| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T S Doi, M W Marino, T Takahashi, T Yoshida, T Sakakura, L J Old, Y Obat. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 6. 1999-05-20. PMID:10077625. |
fibroblasts and macrophages isolated from rela-/- embryos were found to be highly sensitive to tumor necrosis factor (tnf) cytotoxicity, raising the possibility that endogenous tnf is the cause of liver cell apoptosis. |
1999-05-20 |
2023-08-12 |
mouse |
| P F Piguet, C Vesin, Y Donati, C Barazzon. TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 4. 1999-05-13. PMID:10212002. |
injection of mouse recombinant tnf to mice induced apoptosis and detachment of the enterocytes of the tip of the villi, evident after 30 to 90 minutes, which resulted in a shrinkage of the villi. |
1999-05-13 |
2023-08-12 |
mouse |
| P F Piguet, C Vesin, Y Donati, C Barazzon. TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 4. 1999-05-13. PMID:10212002. |
caspase 1 and 3 were not induced in tnfr1-deficient mice in which tnf does not induce apoptosis and detachment. |
1999-05-13 |
2023-08-12 |
mouse |
| E Fujita, Y Kouroku, Y Miho, T Tsukahara, S Ishiura, T Momo. Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas. Cell death and differentiation. vol 5. issue 4. 1999-05-11. PMID:10200474. |
cpp32/apopain (caspase-3), a protease of the ced-3/ice family, is a central mediator in the apoptosis induced by tnf or anti-fas. |
1999-05-11 |
2023-08-12 |
Not clear |
| J L Dickinson, B J Norris, P H Jensen, T M Antali. The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis. Cell death and differentiation. vol 5. issue 2. 1999-05-07. PMID:10200461. |
the serine proteinase inhibitor (serpin), plasminogen activator inhibitor type 2 (pai-2), has been reported to inhibit tumor necrosis factor-alpha (tnf) induced apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| J L Dickinson, B J Norris, P H Jensen, T M Antali. The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF-alpha induced apoptosis. Cell death and differentiation. vol 5. issue 2. 1999-05-07. PMID:10200461. |
the data demonstrate that the pai-2 c-d interhelical domain is functionally important in pai-2 protection from tnf induced apoptosis and suggest a novel function for the c-d interhelical domain in the protective mechanism. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
we report here that rapid apoptosis induced by tnf in u937 cells or anti-fas in jurkat cells, in the presence of cycloheximide, induced only a very low increase (<20%) in the cell ceramide content. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
neither treatment with inhibitors of sphingomyelinases nor incubation of cells with fumonisin b1, which inhibits de novo ceramide synthesis, prevented tnf and fas-mediated apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
increasing or depleting the cell ceramide content by prolonged culture in the presence of monensin or fumonisin b1, respectively, did not prevent tnf and fas-mediated apoptosis. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Gamen, A Anel, A Piñeiro, J Nava. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. Cell death and differentiation. vol 5. issue 3. 1999-05-07. PMID:10200470. |
these results indicate that while ceramide does not seem to act as a critical mediator of tnf and fas-induced apoptosis, it is generated as a consequence of cpp32 activation and could contribute to the spread of the intracellular death signal. |
1999-05-07 |
2023-08-12 |
Not clear |
| S Schütze, T Machleidt, D Adam, R Schwandner, K Wiegmann, M L Kruse, M Heinrich, M Wickel, M Krönk. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. The Journal of biological chemistry. vol 274. issue 15. 1999-05-03. PMID:10187805. |
