| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Inagaki-Ohara, S Yada, N Takamura, M Reaves, X Yu, E Liu, I Rooney, S Nicholas, A Castro, C F Ware, D R Green, T Li. p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system. Oncogene. vol 20. issue 7. 2001-05-10. PMID:11314015. |
we demonstrate that mice genetically engineered to be deficient in tnf receptor type 1 (tnfr1(-/-)) and mice injected with tnfr1-fusion chimeric protein (tnfr1-fc; a competitive inhibitor of tnfr1) were partially protected (30-40%) from p53-dependent radiation-induced iec apoptosis. |
2001-05-10 |
2023-08-12 |
mouse |
| K Inagaki-Ohara, S Yada, N Takamura, M Reaves, X Yu, E Liu, I Rooney, S Nicholas, A Castro, C F Ware, D R Green, T Li. p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system. Oncogene. vol 20. issue 7. 2001-05-10. PMID:11314015. |
interestingly, we found that injection of tnf readily induced iec apoptosis and that radiation induced a p53-dependent increase in the intestinal level of tnf. |
2001-05-10 |
2023-08-12 |
mouse |
| K Inagaki-Ohara, S Yada, N Takamura, M Reaves, X Yu, E Liu, I Rooney, S Nicholas, A Castro, C F Ware, D R Green, T Li. p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system. Oncogene. vol 20. issue 7. 2001-05-10. PMID:11314015. |
overall, these results suggest that p53-dependent radiation-induced iec apoptosis is mediated in part through ability of p53 to regulate tnf, which subsequently induces iec apoptosis through tnfr1. |
2001-05-10 |
2023-08-12 |
mouse |
| A Kumar, A Jasmin, M T Eby, P M Chaudhar. Cytotoxicity of Tumor necrosis factor related apoptosis-inducing ligand towards Ewing's sarcoma cell lines. Oncogene. vol 20. issue 8. 2001-05-10. PMID:11314037. |
death ligands of the tumor necrosis factor (tnf) family are known to induce apoptosis upon binding to their cognate receptors. |
2001-05-10 |
2023-08-12 |
Not clear |
| A Murakami, Y Suminami, H Hirakawa, S Nawata, F Numa, H Kat. Squamous cell carcinoma antigen suppresses radiation-induced cell death. British journal of cancer. vol 84. issue 6. 2001-05-03. PMID:11259103. |
previous study has demonstrated that squamous cell carcinoma antigen (scca) 1 attenuates apoptosis induced by tnf alpha, nk cell or anticancer drug. |
2001-05-03 |
2023-08-12 |
Not clear |
| R Wang, L Zhang, X Zhang, J Moreno, X Luo, M Tondravi, Y Sh. Differential regulation of the expression of CD95 ligand, receptor activator of nuclear factor-kappa B ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-alpha during T cell activation. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 3. 2001-04-19. PMID:11160247. |
members of tnf superfamily are characterized by their ability to inflict apoptosis upon binding to their cognate receptors in a homotrimeric manner. |
2001-04-19 |
2023-08-12 |
Not clear |
| Q Chang, B L Tepperma. The role of protein kinase C isozymes in TNF-alpha-induced cytotoxicity to a rat intestinal epithelial cell line. American journal of physiology. Gastrointestinal and liver physiology. vol 280. issue 4. 2001-04-19. PMID:11254483. |
tumor necrosis factor (tnf)-alpha can induce cytotoxicity and apoptosis in a number of cell types and has been implicated in the regulation of many inflammatory processes. |
2001-04-19 |
2023-08-12 |
rat |
| E Arzt, D Kovalovsky, L M Igaz, M Costas, P Plazas, D Refojo, M Páez-Pereda, J M Reul, G Stalla, F Holsboe. Functional cross-talk among cytokines, T-cell receptor, and glucocorticoid receptor transcriptional activity and action. Annals of the New York Academy of Sciences. vol 917. 2001-04-19. PMID:11268396. |
as a functional physiological correlate, priming of fibroblastic cells with a low dose of tnf significantly increases the sensitivity to glucocorticoid inhibition of tnf-induced apoptosis (without involving nf-kappa b). |
2001-04-19 |
2023-08-12 |
mouse |
| D Kaioumova, C Süsal, G Opel. Induction of apoptosis in human lymphocytes by the herbicide 2,4-dichlorophenoxyacetic acid. Human immunology. vol 62. issue 1. 2001-04-05. PMID:11165716. |
apoptosis induced by dma-2,4-d was dose and time dependent, independent of fas, tnf receptor 1 or the aromatic hydrocarbon receptor, and involved disruption of the mitochondrial transmembrane potential and activation of caspase-9. |
2001-04-05 |
2023-08-12 |
human |
| P Tesarová, J Kvasnicka, A Umlaufová, H Homolková, M Jirsa, V Tesa. Soluble TNF and IL-2 receptors in patients with breast cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 6. issue 4. 2001-04-05. PMID:11208388. |
