| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Taniwaki, T Yamada, H Asahara, Y Ohyagi, J Kir. Ceramide induces apoptosis to immature cerebellar granule cells in culture. Neurochemical research. vol 24. issue 5. 1999-07-01. PMID:10344598. |
a recent study revealed that ceramide acts as a second messenger in the sphingomyelin pathway and thus plays an important regulatory role in programmed cell death (apoptosis) to cell the lines induced by tumor-necrosis factor (tnf)-alpha and interleukin (il)-1beta, although its effect remains controversial regarding primary neuronal culture. |
1999-07-01 |
2023-08-12 |
Not clear |
| A Mukhopadhyay, J Ni, Y Zhai, G L Yu, B B Aggarwa. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. The Journal of biological chemistry. vol 274. issue 23. 1999-07-01. PMID:10347144. |
identification and characterization of a novel cytokine, thank, a tnf homologue that activates apoptosis, nuclear factor-kappab, and c-jun nh2-terminal kinase. |
1999-07-01 |
2023-08-12 |
human |
| A Mukhopadhyay, J Ni, Y Zhai, G L Yu, B B Aggarwa. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase. The Journal of biological chemistry. vol 274. issue 23. 1999-07-01. PMID:10347144. |
thus our results indicate that thank is a novel cytokine that belongs to the tnf family and activates apoptosis, nf-kappab, and jnk through a distinct receptor. |
1999-07-01 |
2023-08-12 |
human |
| A J Bruce-Keller, J W Geddes, P E Knapp, R W McFall, J N Keller, F W Holtsberg, S Parthasarathy, S M Steiner, M P Mattso. Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD. Journal of neuroimmunology. vol 93. issue 1-2. 1999-07-01. PMID:10378869. |
tnf pretreatment and mnsod overexpression prevented 3-np induced apoptosis, and shifted the mode of death from necrosis to apoptosis in response to high levels of 3-np. |
1999-07-01 |
2023-08-12 |
mouse |
| S S Cha, H C Shin, K Y Choi, B H O. Expression, purification and crystallization of recombinant human TRAIL. Acta crystallographica. Section D, Biological crystallography. vol 55. issue Pt 5. 1999-06-30. PMID:10216319. |
trail (also known as apo-2l) belongs to the tumour necrosis factor (tnf) cytokine family and induces rapid apoptosis in a wide variety of tumour cell lines upon binding to the death-signalling receptors on the cell membrane. |
1999-06-30 |
2023-08-12 |
human |
| R D Pettersen, K Hestdal, M K Olafsen, S O Lie, F P Lindber. CD47 signals T cell death. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 12. 1999-06-30. PMID:10358145. |
activation-induced death of t cells regulates immune responses and is considered to involve apoptosis induced by ligation of fas and tnf receptors. |
1999-06-30 |
2023-08-12 |
Not clear |
| Y G Ko, J S Lee, Y S Kang, J H Ahn, J S Se. TNF-alpha-mediated apoptosis is initiated in caveolae-like domains. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 12. 1999-06-30. PMID:10358168. |
immunoblotting and immunofluorescent data showed that tnf receptor 1 colocalized with cd36 in clds, suggesting that tnf-alpha-initiated apoptosis occurs in clds. |
1999-06-30 |
2023-08-12 |
Not clear |
| R Ichimi, T Jin-no, M It. Induction of apoptosis in cord blood lymphocytes by HHV-6. Journal of medical virology. vol 58. issue 1. 1999-06-29. PMID:10223548. |
the addition of anti-fas antibody, anti-fas ligand antibody, and anti-tnf-alpha antibody did not affect the induction of apoptosis by hhv-6, indicating that the fas-fas ligand pathway and tnf pathway did not contribute to the apoptosis induced by hhv-6. |
1999-06-29 |
2023-08-12 |
human |
| M K Chen, L F Strande, E A Beierle, M S Kain, B D Geldziler, E J Dooli. Fas-mediated induction of hepatocyte apoptosis in a neuroblastoma and hepatocyte coculture model. The Journal of surgical research. vol 84. issue 1. 1999-06-28. PMID:10334894. |
death receptors in the tumor necrosis factor (tnf) family such as tnfr1 and fas have been identified as regulators of apoptosis and may be responsible for the altered regulation of apoptosis seen in our coculture model. |
1999-06-28 |
2023-08-12 |
Not clear |
