| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Y Lee, W Chang, D Qiu, P N Kao, G D Rose. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224110. |
members of the tumor necrosis factor (tnf) family, however, induce apoptosis regardless of the p53 phenotype. |
1999-06-03 |
2023-08-12 |
Not clear |
| L A Madge, M R Sierra-Honigmann, J S Pobe. Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224136. |
these data suggest that several putative inhibitors of tnf signaling work by triggering apoptosis and that an early event coincident with the initiation of apoptosis, preceding evidence of injury, is loss of tnfr1. |
1999-06-03 |
2023-08-12 |
Not clear |
| R Bachmann, H P Eugster, K Frei, A Fontana, H Lassman. Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice. The American journal of pathology. vol 154. issue 5. 1999-06-03. PMID:10329594. |
impairment of the tnf receptor 1 pathway led to a 50% reduction of t-cell apoptosis in the central nervous system lesions, whereas the other genetic deletions showed no significant effect. |
1999-06-03 |
2023-08-12 |
mouse |
| E M Yazlovitskaya, J C Pelling, D L Person. Association of apoptosis with the inhibition of extracellular signal-regulated protein kinase activity in the tumor necrosis factor alpha-resistant ovarian carcinoma cell line UCI 101. Molecular carcinogenesis. vol 25. issue 1. 1999-05-27. PMID:10331740. |
thus, the inhibition of tnf alpha-induced erk1/2 activity was associated with induction of apoptosis in the tnf alpha-resistant cell line uci 101. |
1999-05-27 |
2023-08-12 |
Not clear |
| A P Soler, C W Marano, M Bryans, R D Miller, L A Garulacan, S K Mauldin, T D Stamato, J M Mulli. Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis. European journal of cell biology. vol 78. issue 1. 1999-05-25. PMID:10082424. |
tumor necrosis factor-alpha (tnf) induces apoptosis in confluent llc-pk1 epithelial cells, but also activates nf-kappab, a negative regulator of apoptosis. |
1999-05-25 |
2023-08-12 |
Not clear |
| T S Doi, M W Marino, T Takahashi, T Yoshida, T Sakakura, L J Old, Y Obat. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 6. 1999-05-20. PMID:10077625. |
fibroblasts and macrophages isolated from rela-/- embryos were found to be highly sensitive to tumor necrosis factor (tnf) cytotoxicity, raising the possibility that endogenous tnf is the cause of liver cell apoptosis. |
1999-05-20 |
2023-08-12 |
mouse |
| P F Piguet, C Vesin, Y Donati, C Barazzon. TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 4. 1999-05-13. PMID:10212002. |
injection of mouse recombinant tnf to mice induced apoptosis and detachment of the enterocytes of the tip of the villi, evident after 30 to 90 minutes, which resulted in a shrinkage of the villi. |
1999-05-13 |
2023-08-12 |
mouse |
| P F Piguet, C Vesin, Y Donati, C Barazzon. TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 4. 1999-05-13. PMID:10212002. |
caspase 1 and 3 were not induced in tnfr1-deficient mice in which tnf does not induce apoptosis and detachment. |
1999-05-13 |
2023-08-12 |
mouse |
| E Fujita, Y Kouroku, Y Miho, T Tsukahara, S Ishiura, T Momo. Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas. Cell death and differentiation. vol 5. issue 4. 1999-05-11. PMID:10200474. |
cpp32/apopain (caspase-3), a protease of the ced-3/ice family, is a central mediator in the apoptosis induced by tnf or anti-fas. |
1999-05-11 |
2023-08-12 |
Not clear |
| J L Dickinson, B J Norris, P H Jensen, T M Antali. The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis. Cell death and differentiation. vol 5. issue 2. 1999-05-07. PMID:10200461. |
the serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (pai-2), has been reported to inhibit tumor necrosis factor-alpha (tnf) induced apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| J L Dickinson, B J Norris, P H Jensen, T M Antali. The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis. Cell death and differentiation. vol 5. issue 2. 1999-05-07. PMID:10200461. |
the data demonstrate that the pai-2 c-d interhelical domain is functionally important in pai-2 protection from tnf induced apoptosis and suggest a novel function for the c-d interhelical domain in the protective mechanism. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
we report here that rapid apoptosis induced by tnf in u937 cells or anti-fas in jurkat cells, in the presence of cycloheximide, induced only a very low increase (<20%) in the cell ceramide content. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
neither treatment with inhibitors of sphingomyelinases nor incubation of cells with fumonisin b1, which inhibits de novo ceramide synthesis, prevented tnf and fas-mediated apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
increasing or depleting the cell ceramide content by prolonged culture in the presence of monensin or fumonisin b1, respectively, did not prevent tnf and fas-mediated apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
these results indicate that while ceramide does not seem to act as a critical mediator of tnf and fas-induced apoptosis, it is generated as a consequence of cpp32 activation and could contribute to the spread of the intracellular death signal. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Schütze, T Machleidt, D Adam, R Schwandner, K Wiegmann, M L Kruse, M Heinrich, M Wickel, M Krönk. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187805. |
in contrast, activation of signaling enzymes that are linked to the "death domain" of tr55, like acid sphingomyelinase and c-jun-n-terminal protein kinase as well as tnf signaling of apoptosis in u937 and l929 cells, are blocked in the presence of mdc. |
1999-05-03 |
2023-08-12 |
Not clear |
| L E Bermudez, A Parker, M Petrofsk. Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases. Clinical and experimental immunology. vol 116. issue 1. 1999-04-30. PMID:10209511. |
apoptosis of mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (tnf) and fas, and involves the activation of caspases. |
1999-04-30 |
2023-08-12 |
human |
| P A Barke. p75NTR: A study in contrasts. Cell death and differentiation. vol 5. issue 5. 1999-04-29. PMID:10200483. |
in cells lacking trk expression, p75ntr can act autonomously to activate ligand-dependent signaling cascades that may in some circumstances result in apoptosis but probably not through pathways utilized by its apoptotic brethren in the tnf receptor superfamily. |
1999-04-29 |
2023-08-12 |
Not clear |
| G T Baxter, R C Kuo, O J Jupp, P Vandenabeele, D J MacEwa. Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092639. |
mitotically active cells in log growth respond to tnf by rapidly undergoing apoptosis whereas tnf exposure stimulates cellular proliferation in mitotically quiescent cells. |
1999-04-27 |
2023-08-12 |
human |
| G T Baxter, R C Kuo, O J Jupp, P Vandenabeele, D J MacEwa. Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092639. |
expression levels of the type ii tnf receptor subtype (p75tnfr) were found to correlate with sensitivity to tnf-induced apoptosis. |
1999-04-27 |
2023-08-12 |
human |