| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Kassiotis, J Bauer, K Akassoglou, H Lassmann, G Kollias, L Prober. A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice. European journal of immunology. vol 29. issue 3. 1999-04-21. PMID:10092095. |
we have reported previously that in the central nervous system (cns) local expression of tumor necrosis factor (tnf) transgenes can trigger the development of oligodendrocyte apoptosis, primary inflammatory demyelination and neurological dysfunction, accompanied by lymphocyte and macrophage infiltration into the cns. |
1999-04-21 |
2023-08-12 |
mouse |
| H Dürkop, H D Foss, G Demel, H Klotzbach, C Hahn, H Stei. Tumor necrosis factor receptor-associated factor 1 is overexpressed in Reed-Sternberg cells of Hodgkin's disease and Epstein-Barr virus-transformed lymphoid cells. Blood. vol 93. issue 2. 1999-04-20. PMID:9885224. |
it takes part in the signal transduction of the tnf receptor 2 (tnfr2), the lymphotoxin-beta receptor (lt-betar), cd40, cd30, and lmp1; is induced by lmp1 in vitro; and protects lymphoid cells from apoptosis. |
1999-04-20 |
2023-08-12 |
Not clear |
| N Bonnefoy-Berard, L Genestier, X Preville, J P Revillar. TNF alpha and CD95-L contribute to apoptosis of activated lymphocytes triggered by ATGs. Transplantation proceedings. vol 31. issue 1-2. 1999-04-15. PMID:10083328. |
tnf alpha and cd95-l contribute to apoptosis of activated lymphocytes triggered by atgs. |
1999-04-15 |
2023-08-12 |
Not clear |
| N Kayagaki, N Yamaguchi, M Nakayama, A Kawasaki, H Akiba, K Okumura, H Yagit. Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 5. 1999-04-14. PMID:10072506. |
tnf-related apoptosis-inducing ligand (trail) has been identified as a member of the tnf family that induces apoptosis in a variety of tumor cells, but its physiological functions are largely unknown. |
1999-04-14 |
2023-08-12 |
human |
| K E Noble, R G Wickremasinghe, C DeCornet, P Panayiotidis, K L Yon. Monocytes stimulate expression of the Bcl-2 family member, A1, in endothelial cells and confer protection against apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973392. |
stimulation of endothelial cell a1 mrna by monocytes was not inhibited by anti-beta2 integrin abs, but anti-platelet endothelial cell adhesion molecule-1 (pecam-1) mab reduced a1 transcript levels at 21 h. studies employing either tnf on its own, or anti-tnf in endothelium/monocyte cocultures showed that tnf plays a role in the early (6-h) stimulation of a1, but is less important for the sustained elevation of a1 levels at 21 h. serum-starved endothelial cells demonstrated increased survival and decreased apoptosis after coculture with monocytes. |
1999-04-13 |
2023-08-12 |
Not clear |
| L Zhuang, B Wang, G A Shinder, G M Shivji, T W Mak, D N Saude. TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973400. |
tnf receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet b irradiation. |
1999-04-13 |
2023-08-12 |
mouse |
| L Zhuang, B Wang, G A Shinder, G M Shivji, T W Mak, D N Saude. TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973400. |
in order to confirm this hypothesis and to further delineate which type of tnf receptor signaling mediates the apoptosis pathway, we performed both in vivo and in vitro experiments using gene-targeted knockout mice lacking either the tnf p55 receptor or the tnf p75 receptor. |
1999-04-13 |
2023-08-12 |
mouse |
| L Zhuang, B Wang, G A Shinder, G M Shivji, T W Mak, D N Saude. TNF receptor p55 plays a pivotal role in murine keratinocyte apoptosis induced by ultraviolet B irradiation. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973400. |
both in vivo and in vitro studies demonstrated that the deletion of tnf receptor p55 could suppress uvb-induced apoptosis in keratinocytes. |
1999-04-13 |
2023-08-12 |
mouse |
| S K Manna, B B Aggarwa. Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973408. |
besides tnf, the apoptosis induced by taxol and okadaic acid was also sensitive to lps-induced nf-kappab activation, whereas that induced by h2o2, doxorubicin, daunomycin, vincristine, and vinblastine was nf-kappab insensitive. |
