| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Kothny-Wilkes, D Kulms, T A Luger, M Kubin, T Schwar. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. The Journal of biological chemistry. vol 274. issue 41. 1999-11-09. PMID:10506136. |
tumor necrosis factor-related apoptosis-inducing ligand (trail), a new member of the tumor necrosis factor (tnf) family, induces apoptosis primarily of transformed cells. |
1999-11-09 |
2023-08-12 |
Not clear |
| G Kothny-Wilkes, D Kulms, T A Luger, M Kubin, T Schwar. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. The Journal of biological chemistry. vol 274. issue 41. 1999-11-09. PMID:10506136. |
accordingly, enhanced apoptosis was reduced by blocking the tnf receptor-1. |
1999-11-09 |
2023-08-12 |
Not clear |
| M K Balcewicz-Sablinska, H Gan, H G Remol. Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-alpha activity. The Journal of infectious diseases. vol 180. issue 4. 1999-11-08. PMID:10479152. |
normal human macrophages respond to infection with mycobacterium avium, serovar 4, by producing tumor necrosis factor (tnf)-alpha, which mediates apoptosis, and by elaborating interleukin (il)-10, a tnf-alpha antagonist. |
1999-11-08 |
2023-08-12 |
human |
| M K Balcewicz-Sablinska, H Gan, H G Remol. Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-alpha activity. The Journal of infectious diseases. vol 180. issue 4. 1999-11-08. PMID:10479152. |
we show that il-10 down-regulates apoptosis by inhibiting the tnf-alpha production of the inoculated macrophages and by inducing the release of soluble tnf receptor type 2 from the macrophages, which leads to inactivation of tnf-alpha. |
1999-11-08 |
2023-08-12 |
human |
| b' I S Mathiasen, U Lademann, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. Cancer research. vol 59. issue 19. 1999-11-04. PMID:10519395.' |
inhibition of caspase activation by overexpression of a cowpox-derived caspase inhibitor crma or by addition of inhibitory peptides acetyl-asp-glu-val-asp-aldehyde (200 microm), acetyl-ile-glu-thr-asp-aldehyde (50 microm), and z-val-ala-d,l-asp-fluoromethylketone (1 microm) showed no effect on the induction of growth arrest or apoptosis by vitamin d compounds under assay conditions in which apoptosis induced by tnf or staurosporine was effectively inhibited. |
1999-11-04 |
2023-08-12 |
human |
| Y Takada, M Hachiya, Y Osawa, Y Hasegawa, K Ando, Y Kobayashi, M Akash. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells. The Journal of biological chemistry. vol 274. issue 40. 1999-11-02. PMID:10497185. |
we also found that the induction of apoptosis by tpa was increased in cells overexpressed with tnf receptor 1 but not in control cells. |
1999-11-02 |
2023-08-12 |
human |
| B L Musgrave, T Phu, J J Butler, A P Makrigiannis, D W Hoski. Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by rapamycin, cyclosporin A, and inhibitors of phosphatidylinositol 3-kinase, protein kinase C, and protein tyrosine kinases: evidence for TRAIL induction via the T cell receptor signaling pathway. Experimental cell research. vol 252. issue 1. 1999-11-01. PMID:10502402. |
trail (tnf-related apoptosis inducing ligand), like other members of the tnf family of proteins, is able to induce apoptosis in sensitive target cells. |
1999-11-01 |
2023-08-12 |
mouse |
| J L Cook, B A Routes, C Y Leu, T A Walker, K L Colvi. E1A oncogene-induced cellular sensitization to immune-mediated apoptosis is independent of p53 and resistant to blockade by E1B 19 kDa protein. Experimental cell research. vol 252. issue 1. 1999-11-01. PMID:10502412. |
in this study, the roles of p53 and e1b 19 kda were tested for e1a sensitization to cl-induced apoptosis in contrast with apoptosis triggered by tnf alpha or chemical injuries. |
1999-11-01 |
2023-08-12 |
mouse |
| B Hennig, P Meerarani, P Ramadass, M Toborek, A Malecki, R Slim, C J McClai. Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. Nutrition (Burbank, Los Angeles County, Calif.). vol 15. issue 10. 1999-10-29. PMID:10501286. |
apoptosis is a morphologically distinct mechanism of programmed cell death which involves the activation of a cell-intrinsic suicide program, and there is evidence that factors such as inflammatory cytokines (e.g., tumor necrosis factor [tnf]) and pure or oxidized lipids are necessary to induce the cell death pathway. |
1999-10-29 |
2023-08-12 |
Not clear |
