| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Suzuki, T Hasegawa, C Sakamoto, Y M Zhou, F Hato, M Hino, N Tatsumi, S Kitagaw. Cleavage of mitogen-activated protein kinases in human neutrophils undergoing apoptosis: role in decreased responsiveness to inflammatory cytokines. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 2. 2001-03-08. PMID:11145700. |
both molecules were cleaved at the n-terminal portion in neutrophils undergoing apoptosis induced by in vitro culture alone or treatment with tnf and/or cycloheximide. |
2001-03-08 |
2023-08-12 |
human |
| F Ozawa, H Friess, J Kleeff, Z W Xu, A Zimmermann, M S Sheikh, M W Büchle. Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. Cancer letters. vol 163. issue 1. 2001-03-08. PMID:11163110. |
pancreatic cancer cells are usually resistant to apoptosis mediated by tumor necrosis factor (tnf)-alpha or fasl, and their toxicity towards normal cells hampers their application for therapeutic use. |
2001-03-08 |
2023-08-12 |
human |
| F Ozawa, H Friess, J Kleeff, Z W Xu, A Zimmermann, M S Sheikh, M W Büchle. Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. Cancer letters. vol 163. issue 1. 2001-03-08. PMID:11163110. |
tnf-related apoptosis-inducing ligand (trail), a novel member of the tnf family, triggers apoptosis in a variety of malignant cells, but exhibits less cytotoxicity in normal cells. |
2001-03-08 |
2023-08-12 |
human |
| E J Kim, A Suliman, A Lam, R K Srivastav. Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand. International journal of oncology. vol 18. issue 1. 2001-02-15. PMID:11115558. |
tumor necrosis (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf family of cytokines that promotes apoptosis. |
2001-02-15 |
2023-08-12 |
Not clear |
| K Clodi, D Wimmer, Y Li, R Goodwin, U Jaeger, G Mann, H Gadner, A Youne. Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells. British journal of haematology. vol 111. issue 2. 2001-02-15. PMID:11122106. |
expression of tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors and sensitivity to trail-induced apoptosis in primary b-cell acute lymphoblastic leukaemia cells. |
2001-02-15 |
2023-08-12 |
Not clear |
| Y L Wu, X R Jiang, D M Lillington, A C Newland, S M Kelse. Upregulation of lipocortin 1 inhibits tumour necrosis factor-induced apoptosis in human leukaemic cells: a possible mechanism of resistance to immune surveillance. British journal of haematology. vol 111. issue 3. 2001-02-15. PMID:11122142. |
the signal transduction pathway through which tumour necrosis factor (tnf) induces apoptosis in leukaemic cells may involve activation of cytosolic phospholipase a(2) (cpla(2)). |
2001-02-15 |
2023-08-12 |
human |
| Y L Wu, X R Jiang, D M Lillington, A C Newland, S M Kelse. Upregulation of lipocortin 1 inhibits tumour necrosis factor-induced apoptosis in human leukaemic cells: a possible mechanism of resistance to immune surveillance. British journal of haematology. vol 111. issue 3. 2001-02-15. PMID:11122142. |
our data suggest that dex confers the resistance of u937 cells to tnf-induced apoptosis by upregulating intracellular levels of lc1 and by facilitating a negative-feedback loop, which is activated upon stimulation with tnf. |
2001-02-15 |
2023-08-12 |
human |
| D Kobayashi, N Watanabe, N Yamauchi, T Okamoto, N Tsuji, H Sasaki, T Sato, Y Niits. Heat-induced apoptosis via caspase-3 activation in tumour cells carrying mutant p53. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. vol 16. issue 6. 2001-02-08. PMID:11129259. |
in the present study, the signal transduction pathway underlying heat-induced apoptosis was investigated in heat-resistant hela cells carrying mutant p53 gene and heat sensitive hela cells that had been transduced with an antisense tnf gene. |
2001-02-08 |
2023-08-12 |
Not clear |
| S C Hasmall, D A West, K Olsen, R A Robert. Role of hepatic non-parenchymal cells in the response of rat hepatocytes to the peroxisome proliferator nafenopin in vitro. Carcinogenesis. vol 21. issue 12. 2001-02-08. PMID:11133804. |
removal of non-parenchymal cells from normal hepatocyte cultures prevented both the nafenopin- and tnf alpha-induced increase in dna synthesis and suppression of hepatocyte apoptosis; this response was restored by returning non-parenchymal cells to the purified hepatocytes. |
2001-02-08 |
2023-08-12 |
rat |
| S Aggarwal, S Gollapudi, L Yel, A S Gupta, S Gupt. TNF-alpha-induced apoptosis in neonatal lymphocytes: TNFRp55 expression and downstream pathways of apoptosis. Genes and immunity. vol 1. issue 4. 2001-02-08. PMID:11196704. |