1999-04-13 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973408. |
tumor cells that constitutively expressed nf-kappab also showed resistance to the apoptotic effects of tnf, taxol, and okadaic acid, but sensitivity to all other agents, indicating the critical role of nf-kappab in blocking apoptosis induced by certain agents. |
1999-04-13 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 3. 1999-04-13. PMID:9973408. |
overall, these results indicate that lps induces resistance to the apoptotic effects of tnf and other agents, and that nf-kappab activation, whether induced or constitutive, inhibits this apoptosis. |
1999-04-13 |
2023-08-12 |
human |
| J Dellacasagrande, C Capo, D Raoult, J L Meg. IFN-gamma-mediated control of Coxiella burnetii survival in monocytes: the role of cell apoptosis and TNF. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 4. 1999-04-13. PMID:9973502. |
ifn-gamma-mediated control of coxiella burnetii survival in monocytes: the role of cell apoptosis and tnf. |
1999-04-13 |
2023-08-12 |
Not clear |
| A Z Badrichani, D M Stroka, G Bilbao, D T Curiel, F H Bach, C Ferra. Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB. The Journal of clinical investigation. vol 103. issue 4. 1999-04-13. PMID:10021463. |
overexpression of bcl-2 or bcl-xl protects ec from tumor necrosis factor (tnf)-mediated apoptosis. |
1999-04-13 |
2023-08-12 |
Not clear |
| A Huwiler, J Pfeilschifter, H van den Bosc. Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. The Journal of biological chemistry. vol 274. issue 11. 1999-04-13. PMID:10066779. |
moreover, tnf fails to induce apoptosis in mesangial cells. |
1999-04-13 |
2023-08-12 |
rat |
| M I Pörn-Ares, A Samali, S Orreniu. Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell death and differentiation. vol 5. issue 12. 1999-04-01. PMID:9894609. |
the 110-120 kda calpastatin protein of jurkat t-lymphocytes and u937 monocytic leukemia cells was cleaved to a 65-70 kda form after the induction of apoptosis with anti-cd95 monoclonal antibody, staurosporine or tnf. |
1999-04-01 |
2023-08-12 |
Not clear |
| b' D Wissing, H Mouritzen, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20. Free radical biology & medicine. vol 25. issue 1. 1999-03-30. PMID:9655522.' |
it functions as a negative regulator of the tumor necrosis factor (tnf) inhibiting both tnf-mediated apoptosis and activation of transcription factors. |
1999-03-30 |
2023-08-12 |
Not clear |
| J J Lemasters, T Qian, S P Elmore, L C Trost, Y Nishimura, B Herman, C A Bradham, D A Brenner, A L Niemine. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. BioFactors (Oxford, England). vol 8. issue 3-4. 1999-03-24. PMID:9914830. |
the mpt is a causative event in many types of necrotic and apoptotic cell death, including oxidative stress, ischemia/reperfusion injury, ca2+ ionophore toxicity and tumor necrosis factor alpha (tnf alpha) induced apoptosis, and may contribute to reye's-related drug toxicity. |
1999-03-24 |
2023-08-12 |
Not clear |
| J J Lemasters, T Qian, S P Elmore, L C Trost, Y Nishimura, B Herman, C A Bradham, D A Brenner, A L Niemine. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. BioFactors (Oxford, England). vol 8. issue 3-4. 1999-03-24. PMID:9914830. |
the mpt can also be directly visualized during tnf alpha-induced apoptosis to hepatocytes. |
1999-03-24 |
2023-08-12 |
Not clear |
| T Arai, Y Akiyama, S Okabe, K Saito, T Iwai, Y Yuas. Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. Cancer letters. vol 133. issue 2. 1999-03-23. PMID:10072170. |
the dr5/trail receptor 2 gene is a novel tnf receptor family member and induces apoptosis by overexpression of its product. |
1999-03-23 |
2023-08-12 |
Not clear |
| L Rapp, Y Liu, Y Hong, E J Androphy, J J Che. The bovine papillomavirus type 1 E6 oncoprotein sensitizes cells to tumor necrosis factor alpha-induced apoptosis. Oncogene. vol 18. issue 3. 1999-03-16. PMID:9989810. |
these cells showed increased apoptosis in response to tnf, as measured by several criteria. |
1999-03-16 |
2023-08-12 |
cattle |