| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Derby, V Reddy, W Kopp, E Nelson, M Baseler, T Sayers, A Malyguin. Three-color flow cytometric assay for the study of the mechanisms of cell-mediated cytotoxicity. Immunology letters. vol 78. issue 1. 2001-10-11. PMID:11470149. |
cytotoxic lymphocytes kill tumor or virus-infected target cells utilizing two mechanisms (1) release of lytic granules (containing perforin and granzymes) and (2) fas ligand (fasl)/fas or tnf initiated apoptosis. |
2001-10-11 |
2023-08-12 |
human |
| S K Jo, S Y Yun, K H Chang, D R Cha, W Y Cho, H K Kim, N H Wo. alpha-MSH decreases apoptosis in ischaemic acute renal failure in rats: possible mechanism of this beneficial effect. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 16. issue 8. 2001-10-11. PMID:11477159. |
fas belongs to the tumour necrosis factor (tnf)/nerve growth factor superfamily and engagement by fas ligand induces apoptosis in various epithelial cells. |
2001-10-11 |
2023-08-12 |
rat |
| A E Tollefson, K Toth, K Doronin, M Kuppuswamy, O A Doronina, D L Lichtenstein, T W Hermiston, C A Smith, W S Wol. Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins. Journal of virology. vol 75. issue 19. 2001-10-11. PMID:11533151. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis through two receptors, trail-r1 (also known as death receptor 4) and trail-r2 (also known as death receptor 5), that are members of the tnf receptor superfamily of death domain-containing receptors. |
2001-10-11 |
2023-08-12 |
human |
| A E Tollefson, K Toth, K Doronin, M Kuppuswamy, O A Doronina, D L Lichtenstein, T W Hermiston, C A Smith, W S Wol. Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins. Journal of virology. vol 75. issue 19. 2001-10-11. PMID:11533151. |
rid was also shown previously to internalize and degrade another death domain receptor, fas, and to prevent apoptosis through fas and the tnf receptor. |
2001-10-11 |
2023-08-12 |
human |
| A E Tollefson, K Toth, K Doronin, M Kuppuswamy, O A Doronina, D L Lichtenstein, T W Hermiston, C A Smith, W S Wol. Inhibition of TRAIL-induced apoptosis and forced internalization of TRAIL receptor 1 by adenovirus proteins. Journal of virology. vol 75. issue 19. 2001-10-11. PMID:11533151. |
e1b-19k was shown previously to block apoptosis through fas, and both e1b-19k and e3-14.7k were found to prevent apoptosis through the tnf receptor. |
2001-10-11 |
2023-08-12 |
human |
| I Dybedal, D Bryder, A Fossum, L S Rusten, S E Jacobse. Tumor necrosis factor (TNF)-mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells. Blood. vol 98. issue 6. 2001-10-11. PMID:11535512. |
tnf did not appear to enhance apoptosis or affect cell-cycle distribution of cultured progenitors, but rather promoted myeloid differentiation. |
2001-10-11 |
2023-08-12 |
mouse |
| W S Chen, P Z Xu, K Gottlob, M L Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Ha. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes & development. vol 15. issue 17. 2001-10-11. PMID:11544177. |
finally, akt1(-/-) mouse embryo fibroblasts (mefs) are more susceptible to apoptosis induced by tnf, anti-fas, uv irradiation, and serum withdrawal. |
2001-10-11 |
2023-08-12 |
mouse |
| J Soboloff, H Sasaki, B K Tsan. Follicular stage-dependent tumor necrosis factor alpha-induced hen granulosa cell integrin production and survival in the presence of transforming growth factor alpha in vitro. Biology of reproduction. vol 65. issue 2. 2001-09-27. PMID:11466216. |
however, fluorometric analysis indicated that the primary type of cell death exhibited by f5,6 granulosa cells during extended culture and attenuated by the presence of tnf alpha and tgf alpha was necrosis and not apoptosis. |
2001-09-27 |
2023-08-12 |
Not clear |
| T Mizuno, Y Goto, K Baba, K Masuda, K Ohno, H Tsujimot. TNF-alpha-induced cell death in feline immunodeficiency virus-infected cells is mediated by the caspase cascade. Virology. vol 287. issue 2. 2001-09-27. PMID:11531421. |
the present study indicates that tnf-alpha-induced apoptosis in fiv-infected crfk cells is mediated by the activation of the caspase cascade, but not by either upregulation of tnf receptor or inhibition of nf-kappab. |
2001-09-27 |
2023-08-12 |
Not clear |
| F Peiretti, S Lopez, P Deprez-Beauclair, B Bonardo, I Juhan-Vague, G Nalbon. Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis. The Journal of biological chemistry. vol 276. issue 34. 2001-09-20. PMID:11402043. |
in conclusion, these results indicate that inhibition of p70(s6k) phosphorylation during tgf/d3-induced monocyte differentiation of hl-60 cells is a determinant factor that allows tnf to exert its up-regulating effect on pai-1 synthesis while protecting cells from apoptosis. |
2001-09-20 |
2023-08-12 |
human |
| S Gilbert, A Loranger, N Daigle, N Marcea. Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. The Journal of cell biology. vol 154. issue 4. 2001-09-20. PMID:11514590. |
