| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiro Yamana, Eric F Morand, Tsuno Manabu, Katsue Sunahori, Kouji Takasugi, Hirofumi Makino, Masahiro Yamamur. Inhibition of TNF-induced IL-6 by the TWEAK-Fn14 interaction in rheumatoid arthritis fibroblast like synoviocytes. Cellular immunology. vol 272. issue 2. 2012-04-30. PMID:22055894. |
tnf-like weak inducer of apoptosis (tweak), a member of the tnf superfamily, has been shown to increase cytokine production by rheumatoid arthritis (ra) fibroblast-like synoviocytes (fls). |
2012-04-30 |
2023-08-12 |
Not clear |
| Chung-Ting Tsai, Kazuya Ikematsu, Sayaka Sakai, Aya Matsuo, Ichiro Nakason. Expression of Bcl2l1, Clcf1, IL-28ra and Pias1 in the mouse heart after single and repeated administration of chlorpromazine. Legal medicine (Tokyo, Japan). vol 13. issue 5. 2012-04-11. PMID:21683644. |
after stimulation of tnf, the janus kinase signal transducer and activator of transcription (jak-stat) signaling pathway is activated via tnf receptor (tnf-r), and the pathway participates in the regulation of cellular responses such as apoptosis [1]. |
2012-04-11 |
2023-08-12 |
mouse |
| N Vanlangenakker, M J M Bertrand, P Bogaert, P Vandenabeele, T Vanden Bergh. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell death & disease. vol 2. 2012-04-10. PMID:22089168. |
we previously reported that cellular inhibitor of apoptosis protein-mediated receptor-interacting protein 1 (rip1) ubiquitination acts as a cytoprotective mechanism, whereas knockdown of cylindromatosis, a rip1-deubiquitinating enzyme, protects against tumor necrosis factor (tnf)-induced necroptosis. |
2012-04-10 |
2023-08-12 |
Not clear |
| Alberto Anel, Luis Martinez-Losta. APO2L/TRAIL: new insights in the treatment of autoimmune disorders. Recent patents on inflammation & allergy drug discovery. vol 5. issue 3. 2012-04-06. PMID:21827400. |
apo2 ligand/tnf related apoptosis-inducing ligand (apo2l/trail) is a cytokine that belongs to the tnf superfamilily that was described as capable of inducing apoptosis on tumor cells through activation of the extrinsic pathway in a fas-independent manner. |
2012-04-06 |
2023-08-12 |
Not clear |
| Fabrice Moore, Daniel A Cunha, Hindrik Mulder, Decio L Eiziri. Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells. Methods in molecular biology (Clifton, N.J.). vol 820. 2012-03-28. PMID:22131032. |
in vitro exposure of beta cells to the cytokines interleukin(il)-1β + interferon(ifn)-γ or to tumor necrosis factor(tnf)-α + ifn-γ induces beta cell dysfunction and ultimately apoptosis. |
2012-03-28 |
2023-08-12 |
Not clear |
| Yoko Ishimoto, Hideo Satsu, Mamoru Totsuka, Makoto Shimiz. IEX-1 suppresses apoptotic damage in human intestinal epithelial Caco-2 cells induced by co-culturing with macrophage-like THP-1 cells. Bioscience reports. vol 31. issue 5. 2012-03-26. PMID:21250941. |
increases in caspase 3 activity and tnfr1 (tnf receptor 1) mrna expression were shown in iex-1-knockdown caco-2 cells, suggesting that iex-1 plays a role in the suppression of apoptosis and protects cells by controlling sensitivity to tnfα under both normal and inflammatory conditions. |
2012-03-26 |
2023-08-12 |
human |
| Kyung-Jin Park, Chang-Han Lee, Aeyung Kim, Ki Jun Jeong, Chul-Ho Kim, Yong-Sung Ki. Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death. The Journal of biological chemistry. vol 287. issue 5. 2012-03-22. PMID:22158615. |
stimulation of the proapoptotic tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors, death receptors 4 (dr4) and 5 (dr5), conventionally induces caspase-dependent apoptosis in tumor cells. |
2012-03-22 |
2023-08-12 |
human |
| R Yerbes, C Palacios, A López-Riva. The therapeutic potential of TRAIL receptor signalling in cancer cells. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 13. issue 12. 2012-03-20. PMID:22126726. |
the tumour necrosis-related apoptosisinducing ligand (trail) is a member of the tnf family capable of inducing apoptosis in a wide variety of cancer cells upon binding to pro-apoptotic receptors, while having no effect on the majority of normal human cells tested. |
2012-03-20 |
2023-08-12 |
mouse |
| Bharat B Aggarwal, Subash C Gupta, Ji Hye Ki. Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey. Blood. vol 119. issue 3. 2012-03-13. PMID:22053109. |
the roles of the tnf superfamily in inflammation, apoptosis, proliferation, invasion, angiogenesis, metastasis, and morphogenesis have been documented. |
2012-03-13 |
2023-08-12 |
Not clear |
| Joan Fernando, Patricia Sancho, Conrado M Fernández-Rodriguez, José L Lledó, Laia Caja, Jean S Campbell, Nelson Fausto, Isabel Fabrega. Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli. Journal of cellular physiology. vol 227. issue 4. 2012-03-05. PMID:21604268. |