| A C Johnsen, J Haux, B Steinkjer, U Nonstad, K Egeberg, A Sundan, A Ashkenazi, T Espevi. Regulation of APO-2 ligand/trail expression in NK cells-involvement in NK cell-mediated cytotoxicity. Cytokine. vol 11. issue 9. 1999-10-21. PMID:10479402. |
apo-2l is a new member of the tumour necrosis factor (tnf) family shown to induce apoptosis in a number of tumour cell lines. |
1999-10-21 |
2023-08-12 |
human |
| N S Chan. IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells. Biochemical and biophysical research communications. vol 263. issue 1. 1999-10-21. PMID:10486261. |
early activation of c-jun n-terminal kinase (jnk) is believed to block apoptosis in response to death signals such as tumor necrosis factor (tnf). |
1999-10-21 |
2023-08-12 |
Not clear |
| N Hagimoto, K Kuwano, M Kawasaki, M Yoshimi, Y Kaneko, R Kunitake, T Maeyama, T Tanaka, N Har. Induction of interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by Fas ligation. American journal of respiratory cell and molecular biology. vol 21. issue 3. 1999-10-19. PMID:10460762. |
bronchiolar epithelial cells underwent apoptosis and also secreted il-8 in response to tumor necrosis factor (tnf)-alpha or fas ligation. |
1999-10-19 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
gene targeting in the analysis of mammalian apoptosis and tnf receptor superfamily signaling. |
1999-10-18 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
it is only in the past 4 years that studies of signal transduction via members of the tumor necrosis factor (tnf) receptor superfamily have identified a plethora of novel signaling proteins, including molecules that are directly involved in apoptosis signaling, and others that regulate the induction of cell death. |
1999-10-18 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
this two-part review focuses on the biology of apoptosis and signaling through members of the tnf receptor superfamily as revealed by the study of gene-targeted "knockout" mice. |
1999-10-18 |
2023-08-12 |
mouse |
| L A Wolf, S M Laste. Characterization of arachidonic acid-induced apoptosis. Cell biochemistry and biophysics. vol 30. issue 3. 1999-10-14. PMID:10403056. |
tumor necrosis factor (tnf) can induce apoptosis in a number of different cell types. |
1999-10-14 |
2023-08-12 |
human |
| D Kitsberg, E Formstecher, M Fauquet, M Kubes, J Cordier, B Canton, G Pan, M Rolli, J Glowinski, H Chneiweis. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493725. |
indeed, astrocytes express receptors for tumor necrosis factor (tnf) alpha, a cytokine demonstrated on many cells and tissues to mediate apoptosis after recruitment of adaptor proteins containing a death effector domain (ded). |
1999-10-14 |
2023-08-12 |
mouse |
| M A Sortino, F Condorelli, C Vancheri, P L Canonic. Tumor necrosis factor-alpha induces apoptosis in immortalized hypothalamic neurons: involvement of ceramide-generating pathways. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499544. |
the involvement of acidic sphingomyelinase in tnf alpha action was demonstrated by the partial prevention of ceramide generation, apoptosis, and reduced cell growth by the inhibitor of the acidic sphingomyelinase-generating pathway, d609, whereas the involvement of ceramide was proved by complete prevention of tnf alpha-induced effects by treatment with okadaic acid at concentrations inhibiting ceramide-dependent protein phosphatase. |
1999-10-12 |
2023-08-12 |
Not clear |
| R Ferrar. The role of TNF in cardiovascular disease. Pharmacological research. vol 40. issue 2. 1999-10-08. PMID:10433867. |
in this later condition, tnf could be responsible for further ventricular remodelling; down-regulation of myocardial contractility; increased rate of apoptosis of the endothelial cell and of the myocytes, alteration of the expression and function of the enzymes regulating nitric oxide production and, of course, the induction of cachexia resulting in further peripheral muscle dysfunction. |
1999-10-08 |
2023-08-12 |
Not clear |
| G Feldman. [Apoptosis]. Annales pharmaceutiques francaises. vol 57. issue 4. 1999-10-07. PMID:10472702. |
cell integration of these new findings with regard to apoptosis is illustrated by the description of the apoptotic fas pathway, the mode of action of the proapoptotic cytokine tnf alpha and the analysis of the apoptosis mechanism when dna is damaged and when the p53 gene is overexpressed. |
1999-10-07 |
2023-08-12 |
human |