in contrast, no difference in apoptosis is observed between cultured k8-null and wt hepatocytes after addition of the fas-related death-factors tumor necrosis factor (tnf) alpha or tnf-related apoptosis-inducing ligand. |
2001-09-20 |
2023-08-12 |
mouse |
| S Fiorucci, E Distrutti, M N Ajuebor, A Mencarelli, R Mannucci, B Palazzetti, P Del Soldato, A Morelli, J L Wallac. NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines. American journal of physiology. Gastrointestinal and liver physiology. vol 281. issue 3. 2001-09-20. PMID:11518677. |
the activation of a self-amplifying cascade of caspases, of which caspase-8 is the apical protease, mediates fas-, tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-, and tnf-alpha-induced apoptosis in colon cell lines. |
2001-09-20 |
2023-08-12 |
Not clear |
| T Hattori, H Hayashi, T Chiba, K Onozak. Activation of two distinct anti-proliferative pathways, apoptosis and p38 MAP kinase-dependent cell cycle arrest, by tumor necrosis factor in human melanoma cell line A375. European cytokine network. vol 12. issue 2. 2001-09-06. PMID:11399512. |
evidence in support of this notion includes (1) tnf-induced apoptosis only in a375-r8, but not a375-6 cells; (2) cycloheximide enabled tnf to induce apoptosis even in a375-6 cells; and (3) somatic hybrid cells between a375-6 and a375-r8 cells are resistant to tnf-induced apoptosis. |
2001-09-06 |
2023-08-12 |
human |
| T Hattori, H Hayashi, T Chiba, K Onozak. Activation of two distinct anti-proliferative pathways, apoptosis and p38 MAP kinase-dependent cell cycle arrest, by tumor necrosis factor in human melanoma cell line A375. European cytokine network. vol 12. issue 2. 2001-09-06. PMID:11399512. |
our results indicate that tnf activates two distinct anti-proliferative pathways including p38 mapk-dependent cell cycle arrest and caspase-mediated apoptosis, as well as an anti-apoptotic mechanism in melanoma cells. |
2001-09-06 |
2023-08-12 |
human |
| G J Schuurhuis, M M Muijen, J W Oberink, F de Boer, G J Ossenkoppele, H J Broxterma. Large populations of non-clonogenic early apoptotic CD34-positive cells are present in frozen-thawed peripheral blood stem cell transplants. Bone marrow transplantation. vol 27. issue 5. 2001-08-30. PMID:11313682. |
in the present study the vital stain sytor 16 in combination with the permeability marker 7-amino actinomycin d, (7-aad) has been used to identify an early stage of apoptosis, not detected with trypan blue or 7-aad alone or with conventional apoptosis tests and not consistently and only partly detected by the early apoptosis marker annexin v. the method was established using solid tumour cell lines treated with tnf. |
2001-08-30 |
2023-08-12 |
Not clear |
| H Wajant, D Moosmayer, T Wüest, T Bartke, E Gerlach, U Schönherr, N Peters, P Scheurich, K Pfizenmaie. Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative. Oncogene. vol 20. issue 30. 2001-08-30. PMID:11494138. |
tnf-related apoptosis-inducing ligand (trail) is a typical member of the tumor necrosis factor (tnf) ligand family that is expressed as a type ii membrane protein (memtrail) and signals apoptosis via the death domain-containing receptors trail-r1 and -2. |
2001-08-30 |
2023-08-12 |
human |
| D Bernard, B Quatannens, B Vandenbunder, C Abbadi. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. The Journal of biological chemistry. vol 276. issue 29. 2001-08-23. PMID:11350953. |
rel/nf-kappab transcription factors protect against tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis by up-regulating the trail decoy receptor dcr1. |
2001-08-23 |
2023-08-12 |
Not clear |
| D Bernard, B Quatannens, B Vandenbunder, C Abbadi. Rel/NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1. The Journal of biological chemistry. vol 276. issue 29. 2001-08-23. PMID:11350953. |
we found using dna arrays, reverse transcription-polymerase chain reaction, and immunofluorescence that rel/nf-kappab factors up-regulate dcr1, a receptor for tnf-related apoptosis-inducing ligand (trail), a cytokine of the tnf family that induces apoptosis in tumor cells. |
2001-08-23 |
2023-08-12 |
Not clear |
| S A Beresford, M A Davies, G E Gallick, N J Donat. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 21. issue 5. 2001-08-23. PMID:11429162. |
tnf or trail alone failed to activate apoptosis in either lncap or pc-3 cells, and drug-mediated inhibition of the pi3k/akt cascade caused only minimal activation of apoptosis in either cell line. |
2001-08-23 |
2023-08-12 |
Not clear |
| S A Beresford, M A Davies, G E Gallick, N J Donat. Differential effects of phosphatidylinositol-3/Akt-kinase inhibition on apoptotic sensitization to cytokines in LNCaP and PCc-3 prostate cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 21. issue 5. 2001-08-23. PMID:11429162. |
adenovirus-mediated pten/mmac1 expression in lncap cells reduced akt activation, activated apoptosis, and sensitized cells to tnf but not to trail. |
2001-08-23 |
2023-08-12 |
Not clear |