| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Liu, C R Lo, B E Jones, Z Pradhan, A Srinivasan, K L Valentino, R J Stockert, M J Czaj. Inhibition of c-Myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis. The Journal of biological chemistry. vol 275. issue 51. 2001-02-01. PMID:11016920. |
while s-myc cells proliferated in response to tnf treatment, an-myc cells underwent 32% cell death within 6 h. fluorescent microscopic studies indicated that tnf induced apoptosis and necrosis in an-myc cells. |
2001-02-01 |
2023-08-12 |
rat |
| J Wen, N Ramadevi, D Nguyen, C Perkins, E Worthington, K Bhall. Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. Blood. vol 96. issue 12. 2001-02-01. PMID:11090076. |
in present studies, treatment with tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail, also known as apo-2 ligand [apo-2l]) is shown to induce apoptosis of the human acute leukemia hl-60, u937, and jurkat cells in a dose-dependent manner, with the maximum effect seen following treatment of jurkat cells with 0.25 microg/ml of apo-2l (95.0% +/- 3.5% of apoptotic cells). |
2001-02-01 |
2023-08-12 |
human |
| N Takabatake, H Nakamura, S Inoue, K Terashita, H Yuki, S Kato, S Yasumura, H Tomoik. Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease. Respiratory medicine. vol 94. issue 12. 2001-02-01. PMID:11192958. |
fas- and tumour necrosis factor (tnf) receptor-mediated apoptosis are known to be two principal apoptotic mechanisms in humans. |
2001-02-01 |
2023-08-12 |
Not clear |
| M Pinti, M Nasi, L Moretti, C Mussini, D Petrusca, R Esposito, A Cossarizz. Quantitation of CD95 and CD95L mRNA expression in chronic and acute HIV-1 infection by competitive RT-PCR. Annals of the New York Academy of Sciences. vol 926. 2001-02-01. PMID:11193040. |
apoptosis can be triggered by signals that arise from within the cell, or by signals that are elicited by binding of extracellular "death ligands" to their "death receptors," most of which belong to the tumor necrosis factor (tnf)-receptor family, such as cd95 (fas/apo-1). |
2001-02-01 |
2023-08-12 |
human |
| J Sträter, P Mölle. Expression and function of death receptors and their natural ligands in the intestine. Annals of the New York Academy of Sciences. vol 915. 2001-02-01. PMID:11193573. |
apoptosis is induced upon trimerization of the receptors by their natural ligands' constituting the complementary tnf family. |
2001-02-01 |
2023-08-12 |
Not clear |
| J Sträter, P Mölle. Expression and function of death receptors and their natural ligands in the intestine. Annals of the New York Academy of Sciences. vol 915. 2001-02-01. PMID:11193573. |
a more recently described member of the tnf family is trail, which is also able to induce apoptosis. |
2001-02-01 |
2023-08-12 |
Not clear |
| A Friedman, S Weiss, N Levy, R Meida. Role of tumor necrosis factor alpha and its type I receptor in luteal regression: induction of programmed cell death in bovine corpus luteum-derived endothelial cells. Biology of reproduction. vol 63. issue 6. 2001-01-26. PMID:11090464. |
in conclusion, this study suggests that tnf alpha-induced pcd during structural luteolysis is mediated by tnfri, primarily affects endothelial cells, and that the decline in progesterone, preceding structural luteolysis, is a prerequisite for the initiation of apoptosis in endothelial cells. |
2001-01-26 |
2023-08-12 |
cattle |
| F Diaz, L Y Bourguigno. Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells. Cell calcium. vol 27. issue 6. 2001-01-18. PMID:11013462. |
selective down-regulation of ip(3)receptor subtypes by caspases and calpain during tnf alpha -induced apoptosis of human t-lymphoma cells. |
2001-01-18 |
2023-08-12 |
human |
| V Maguer-Satta, R Oostendorp, D Reid, C J Eave. Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates. Blood. vol 96. issue 13. 2001-01-18. PMID:11110682. |
these findings indicate that tnf can directly modulate the ability of cd34(+)cd38(-) cells to maintain their ltc-ic function at doses below those required to initiate apoptosis, cell cycle arrest, or both, and they suggest that this may be mediated by the tnf-induced generation of intracellular ceramide. |
2001-01-18 |
2023-08-12 |
human |
