| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Van Molle, G Denecker, I Rodriguez, P Brouckaert, P Vandenabeele, C Liber. Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins. Journal of immunology (Baltimore, Md. : 1950). vol 163. issue 10. 1999-12-02. PMID:10553044. |
lethal hepatitis can be induced by an agonistic anti-fas ab in normal mice or by tnf in mice sensitized to d -(+)-galactosamine or actinomycin d. in all three models, we found that apoptosis of hepatocytes is an early and necessary step to cause lethality. |
1999-12-02 |
2023-08-12 |
mouse |
| Y Kashii, R Giorda, R B Herberman, T L Whiteside, N L Vujanovi. Constitutive expression and role of the TNF family ligands in apoptotic killing of tumor cells by human NK cells. Journal of immunology (Baltimore, Md. : 1950). vol 163. issue 10. 1999-12-02. PMID:10553060. |
these findings demonstrate that human nk cells constitutively express several of the tnf family ligands and induce apoptosis in tumor cells by simultaneous engagement of at least three of these cytotoxic molecules. |
1999-12-02 |
2023-08-12 |
human |
| E S Berleth, S Nadadur, A D Henn, C Eppolito, S Shiojiri, H L Gurtoo, M J Ehrke, E Mihic. Identification, characterization, and cloning of TIP-B1, a novel protein inhibitor of tumor necrosis factor-induced lysis. Cancer research. vol 59. issue 21. 1999-12-02. PMID:10554026. |
to further elucidate the factors that contribute to the susceptibility of a cell to apoptosis, these investigations were designed to identify proteins isolated from cells exposed to low concentrations of tumor necrosis factor (tnf) that, when incubated with normally tnf-sensitive cells, protect these cells from tnf-induced cytotoxicity. |
1999-12-02 |
2023-08-12 |
human |
| M Yoshikawa, M Toyohara, S Ueda, A Shiroi, H Takeuchi, T Nishiyama, T Yamada, H Fukui, S Ishizak. Glycyrrhizin inhibits TNF-induced, but not Fas-mediated, apoptosis in the human hepatoblastoma line HepG2. Biological & pharmaceutical bulletin. vol 22. issue 9. 1999-11-24. PMID:10513619. |
to determine the transaminase-lowering action of glycyrrhizin (gl) immunologically, the effect of gl on tumor necrosis factor (tnf)-alpha- and fas-mediated apoptosis was assessed using a human hepatoblastoma line, hepg2 cells. |
1999-11-24 |
2023-08-12 |
human |
| D Li, B Yang, J L Meht. Tumor necrosis factor-alpha enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C. Cardiovascular research. vol 42. issue 3. 1999-11-24. PMID:10533621. |
tumor necrosis factor-alpha enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase c. ischemia and tumor necrosis factor-alpha (tnf alpha) released during ischemia both cause apoptosis and necrosis of myocardial tissues. |
1999-11-24 |
2023-08-12 |
human |
| D Li, B Yang, J L Meht. Tumor necrosis factor-alpha enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C. Cardiovascular research. vol 42. issue 3. 1999-11-24. PMID:10533621. |
since endothelium may be critically important in determination of cardiac function, we examined the interaction between tnf alpha and hypoxia-reoxygenation with regard to induction of apoptosis and underlying signaling pathway in cultured human coronary artery endothelial cells (hcaecs). |
1999-11-24 |
2023-08-12 |
human |
| M D Esposti, I Hatzinisiriou, H McLennan, S Ralp. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. The Journal of biological chemistry. vol 274. issue 42. 1999-11-19. PMID:10514462. |
we evaluated for the first time the effect of bcl-2 expression on the intracellular distribution and production of hydrogen peroxide, under basal conditions and after treatment with apoptosis inducing agents, ceramide analogs and tumor necrosis factor (tnf)-alpha. |
1999-11-19 |
2023-08-12 |
Not clear |
| K P Hoeflich, W C Yeh, Z Yao, T W Mak, J R Woodget. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. vol 18. issue 42. 1999-11-19. PMID:10523862. |
mediation of tnf receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ask1). |
1999-11-19 |
2023-08-12 |
Not clear |
| K P Hoeflich, W C Yeh, Z Yao, T W Mak, J R Woodget. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene. vol 18. issue 42. 1999-11-19. PMID:10523862. |
hence, ask1 is a common mediator of traf-regulated sapk and apoptosis signaling, and the traf2 - ask1 connection completes the signaling cascade from tnf to sapk/jnk activation. |
1999-11-19 |
2023-08-12 |
Not clear |
| M Fleck, J D Mountz, H C Hsu, J Wu, C K Edwards, E R Ker. Herpes simplex virus type 2 infection induced apoptosis in peritoneal macrophages independent of Fas and tumor necrosis factor-receptor signaling. Viral immunology. vol 12. issue 3. 1999-11-19. PMID:10532654. |
