| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
neither transduction of ikappabdn nor treatment with tnf protein alone induced apoptosis in u251 and t-98g cells, whereas both cell lines underwent drastic tnf-induced apoptosis after transduction of ikappabdn. |
2000-04-19 |
2023-08-12 |
human |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
u-373mg cells underwent drastically increased apoptosis when co-transduced with the ikappabdn and bax gene in the presence of tnf. |
2000-04-19 |
2023-08-12 |
human |
| W Song, X Lu, Q Fen. Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovascular research. vol 45. issue 3. 2000-04-13. PMID:10728381. |
it has been demonstrated that tumor necrosis factor-alpha (tnf alpha) induces apoptosis in cardiac myocytes. |
2000-04-13 |
2023-08-12 |
mouse |
| W Song, X Lu, Q Fen. Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovascular research. vol 45. issue 3. 2000-04-13. PMID:10728381. |
in the present study, we hypothesized that tnf alpha induces myocardial apoptosis by induction of inducible nitric oxide synthase (inos). |
2000-04-13 |
2023-08-12 |
mouse |
| A Wiesmann, R L Phillips, M Mojica, L J Pierce, A E Searles, G J Spangrude, I Lemischk. Expression of CD27 on murine hematopoietic stem and progenitor cells. Immunity. vol 12. issue 2. 2000-04-07. PMID:10714685. |
one molecule specifically expressed in immature cells is cd27, a member of the tnf receptor family previously shown to play roles in lymphoid proliferation, differentiation, and apoptosis. |
2000-04-07 |
2023-08-12 |
mouse |
| B Bonetti, P Valdo, C Stegagno, R Tanel, G L Zanusso, D Ramarli, E Fiorini, S Turazzi, M Carner, G Morett. Tumor necrosis factor alpha and human Schwann cells: signalling and phenotype modulation without cell death. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744037. |
by immunocytochemical and functional assays, we found that sc expressed tnf receptors and that tnfalpha promoted in sc cultures transient activation of transcription factors nfkappab and c-jun in the absence of apoptosis. |
2000-04-07 |
2023-08-12 |
human |
| W Van Molle, J Vanden Berghe, P Brouckaert, C Liber. Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH. FEBS letters. vol 467. issue 2-3. 2000-03-31. PMID:10675538. |
the molecular mechanism by which tnf induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. |
2000-03-31 |
2023-08-12 |
mouse |
| S Q Xu, W S El-Deir. p21(WAF1/CIP1) inhibits initiator caspase cleavage by TRAIL death receptor DR4. Biochemical and biophysical research communications. vol 269. issue 1. 2000-03-31. PMID:10694497. |
death receptors of the tumor necrosis factor (tnf) family form membrane-bound self-activating signaling complexes that initiate apoptosis through cleavage of proximal caspases including casp8 and 10. |
2000-03-31 |
2023-08-12 |
human |
| M E Rosenfeld, L Prichard, N Shiojiri, N Faust. Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. The American journal of pathology. vol 156. issue 3. 2000-03-23. PMID:10702415. |
we therefore hypothesized that, in the absence of rela, embryos were sensitized to tumor necrosis factor (tnf) receptor 1 (tnfr-1)-mediated apoptosis. |
2000-03-23 |
2023-08-12 |
mouse |
| M Nagane, G Pan, J J Weddle, V M Dixit, W K Cavenee, H J Huan. Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706092. |
tumor necrosis factor-related apoptosis-inducing ligand (trail) is a novel member of the tumor necrosis factor (tnf) family that induces apoptosis preferentially in tumor cells through binding to its cognate death receptors, dr4 and dr5. |
2000-03-20 |
2023-08-12 |
mouse |
| Z X Liu, S Govindarajan, S Okamoto, G Denner. Fas- and tumor necrosis factor receptor 1-dependent but not perforin-dependent pathways cause injury in livers infected with an adenovirus construct in mice. Hepatology (Baltimore, Md.). vol 31. issue 3. 2000-03-15. PMID:10706557. |
making use of mice in which the genes coding for fas, fasl, tnf receptors (tnfrs), and perforin are inactivated, as well as recombinant proteins that inhibit fas- and tnf-alpha-mediated apoptosis, it is shown that a functional perforin-mediated mechanism is not obligatory for cellular infiltration and progression of liver injury. |
2000-03-15 |
2023-08-12 |
mouse |
