| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D C Mares, K M Heidler, G N Smith, O W Cummings, E R Harris, B Foresman, D S Wilke. Type V collagen modulates alloantigen-induced pathology and immunology in the lung. American journal of respiratory cell and molecular biology. vol 23. issue 1. 2000-08-14. PMID:10873154. |
we developed a murine model in which instillations of allogeneic bronchoalveolar lavage (bal) cells (c57bl/6, i-a(b), h-2(b)) into lungs of balb/c mice (i-a(d), h-2(d)) induce histology similar to grades 1 and 2 acute lung allograft rejection, apoptosis of airway epithelium and vascular endothelium, and upregulate tumor necrosis factor (tnf)-alpha production locally. |
2000-08-14 |
2023-08-12 |
mouse |
| J Xaus, M Comalada, A F Valledor, J Lloberas, F López-Soriano, J M Argilés, C Bogdan, A Celad. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha. Blood. vol 95. issue 12. 2000-08-10. PMID:10845916. |
in contrast, early apoptosis was paralleled by the rapid secretion of tnf and was almost absent in macrophages from mice deficient for one (p55) or both (p55 and p75) tnf-receptors. |
2000-08-10 |
2023-08-12 |
mouse |
| J Xaus, M Comalada, A F Valledor, J Lloberas, F López-Soriano, J M Argilés, C Bogdan, A Celad. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha. Blood. vol 95. issue 12. 2000-08-10. PMID:10845916. |
no-mediated cell death, but not apoptosis induced by tnf, correlated with the induction of p53 and bax genes. |
2000-08-10 |
2023-08-12 |
mouse |
| E Nisoli, L Briscini, A Giordano, C Tonello, S M Wiesbrock, K T Uysal, S Cinti, M O Carruba, G S Hotamisligi. Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10884431. |
the absence of both tnf receptors or p55 receptor alone resulted in a significant reduction in brown adipocyte apoptosis and an increase in beta(3)-adrenoreceptor and uncoupling protein-1 expression in obese mice. |
2000-08-10 |
2023-08-12 |
mouse |
| E A Slee, S A Keogh, S J Marti. Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release. Cell death and differentiation. vol 7. issue 6. 2000-08-08. PMID:10822279. |
bid, a pro-apoptotic bcl-2 family member, promotes cytochrome c release during apoptosis initiated by cd95l or tnf. |
2000-08-08 |
2023-08-12 |
Not clear |
| R H Pierce, J S Campbell, A B Stephenson, C C Franklin, M Chaisson, M Poot, T J Kavanagh, P S Rabinovitch, N Faust. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880392. |
we investigated the mechanisms by which tnf causes apoptosis in hepatocytes focusing on the role of oxidative stress, antioxidant defenses, and mitochondrial damage. |
2000-08-08 |
2023-08-12 |
Not clear |
| R H Pierce, J S Campbell, A B Stephenson, C C Franklin, M Chaisson, M Poot, T J Kavanagh, P S Rabinovitch, N Faust. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. The American journal of pathology. vol 157. issue 1. 2000-08-08. PMID:10880392. |
as is the case for hepatocytes in vivo, aml12 cells were not sensitive to cell death by tnf alone, but died by apoptosis when exposed to tnf and a small dose of actinomycin d (act d). |
2000-08-08 |
2023-08-12 |
Not clear |
| H J Deeg, C Beckham, M R Loken, E Bryant, M Lesnikova, H M Shulman, T Goole. Negative regulators of hemopoiesis and stroma function in patients with myelodysplastic syndrome. Leukemia & lymphoma. vol 37. issue 3-4. 2000-08-03. PMID:10752992. |
there is evidence, however, that regulatory molecules such as tumor necrosis factor (tnf)-alpha, fas (cd95), and fas-ligand, which negatively affect hemopoiesis by way of apoptosis are upregulated. |
2000-08-03 |
2023-08-12 |
Not clear |
| T Saito, G Dworacki, W Gooding, M T Lotze, T L Whitesid. Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 6. issue 4. 2000-08-03. PMID:10778963. |
to demonstrate that the tnf family of receptors and ligands was involved in this type of apoptosis, pbmcs were incubated in the presence of agonistic anti-fas antibody (ch-11) or tnf-alpha. |
2000-08-03 |
2023-08-12 |
Not clear |
| M Latta, G Künstle, M Leist, A Wende. Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. The Journal of experimental medicine. vol 191. issue 11. 2000-08-03. PMID:10839812. |