interestingly, sensitization to sorafenib-induced apoptosis is characteristic of liver tumor cells, since untransformed hepatocytes did not respond to sorafenib inducing apoptosis, either alone or in combination with tgf-β or tnf. |
2012-03-05 |
2023-08-12 |
human |
| I Ikonomidis, S Tzortzis, J Lekakis, I Paraskevaidis, P Dasou, J Parissis, M Nikolaou, S L Markantonis, P Katsimbri, G Skarantavos, I Andreadou, M Anastasiou-Nan. Association of soluble apoptotic markers with impaired left ventricular deformation in patients with rheumatoid arthritis. Effects of inhibition of interleukin-1 activity by anakinra. Thrombosis and haemostasis. vol 106. issue 5. 2012-02-29. PMID:21947196. |
at baseline, 3 h and 30 days after treatment, we measured circulating il-1β, tumour necrosis factor (tnf)-α, fas, fas-ligand and caspase-9 to assess apoptosis. |
2012-02-29 |
2023-08-12 |
Not clear |
| Andreas Kerstan, E-B Bröcker, A Trautman. Decisive role of tumor necrosis factor-α for spongiosis formation in acute eczematous dermatitis. Archives of dermatological research. vol 303. issue 9. 2012-02-24. PMID:21553284. |
as compared to cd95-triggering alone, synchronous cd95 and tnf receptor cross-linking in the presence of ifn-γ only marginally enhanced kc apoptosis. |
2012-02-24 |
2023-08-12 |
human |
| Carlo V Hojilla, Hartland W Jackson, Rama Khokh. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053204. |
timp3 regulates mammary epithelial apoptosis with immune cell recruitment through differential tnf dependence. |
2012-02-24 |
2023-08-12 |
mouse |
| Carlo V Hojilla, Hartland W Jackson, Rama Khokh. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053204. |
here we show that timp3 deficiency leads to tnf dysregulation, earlier caspase activation and onset of mitochondrial apoptosis. |
2012-02-24 |
2023-08-12 |
mouse |
| Carlo V Hojilla, Hartland W Jackson, Rama Khokh. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. PloS one. vol 6. issue 10. 2012-02-24. PMID:22053204. |
the data indicate that timp3 differentially impacts apoptosis and inflammatory cell influx, based on involvement of tnf, during the process of mammary involution. |
2012-02-24 |
2023-08-12 |
mouse |
| [Polymorphism of TNF gene and CPOX gene in chemical industry workers]. Meditsina truda i promyshlennaia ekologiia. issue 11. 2012-02-23. PMID:22288185. |
findings are peculiarities of genetic polymorphism of cpox gene and tnf gene, and their association with biologic media contamination with methylated phenols (m-cresol) and apoptosis disorders. |
2012-02-23 |
2023-08-12 |
Not clear |
| Woe Yeon Kim, Sun Yong Lee, Young Jun Jung, Ho Byoung Chae, Ganesh M Nawkar, Mi Rim Shin, Sun Young Kim, Jin Ho Park, Chang Ho Kang, Yong Hun Chi, Il Pyung Ahn, Dae Jin Yun, Kyun Oh Lee, Young-Myeong Kim, Min Gab Kim, Sang Yeol Le. Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systems. The Journal of biological chemistry. vol 286. issue 49. 2012-02-21. PMID:21926169. |
the expression of atilp in hela cells conferred resistance against tumor necrosis factor (tnf)-α/actd-induced apoptosis through the inactivation of caspase activity. |
2012-02-21 |
2023-08-12 |
Not clear |
| Yingying Li, Lin Wan, Hao Yang, Shan Liu, Huawei Cai, Xiaofeng L. [Cloning and recombinant expression of human soluble TRAIL in Pichia pastoris]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 27. issue 6. 2012-02-16. PMID:21374984. |
tnf-related apoptosis-inducing ligand (trail) is a member of factor tnf family, which could be potentially developed as novel antitumor agent due to its selective and efficient induction of apoptosis in tumor cells. |
2012-02-16 |
2023-08-12 |
human |
| Linda C Burkly, Jennifer S Michaelson, Timothy S Zhen. TWEAK/Fn14 pathway: an immunological switch for shaping tissue responses. Immunological reviews. vol 244. issue 1. 2012-02-09. PMID:22017434. |
while much of the molecular basis underlying the immune regulation of tissue responses remains to be delineated, the tumor necrosis factor (tnf) superfamily ligand/receptor pair of tnf-like weak inducer of apoptosis (tweak) and fibroblast growth factor-inducible molecule 14 (fn14) has now emerged as a key piece of this puzzle. |
2012-02-09 |
2023-08-12 |
Not clear |
| Raja Atreya, Michael Zimmer, Brigitte Bartsch, Maximilian J Waldner, Imke Atreya, Helmut Neumann, Kai Hildner, Arthur Hoffman, Ralf Kiesslich, Andreas D Rink, Tilman T Rau, Stefan Rose-John, Hermann Kessler, Jan Schmidt, Markus F Neurat. Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages. Gastroenterology. vol 141. issue 6. 2012-02-06. PMID:21875498. |
antibodies against tumor necrosis factor (tnf) induce t-cell apoptosis in patients with inflammatory bowel diseases via tnf receptor 2 and intestinal cd14⁺ macrophages. |
2012-02-06 |
2023-08-12 |
Not clear |