| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N S Chang, N Pratt, J Heath, L Schultz, D Sleve, G B Carey, N Zevote. Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity. The Journal of biological chemistry. vol 276. issue 5. 2001-06-21. PMID:11058590. |
the ww domains failed to modulate the expression of these proteins, but sensitized cos-7 cells to tnf killing and mediated apoptosis in various cancer cells independently of caspases. |
2001-06-21 |
2023-08-12 |
Not clear |
| E Leo, Q L Deveraux, C Buchholtz, K Welsh, S Matsuzawa, H R Stennicke, G S Salvesen, J C Ree. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11098060. |
significant enhancement of tnf receptor-1 (cd120a)- and, to a lesser extent, fas (cd95)-mediated apoptosis was observed when overexpressing the c-terminal traf1 fragment in hek293t and ht1080 cells. |
2001-06-21 |
2023-08-12 |
Not clear |
| E Leo, Q L Deveraux, C Buchholtz, K Welsh, S Matsuzawa, H R Stennicke, G S Salvesen, J C Ree. TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis. The Journal of biological chemistry. vol 276. issue 11. 2001-06-21. PMID:11098060. |
the same fragment was capable of potently suppressing tnf receptor-1- and traf2-mediated nuclear factor-kappab activation in reporter gene assays, providing a potential mechanism for the enhancement of tnf-mediated apoptosis. |
2001-06-21 |
2023-08-12 |
Not clear |
| M Déjosez, U Ramp, C Mahotka, A Krieg, H Walczak, H E Gabbert, C D Gerhar. Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. Cell death and differentiation. vol 7. issue 11. 2001-06-21. PMID:11139287. |
trail (apo-2l) is a newly identified member of the tnf family and induces apoptosis in cancer cells without affecting most non-neoplastic cells, both in vitro and in vivo. |
2001-06-21 |
2023-08-12 |
human |
| B Nagy, W C Yeh, T W Mak, S M Chiu, D Separovi. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Archives of biochemistry and biophysics. vol 385. issue 1. 2001-06-21. PMID:11361017. |
oxidative stress, such as photodynamic therapy with the silicon phthalocyanine pc 4 (pc 4-pdt), can induce apoptosis and tumor necrosis factor alpha (tnf) production. |
2001-06-21 |
2023-08-12 |
mouse |
| B Nagy, W C Yeh, T W Mak, S M Chiu, D Separovi. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Archives of biochemistry and biophysics. vol 385. issue 1. 2001-06-21. PMID:11361017. |
tnf receptors, as well as other death receptors, have been implicated in stress-induced apoptosis. |
2001-06-21 |
2023-08-12 |
mouse |
| B Nagy, W C Yeh, T W Mak, S M Chiu, D Separovi. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Archives of biochemistry and biophysics. vol 385. issue 1. 2001-06-21. PMID:11361017. |
in contrast to pc 4 photosensitization, tnf did not induce either apoptosis or ceramide accumulation in fadd k/o cells. |
2001-06-21 |
2023-08-12 |
mouse |
| B Nagy, W C Yeh, T W Mak, S M Chiu, D Separovi. FADD null mouse embryonic fibroblasts undergo apoptosis after photosensitization with the silicon phthalocyanine Pc 4. Archives of biochemistry and biophysics. vol 385. issue 1. 2001-06-21. PMID:11361017. |
fb-sensitive ceramide production accompanies, but does not suffice, for apoptosis after pc 4 photosensitization or tnf. |
2001-06-21 |
2023-08-12 |
mouse |
| H Gisslinger, R Kurzrock, B Gisslinger, S Jiang, S Li, I Virgolini, W Woloszczuk, M Andreeff, M Talpa. Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon alpha: involvement of tumor necrosis factor as ligand for the CD95 receptor. Blood. vol 97. issue 9. 2001-06-14. PMID:11313273. |
although supernatants of ifn-treated daudi cells induced apoptosis of cd95-sensitive jurkat cells, cd95l was undetectable on protein or on messenger rna levels, and the weak initial expression of tnf receptor 1 increased only slightly during ifn treatment. |
2001-06-14 |
2023-08-12 |
human |
| I Petrache, A D Verin, M T Crow, A Birukova, F Liu, J G Garci. Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. American journal of physiology. Lung cellular and molecular physiology. vol 280. issue 6. 2001-06-14. PMID:11350795. |
tumor necrosis factor (tnf)-alpha is released in acute inflammatory lung syndromes linked to the extensive vascular dysfunction associated with increased permeability and endothelial cell apoptosis. |
2001-06-14 |
2023-08-12 |
Not clear |
| J H Vernooy, M A Dentener, R J van Suylen, W A Buurman, E F Wouter. Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-alpha and infiltrating neutrophils. American journal of respiratory cell and molecular biology. vol 24. issue 5. 2001-06-14. PMID:11350826. |