| U Mahlknecht, C Deng, M C Lu, T C Greenough, J L Sullivan, W A O'Brien, G Herbei. Resistance to apoptosis in HIV-infected CD4+ T lymphocytes is mediated by macrophages: role for Nef and immune activation in viral persistence. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 11. 2001-01-11. PMID:11086083. |
tnf-alpha (tnf) expressed on the surface of macrophages prevented apoptosis in nef-expressing, productively infected cd4(+) t lymphocytes. |
2001-01-11 |
2023-08-12 |
Not clear |
| U Mahlknecht, C Deng, M C Lu, T C Greenough, J L Sullivan, W A O'Brien, G Herbei. Resistance to apoptosis in HIV-infected CD4+ T lymphocytes is mediated by macrophages: role for Nef and immune activation in viral persistence. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 11. 2001-01-11. PMID:11086083. |
similarly, following tnf stimulation, apoptosis was diminished in jurkat t cells transfected with a nef-expressing plasmid. |
2001-01-11 |
2023-08-12 |
Not clear |
| M Nagaki, T Naiki, D A Brenner, Y Osawa, M Imose, H Hayashi, Y Banno, S Nakashima, H Moriwak. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. Hepatology (Baltimore, Md.). vol 32. issue 6. 2001-01-04. PMID:11093734. |
tumor necrosis factor alpha (tnf-alpha) binding to the tnf receptor (tnfr) initiates apoptosis and simultaneously activates the transcription factor, nuclear factor-kappab (nf-kappab), which suppresses apoptosis by an unknown mechanism. |
2001-01-04 |
2023-08-12 |
mouse |
| A Schulz, G Baue. Selective effect of tumor necrosis factor on transformed versus nontransformed cells: nonselective signal recognition but differential target cell response. Anticancer research. vol 20. issue 5B. 2001-01-04. PMID:11131645. |
in contrast, in nontransformed cells, due to their higher initial concentration of endogenous survival factors, down-modulation by tnf is not complete and therefore apoptosis is still prevented. |
2001-01-04 |
2023-08-12 |
Not clear |
| S Bang, E J Jeong, I K Kim, Y K Jung, K S Ki. Fas- and tumor necrosis factor-mediated apoptosis uses the same binding surface of FADD to trigger signal transduction. A typical model for convergent signal transduction. The Journal of biological chemistry. vol 275. issue 46. 2000-12-29. PMID:10952991. |
fadd is known to function as a common signaling conduit in fas- and tumor necrosis factor (tnf)-mediated apoptosis. |
2000-12-29 |
2023-08-12 |
Not clear |
| A Kaptein, M Jansen, G Dilaver, J Kitson, L Dash, E Wang, M J Owen, J L Bodmer, J Tschopp, S N Farro. Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS letters. vol 485. issue 2-3. 2000-12-28. PMID:11094155. |
wsl-1/tramp (dr3) is a member of the tumour necrosis factor (tnf) receptor superfamily which exhibits effects on nf-kappab activation and apoptosis. |
2000-12-28 |
2023-08-12 |
mouse |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
tnf regulates thymocyte production by apoptosis and proliferation of the triple negative (cd3-cd4-cd8-) subset. |
2000-12-22 |
2023-08-12 |
mouse |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
our studies showed that tnf regulates mouse thymocyte production, inducing both apoptosis and proliferation of the most immature cd3(-)cd4(-)cd8(-) triple negative (tn) subset within a broad range of dosages (10(1)-10(5) pg/ml) in the presence of il-7. |
2000-12-22 |
2023-08-12 |
mouse |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
tnf apoptosis affected only the tn3 (cd44(-)cd25(+)) and tn4 (cd44(-)cd25(-)) subsets that expressed both tnfr-p55 and -p75. |
2000-12-22 |
2023-08-12 |
mouse |
| J G Baseta, O Stutma. TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 10. 2000-12-22. PMID:11067918. |
although each tnfr alone could mediate tnf apoptosis, maximal apoptosis was seen in c57bl/6j wild type, which expressed both tnfrs. |
2000-12-22 |
2023-08-12 |
mouse |
| R Rückert, G Lindner, S Bulfone-Paus, R Pau. High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo. The British journal of dermatology. vol 143. issue 5. 2000-12-08. PMID:11069516. |
while the effects of different cytokines or other apoptosis stimulating agents such as interferon (ifn)-gamma or tumour necrosis factor (tnf)-alpha on kc apoptosis in vitro have been addressed in several studies, little is known about the effects of proinflammatory cytokines on kc apoptosis in vivo. |
2000-12-08 |
2023-08-12 |
Not clear |