| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Kleeff, M Kornmann, H Sawhney, M Kor. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. International journal of cancer. vol 86. issue 3. 2000-05-02. PMID:10760829. |
pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as fas and tnf receptor or by serum or growth factor withdrawal. |
2000-05-02 |
2023-08-12 |
Not clear |
| J B Domachowske, C A Bonville, A J Mortelliti, C B Colella, U Kim, H F Rosenber. Respiratory syncytial virus infection induces expression of the anti-apoptosis gene IEX-1L in human respiratory epithelial cells. The Journal of infectious diseases. vol 181. issue 3. 2000-04-27. PMID:10720500. |
because iex-1l is reported to protect cells from apoptosis induced by tumor necrosis factor (tnf)-alpha, the effect of tnf-alpha on epithelial cell apoptosis in the context of rsv infection was determined. |
2000-04-27 |
2023-08-12 |
human |
| S C Hasmall, N H James, N Macdonald, F J Gonzalez, J M Peters, R A Robert. Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha. Mutation research. vol 448. issue 2. 2000-04-27. PMID:10725472. |
in vitro, high concentrations (>500 u/ml) of exogenous tumour necrosis factor (tnfalpha) [m. rolfe, n.h. james, r.a. roberts, tnf suppresses apoptosis and induces s-phase in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators?, carcinogenesis 18 (1997) 2277-2280] are also able to stimulate hepatocyte dna synthesis and suppress apoptosis, implicating tnfalpha in mediating or permitting the liver growth response to pps. |
2000-04-27 |
2023-08-12 |
mouse |
| M N'cho, Z Brahm. Fas-mediated apoptosis in T cells involves the dephosphorylation of the retinoblastoma protein by type 1 protein phosphatases. Human immunology. vol 60. issue 12. 2000-04-20. PMID:10626732. |
apoptosis is triggered by a number of different stimuli including the activation of fas antigen, a member of the tnf family, by the fas ligand. |
2000-04-20 |
2023-08-12 |
Not clear |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
adenovirus-mediated gene transduction of ikappab or ikappab plus bax gene drastically enhances tumor necrosis factor (tnf)-induced apoptosis in human gliomas. |
2000-04-19 |
2023-08-12 |
human |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
neither transduction of ikappabdn nor treatment with tnf protein alone induced apoptosis in u251 and t-98g cells, whereas both cell lines underwent drastic tnf-induced apoptosis after transduction of ikappabdn. |
2000-04-19 |
2023-08-12 |
human |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
u-373mg cells underwent drastically increased apoptosis when co-transduced with the ikappabdn and bax gene in the presence of tnf. |
2000-04-19 |
2023-08-12 |
human |
| W Song, X Lu, Q Fen. Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovascular research. vol 45. issue 3. 2000-04-13. PMID:10728381. |
it has been demonstrated that tumor necrosis factor-alpha (tnf alpha) induces apoptosis in cardiac myocytes. |
2000-04-13 |
2023-08-12 |
mouse |
| W Song, X Lu, Q Fen. Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovascular research. vol 45. issue 3. 2000-04-13. PMID:10728381. |
in the present study, we hypothesized that tnf alpha induces myocardial apoptosis by induction of inducible nitric oxide synthase (inos). |
2000-04-13 |
2023-08-12 |
mouse |
| A Wiesmann, R L Phillips, M Mojica, L J Pierce, A E Searles, G J Spangrude, I Lemischk. Expression of CD27 on murine hematopoietic stem and progenitor cells. Immunity. vol 12. issue 2. 2000-04-07. PMID:10714685. |
one molecule specifically expressed in immature cells is cd27, a member of the tnf receptor family previously shown to play roles in lymphoid proliferation, differentiation, and apoptosis. |
2000-04-07 |
2023-08-12 |
mouse |
| B Bonetti, P Valdo, C Stegagno, R Tanel, G L Zanusso, D Ramarli, E Fiorini, S Turazzi, M Carner, G Morett. Tumor necrosis factor alpha and human Schwann cells: signalling and phenotype modulation without cell death. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744037. |