| L M Siemankowski, J Morreale, M M Brieh. Antioxidant defenses in the TNF-treated MCF-7 cells: selective increase in MnSOD. Free radical biology & medicine. vol 26. issue 7-8. 1999-06-23. PMID:10232835. |
oxidative stress has been implicated in the mechanism of tumor necrosis factor-alpha (tnf)-induced apoptosis, raising a question about the status of antioxidant defenses in tnf-sensitive cells. |
1999-06-23 |
2023-08-12 |
Not clear |
| L M Siemankowski, J Morreale, M M Brieh. Antioxidant defenses in the TNF-treated MCF-7 cells: selective increase in MnSOD. Free radical biology & medicine. vol 26. issue 7-8. 1999-06-23. PMID:10232835. |
cell morphology and dna fragmentation assays were used to confirm increased apoptosis as a result of tnf treatment. |
1999-06-23 |
2023-08-12 |
Not clear |
| R K Doman, M Perez, N J Donat. JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 19. issue 3. 1999-06-15. PMID:10213465. |
tumor necrosis factor (tnf) signal transduction is a complex process involving activation of receptor-linked and stress-sensitive signaling cascades that stimulate apoptosis in some tumor cell lines. |
1999-06-15 |
2023-08-12 |
Not clear |
| R K Doman, M Perez, N J Donat. JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 19. issue 3. 1999-06-15. PMID:10213465. |
as tnf induces cellular stress and activates several stress-sensitive cascades that may play a role in apoptosis, tnf-induced stress signaling was examined in mcf-7 cells and compared with a variant mcf-7 cell line resistant to tnf-mediated apoptosis (mcf-7/3e9). |
1999-06-15 |
2023-08-12 |
Not clear |
| C Magnusson, D L Vau. Signalling by CD95 and TNF receptors: not only life and death. Immunology and cell biology. vol 77. issue 1. 1999-06-09. PMID:10101685. |
the recent rapid progress in the understanding of the mechanisms of apoptosis has been accompanied by assumptions that tnf family receptors such as cd95(fas/apo-1) only have a role in regulating cell survival. |
1999-06-09 |
2023-08-12 |
Not clear |
| C Magnusson, D L Vau. Signalling by CD95 and TNF receptors: not only life and death. Immunology and cell biology. vol 77. issue 1. 1999-06-09. PMID:10101685. |
the present review will focus on signalling of some tnf family receptors in the immune system, not only for apoptosis, but also for survival or activation. |
1999-06-09 |
2023-08-12 |
Not clear |
| K Y Lee, W Chang, D Qiu, P N Kao, G D Rose. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224110. |
members of the tumor necrosis factor (tnf) family, however, induce apoptosis regardless of the p53 phenotype. |
1999-06-03 |
2023-08-12 |
Not clear |
| L A Madge, M R Sierra-Honigmann, J S Pobe. Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224136. |
these data suggest that several putative inhibitors of tnf signaling work by triggering apoptosis and that an early event coincident with the initiation of apoptosis, preceding evidence of injury, is loss of tnfr1. |
1999-06-03 |
2023-08-12 |
Not clear |
| R Bachmann, H P Eugster, K Frei, A Fontana, H Lassman. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. The American journal of pathology. vol 154. issue 5. 1999-06-03. PMID:10329594. |
impairment of the tnf receptor 1 pathway led to a 50% reduction of t-cell apoptosis in the central nervous system lesions, whereas the other genetic deletions showed no significant effect. |
1999-06-03 |
2023-08-12 |
mouse |
| E M Yazlovitskaya, J C Pelling, D L Person. Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor alpha-resistant ovarian carcinoma cell line UCI 101. Molecular carcinogenesis. vol 25. issue 1. 1999-05-27. PMID:10331740. |
thus, the inhibition of tnf alpha-induced erk1/2 activity was associated with induction of apoptosis in the tnf alpha-resistant cell line uci 101. |
1999-05-27 |
2023-08-12 |
Not clear |
| A P Soler, C W Marano, M Bryans, R D Miller, L A Garulacan, S K Mauldin, T D Stamato, J M Mulli. Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis. European journal of cell biology. vol 78. issue 1. 1999-05-25. PMID:10082424. |
tumor necrosis factor-alpha (tnf) induces apoptosis in confluent llc-pk1 epithelial cells, but also activates nf-kappab, a negative regulator of apoptosis. |
1999-05-25 |
2023-08-12 |
Not clear |