| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S K Manna, N K Sah, B B Aggarwa. Protein tyrosine kinase p56lck is required for ceramide-induced but not tumor necrosis factor-induced activation of NF-kappa B, AP-1, JNK, and apoptosis. The Journal of biological chemistry. vol 275. issue 18. 2000-06-01. PMID:10788436. |
overall our results demonstrate that p56(lck) plays a critical role in the activation of nf-kappab, ap-1, jnk, and apoptosis by ceramide but has minimal or no role in activation of these responses by tnf. |
2000-06-01 |
2023-08-12 |
Not clear |
| P R Turner, S Mefford, S Christakos, R A Nissenso. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Molecular endocrinology (Baltimore, Md.). vol 14. issue 2. 2000-05-25. PMID:10674397. |
these results suggest that 1) apoptosis produced by pthr and tnf receptor signaling involve converging pathways; and 2) gq-mediated phospholipase c/ca2+ signaling, rather than gs-mediated camp signaling, is required for the apoptotic effects of pthr activation. |
2000-05-25 |
2023-08-12 |
Not clear |
| K J Hamann, J E Vieira, A J Halayko, D Dorscheid, S R White, S M Forsythe, B Camoretti-Mercado, K F Rabe, J Solwa. Fas cross-linking induces apoptosis in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 278. issue 3. 2000-05-24. PMID:10710535. |
we therefore tested the hypotheses that 1) human airway smooth muscle (hasm) expresses fas, 2) fas cross-linking induces apoptosis in these cells, and 3) tumor necrosis factor (tnf)-alpha potentiates fas-mediated airway myocyte killing. |
2000-05-24 |
2023-08-12 |
human |
| L Zheng, T J Dengler, M S Kluger, L A Madge, J S Schechner, S E Maher, J S Pober, A L Bothwel. Cytoprotection of human umbilical vein endothelial cells against apoptosis and CTL-mediated lysis provided by caspase-resistant Bcl-2 without alterations in growth or activation responses. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 9. 2000-05-22. PMID:10779771. |
however, compared with egfp-transduced huvec, the bcl-2-transduced cells are resistant to the apoptotic effects of serum and growth factor withdrawal and are also resistant to the induction of apoptosis by staurosporine or by ceramide, with or without tnf. |
2000-05-22 |
2023-08-12 |
human |
| D J Brick, R D Burke, A A Minkley, C Upto. Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis. The Journal of general virology. vol 81. issue Pt 4. 2000-05-18. PMID:10725436. |
here, we report that both evp28 and overexpression of sfv n1r in poxvirus-infected hela cells protect specifically from uv light-induced apoptosis, but not from apoptosis induced by fas or tnf. |
2000-05-18 |
2023-08-12 |
Not clear |
| D J Brick, R D Burke, A A Minkley, C Upto. Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis. The Journal of general virology. vol 81. issue Pt 4. 2000-05-18. PMID:10725436. |
further, we report that both vv and ev protect from apoptosis induced by uv, fas and tnf. |
2000-05-18 |
2023-08-12 |
Not clear |
| R R Mohan, R R Mohan, W J Kim, S E Wilso. Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kappaB. Investigative ophthalmology & visual science. vol 41. issue 6. 2000-05-15. PMID:10798647. |
previous studies have suggested no role for tumor necrosis factor (tnf)-alpha in the modulation of apoptosis in corneal fibroblasts. |
2000-05-15 |
2023-08-12 |
Not clear |
| N Hosaka, N Oyaizu, S Than, S Pahw. Correlation of loss of CD4 T cells with plasma levels of both soluble form Fas (CD95) Fas ligand (FasL) in HIV-infected infants. Clinical immunology (Orlando, Fla.). vol 95. issue 1 Pt 1. 2000-05-12. PMID:10794428. |
fas and fas ligand (fasl), members of the tnfr and tnf families of molecules involved in apoptosis, respectively, are expressed in membrane-associated as well as soluble forms. |
2000-05-12 |
2023-08-12 |
Not clear |
| X D Zhang, A V Franco, T Nguyen, C P Gray, P Herse. Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 8. 2000-05-09. PMID:10754286. |
induction of apoptosis in cells by tnf-related apoptosis-inducing ligand (trail), a member of the tnf family, is believed to be regulated by expression of two death-inducing and two inhibitory (decoy) receptors on the cell surface. |
2000-05-09 |
2023-08-12 |
human |
| S A Keogh, H Walczak, L Bouchier-Hayes, S J Marti. Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis. FEBS letters. vol 471. issue 1. 2000-05-09. PMID:10760520. |
tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf family of cytokines that promotes apoptosis and nf-kappab activation. |
2000-05-09 |
2023-08-12 |
Not clear |