by immunocytochemical and functional assays, we found that sc expressed tnf receptors and that tnfalpha promoted in sc cultures transient activation of transcription factors nfkappab and c-jun in the absence of apoptosis. |
2000-04-07 |
2023-08-12 |
human |
| W Van Molle, J Vanden Berghe, P Brouckaert, C Liber. Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH. FEBS letters. vol 467. issue 2-3. 2000-03-31. PMID:10675538. |
the molecular mechanism by which tnf induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. |
2000-03-31 |
2023-08-12 |
mouse |
| S Q Xu, W S El-Deir. p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. Biochemical and biophysical research communications. vol 269. issue 1. 2000-03-31. PMID:10694497. |
death receptors of the tumor necrosis factor (tnf) family form membrane-bound self-activating signaling complexes that initiate apoptosis through cleavage of proximal caspases including casp8 and 10. |
2000-03-31 |
2023-08-12 |
human |
| M E Rosenfeld, L Prichard, N Shiojiri, N Faust. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. The American journal of pathology. vol 156. issue 3. 2000-03-23. PMID:10702415. |
we therefore hypothesized that, in the absence of rela, embryos were sensitized to tumor necrosis factor (tnf) receptor 1 (tnfr-1)-mediated apoptosis. |
2000-03-23 |
2023-08-12 |
mouse |
| M Nagane, G Pan, J J Weddle, V M Dixit, W K Cavenee, H J Huan. Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706092. |
tumor necrosis factor-related apoptosis-inducing ligand (trail) is a novel member of the tumor necrosis factor (tnf) family that induces apoptosis preferentially in tumor cells through binding to its cognate death receptors, dr4 and dr5. |
2000-03-20 |
2023-08-12 |
mouse |
| Z X Liu, S Govindarajan, S Okamoto, G Denner. Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice. Hepatology (Baltimore, Md.). vol 31. issue 3. 2000-03-15. PMID:10706557. |
making use of mice in which the genes coding for fas, fasl, tnf receptors (tnfrs), and perforin are inactivated, as well as recombinant proteins that inhibit fas- and tnf-alpha-mediated apoptosis, it is shown that a functional perforin-mediated mechanism is not obligatory for cellular infiltration and progression of liver injury. |
2000-03-15 |
2023-08-12 |
mouse |
| G S Pryhuber, H L Huyck, R J Staversky, J N Finkelstein, M A O'Reill. Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. American journal of respiratory cell and molecular biology. vol 22. issue 2. 2000-03-09. PMID:10657935. |
tumor necrosis factor (tnf) receptor (tnfr)-associated factors 1 and 2 (traf1 and traf2) and inhibitor of apoptosis proteins ciap1 (mihb) and ciap2 (mihc) were recently identified as proteins that associate with the tnf-alpha receptors tnfri (p55) and tnfrii (p75) and inhibit tnf-alpha-induced programmed cell death or apoptosis. |
2000-03-09 |
2023-08-12 |
mouse |
| C Tribouley, M Wallroth, V Chan, X Paliard, E Fang, G Lamson, D Pot, J Escobedo, L T William. Characterization of a new member of the TNF family expressed on antigen presenting cells. Biological chemistry. vol 380. issue 12. 2000-03-07. PMID:10661873. |
the tnf family is involved in the regulation of the immune system, and its members have been implicated in a variety of biological events such as apoptosis, cell proliferation, differentiation and survival. |
2000-03-07 |
2023-08-12 |
human |
| G Feng, N Kaplowit. Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. The Journal of clinical investigation. vol 105. issue 3. 2000-03-06. PMID:10675359. |
remarkably, fas and tnf receptor-1 mrna and intracellular protein levels increased after colchicine treatment, indicating that colchicine protects against death ligand-induced apoptosis in the liver by decreasing death-receptor targeting to the cell surface. |
2000-03-06 |
2023-08-12 |
mouse |
| E Pascher, A Perniok, A Becker, J Feldkam. Effect of 1alpha,25(OH)2-vitamin D3 on TNF alpha-mediated apoptosis of human primary osteoblast-like cells in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 12. 2000-02-29. PMID:10668917. |
effect of 1alpha,25(oh)2-vitamin d3 on tnf alpha-mediated apoptosis of human primary osteoblast-like cells in vitro. |
2000-02-29 |
2023-08-12 |
human |