| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Takada, M Hachiya, Y Osawa, Y Hasegawa, K Ando, Y Kobayashi, M Akash. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells. The Journal of biological chemistry. vol 274. issue 40. 1999-11-02. PMID:10497185. |
we also found that the induction of apoptosis by tpa was increased in cells overexpressed with tnf receptor 1 but not in control cells. |
1999-11-02 |
2023-08-12 |
human |
| B L Musgrave, T Phu, J J Butler, A P Makrigiannis, D W Hoski. Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by rapamycin, cyclosporin A, and inhibitors of phosphatidylinositol 3-kinase, protein kinase C, and protein tyrosine kinases: evidence for TRAIL induction via the T cell receptor signaling pathway. Experimental cell research. vol 252. issue 1. 1999-11-01. PMID:10502402. |
trail (tnf-related apoptosis inducing ligand), like other members of the tnf family of proteins, is able to induce apoptosis in sensitive target cells. |
1999-11-01 |
2023-08-12 |
mouse |
| J L Cook, B A Routes, C Y Leu, T A Walker, K L Colvi. E1A oncogene-induced cellular sensitization to immune-mediated apoptosis is independent of p53 and resistant to blockade by E1B 19 kDa protein. Experimental cell research. vol 252. issue 1. 1999-11-01. PMID:10502412. |
in this study, the roles of p53 and e1b 19 kda were tested for e1a sensitization to cl-induced apoptosis in contrast with apoptosis triggered by tnf alpha or chemical injuries. |
1999-11-01 |
2023-08-12 |
mouse |
| B Hennig, P Meerarani, P Ramadass, M Toborek, A Malecki, R Slim, C J McClai. Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. Nutrition (Burbank, Los Angeles County, Calif.). vol 15. issue 10. 1999-10-29. PMID:10501286. |
apoptosis is a morphologically distinct mechanism of programmed cell death which involves the activation of a cell-intrinsic suicide program, and there is evidence that factors such as inflammatory cytokines (e.g., tumor necrosis factor [tnf]) and pure or oxidized lipids are necessary to induce the cell death pathway. |
1999-10-29 |
2023-08-12 |
Not clear |
| A C Johnsen, J Haux, B Steinkjer, U Nonstad, K Egeberg, A Sundan, A Ashkenazi, T Espevi. Regulation of APO-2 ligand/trail expression in NK cells-involvement in NK cell-mediated cytotoxicity. Cytokine. vol 11. issue 9. 1999-10-21. PMID:10479402. |
apo-2l is a new member of the tumour necrosis factor (tnf) family shown to induce apoptosis in a number of tumour cell lines. |
1999-10-21 |
2023-08-12 |
human |
| N S Chan. IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells. Biochemical and biophysical research communications. vol 263. issue 1. 1999-10-21. PMID:10486261. |
early activation of c-jun n-terminal kinase (jnk) is believed to block apoptosis in response to death signals such as tumor necrosis factor (tnf). |
1999-10-21 |
2023-08-12 |
Not clear |
| N Hagimoto, K Kuwano, M Kawasaki, M Yoshimi, Y Kaneko, R Kunitake, T Maeyama, T Tanaka, N Har. Induction of interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by Fas ligation. American journal of respiratory cell and molecular biology. vol 21. issue 3. 1999-10-19. PMID:10460762. |
bronchiolar epithelial cells underwent apoptosis and also secreted il-8 in response to tumor necrosis factor (tnf)-alpha or fas ligation. |
1999-10-19 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
gene targeting in the analysis of mammalian apoptosis and tnf receptor superfamily signaling. |
1999-10-18 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
it is only in the past 4 years that studies of signal transduction via members of the tumor necrosis factor (tnf) receptor superfamily have identified a plethora of novel signaling proteins, including molecules that are directly involved in apoptosis signaling, and others that regulate the induction of cell death. |
1999-10-18 |
2023-08-12 |
mouse |
| W C Yeh, R Hakem, M Woo, T W Ma. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling. Immunological reviews. vol 169. 1999-10-18. PMID:10450525. |
this two-part review focuses on the biology of apoptosis and signaling through members of the tnf receptor superfamily as revealed by the study of gene-targeted "knockout" mice. |
1999-10-18 |
2023-08-12 |
mouse |
| L A Wolf, S M Laste. Characterization of arachidonic acid-induced apoptosis. Cell biochemistry and biophysics. vol 30. issue 3. 1999-10-14. PMID:10403056. |
