| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Wajant, D Moosmayer, T Wüest, T Bartke, E Gerlach, U Schönherr, N Peters, P Scheurich, K Pfizenmaie. Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative. Oncogene. vol 20. issue 30. 2001-08-30. PMID:11494138. |
tnf-related apoptosis-inducing ligand (trail) is a typical member of the tumor necrosis factor (tnf) ligand family that is expressed as a type ii membrane protein (memtrail) and signals apoptosis via the death domain-containing receptors trail-r1 and -2. |
2001-08-30 |
2023-08-12 |
human |
| D Bernard, B Quatannens, B Vandenbunder, C Abbadi. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. The Journal of biological chemistry. vol 276. issue 29. 2001-08-23. PMID:11350953. |
rel/nf-kappab transcription factors protect against tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis by up-regulating the trail decoy receptor dcr1. |
2001-08-23 |
2023-08-12 |
Not clear |
| D Bernard, B Quatannens, B Vandenbunder, C Abbadi. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. The Journal of biological chemistry. vol 276. issue 29. 2001-08-23. PMID:11350953. |
we found using dna arrays, reverse transcription-polymerase chain reaction, and immunofluorescence that rel/nf-kappab factors up-regulate dcr1, a receptor for tnf-related apoptosis-inducing ligand (trail), a cytokine of the tnf family that induces apoptosis in tumor cells. |
2001-08-23 |
2023-08-12 |
Not clear |
| S A Beresford, M A Davies, G E Gallick, N J Donat. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 21. issue 5. 2001-08-23. PMID:11429162. |
tnf or trail alone failed to activate apoptosis in either lncap or pc-3 cells, and drug-mediated inhibition of the pi3k/akt cascade caused only minimal activation of apoptosis in either cell line. |
2001-08-23 |
2023-08-12 |
Not clear |
| S A Beresford, M A Davies, G E Gallick, N J Donat. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 21. issue 5. 2001-08-23. PMID:11429162. |
adenovirus-mediated pten/mmac1 expression in lncap cells reduced akt activation, activated apoptosis, and sensitized cells to tnf but not to trail. |
2001-08-23 |
2023-08-12 |
Not clear |
| D I Tai, S L Tsa. Apoptosis in viral hepatitis B and C. Chang Gung medical journal. vol 24. issue 5. 2001-08-23. PMID:11480324. |
apoptosis in viral hepatitis b and c. tumor necrosis factor (tnf) and tnf receptors (tnfr) are members of the growing tnf ligand and receptor families known to be involved in apoptosis, viral pathogenesis and immune regulation. |
2001-08-23 |
2023-08-12 |
Not clear |
| D I Tai, S L Tsa. Apoptosis in viral hepatitis B and C. Chang Gung medical journal. vol 24. issue 5. 2001-08-23. PMID:11480324. |
the present report will focus on the role of apoptosis in the pathogenesis of viral hepatitis b and c. although tnf was reported years ago to modulate viral infections, recent findings on the molecular pathways involved in tnfr signaling have allowed a better understanding of the molecular interactions between cellular and viral factors within the infected cell. |
2001-08-23 |
2023-08-12 |
Not clear |
| A Hernandez, Q D Wang, S A Schwartz, B M Ever. Sensitization of human colon cancer cells to TRAIL-mediated apoptosis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. vol 5. issue 1. 2001-08-16. PMID:11309649. |
tnf-related apoptosis-inducing ligand (trail), a novel member of the tumor necrosis factor (tnf) family, is thought to induce apoptosis preferentially in cancer cells; however, increasing evidence suggests that a number of cancers are resistant to trail treatment. |
2001-08-16 |
2023-08-12 |
human |
| P Schotte, G Van Loo, I Carpentier, P Vandenabeele, R Beyaer. Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein. The Journal of biological chemistry. vol 276. issue 28. 2001-08-16. PMID:11342564. |
lithium sensitizes tumor cells in an nf-kappa b-independent way to caspase activation and apoptosis induced by tumor necrosis factor (tnf). |
2001-08-16 |
2023-08-12 |
Not clear |
| Z You, H Ouyang, D Lopatin, P J Polver, C Y Wan. Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity. The Journal of biological chemistry. vol 276. issue 28. 2001-08-16. PMID:11346652. |
activation of the transcription factor nuclear factor-kappa b (nf-kappa b) has been found to play an essential role in the inhibition of tumor necrosis factor (tnf)-mediated apoptosis. |