after the activation of the tumor necrosis factor (tnf) receptor or cd95, the extent of hepatocyte apoptosis and liver damage was quantified. |
2000-08-03 |
2023-08-12 |
mouse |
| M R Sprick, M A Weigand, E Rieser, C T Rauch, P Juo, J Blenis, P H Krammer, H Walcza. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. vol 12. issue 6. 2000-07-31. PMID:10894160. |
apoptosis induced by tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail/apo-2l) has been shown to exert important functions during various immunological processes. |
2000-07-31 |
2023-08-12 |
Not clear |
| F C Kischkel, D A Lawrence, A Chuntharapai, P Schow, K J Kim, A Ashkenaz. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. vol 12. issue 6. 2000-07-31. PMID:10894161. |
the tnf homolog apo2l/trail triggers apoptosis through two distinct death receptors, dr4 and dr5; however, receptor over-expression studies have yielded conflicting results on the ligand's signaling mechanism. |
2000-07-31 |
2023-08-12 |
Not clear |
| G Lavie, D Meruelo, K Aroyo, M Mande. Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases. International immunology. vol 12. issue 4. 2000-07-25. PMID:10744649. |
the findings suggest that the action of hypericin targets the effector ctl; however, apoptosis induced in murine l-cells with recombinant tumor necrosis factor (tnf)-alpha was also prevented by hypericin. |
2000-07-25 |
2023-08-12 |
Not clear |
| S Y Hong, W H Yoon, J H Park, S G Kang, J H Ahn, T H Le. Involvement of two NF-kappa B binding elements in tumor necrosis factor alpha -, CD40-, and epstein-barr virus latent membrane protein 1-mediated induction of the cellular inhibitor of apoptosis protein 2 gene. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10751398. |
among the antiapoptotic genes, cellular inhibitor of apoptosis protein 2 (c-iap2/hiap-1/mihc) is originally identified as a molecule recruited to the tumor necrosis factor (tnf) receptor complex, and its expression is preferentially up-regulated by tnf and other stimuli activating nf-kappab. |
2000-07-20 |
2023-08-12 |
Not clear |
| P J Duriez, F Wong, K Dorovini-Zis, R Shahidi, A Karsa. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10849436. |
tumor necrosis factor (tnf) does not cause endothelial apoptosis unless the expression of cytoprotective genes is blocked. |
2000-07-20 |
2023-08-12 |
Not clear |
| P J Duriez, F Wong, K Dorovini-Zis, R Shahidi, A Karsa. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10849436. |
in this report we demonstrate that, as with other cell types, inhibition of nfkappab initiates microvascular endothelial apoptosis in response to tnf. |
2000-07-20 |
2023-08-12 |
Not clear |
| P J Duriez, F Wong, K Dorovini-Zis, R Shahidi, A Karsa. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10849436. |
in contrast, a1 is not able to prevent endothelial apoptosis by tnf over 72 h, when nfkappab signaling is blocked. |
2000-07-20 |
2023-08-12 |
Not clear |
| P J Duriez, F Wong, K Dorovini-Zis, R Shahidi, A Karsa. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. The Journal of biological chemistry. vol 275. issue 24. 2000-07-20. PMID:10849436. |
on the other hand, the caspase inhibitor, benzyloxycarbonyl-vad-formylmethyl ketone, completely blocks tnf-induced endothelial apoptosis over 72 h. our findings indicate that a1 is able to maintain temporary survival of endothelial cells in response to tnf by maintaining mitochondrial viability and function. |
2000-07-20 |
2023-08-12 |
Not clear |
| R Göke, A Göke, B Göke, Y Che. Regulation of TRAIL-induced apoptosis by transcription factors. Cellular immunology. vol 201. issue 2. 2000-07-13. PMID:10831316. |
unlike many other members of the tnf family, trail selectively induces apoptosis of tumor cells, but not normal cells. |
2000-07-13 |
2023-08-12 |
Not clear |
| R R Mohan, R R Mohan, W J Kim, G R Stark, S E Wilso. Defective keratocyte apoptosis in response to epithelial injury in stat 1 null mice. Experimental eye research. vol 70. issue 4. 2000-07-07. PMID:10865997. |
corneal fibroblast apoptosis in response to tumor necrosis factor (tnf) alpha, with and without inhibitors of nuclear factor kappa b (nf-kappab) activation, was monitored using dna laddering and the methylene blue assay. |
2000-07-07 |
2023-08-12 |
mouse |