| G S Pryhuber, H L Huyck, R J Staversky, J N Finkelstein, M A O'Reill. Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. American journal of respiratory cell and molecular biology. vol 22. issue 2. 2000-03-09. PMID:10657935. |
tumor necrosis factor (tnf) receptor (tnfr)-associated factors 1 and 2 (traf1 and traf2) and inhibitor of apoptosis proteins ciap1 (mihb) and ciap2 (mihc) were recently identified as proteins that associate with the tnf-alpha receptors tnfri (p55) and tnfrii (p75) and inhibit tnf-alpha-induced programmed cell death or apoptosis. |
2000-03-09 |
2023-08-12 |
mouse |
| C Tribouley, M Wallroth, V Chan, X Paliard, E Fang, G Lamson, D Pot, J Escobedo, L T William. Characterization of a new member of the TNF family expressed on antigen presenting cells. Biological chemistry. vol 380. issue 12. 2000-03-07. PMID:10661873. |
the tnf family is involved in the regulation of the immune system, and its members have been implicated in a variety of biological events such as apoptosis, cell proliferation, differentiation and survival. |
2000-03-07 |
2023-08-12 |
human |
| G Feng, N Kaplowit. Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. The Journal of clinical investigation. vol 105. issue 3. 2000-03-06. PMID:10675359. |
remarkably, fas and tnf receptor-1 mrna and intracellular protein levels increased after colchicine treatment, indicating that colchicine protects against death ligand-induced apoptosis in the liver by decreasing death-receptor targeting to the cell surface. |
2000-03-06 |
2023-08-12 |
mouse |
| E Pascher, A Perniok, A Becker, J Feldkam. Effect of 1alpha,25(OH)2-vitamin D3 on TNF alpha-mediated apoptosis of human primary osteoblast-like cells in vitro. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 31. issue 12. 2000-02-29. PMID:10668917. |
effect of 1alpha,25(oh)2-vitamin d3 on tnf alpha-mediated apoptosis of human primary osteoblast-like cells in vitro. |
2000-02-29 |
2023-08-12 |
human |
| S G Hymowitz, M P O'Connell, M H Ultsch, A Hurst, K Totpal, A Ashkenazi, A M de Vos, R F Kelle. A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry. vol 39. issue 4. 2000-02-23. PMID:10651627. |
apoptosis-inducing ligand 2 (apo2l, also called trail), a member of the tumor necrosis factor (tnf) family, induces apoptosis in a variety of human tumor cell lines but not in normal cells [wiley, s. r., schooley, k., smolak, p. j., din, w. s., huang, c.-p., nicholl, j. k., sutherland, g. r., smith, t. d., rauch, c., smith, c. a., and goodwin, r. g. (1995) immunity 3, 673-682; pitti, r. m., marsters, s. a., ruppert, s., donahue, c. j., moore, a., and ashkenazi, a. |
2000-02-23 |
2023-08-12 |
human |
| K Heyninck, G Denecker, D De Valck, W Fiers, R Beyaer. Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. Anticancer research. vol 19. issue 4B. 2000-02-15. PMID:10652565. |
these results demonstrate that a20 not only inhibits tnf-induced apoptosis but also tnf-induced necrosis, suggesting that it interferes with an early step in tnf signalling which is required for both types of cell death. |
2000-02-15 |
2023-08-12 |
Not clear |
| M Sabatini, G Rolland, S Léonce, M Thomas, C Lesur, V Pérez, G de Nanteuil, J Bonne. Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. Biochemical and biophysical research communications. vol 267. issue 1. 2000-02-08. PMID:10623638. |
the lipid messenger ceramide is implicated in signal transduction of the catabolic cytokines tumor necrosis factor (tnf) and interleukin-1 (il-1), as well as in apoptosis. |
2000-02-08 |
2023-08-12 |
rabbit |
| M Yamaguchi, S Nadler, J W Lee, H J Dee. Induction of negative regulators of haematopoiesis in human bone marrow cells by HLA-DR cross-linking. Transplant immunology. vol 7. issue 3. 2000-02-07. PMID:10608299. |
furthermore, mab h81.9-induced apoptosis was prevented by anti-tnf alpha mab and by the soluble fas receptor, fas-ig, providing further evidence that the tnf effect was mediated via fas. |
2000-02-07 |
2023-08-12 |
human |
| M L Mikkola, J Pispa, M Pekkanen, L Paulin, P Nieminen, J Kere, I Theslef. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mechanisms of development. vol 88. issue 2. 2000-01-31. PMID:10534613. |
members of the tnf family are critically involved in host defence and immune response often mediating either apoptosis or cell survival. |
2000-01-31 |
2023-08-12 |
mouse |