2001-08-16 |
2023-08-12 |
Not clear |
| J Varghese, S Chattopadhaya, A Sari. Inhibition of p38 kinase reveals a TNF-alpha-mediated, caspase-dependent, apoptotic death pathway in a human myelomonocyte cell line. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 11. 2001-08-16. PMID:11359809. |
tnf induced expression of the antiapoptotic protein c-iap2 (cytoplasmic inhibitor of apoptosis protein 2), and was blocked in the presence of a p38 mapk inhibitor, which also induced caspase-dependent, tnf-mediated apoptosis in u937 cells. |
2001-08-16 |
2023-08-12 |
human |
| J Varghese, S Chattopadhaya, A Sari. Inhibition of p38 kinase reveals a TNF-alpha-mediated, caspase-dependent, apoptotic death pathway in a human myelomonocyte cell line. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 11. 2001-08-16. PMID:11359809. |
collectively, these data show that activation of p38 mapk is critical to cell survival by tnf in u937 cells, and demonstrate lineage-specific regulation of tnf-triggered signals of activation or apoptosis. |
2001-08-16 |
2023-08-12 |
human |
| Y Nakamura, K Sato, N Wakimoto, F Kimura, A Okuyama, K Motoyosh. A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis. Leukemia. vol 15. issue 8. 2001-08-16. PMID:11480563. |
a new matrix metalloproteinase inhibitor si-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to tnf alpha-induced apoptosis. |
2001-08-16 |
2023-08-12 |
human |
| H U Kontny, K Hämmerle, R Klein, P Shayan, C L Mackall, C M Niemeye. Sensitivity of Ewing's sarcoma to TRAIL-induced apoptosis. Cell death and differentiation. vol 8. issue 5. 2001-08-09. PMID:11423911. |
trail was the most potent inducer of apoptosis when compared to fas ligand or tnf. |
2001-08-09 |
2023-08-12 |
Not clear |
| D Yui, T Yoneda, K Oono, T Katayama, K Imaizumi, M Tohyam. Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene. vol 20. issue 32. 2001-08-09. PMID:11466612. |
previously, we have demonstrated that bcl10 potentially interacts with the other apoptosis regulator, tnf receptor associated factor-2 (traf2) and inhibitor of apoptosis proteins (ciaps). |
2001-08-09 |
2023-08-12 |
Not clear |
| D Javelaud, F Besanço. NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B. Oncogene. vol 20. issue 32. 2001-08-09. PMID:11466617. |
pretreatment of control cells with the phosphatase inhibitor vanadate greatly prolonged jnk activation by tnf alpha and resulted in induction of apoptosis by this cytokine. |
2001-08-09 |
2023-08-12 |
Not clear |
| D Javelaud, F Besanço. NF-kappa B activation results in rapid inactivation of JNK in TNF alpha-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-kappa B. Oncogene. vol 20. issue 32. 2001-08-09. PMID:11466617. |
moreover, overexpression of a dominant-negative mutant of jnk1 decreased tnf alpha-induced apoptosis in cells expressing the super repressor of nf-kappa b, indicating that the sustained activation of jnk1 participated in death signaling triggered by tnf alpha. |
2001-08-09 |
2023-08-12 |
Not clear |
| E Solito, C de Coupade, S Canaider, N J Goulding, M Perrett. Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. British journal of pharmacology. vol 133. issue 2. 2001-08-02. PMID:11350857. |
in addition, over-expression of the n-terminal and the first domain of the protein (144 amino acids, clone anx1-s), which does not contain the ca2+ binding sites, gives susceptibility to cell apoptosis following activation by either 5 ng ml(-1) tumour necrosis factor (tnf)-alpha or 1 - 40 microg ml-1 etoposide. |
2001-08-02 |
2023-08-12 |
Not clear |
| C Jones, J R Ciacci-Zanella, Y Zhang, G Henderson, M Dickma. Analysis of fumonisin B1-induced apoptosis. Environmental health perspectives. vol 109 Suppl 2. 2001-08-02. PMID:11359701. |
cpiap blocks apoptosis induced by the tumor necrosis factor (tnf) pathway as well as other mechanisms. |
2001-08-02 |
2023-08-12 |
mouse |
| C Jones, J R Ciacci-Zanella, Y Zhang, G Henderson, M Dickma. Analysis of fumonisin B1-induced apoptosis. Environmental health perspectives. vol 109 Suppl 2. 2001-08-02. PMID:11359701. |
further support for the involvement of the tnf signal transduction pathway in fb1 induced apoptosis was the cleavage of caspase 8. |
2001-08-02 |
2023-08-12 |
mouse |