further, using three experimental approaches--namely, anti-tumor necrosis factor (tnf)-alpha treatment, it tnf-alpha instillation, and tnf/lymphotoxin-alpha knockout mice--we demonstrate that tnf-alpha, which was elevated in lungs at both messenger rna and protein levels after it lps challenge, was no primary mediator in lps-induced apoptosis at early time points. |
2001-06-14 |
2023-08-12 |
mouse |
| R Nimmanapalli, M Porosnicu, D Nguyen, E Worthington, E O'Bryan, C Perkins, K Bhall. Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 2. 2001-06-07. PMID:11234890. |
tumor necrosis factor (tnf) alpha-related apoptosis-inducing ligand (apo-2l/trail), after binding with its signaling death receptors (dr4 and dr5), triggers the intrinsic "mitochondrial" pathway of apoptosis more efficiently in the cancer than do normal cells. |
2001-06-07 |
2023-08-12 |
human |
| A Suliman, A Lam, R Datta, R K Srivastav. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. Oncogene. vol 20. issue 17. 2001-06-07. PMID:11360196. |
tumor necrosis (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf family of cytokines that promotes apoptosis. |
2001-06-07 |
2023-08-12 |
Not clear |
| H O Pae, W G Seo, G S Oh, M K Shin, H S Lee, H S Lee, S B Kim, H T Chun. Potentiation of tumor necrosis factor-alpha-induced apoptosis by mistletoe lectin. Immunopharmacology and immunotoxicology. vol 22. issue 4. 2001-05-31. PMID:11105782. |
in deed, simultaneous treatment of human cervix carcinoma hela or breast carcinoma mcf-7 cells with mls isolated from european or korean mistletoe rendered them more sensitive to induction of apoptosis by tnf. |
2001-05-31 |
2023-08-12 |
human |
| K Tobiume, A Matsuzawa, T Takahashi, H Nishitoh, K Morita, K Takeda, O Minowa, K Miyazono, T Noda, H Ichij. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO reports. vol 2. issue 3. 2001-05-31. PMID:11266364. |
apoptosis signal-regulating kinase (ask) 1 is activated in response to various cytotoxic stresses including tnf, fas and reactive oxygen species (ros) such as h(2)o(2), and activates c-jun nh(2)-terminal kinase (jnk) and p38. |
2001-05-31 |
2023-08-12 |
mouse |
| M Melnick, H Chen, Y M Zhou, T Jaskol. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells, tissues, organs. vol 168. issue 4. 2001-05-24. PMID:11275690. |
these experiments demonstrate: (1) there is a significant increase of il-6 mrna with progressive smg development, and that this is highly correlated with tnf transcript levels; (2) il-6 and its cognate receptors are immunolocalized in smg branching epithelia from the canalicular stage to the late terminal bud stage, as are other constituents of the il-6 pathway; (3) as compared to controls, il-6-supplemented explants exhibit a substantial increase in overall size and in the number of ductal branches and terminal buds, as well as a highly significant increase in epithelial cell proliferation; (4) smg explants cultured in the presence of anti-il-6 neutralizing antibodies exhibit a marked decrease in epithelial ducts and terminal buds, concomitant with a significant decline in cell proliferation and a highly significant increase in apoptosis. |
2001-05-24 |
2023-08-12 |
mouse |
| K Shiiki, H Yoshikawa, H Kinoshita, M Takeda, A Ueno, Y Nakajima, K Tasak. Potential mechanisms of resistance to TRAIL/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation. Cell death and differentiation. vol 7. issue 10. 2001-05-24. PMID:11279540. |
trail (tnf-related apoptosis-inducing ligand) which is also known as apo2 ligand (apo2l), a new member of tnf family, can induce apoptosis in some tumor cells but not in many normal cells. |
2001-05-24 |
2023-08-12 |
human |
| P Storz, H Döppler, J Horn-Müller, G Müller, K Pfizenmaie. TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells. Cell death and differentiation. vol 7. issue 10. 2001-05-24. PMID:11279542. |
tnf down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of kym-1 rhabdomyosarcoma cells. |
2001-05-24 |
2023-08-12 |
Not clear |
| P Storz, H Döppler, J Horn-Müller, G Müller, K Pfizenmaie. TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells. Cell death and differentiation. vol 7. issue 10. 2001-05-24. PMID:11279542. |
depending on the presence or absence of the caspase inhibitor z-vad-fmk, tnf induced full growth arrest or apoptosis, respectively, indicating dominance of tnf over mitogenic signal pathways in kym-1 cells. |
2001-05-24 |
2023-08-12 |
Not clear |
| Y Zhang, C Jones, M B Dickma. Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 39. issue 1. 2001-05-21. PMID:11259850. |
the baculovirus iap gene (inhibitor of apoptosis), which blocks tumor necrosis factor (tnf)-induced apoptosis, protects several fibroblast cell types from apoptosis, suggesting the tnf pathway is important for fb(1)-induced apoptosis. |
2001-05-21 |
2023-08-12 |
mouse |