in this study, we compared tumor necrosis factor (tnf)-alpha-induced apoptosis in t lymphocytes and their subsets between cord blood and peripheral blood from healthy young controls. |
2001-02-08 |
2023-08-12 |
Not clear |
| S K Manna, V Haridas, B B Aggarwa. Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 20. issue 8. 2001-02-02. PMID:10954916. |
tumor necrosis factor (tnf) is a multipotential cytokine that induces apoptosis and activates nuclear factor-kappa b (nf-kappab), activation protein 1 (ap-1), mitogen-activated protein kinase (mapk), and c-jun n-terminal kinase (jnk). |
2001-02-02 |
2023-08-12 |
human |
| S K Manna, V Haridas, B B Aggarwa. Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 20. issue 8. 2001-02-02. PMID:10954916. |
overall, our results demonstrate that bcl-x(l) inhibits tnf signaling at an early step common to induction of activation of apoptosis, nf-kappab, ap-1, mapk, and jnk. |
2001-02-02 |
2023-08-12 |
human |
| T Nguyen, W Thomas, X D Zhang, C Gray, P Herse. Immunologically-mediated tumour cell apoptosis: the role of TRAIL in T cell and cytokine-mediated responses to melanoma. Forum (Genoa, Italy). vol 10. issue 3. 2001-02-02. PMID:11007932. |
our studies have shown that cd4 t cells appear to kill melanoma by means of a member of the tumour necrosis factor (tnf) family expressed on their surface and called tnf related apoptosis inducing ligand (trail). |
2001-02-02 |
2023-08-12 |
human |
| A Eggert, H Sieverts, N Ikegaki, G M Brodeu. p75 mediated apoptosis in neuroblastoma cells is inhibited by expression of TrkA. Medical and pediatric oncology. vol 35. issue 6. 2001-02-02. PMID:11107120. |
the p75 receptor belongs to the tumor necrosis factor (tnf) family of death receptors and has been suggested as a receptor that mediates apoptosis in neuronal and nb cells. |
2001-02-02 |
2023-08-12 |
Not clear |
| F Zhu, W Yan, Z L Zhao, Y B Chai, F Lu, Q Wang, W D Peng, A G Yang, C J Wan. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. BioTechniques. vol 29. issue 2. 2001-02-01. PMID:10948432. |
apr-1, apr-2, apr-3 and tnf were reidentified by reverse dot blot, and it is suggested that they might be related to apoptosis. |
2001-02-01 |
2023-08-12 |
human |
| H Liu, C R Lo, B E Jones, Z Pradhan, A Srinivasan, K L Valentino, R J Stockert, M J Czaj. Inhibition of c-Myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis. The Journal of biological chemistry. vol 275. issue 51. 2001-02-01. PMID:11016920. |
while s-myc cells proliferated in response to tnf treatment, an-myc cells underwent 32% cell death within 6 h. fluorescent microscopic studies indicated that tnf induced apoptosis and necrosis in an-myc cells. |
2001-02-01 |
2023-08-12 |
rat |
| J Wen, N Ramadevi, D Nguyen, C Perkins, E Worthington, K Bhall. Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. Blood. vol 96. issue 12. 2001-02-01. PMID:11090076. |
in present studies, treatment with tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail, also known as apo-2 ligand [apo-2l]) is shown to induce apoptosis of the human acute leukemia hl-60, u937, and jurkat cells in a dose-dependent manner, with the maximum effect seen following treatment of jurkat cells with 0.25 microg/ml of apo-2l (95.0% +/- 3.5% of apoptotic cells). |
2001-02-01 |
2023-08-12 |
human |
| N Takabatake, H Nakamura, S Inoue, K Terashita, H Yuki, S Kato, S Yasumura, H Tomoik. Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease. Respiratory medicine. vol 94. issue 12. 2001-02-01. PMID:11192958. |
fas- and tumour necrosis factor (tnf) receptor-mediated apoptosis are known to be two principal apoptotic mechanisms in humans. |
2001-02-01 |
2023-08-12 |
Not clear |
| M Pinti, M Nasi, L Moretti, C Mussini, D Petrusca, R Esposito, A Cossarizz. Quantitation of CD95 and CD95L mRNA expression in chronic and acute HIV-1 infection by competitive RT-PCR. Annals of the New York Academy of Sciences. vol 926. 2001-02-01. PMID:11193040. |
apoptosis can be triggered by signals that arise from within the cell, or by signals that are elicited by binding of extracellular "death ligands" to their "death receptors," most of which belong to the tumor necrosis factor (tnf)-receptor family, such as cd95 (fas/apo-1). |
2001-02-01 |
2023-08-12 |
human |
| J Sträter, P Mölle. Expression and function of death receptors and their natural ligands in the intestine. Annals of the New York Academy of Sciences. vol 915. 2001-02-01. PMID:11193573. |
apoptosis is induced upon trimerization of the receptors by their natural ligands' constituting the complementary tnf family. |
2001-02-01 |
2023-08-12 |
Not clear |