in contrast, activation of signaling enzymes that are linked to the "death domain" of tr55, like acid sphingomyelinase and c-jun-n-terminal protein kinase as well as tnf signaling of apoptosis in u937 and l929 cells, are blocked in the presence of mdc. |
1999-05-03 |
2023-08-12 |
Not clear |
| L E Bermudez, A Parker, M Petrofsk. Apoptosis of Mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (TNF) and Fas, and involves the activation of caspases. Clinical and experimental immunology. vol 116. issue 1. 1999-04-30. PMID:10209511. |
apoptosis of mycobacterium avium-infected macrophages is mediated by both tumour necrosis factor (tnf) and fas, and involves the activation of caspases. |
1999-04-30 |
2023-08-12 |
human |
| P A Barke. p75NTR: A study in contrasts. Cell death and differentiation. vol 5. issue 5. 1999-04-29. PMID:10200483. |
in cells lacking trk expression, p75ntr can act autonomously to activate ligand-dependent signaling cascades that may in some circumstances result in apoptosis but probably not through pathways utilized by its apoptotic brethren in the tnf receptor superfamily. |
1999-04-29 |
2023-08-12 |
Not clear |
| G T Baxter, R C Kuo, O J Jupp, P Vandenabeele, D J MacEwa. Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092639. |
mitotically active cells in log growth respond to tnf by rapidly undergoing apoptosis whereas tnf exposure stimulates cellular proliferation in mitotically quiescent cells. |
1999-04-27 |
2023-08-12 |
human |
| G T Baxter, R C Kuo, O J Jupp, P Vandenabeele, D J MacEwa. Tumor necrosis factor-alpha mediates both apoptotic cell death and cell proliferation in a human hematopoietic cell line dependent on mitotic activity and receptor subtype expression. The Journal of biological chemistry. vol 274. issue 14. 1999-04-27. PMID:10092639. |
expression levels of the type ii tnf receptor subtype (p75tnfr) were found to correlate with sensitivity to tnf-induced apoptosis. |
1999-04-27 |
2023-08-12 |
human |
| C Gu, P Casaccia-Bonnefil, A Srinivasan, M V Cha. Oligodendrocyte apoptosis mediated by caspase activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 8. 1999-04-27. PMID:10191321. |
these data suggest that the mechanism of apoptosis by ngf through the p75 receptor is different from tnf and fas-mediated killing. |
1999-04-27 |
2023-08-12 |
Not clear |
| S Vasseur, G Vidal Mallo, F Fiedler, H Bödeker, E Cánepa, S Moreno, J L Iovann. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. European journal of biochemistry. vol 259. issue 3. 1999-04-22. PMID:10092851. |
response to tnf alpha and staurosporine-induced apoptosis was not modified by p8 expression. |
1999-04-22 |
2023-08-12 |
human |
| T Horie, K Dobashi, K Iizuka, A Yoshii, Y Shimizu, T Nakazawa, M Mor. Interferon-gamma rescues TNF-alpha-induced apoptosis mediated by up-regulation of TNFR2 on EoL-1 cells. Experimental hematology. vol 27. issue 3. 1999-04-21. PMID:10089914. |
using a human myeloblastic leukemia cell line, eol-1, we investigated the effect of interferon-gamma (ifn-gamma), which differentiates eol-1 into monocyte/macrophage-like cells on fas antigen (fas)- and tumor necrosis factor-alpha (tnf alpha)-induced apoptosis. |
1999-04-21 |
2023-08-12 |
human |
| T Horie, K Dobashi, K Iizuka, A Yoshii, Y Shimizu, T Nakazawa, M Mor. Interferon-gamma rescues TNF-alpha-induced apoptosis mediated by up-regulation of TNFR2 on EoL-1 cells. Experimental hematology. vol 27. issue 3. 1999-04-21. PMID:10089914. |
both tnf and anti-fas monoclonal antibody (ch-11) induced apoptosis of eol-1 cells. |
1999-04-21 |
2023-08-12 |
human |
| E Dudley, F Hornung, L Zheng, D Scherer, D Ballard, M Lenard. NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes. European journal of immunology. vol 29. issue 3. 1999-04-21. PMID:10092091. |
in addition, blocking tnf, itself a positive regulator of nf-kappab, with neutralizing antibodies renders the cells more susceptible to anti-fas-mediated apoptosis. |
1999-04-21 |
2023-08-12 |
mouse |