMID:21853060. |
apoptosis and tight junctions are also important for epithelial tissue morphogenesis, but the effect of tnf and ifnγ on the process of intestinal epithelial morphogenesis is unknown. |
2011-12-19 |
2023-08-12 |
Not clear |
| Julie Devallière, Béatrice Charrea. The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling. Biochemical pharmacology. vol 82. issue 10. 2011-12-16. PMID:21723852. |
in ec, lnk is a negative regulator of tnf signaling that reduce proinflammatory phenotype and prevent ec from apoptosis. |
2011-12-16 |
2023-08-12 |
Not clear |
| Byoungduck Park, Bokyung Sung, Vivek R Yadav, Madan M Chaturvedi, Bharat B Aggarwa. Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway. Biochemical pharmacology. vol 82. issue 9. 2011-12-16. PMID:21820422. |
this led to enhancement of apoptosis induced by tnf, taxol, and thalidomide by the diterpene and to suppression of tumor invasion. |
2011-12-16 |
2023-08-12 |
Not clear |
| G K Deb, S R Dey, J I Bang, S J Cho, H C Park, J G Lee, I K Kon. 9-cis retinoic acid improves developmental competence and embryo quality during in vitro maturation of bovine oocytes through the inhibition of oocyte tumor necrosis factor-α gene expression. Journal of animal science. vol 89. issue 9. 2011-12-14. PMID:21478451. |
moreover, 9-cis ra rescued (p < 0.001) development rates (24.5 ± 11.1 vs. 15.6 ± 9.0%), increased total cell number (124.6 ± 36.5 vs. 106.9 ± 31.1), and reduced apoptosis (5.8 ± 2.0 vs. 8.1 ± 3.1%) in blastocysts exposed to tnf-α (tnf group). |
2011-12-14 |
2023-08-12 |
cattle |
| Adrienne Chen, H Steven Seifer. Neisseria gonorrhoeae-mediated inhibition of apoptotic signalling in polymorphonuclear leukocytes. Infection and immunity. vol 79. issue 11. 2011-12-08. PMID:21844239. |
we developed and validated an hl-60 myeloid leukemia cell culture model for pmn infection and used both these cells and primary pmns to show that n. gonorrhoeae infection alone does not induce apoptosis and furthermore that n. gonorrhoeae can inhibit both spontaneous apoptosis and apoptosis induced by the intrinsic and extrinsic apoptosis inducers staurosporine (sts) and tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), respectively. |
2011-12-08 |
2023-08-12 |
human |
| Jennifer K Schroeder, Cherie A Kessler, Stuart Handwerge. Critical role for TWIST1 in the induction of human uterine decidualization. Endocrinology. vol 152. issue 11. 2011-12-08. PMID:21914771. |
the huf cells pretreated with the twist1 sirna also underwent less apoptosis during decidualization than the control cells, as evidenced by a 20% decrease in dna fragmentation (terminal deoxynucleotidyl transferase 2'-deoxyuridine, 5'-triphosphate nick end labeling assay) and a 43-48% decrease in caspase 3, bcl2-associated x protein, and tnf receptor superfamily member 6 mrna levels. |
2011-12-08 |
2023-08-12 |
human |