| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B B Aggarwa. Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Annals of the rheumatic diseases. vol 59 Suppl 1. 2000-11-21. PMID:11053079. |
tumour necrosis factor (tnf) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. |
2000-11-21 |
2023-08-12 |
Not clear |
| B M Segal, A H Cros. Fas(t) track to apoptosis in MS: TNF receptors may suppress or potentiate CNS demyelination. Neurology. vol 55. issue 7. 2000-11-21. PMID:11061241. |
fas(t) track to apoptosis in ms: tnf receptors may suppress or potentiate cns demyelination. |
2000-11-21 |
2023-08-12 |
Not clear |
| S P Kantrow, J L Gierman, V R Jaligam, P Zhang, C A Piantadosi, W R Summer, J R Lancaste. Regulation of tumor necrosis factor cytotoxicity by calcineurin. FEBS letters. vol 483. issue 2-3. 2000-11-15. PMID:11042265. |
cyclosporin (csa) inhibits mitochondrial death signaling and opposes tumor necrosis factor (tnf)-induced apoptosis in vitro. |
2000-11-15 |
2023-08-12 |
rat |
| F Mühlenbeck, P Schneider, J L Bodmer, R Schwenzer, A Hauser, G Schubert, P Scheurich, D Moosmayer, J Tschopp, H Wajan. The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation. The Journal of biological chemistry. vol 275. issue 41. 2000-11-13. PMID:10807904. |
overexpression of the tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors, trail-r1 and trail-r2, induces apoptosis and activation of nf-kappab in cultured cells. |
2000-11-13 |
2023-08-12 |
Not clear |
| Y Liu, Y Hong, E J Androphy, J J Che. Rb-independent induction of apoptosis by bovine papillomavirus type 1 E7 in response to tumor necrosis factor alpha. The Journal of biological chemistry. vol 275. issue 40. 2000-11-13. PMID:10887172. |
our results indicate that expression of bpv-1 e7 sensitizes cells to tumor necrosis factor alpha (tnf)-induced apoptosis. |
2000-11-13 |
2023-08-12 |
human |
| L Molnár, T Berki, A Hussain, P Németh, H Losoncz. [The role of TNF-alpha in myelodysplastic syndrome: immunoserologic and immunohistochemical studies] . Orvosi hetilap. vol 141. issue 33. 2000-11-09. PMID:10979309. |
in conclusion we suppose that increased tnf alpha expression and production by pbmc may be a further indirect evidence of the role of increased apoptosis in low risk mds patients, in the course of progression the cytokine expression and production decreases. |
2000-11-09 |
2023-08-12 |
Not clear |
| M Lucas, P E Rose, A G Morri. Contrasting effects of HSP72 expression on apoptosis in human umbilical vein endothelial cells and an angiogenic cell line, ECV304. British journal of haematology. vol 110. issue 4. 2000-11-09. PMID:11054088. |
transient overexpression of hsp72 was achieved using an adenoviral vector (advhsp72) and apoptosis was induced by heat shock, tumour necrosis factor (tnf)-alpha with cycloheximide (chx), lipopolysaccharide (lps) with tnf-alpha and verocytotoxin (vt). |
2000-11-09 |
2023-08-12 |
human |
| C Napoli, O Quehenberger, F De Nigris, P Abete, C K Glass, W Palinsk. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 13. 2000-11-08. PMID:11023984. |
blocking of fas ligand (fasl) reduced apoptosis by 50% and simultaneous blocking of fasl and tnf receptors by 70%. |
2000-11-08 |
2023-08-12 |
human |
| C Napoli, O Quehenberger, F De Nigris, P Abete, C K Glass, W Palinsk. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 13. 2000-11-08. PMID:11023984. |
our results provide the first evidence that oxldl-induced apoptosis involves tnf receptors and jun activation. |
2000-11-08 |
2023-08-12 |
human |
| D W Pyatt, Y Yang, W S Stillman, L L Cano, R D Iron. Hydroquinone inhibits PMA-induced activation of NFkappaB in primary human CD19+ B lymphocytes. Cell biology and toxicology. vol 16. issue 1. 2000-11-07. PMID:10890505. |
inhibition of nfkappab is accompanied by a dose-dependent decrease in pma-stimulated production of tnf with no corresponding loss in viability or increased apoptosis. |
2000-11-07 |
2023-08-12 |
human |
| V Bours, M Bentires-Alj, A C Hellin, P Viatour, P Robe, S Delhalle, V Benoit, M P Mervill. Nuclear factor-kappa B, cancer, and apoptosis. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007945. |