| A O Hueber, M Zörnig, A M Bernard, M Chautan, G Eva. A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts. The Journal of biological chemistry. vol 275. issue 14. 2000-05-08. PMID:10744735. |
death domain-containing members of the tumor necrosis factor (tnf) receptor family ("death receptors") can induce apoptosis upon stimulation by their natural ligands or by agonistic antibodies. |
2000-05-08 |
2023-08-12 |
mouse |
| E Okuma, K Saeki, M Shimura, Y Ishizaka, E Yasugi, A Yu. Induction of apoptosis in human hematopoietic U937 cells by granulocyte-macrophage colony-stimulating factor: possible existence of caspase 3-like pathway. Leukemia. vol 14. issue 4. 2000-05-04. PMID:10764146. |
granulocyte-macrophage colony-stimulating factor (gm-csf) induced apoptosis in human hematopoietic u937 cells by itself and in a synergistic manner with tumor necrosis factor (tnf). |
2000-05-04 |
2023-08-12 |
human |
| E Okuma, K Saeki, M Shimura, Y Ishizaka, E Yasugi, A Yu. Induction of apoptosis in human hematopoietic U937 cells by granulocyte-macrophage colony-stimulating factor: possible existence of caspase 3-like pathway. Leukemia. vol 14. issue 4. 2000-05-04. PMID:10764146. |
these results indicate that gm-csf induces apoptosis of u937 cells via unknown pathway, which seems to be mediated by caspase 3-like activity, yet not caspase 3 itself, resistant to the caspase inhibitors, and synergistically interacts with conventional caspase 3 pathway of tnf. |
2000-05-04 |
2023-08-12 |
human |
| M M Remacle-Bonnet, F L Garrouste, S Heller, F André, J L Marvaldi, G J Pommie. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766192. |
we report here that insulin and insulin-like growth factor-i (igf-i) fully protect ht29-d4 colon carcinoma cells from ifn-gamma/tumor necrosis factor-alpha (tnf) induced apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| M M Remacle-Bonnet, F L Garrouste, S Heller, F André, J L Marvaldi, G J Pommie. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766192. |
in agreement with this model, we show that it was possible to render ht29-d4 cells resistant to fas-induced apoptosis provided that igf-i and tnf receptors were activated simultaneously. |
2000-05-04 |
2023-08-12 |
Not clear |
| J Kleeff, M Kornmann, H Sawhney, M Kor. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. International journal of cancer. vol 86. issue 3. 2000-05-02. PMID:10760829. |
pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as fas and tnf receptor or by serum or growth factor withdrawal. |
2000-05-02 |
2023-08-12 |
Not clear |
| J B Domachowske, C A Bonville, A J Mortelliti, C B Colella, U Kim, H F Rosenber. Respiratory syncytial virus infection induces expression of the anti-apoptosis gene IEX-1L in human respiratory epithelial cells. The Journal of infectious diseases. vol 181. issue 3. 2000-04-27. PMID:10720500. |
because iex-1l is reported to protect cells from apoptosis induced by tumor necrosis factor (tnf)-alpha, the effect of tnf-alpha on epithelial cell apoptosis in the context of rsv infection was determined. |
2000-04-27 |
2023-08-12 |
human |
| S C Hasmall, N H James, N Macdonald, F J Gonzalez, J M Peters, R A Robert. Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha. Mutation research. vol 448. issue 2. 2000-04-27. PMID:10725472. |
in vitro, high concentrations (>500 u/ml) of exogenous tumour necrosis factor (tnfalpha) [m. rolfe, n.h. james, r.a. roberts, tnf suppresses apoptosis and induces s-phase in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators?, carcinogenesis 18 (1997) 2277-2280] are also able to stimulate hepatocyte dna synthesis and suppress apoptosis, implicating tnfalpha in mediating or permitting the liver growth response to pps. |
2000-04-27 |
2023-08-12 |
mouse |
| M N'cho, Z Brahm. Fas-mediated apoptosis in T cells involves the dephosphorylation of the retinoblastoma protein by type 1 protein phosphatases. Human immunology. vol 60. issue 12. 2000-04-20. PMID:10626732. |
apoptosis is triggered by a number of different stimuli including the activation of fas antigen, a member of the tnf family, by the fas ligand. |
2000-04-20 |
2023-08-12 |
Not clear |
| N Shinoura, N Yamamoto, Y Yoshida, T Fujita, N Saito, A Asai, T Kirino, H Hamad. Adenovirus-mediated gene transduction of IkappaB or IkappaB plus Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in human gliomas. Japanese journal of cancer research : Gann. vol 91. issue 1. 2000-04-19. PMID:10744043. |
adenovirus-mediated gene transduction of ikappab or ikappab plus bax gene drastically enhances tumor necrosis factor (tnf)-induced apoptosis in human gliomas. |
2000-04-19 |
2023-08-12 |
human |