| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L A Madge, J S Pobe. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. The Journal of biological chemistry. vol 275. issue 20. 2000-06-21. PMID:10748004. |
consistent with these biochemical observations, tnf and il-1 reduce apoptosis caused by growth factor and serum deprivation, and this action is also blocked by ly294002. |
2000-06-21 |
2023-08-12 |
human |
| J Plümpe, N P Malek, C T Bock, T Rakemann, M P Manns, C Trautwei. NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644576. |
tumor necrosis factor (tnf)-alpha is a potent inducer of apoptotic cell death in various tissues, whereas the transcription factor nuclear factor (nf)-kappab is essential to protect against tnf-alpha-induced apoptosis. |
2000-06-16 |
2023-08-12 |
mouse |
| A Nasir, H S Arora, H E Kaise. Apoptosis and pathogenesis of viral hepatitis C--an update. In vivo (Athens, Greece). vol 14. issue 1. 2000-06-16. PMID:10757089. |
possible inducers of apoptosis in hepatitis c include cytokines, especially tumor necrosis factor-alpha (tnf-alpha), released by inflammatory cells, and acting through tnf and other cytokine receptors. |
2000-06-16 |
2023-08-12 |
Not clear |
| K M Kurrelmeyer, L H Michael, G Baumgarten, G E Taffet, J J Peschon, N Sivasubramanian, M L Entman, D L Man. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 10. 2000-06-13. PMID:10779546. |
these data suggest that tnf signaling gives rise to one or more cytoprotective signals that prevent and/or delay the development of cardiac myocyte apoptosis after acute ischemic injury. |
2000-06-13 |
2023-08-12 |
mouse |
| M Kawanish. The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells: the role of LMP1 C-terminal activation regions 1 and 2. Virology. vol 270. issue 2. 2000-06-13. PMID:10792984. |
the epstein-barr virus latent membrane protein 1 (lmp1) enhances tnf alpha-induced apoptosis of intestine 407 epithelial cells: the role of lmp1 c-terminal activation regions 1 and 2. |
2000-06-13 |
2023-08-12 |
Not clear |
| M Kawanish. The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells: the role of LMP1 C-terminal activation regions 1 and 2. Virology. vol 270. issue 2. 2000-06-13. PMID:10792984. |
in contrast, the present study showed that the expression of lmp1 induced high susceptibility to tumor necrosis factor alpha (tnfalpha)-induced apoptosis in intestine 407 epithelial cells, without affecting expression of tnf receptors i and ii. |
2000-06-13 |
2023-08-12 |
Not clear |
| M E Burow, C B Weldon, L I Melnik, B N Duong, B M Collins-Burow, B S Beckman, J A McLachla. PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochemical and biophysical research communications. vol 271. issue 2. 2000-06-13. PMID:10799299. |
we found that in mcf-7 breast carcinoma cells, pi3k and akt suppressed a dose-dependent induction of apoptosis by tumor necrosis factor alpha (tnf). |
2000-06-13 |
2023-08-12 |
Not clear |
| M D Josephs, F R Bahjat, K Fukuzuka, R Ksontini, C C Solorzano, C K Edwards, C L Tannahill, S L MacKay, E M Copeland, L L Moldawe. Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 5. 2000-06-08. PMID:10801287. |
tumor necrosis factor (tnf)-alpha and fas ligand (fasl) are trimeric proteins that induce apoptosis through similar caspase-dependent pathways. |
2000-06-08 |
2023-08-12 |
mouse |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
all-trans-retinoic acid upregulates tnf receptors and potentiates tnf-induced activation of nuclear factors-kappab, activated protein-1 and apoptosis in human lung cancer cells. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
the increase in tnf receptors sensitized h596 cells to tnf-induced activation of nf-kappab, ap-1 and apoptosis. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
overall our results indicate that atra induces the tnf receptors in human lung cancer cells, which sensitizes them to tnf-induced signaling leading to activation of nf-kappab, ap-1 and apoptosis. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799874. |
hiv-tat protein, like tnf, activates a wide variety of cellular responses, including nf-kappa b, ap-1, c-jun n-terminal kinase (jnk), and apoptosis. |
2000-06-07 |
2023-08-12 |
Not clear |
| S K Manna, B B Aggarwa. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799874. |
overall, our results demonstrate that p56lck plays a critical role in the activation of nf-kappa b, ap-1, jnk, and apoptosis by hiv-tat protein but has minimal or no role in activation of these responses by tnf. |
2000-06-07 |
2023-08-12 |
Not clear |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
the effects of polyunsaturated fatty acids and vitamin e on tumor necrosis factor (tnf)-induced apoptosis of human monocytic u937 cells was explored to assess to what extent these nutrients could attenuate apoptosis. |
2000-06-07 |
2023-08-12 |
human |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
eicosapentaenoic acid slightly but significantly reduced the proportion of apoptotic cells only when apoptosis was induced by tnf without cycloheximide (chi). |
2000-06-07 |
2023-08-12 |
human |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
in contrast, preincubation with docosahexaenoic acid (dha) greatly (40 approximately 70%) attenuated apoptosis induced by stimulation with either tnf or tnf + chi for 3 h. the inhibition of apoptosis was accompanied by enrichment of dha in membrane phospholipids, indicating that dha probably exerted its inhibitory activity after being incorporated into the phospholipids. |
2000-06-07 |
2023-08-12 |
human |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
vitamin e also played a role as a partial inhibitor of apoptosis 3 h after tnf addition. |
2000-06-07 |
2023-08-12 |
human |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
longer-range stimulation of u937 cells with tnf showed that inhibition of apoptosis by preincubating cells with either dha or vitamin e was not significant 9 h after tnf addition, but that preincubation with both dha and vitamin e could reduce the proportion of apoptotic cells even at this time point. |
2000-06-07 |
2023-08-12 |
human |
| Y Higami, I Shimokawa, K Ando, K Tanaka, T Tsuchiy. Dietary restriction reduces hepatocyte proliferation and enhances p53 expression but does not increase apoptosis in normal rats during development. Cell and tissue research. vol 299. issue 3. 2000-06-06. PMID:10772250. |
we examined the effects of dr on proliferation and apoptosis of hepatocytes during development and explained these changes subcellularly using immunohistochemistry for bromodeoxyuridine (brdu) incorporation, proliferating cell nuclear antigen (pcna) and p53, terminal dutp nick end labeling (tunel) and quantitative reverse transcription-polymerase chain reaction (rt-pcr) for tgfalpha, tgfbeta1, p53, fas and tnf receptor (tnfr). |
2000-06-06 |
2023-08-12 |
rat |
| S K Manna, N K Sah, B B Aggarwa. Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis. The Journal of biological chemistry. vol 275. issue 18. 2000-06-01. PMID:10788436. |
both ceramide and tnf activate a wide variety of cellular responses, including nf-kappab, ap-1, jnk, and apoptosis. |
2000-06-01 |
2023-08-12 |
Not clear |