| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G A Bulla, E Givens, S Brown, B Oladiran, D Krau. A common regulatory locus affects both HNF4/HNF1alpha pathway activation and sensitivity to LPS-mediated apoptosis in rat hepatoma cells. Journal of cell science. vol 114. issue Pt 6. 2001-07-05. PMID:11228163. |
lipopolysaccharide (lps) has been shown to protect certain cultured mammalian cells from undergoing programmed cell death (apoptosis) when exposed to tumor necrosis factor (tnf). |
2001-07-05 |
2023-08-12 |
mouse |
| M N'cho, Z Brahm. Evidence that Fas-induced apoptosis leads to S phase arrest. Human immunology. vol 62. issue 4. 2001-07-05. PMID:11295463. |
triggering of fas, a member of the tumor necrosis factor (tnf) receptor superfamily, by anti-fas antibodies or by the fas ligand (fasl), has been shown to cause cell death by apoptosis. |
2001-07-05 |
2023-08-12 |
Not clear |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
we examined the effects of insulin and the synthetic glucocorticoid, dexamethasone (dex), on tnf alpha-induced apoptosis and gene expression in human adipocytes and preadipocytes. |
2001-07-05 |
2023-08-12 |
human |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
apoptosis induced by tnf alpha was reduced to control levels (p < 0.01) by dex. |
2001-07-05 |
2023-08-12 |
human |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
insulin had no significant effect on tnf alpha-induced apoptosis and gene expression. |
2001-07-05 |
2023-08-12 |
human |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
in obesity, glucocorticoids may reduce tnf alpha actions in adipose tissue by inhibiting tnf alpha-induced apoptosis, il-1 beta release, and tnf alpha expression. |
2001-07-05 |
2023-08-12 |
human |
| b' I S Mathiasen, C M Hansen, L Foghsgaard, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. International journal of cancer. vol 93. issue 2. 2001-07-05. PMID:11410870.' |
sensitization to tnf-induced apoptosis by 1,25-dihydroxy vitamin d(3) involves up-regulation of the tnf receptor 1 and cathepsin b. |
2001-07-05 |
2023-08-12 |
Not clear |
| b' I S Mathiasen, C M Hansen, L Foghsgaard, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. International journal of cancer. vol 93. issue 2. 2001-07-05. PMID:11410870.' |
before the appearance of apoptotic cells at day 4 after the addition of 1,25(oh)(2)d(3), the mcf-7 cells are sensitized to the caspase-mediated apoptosis induced by tnf. |
2001-07-05 |
2023-08-12 |
Not clear |
| b' I S Mathiasen, C M Hansen, L Foghsgaard, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. International journal of cancer. vol 93. issue 2. 2001-07-05. PMID:11410870.' |
whereas 1,25(oh)(2)d(3) pre-treatment enhanced tnf-induced apoptosis of tnf sensitive mcf-7 cells, it failed to render tnf resistant t47d cells sensitive to this cytokine. |
2001-07-05 |
2023-08-12 |
Not clear |
| b' I S Mathiasen, C M Hansen, L Foghsgaard, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. International journal of cancer. vol 93. issue 2. 2001-07-05. PMID:11410870.' |
the sensitization of mcf-7 cells to tnf-induced apoptosis by pre-treatment with 1,25(oh)(2)d(3) may instead be partially explained by an increased surface expression of the tnf receptor 1 (tnf-r1). |
2001-07-05 |
2023-08-12 |
Not clear |
| b' I S Mathiasen, C M Hansen, L Foghsgaard, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D(3) involves up-regulation of the TNF receptor 1 and cathepsin B. International journal of cancer. vol 93. issue 2. 2001-07-05. PMID:11410870.' |
interestingly, the lysosomal protease cathepsin b, which expression is up-regulated by 1,25(oh)(2)d(3), was released from the lysosomes upon tnf treatment, and inhibition of its activity rescued 1,25(oh)(2)d(3) treated mcf-7 cells from tnf-induced apoptosis. |