tnf alpha may mediate apoptosis and necrosis of cancer cells, while the exact role of il-2 remains to be elucidated. |
2001-04-05 |
2023-08-12 |
Not clear |
| P R Walker, T Calzascia, V Schnuriger, D Chalmers, P Saas, P Y Dietric. Loss of Fas (CD95/APO-1) expression by antigen-specific cytotoxic T cells is reversed by inhibiting DNA methylation. Cellular immunology. vol 206. issue 1. 2001-03-29. PMID:11161437. |
elimination of clonally expanded peripheral cd8 t cells was thought to involve apoptosis induction mediated principally by tnf, but recently fas (cd95/apo-1) has been shown to play a role in certain responses. |
2001-03-29 |
2023-08-12 |
Not clear |
| H D Jang, Y M Chung, J H Baik, Y G Choi, I S Park, Y K Jung, S Y Le. Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death. Biochemical and biophysical research communications. vol 281. issue 2. 2001-03-29. PMID:11181075. |
here we show that traf1 is cleaved by caspase-8 into two fragments during apoptosis induced by tnf. |
2001-03-29 |
2023-08-12 |
Not clear |
| A Shrivastava, B B Aggarwa. Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. Antioxidants & redox signaling. vol 1. issue 2. 2001-03-29. PMID:11228746. |
overall, these results suggest that hydroxyl radicals mediate tnf-induced apoptosis but not activation of nf-kappa b, ap-1, and jnk; superoxide radicals mediate nf-kappa b and jnk activation but potentiate apoptosis; and lipid peroxides are required for all the signals induced by tnf. |
2001-03-29 |
2023-08-12 |
human |
| W W Navarre, A Zychlinsk. Pathogen-induced apoptosis of macrophages: a common end for different pathogenic strategies. Cellular microbiology. vol 2. issue 4. 2001-03-15. PMID:11207583. |
induce apoptosis by suppressing the signalling pathways that lead to the production of tumour necrosis factor (tnf)-alpha, a cytokine essential for the control of this infection. |
2001-03-15 |
2023-08-12 |
Not clear |
| D W Seol, J Li, M H Seol, S Y Park, R V Talanian, T R Billia. Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis. Cancer research. vol 61. issue 3. 2001-03-15. PMID:11221844. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a tnf family member and potent apoptosis inducer. |
2001-03-15 |
2023-08-12 |
Not clear |
| G S Filippatos, K Tsilias, K Venetsanou, E Karambinos, D Manolatos, A Kranidis, J Antonellis, F Kardaras, L Anthopoulos, G Baltopoulo. Leptin serum levels in cachectic heart failure patients. Relationship with tumor necrosis factor-alpha system. International journal of cardiology. vol 76. issue 2-3. 2001-03-08. PMID:11104865. |
to investigate the role of leptin and regulators of apoptosis in cardiac cachexia we compared leptin concentrations and their relation to the tnf system, interleukin 1-beta (il-1b), and soluble fas in patients with heart failure with and without cachexia. |
2001-03-08 |
2023-08-12 |
Not clear |
| M Pelagi, F Curnis, B Colombo, P Rovere, A Sacchi, A A Manfredi, A Cort. Caspase inhibition reveals functional cooperation between p55- and p75-TNF receptors in cell necrosis. European cytokine network. vol 11. issue 4. 2001-03-08. PMID:11125300. |
cytometric analysis after tnf treatment showed that apoptosis was inhibited, while necrosis was highly activated. |
2001-03-08 |
2023-08-12 |
mouse |
| M Pelagi, F Curnis, B Colombo, P Rovere, A Sacchi, A A Manfredi, A Cort. Caspase inhibition reveals functional cooperation between p55- and p75-TNF receptors in cell necrosis. European cytokine network. vol 11. issue 4. 2001-03-08. PMID:11125300. |
in contrast, apoptosis was observed in cells treated with tnf and actinomycin d alone. |
2001-03-08 |
2023-08-12 |
mouse |
| M Pelagi, F Curnis, B Colombo, P Rovere, A Sacchi, A A Manfredi, A Cort. Caspase inhibition reveals functional cooperation between p55- and p75-TNF receptors in cell necrosis. European cytokine network. vol 11. issue 4. 2001-03-08. PMID:11125300. |
stimulation of tnfr1 was sufficient to induce either cell necrosis or apoptosis, even when we blocked endogenous tnf with an anti-murine tnf antibody. |
2001-03-08 |
2023-08-12 |
mouse |
| B N Ditte. Evidence that Fas and FasL contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Archivum immunologiae et therapiae experimentalis. vol 48. issue 5. 2001-03-08. PMID:11140465. |
tnf-alpha and lt-alpha are both members of the tnf family of molecules and cause cell death by apoptosis following interaction with their counter-receptors, the tnfr1 and tnfr2, leading to a cascade of proteolytic events culminating in the blebbing of the cytoplasmic membrane, nuclear condensation and dna fragmentation. |
2001-03-08 |
2023-08-12 |
mouse |