it has also been reported that nf-kappa b activation by tumor necrosis factor (tnf)-alpha, chemotherapeutic drugs, or ionizing radiations can protect several cell types against apoptosis, suggesting that nf-kappa b could participate in resistance to cancer treatment. |
2000-10-31 |
2023-08-12 |
Not clear |
| Q Wang, Y Ji, X Wang, B M Ever. Isolation and molecular characterization of the 5'-upstream region of the human TRAIL gene. Biochemical and biophysical research communications. vol 276. issue 2. 2000-10-27. PMID:11027498. |
trail, a novel member of the tnf family, acts through membrane receptors to induce apoptosis of activated t lymphocytes and may represent a mechanism for the "immune escape" of certain cancers. |
2000-10-27 |
2023-08-12 |
human |
| S S Deshpande, P Angkeow, J Huang, M Ozaki, K Iran. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 14. issue 12. 2000-10-26. PMID:10973919. |
reactive oxygen species (ros) have been implicated as mediators of tumor necrosis factor-alpha (tnf) -induced apoptosis. |
2000-10-26 |
2023-08-12 |
human |
| b' A B Moshnikova, K E Krotova, V V Galat, V N Afanas\'ev, V B Sadovnikov, I P Beletski\\xc4\\xa. [Apoptosis of L929 cells induced by tumor necrosis factor]. Tsitologiia. vol 42. issue 6. 2000-10-12. PMID:10953861.' |
based on morphological and biochemical data it has been shown that l929 cells died after tnf treatment by apoptosis irrespective of tnf dose and protein synthesis inhibition. |
2000-10-12 |
2023-08-12 |
Not clear |
| Y Mochid. [Functional analysis of apoptosis signal-regulating kinase 1 (ASK 1)-binding proteins]. Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan. vol 67. issue 2. 2000-10-04. PMID:10921242. |
apoptosis signal-regulating kinase 1 (ask 1) is a mitogen-activated protein (map) kinase kinase kinase (mapkkk) that is activated by tnf and il-1, and stimulates c-jun n-terminal kinase (jnk also known as sapk; stress-activated protein kinase) and p38 activation. |
2000-10-04 |
2023-08-12 |
Not clear |
| M Wu, A Das, Y Tan, C Zhu, T Cui, M C Won. Induction of apoptosis in glioma cell lines by TRAIL/Apo-2l. Journal of neuroscience research. vol 61. issue 4. 2000-10-03. PMID:10931534. |
trail/apo-2l, a novel cytokine, is a member of the tumor necrosis factor (tnf) family and serves as an extracellular signal triggering apoptosis. |
2000-10-03 |
2023-08-12 |
human |
| A Strelow, K Bernardo, S Adam-Klages, T Linke, K Sandhoff, M Krönke, D Ada. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. The Journal of experimental medicine. vol 192. issue 5. 2000-09-28. PMID:10974027. |
in response to tnf, parental l929 cells display a significant increase in intracellular ceramide correlated with an "atypical apoptosis" characterized by membrane blebbing, dna fragmentation and degradation of poly(adp-ribose) polymerase despite a lack of caspase activity. |
2000-09-28 |
2023-08-12 |
human |
| J Yuan, L Zhou, X Qi. [The relationship between LPS-induced apoptosis in hepatocyte, Kupffer cell and hepatocytic damage]. Zhonghua yi xue za zhi. vol 78. issue 6. 2000-09-26. PMID:10923503. |
to study the role of tumor necrosis factor (tnf alpha) in the mechanisms of liver injury and the relationship between lps-induced apoptosis in hepatocyte (hc), kupffer cell (kc), and hepatic damage. |
2000-09-26 |
2023-08-12 |
Not clear |
| T S Griffith, R D Anderson, B L Davidson, R D Williams, T L Ratlif. Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 5. 2000-09-19. PMID:10946322. |
tnf-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily of cytokines that induces apoptosis in a variety of cancer cells. |
2000-09-19 |
2023-08-12 |
human |
| S Lüschen, S Ussat, G Scherer, D Kabelitz, S Adam-Klage. Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10827087. |
upon binding of their ligands, death receptors belonging to the tumor necrosis factor (tnf) receptor family initiate a signaling pathway leading to the activation of caspases and ultimately apoptosis. |
2000-09-14 |
2023-08-12 |
Not clear |