| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S G Hymowitz, M P O'Connell, M H Ultsch, A Hurst, K Totpal, A Ashkenazi, A M de Vos, R F Kelle. A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL. Biochemistry. vol 39. issue 4. 2000-02-23. PMID:10651627. |
apoptosis-inducing ligand 2 (apo2l, also called trail), a member of the tumor necrosis factor (tnf) family, induces apoptosis in a variety of human tumor cell lines but not in normal cells [wiley, s. r., schooley, k., smolak, p. j., din, w. s., huang, c.-p., nicholl, j. k., sutherland, g. r., smith, t. d., rauch, c., smith, c. a., and goodwin, r. g. (1995) immunity 3, 673-682; pitti, r. m., marsters, s. a., ruppert, s., donahue, c. j., moore, a., and ashkenazi, a. |
2000-02-23 |
2023-08-12 |
human |
| K Heyninck, G Denecker, D De Valck, W Fiers, R Beyaer. Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20. Anticancer research. vol 19. issue 4B. 2000-02-15. PMID:10652565. |
these results demonstrate that a20 not only inhibits tnf-induced apoptosis but also tnf-induced necrosis, suggesting that it interferes with an early step in tnf signalling which is required for both types of cell death. |
2000-02-15 |
2023-08-12 |
Not clear |
| M Sabatini, G Rolland, S Léonce, M Thomas, C Lesur, V Pérez, G de Nanteuil, J Bonne. Effects of ceramide on apoptosis, proteoglycan degradation, and matrix metalloproteinase expression in rabbit articular cartilage. Biochemical and biophysical research communications. vol 267. issue 1. 2000-02-08. PMID:10623638. |
the lipid messenger ceramide is implicated in signal transduction of the catabolic cytokines tumor necrosis factor (tnf) and interleukin-1 (il-1), as well as in apoptosis. |
2000-02-08 |
2023-08-12 |
rabbit |
| M Yamaguchi, S Nadler, J W Lee, H J Dee. Induction of negative regulators of haematopoiesis in human bone marrow cells by HLA-DR cross-linking. Transplant immunology. vol 7. issue 3. 2000-02-07. PMID:10608299. |
furthermore, mab h81.9-induced apoptosis was prevented by anti-tnf alpha mab and by the soluble fas receptor, fas-ig, providing further evidence that the tnf effect was mediated via fas. |
2000-02-07 |
2023-08-12 |
human |
| M L Mikkola, J Pispa, M Pekkanen, L Paulin, P Nieminen, J Kere, I Theslef. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mechanisms of development. vol 88. issue 2. 2000-01-31. PMID:10534613. |
members of the tnf family are critically involved in host defence and immune response often mediating either apoptosis or cell survival. |
2000-01-31 |
2023-08-12 |
mouse |
| P C Rath, B B Aggarwa. TNF-induced signaling in apoptosis. Journal of clinical immunology. vol 19. issue 6. 2000-01-28. PMID:10634209. |
out of the almost 17 members of the tnf superfamily, tnf is probably the most potent inducer of apoptosis. |
2000-01-28 |
2023-08-12 |
Not clear |
| P C Rath, B B Aggarwa. TNF-induced signaling in apoptosis. Journal of clinical immunology. vol 19. issue 6. 2000-01-28. PMID:10634209. |
this cascade also does not explain how type ii tnf receptors which lack the death domain, induce apoptosis. |
2000-01-28 |
2023-08-12 |
Not clear |
| S L Vickers, R G Cowan, R M Harman, D A Porter, S M Quir. Expression and activity of the Fas antigen in bovine ovarian follicle cells. Biology of reproduction. vol 62. issue 1. 2000-01-19. PMID:10611067. |
effects of the cytokines tumor necrosis factor (tnf)-alpha and interferon-gamma (ifn) were studied because of previous demonstrations of their role in fas-mediated apoptosis in other cell types. |
2000-01-19 |
2023-08-12 |
cattle |
| J M Jensen, S Schütze, M Förl, M Krönke, E Proksc. Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. The Journal of clinical investigation. vol 104. issue 12. 2000-01-13. PMID:10606630. |
tnf signaling is mediated by acid and neutral sphingomyelinases (a- and n-smase), which generate ceramide, an important regulator of proliferation, differentiation, and apoptosis. |
2000-01-13 |
2023-08-12 |
mouse |
| I Perry, C Tselepis, J Hoyland, T H Iqbal, D Scott, S A Sanders, B T Cooper, J A Jankowsk. Reduced cadherin/catenin complex expression in celiac disease can be reproduced in vitro by cytokine stimulation. Laboratory investigation; a journal of technical methods and pathology. vol 79. issue 12. 2000-01-13. PMID:10616200. |
celiac disease is characterized by a chronic immune response to dietary gluten, in which t cell responses result in elevated mucosal levels of tumor necrosis factor (tnf)-alpha, interleukin (il)-1, interferon (ifn)-gamma, and transforming growth factor (tgf)-beta, which induce profound mucosal remodeling associated with increased enterocyte proliferation, apoptosis, and migration. |
2000-01-13 |
2023-08-12 |
Not clear |