2001-07-05 |
2023-08-12 |
Not clear |
| S Kreuz, D Siegmund, P Scheurich, H Wajan. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Molecular and cellular biology. vol 21. issue 12. 2001-06-28. PMID:11359904. |
sv80 cells normally show resistance to tnf-related apoptosis-inducing ligand (trail) and tnf, as apoptosis can be induced only in the presence of low concentrations of cycloheximide (chx). |
2001-06-28 |
2023-08-12 |
Not clear |
| b' L Foghsgaard, D Wissing, D Mauch, U Lademann, L Bastholm, M Boes, F Elling, M Leist, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. The Journal of cell biology. vol 153. issue 5. 2001-06-28. PMID:11381085.' |
contrary to caspase inhibitors, a panel of pharmacological cathepsin b inhibitors, the endogenous cathepsin inhibitor cystatin a as well as antisense-mediated depletion of cathepsin b rescued wehi-s cells from apoptosis triggered by tnf or tnf-related apoptosis-inducing ligand. |
2001-06-28 |
2023-08-12 |
human |
| J Zhang, T W Salcedo, X Wan, S Ullrich, B Hu, T Gregorio, P Feng, S Qi, H Chen, Y H Cho, Y Li, P A Moore, J W. Modulation of T-cell responses to alloantigens by TR6/DcR3. The Journal of clinical investigation. vol 107. issue 11. 2001-06-28. PMID:11390428. |
tr6 can bind to fasl and prevent fasl-induced apoptosis; it can also associate with light, another tnf family member. |
2001-06-28 |
2023-08-12 |
mouse |
| N S Chang, N Pratt, J Heath, L Schultz, D Sleve, G B Carey, N Zevote. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11058590. |
enhancement of tnf cytotoxicity by wox1 is due, in part, to its significant down-regulation of the apoptosis inhibitors bcl-2 and bcl-x(l) (>85%), but up-regulation of pro-apoptotic p53 ( approximately 200%) by the adh domain. |
2001-06-21 |
2023-08-12 |
Not clear |
| N S Chang, N Pratt, J Heath, L Schultz, D Sleve, G B Carey, N Zevote. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11058590. |
the ww domains failed to modulate the expression of these proteins, but sensitized cos-7 cells to tnf killing and mediated apoptosis in various cancer cells independently of caspases. |
2001-06-21 |
2023-08-12 |
Not clear |
| E Leo, Q L Deveraux, C Buchholtz, K Welsh, S Matsuzawa, H R Stennicke, G S Salvesen, J C Ree. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11098060. |
significant enhancement of tnf receptor-1 (cd120a)- and, to a lesser extent, fas (cd95)-mediated apoptosis was observed when overexpressing the c-terminal traf1 fragment in hek293t and ht1080 cells. |
2001-06-21 |
2023-08-12 |
Not clear |
| E Leo, Q L Deveraux, C Buchholtz, K Welsh, S Matsuzawa, H R Stennicke, G S Salvesen, J C Ree. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11098060. |
the same fragment was capable of potently suppressing tnf receptor-1- and traf2-mediated nuclear factor-kappab activation in reporter gene assays, providing a potential mechanism for the enhancement of tnf-mediated apoptosis. |
2001-06-21 |
2023-08-12 |
Not clear |
| M Déjosez, U Ramp, C Mahotka, A Krieg, H Walczak, H E Gabbert, C D Gerhar. Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. Cell death and differentiation. vol 7. issue 11. 2001-06-21. PMID:11139287. |
trail (apo-2l) is a newly identified member of the tnf family and induces apoptosis in cancer cells without affecting most non-neoplastic cells, both in vitro and in vivo. |
2001-06-21 |
2023-08-12 |
human |
| B Nagy, W C Yeh, T W Mak, S M Chiu, D Separovi. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Archives of biochemistry and biophysics. vol 385. issue 1. 2001-06-21. PMID:11361017. |
oxidative stress, such as photodynamic therapy with the silicon phthalocyanine pc 4 (pc 4-pdt), can induce apoptosis and tumor necrosis factor alpha (tnf) production. |
2001-06-21 |
2023-08-12 |
mouse |