tumor necrosis factor (tnf) can induce apoptosis in a number of different cell types. |
1999-10-14 |
2023-08-12 |
human |
| D Kitsberg, E Formstecher, M Fauquet, M Kubes, J Cordier, B Canton, G Pan, M Rolli, J Glowinski, H Chneiweis. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 19. 1999-10-14. PMID:10493725. |
indeed, astrocytes express receptors for tumor necrosis factor (tnf) alpha, a cytokine demonstrated on many cells and tissues to mediate apoptosis after recruitment of adaptor proteins containing a death effector domain (ded). |
1999-10-14 |
2023-08-12 |
mouse |
| M A Sortino, F Condorelli, C Vancheri, P L Canonic. Tumor necrosis factor-alpha induces apoptosis in immortalized hypothalamic neurons: involvement of ceramide-generating pathways. Endocrinology. vol 140. issue 10. 1999-10-12. PMID:10499544. |
the involvement of acidic sphingomyelinase in tnf alpha action was demonstrated by the partial prevention of ceramide generation, apoptosis, and reduced cell growth by the inhibitor of the acidic sphingomyelinase-generating pathway, d609, whereas the involvement of ceramide was proved by complete prevention of tnf alpha-induced effects by treatment with okadaic acid at concentrations inhibiting ceramide-dependent protein phosphatase. |
1999-10-12 |
2023-08-12 |
Not clear |
| R Ferrar. The role of TNF in cardiovascular disease. Pharmacological research. vol 40. issue 2. 1999-10-08. PMID:10433867. |
in this later condition, tnf could be responsible for further ventricular remodelling; down-regulation of myocardial contractility; increased rate of apoptosis of the endothelial cell and of the myocytes, alteration of the expression and function of the enzymes regulating nitric oxide production and, of course, the induction of cachexia resulting in further peripheral muscle dysfunction. |
1999-10-08 |
2023-08-12 |
Not clear |
| G Feldman. [Apoptosis]. Annales pharmaceutiques francaises. vol 57. issue 4. 1999-10-07. PMID:10472702. |
cell integration of these new findings with regard to apoptosis is illustrated by the description of the apoptotic fas pathway, the mode of action of the proapoptotic cytokine tnf alpha and the analysis of the apoptosis mechanism when dna is damaged and when the p53 gene is overexpressed. |
1999-10-07 |
2023-08-12 |
human |
| T Saito, I Kuss, G Dworacki, W Gooding, J T Johnson, T L Whitesid. Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 5. issue 6. 1999-09-30. PMID:10389908. |
pbmcs were incubated at 37 degrees c in medium (spontaneous apoptosis) and in the presence of ch-11 antibody (anti-fas) or tumor necrosis factor (tnf)-alpha, both capable of inducing dna fragmentation in activated t cells expressing the tnf family of receptors. |
1999-09-30 |
2023-08-12 |
Not clear |
| Y Liu, V Tergaonkar, S Krishna, E J Androph. Human papillomavirus type 16 E6-enhanced susceptibility of L929 cells to tumor necrosis factor alpha correlates with increased accumulation of reactive oxygen species. The Journal of biological chemistry. vol 274. issue 35. 1999-09-30. PMID:10455154. |
here we report that, although l929 cells underwent dna fragmentation after exposure to tnf, they retained the morphology of intact nuclei while gaining permeability to propidium iodide, features characteristic of necrosis rather than apoptosis. |
1999-09-30 |
2023-08-12 |
human |
| J R Ciacci-Zanella, C Jone. Fumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 37. issue 7. 1999-09-30. PMID:10496371. |
iap blocks apoptosis which is induced by the tumour necrosis factor (tnf) pathway. |
1999-09-30 |
2023-08-12 |
mouse |
| J R Ciacci-Zanella, C Jone. Fumonisin B1, a mycotoxin contaminant of cereal grains, and inducer of apoptosis via the tumour necrosis factor pathway and caspase activation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 37. issue 7. 1999-09-30. PMID:10496371. |
in summary, these results demonstrate that the tnf pathway and caspases plays an important role in fb1-induced apoptosis. |
1999-09-30 |
2023-08-12 |
mouse |
| C Binder, M Schulz, W Hiddemann, M Oelleric. Caspase-activation and induction of inducible nitric oxide-synthase during TNF alpha-triggered apoptosis. Anticancer research. vol 19. issue 3A. 1999-09-20. PMID:10470105. |
caspase-activation and induction of inducible nitric oxide-synthase during tnf alpha-triggered apoptosis. |
1999-09-20 |
2023-08-12 |
Not clear |