| Z Ma, T Otsuki, A Tomokuni, T Aikoh, T Matsuki, H Sakaguchi, Y Isozaki, F Hyodoh, K Uehira, K Isoda, A Uek. Man-made mineral fibers induce apoptosis of human peripheral blood mononuclear cells similarly to chrysotile B. International journal of molecular medicine. vol 4. issue 6. 2000-01-10. PMID:10567675. |
the alteration of the expression for apoptosis related genes at the mrna level during in vitro cultures of pbmc with various mmmf revealed upregulation of flice and apaf-1 genes and down regulation of tnf receptor 1 and bid genes. |
2000-01-10 |
2023-08-12 |
human |
| S B Gibson, R Oyer, A C Spalding, S M Anderson, G L Johnso. Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL. Molecular and cellular biology. vol 20. issue 1. 2000-01-10. PMID:10594023. |
the addition of a soluble tnf decoy receptor (tnfr:fc) was without effect, demonstrating the specificity of dr4 binding ligands in the etoposide-induced apoptosis response. |
2000-01-10 |
2023-08-12 |
Not clear |
| M E Burow, Y Tang, B M Collins-Burow, S Krajewski, J C Reed, J A McLachlan, B S Beckma. Effects of environmental estrogens on tumor necrosis factor alpha-mediated apoptosis in MCF-7 cells. Carcinogenesis. vol 20. issue 11. 2000-01-03. PMID:10545406. |
here we demonstrate that the organochlorine pesticides o, p' ddt and alachlor, like 17beta-estradiol, have the ability to suppress tumor necrosis factor alpha (tnf)-induced apoptosis in estrogen receptor (er)-positive mcf-7 breast carcinoma cells. |
2000-01-03 |
2023-08-12 |
Not clear |
| P Xia, L Wang, J R Gamble, M A Vada. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. The Journal of biological chemistry. vol 274. issue 48. 1999-12-29. PMID:10567432. |
human umbilical vein endothelial cells (huvec), like most normal cells, are resistant to tumor necrosis factor-alpha (tnf)-induced apoptosis in spite of tnf activating sphingomyelinase and generating ceramide, a known inducer of apoptosis. |
1999-12-29 |
2023-08-12 |
human |
| P Xia, L Wang, J R Gamble, M A Vada. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. The Journal of biological chemistry. vol 274. issue 48. 1999-12-29. PMID:10567432. |
here we report that tnf activates another key enzyme, sphingosine kinase (sphk), in the sphingomyelin metabolic pathway resulting in production of sphingosine-1-phosphate (s1p) and that s1p is a potent antagonist of tnf-mediated apoptosis. |
1999-12-29 |
2023-08-12 |
human |
| P Xia, L Wang, J R Gamble, M A Vada. Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. The Journal of biological chemistry. vol 274. issue 48. 1999-12-29. PMID:10567432. |
in contrast to normal huvec, in a spontaneously transformed endothelial cell line (c11) tnf stimulation failed to activate sphk and induced apoptosis as characterized by morphological and biochemical criteria. |
1999-12-29 |
2023-08-12 |
human |
| J A Berzofsky, J D Ahlers, M A Derby, C D Pendleton, T Arichi, I M Belyako. Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections. Immunological reviews. vol 170. 1999-12-22. PMID:10566149. |
high-avidity ctls, however, were found to undergo apoptosis when confronted with high-density antigen, through a mechanism involving tumor necrosis factor (tnf), tnf-rii, and a permissive state induced through the t-cell receptor. |
1999-12-22 |
2023-08-12 |
human |
| W J Murdoch, S A Lun. Prostaglandin-independent anovulatory mechanism of indomethacin action: inhibition of tumor necrosis factor alpha-induced sheep ovarian cell apoptosis. Biology of reproduction. vol 61. issue 6. 1999-12-21. PMID:10570016. |
endothelial secretion of tumor necrosis factor (tnf)-alpha within the apical follicular wall (prospective site of rupture) was not altered by indomethacin; notwithstanding, the apoptosis (dna-fragmentation)-inducing effect of tnf-alpha (a determinant of ovulatory stigma formation) was attenuated by 800 (but not 200) mg indomethacin. |
1999-12-21 |
2023-08-12 |
Not clear |
| H Yamada, S Tada-Oikawa, A Uchida, S Kawanish. TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells. Biochemical and biophysical research communications. vol 265. issue 1. 1999-12-17. PMID:10548502. |
a new member of the tnf family, tumor necrosis factor-related apoptosis-inducing ligand (trail), has been shown to induce apoptosis. |
1999-12-17 |
2023-08-12 |
Not clear |
| Y Itokazu, Y Segawa, N Inoue, T Omat. D-galactosamine-induced mouse hepatic apoptosis: possible involvement with tumor necrosis factor, but not with caspase-3 activity. Biological & pharmaceutical bulletin. vol 22. issue 10. 1999-12-17. PMID:10549870. |
we investigated whether tumor necrosis factor (tnf) and caspase-3 activity are involved in the induction of hepatocellular apoptosis in d-galactosamine (d-galn)-induced hepatotoxicity in mice. |
1999-12-17 |
2023-08-12 |
mouse |