though there was also an upregulation of fas (apo-1/cd95) and tumor necrosis factor (tnf)-receptor 1 (tnf-r1) pathways, inhibition of fas by soluble fas and blocking of tnf-alpha using a tnf-binding protein did not prevent hsv-induced apoptosis. |
1999-11-19 |
2023-08-12 |
mouse |
| Y Lin, A Devin, Y Rodriguez, Z G Li. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes & development. vol 13. issue 19. 1999-11-18. PMID:10521396. |
we report here that the death domain kinase rip, a key component of the tnf signaling complex, was cleaved by caspase-8 in tnf-induced apoptosis. |
1999-11-18 |
2023-08-12 |
Not clear |
| M J Raftery, C K Behrens, A Müller, P H Krammer, H Walczak, G Schönric. Herpes simplex virus type 1 infection of activated cytotoxic T cells: Induction of fratricide as a mechanism of viral immune evasion. The Journal of experimental medicine. vol 190. issue 8. 1999-11-12. PMID:10523608. |
to dissect the underlying molecular events, we used a transgenic mouse model of hsv1 infection to demonstrate that cd95 (apo-1, fas)-triggered apoptosis is essential for hsv1-induced fratricide, whereas tumor necrosis factor (tnf) also contributes to this phenomenon but to a lesser extent. |
1999-11-12 |
2023-08-12 |
mouse |
| N A Fanger, C R Maliszewski, K Schooley, T S Griffit. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). The Journal of experimental medicine. vol 190. issue 8. 1999-11-12. PMID:10523613. |
trail (tnf-related apoptosis-inducing ligand) is a member of the tnf family that induces apoptosis in a variety of cancer cells. |
1999-11-12 |
2023-08-12 |
human |
| G I Botchkina, E Geimonen, M L Bilof, O Villarreal, K J Trace. Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity. Molecular medicine (Cambridge, Mass.). vol 5. issue 6. 1999-11-09. PMID:10415162. |
here we show the distribution and kinetics of nf-kappab activation and the correlation between loss of nf-kappab activity, tnf up-regulation, and apoptosis in a standardized rat model of focal cerebral ischemia. |
1999-11-09 |
2023-08-12 |
rat |
| G I Botchkina, E Geimonen, M L Bilof, O Villarreal, K J Trace. Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity. Molecular medicine (Cambridge, Mass.). vol 5. issue 6. 1999-11-09. PMID:10415162. |
the anatomical area of suppressed nf-kappab activity overlapped significantly with the zones of tnf overexpression and apoptosis. |
1999-11-09 |
2023-08-12 |
rat |
| G Kothny-Wilkes, D Kulms, T A Luger, M Kubin, T Schwar. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. The Journal of biological chemistry. vol 274. issue 41. 1999-11-09. PMID:10506136. |
tumor necrosis factor-related apoptosis-inducing ligand (trail), a new member of the tumor necrosis factor (tnf) family, induces apoptosis primarily of transformed cells. |
1999-11-09 |
2023-08-12 |
Not clear |
| G Kothny-Wilkes, D Kulms, T A Luger, M Kubin, T Schwar. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. The Journal of biological chemistry. vol 274. issue 41. 1999-11-09. PMID:10506136. |
accordingly, enhanced apoptosis was reduced by blocking the tnf receptor-1. |
1999-11-09 |
2023-08-12 |
Not clear |
| M K Balcewicz-Sablinska, H Gan, H G Remol. Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-alpha activity. The Journal of infectious diseases. vol 180. issue 4. 1999-11-08. PMID:10479152. |
normal human macrophages respond to infection with mycobacterium avium, serovar 4, by producing tumor necrosis factor (tnf)-alpha, which mediates apoptosis, and by elaborating interleukin (il)-10, a tnf-alpha antagonist. |
1999-11-08 |
2023-08-12 |
human |
| M K Balcewicz-Sablinska, H Gan, H G Remol. Interleukin 10 produced by macrophages inoculated with Mycobacterium avium attenuates mycobacteria-induced apoptosis by reduction of TNF-alpha activity. The Journal of infectious diseases. vol 180. issue 4. 1999-11-08. PMID:10479152. |
we show that il-10 down-regulates apoptosis by inhibiting the tnf-alpha production of the inoculated macrophages and by inducing the release of soluble tnf receptor type 2 from the macrophages, which leads to inactivation of tnf-alpha. |
1999-11-08 |
2023-08-12 |
human |
| b' I S Mathiasen, U Lademann, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. Cancer research. vol 59. issue 19. 1999-11-04. PMID:10519395.' |
inhibition of caspase activation by overexpression of a cowpox-derived caspase inhibitor crma or by addition of inhibitory peptides acetyl-asp-glu-val-asp-aldehyde (200 microm), acetyl-ile-glu-thr-asp-aldehyde (50 microm), and z-val-ala-d,l-asp-fluoromethylketone (1 microm) showed no effect on the induction of growth arrest or apoptosis by vitamin d compounds under assay conditions in which apoptosis induced by tnf or staurosporine was effectively inhibited. |
1999-11-04 |
2023-08-12 |
human |