| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R R Mohan, R R Mohan, W J Kim, G R Stark, S E Wilso. Defective keratocyte apoptosis in response to epithelial injury in stat 1 null mice. Experimental eye research. vol 70. issue 4. 2000-07-07. PMID:10865997. |
tnf alpha-induced apoptosis only occurred in wild-type mice in the presence of inhibitors of nf-kappab activation. |
2000-07-07 |
2023-08-12 |
mouse |
| R R Mohan, R R Mohan, W J Kim, G R Stark, S E Wilso. Defective keratocyte apoptosis in response to epithelial injury in stat 1 null mice. Experimental eye research. vol 70. issue 4. 2000-07-07. PMID:10865997. |
corneal fibroblast tnf alpha-induced apoptosis was defective in stat 1null corneal fibroblasts whether nf-kappab activation was blocked or not. |
2000-07-07 |
2023-08-12 |
mouse |
| C H Kim, S Gupt. Expression of TRAIL (Apo2L), DR4 (TRAIL receptor 1), DR5 (TRAIL receptor 2) and TRID (TRAIL receptor 3) genes in multidrug resistant human acute myeloid leukemia cell lines that overexpress MDR 1 (HL60/Tax) or MRP (HL60/AR). International journal of oncology. vol 16. issue 6. 2000-06-27. PMID:10811986. |
trail, a member of the tnf receptor family, induces apoptosis in many tumor cells by binding to dr4 (trail receptor 1) and dr5 (trail receptor 2). |
2000-06-27 |
2023-08-12 |
human |
| M E Burow, C B Weldon, T C Chiang, Y Tang, B M Collins-Burow, K Rolfe, S Li, J A McLachlan, B S Beckma. Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. International journal of oncology. vol 16. issue 6. 2000-06-27. PMID:10811993. |
to establish if the difference in apoptotic susceptibility was specific to tnf, the three mcf-7 cell variants were tested for their response to other known inducers of apoptosis: okadaic acid, staurosporine and 4-hydroxy-tamoxifen. |
2000-06-27 |
2023-08-12 |
human |
| A P Sampso. The role of eosinophils and neutrophils in inflammation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. vol 30 Suppl 1. 2000-06-27. PMID:10849470. |
leukotriene b4 and cytokines such as il-8, granulocyte-macrophage colony stimulating factor (gm-csf), and tumour necrosis factor (tnf)alpha chemoattract neutrophils and reduce neutrophil apoptosis, and selective agents directed against these may prevent neutrophil influx and accumulation. |
2000-06-27 |
2023-08-12 |
Not clear |
| L A Madge, J S Pobe. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. The Journal of biological chemistry. vol 275. issue 20. 2000-06-21. PMID:10748004. |
consistent with these biochemical observations, tnf and il-1 reduce apoptosis caused by growth factor and serum deprivation, and this action is also blocked by ly294002. |
2000-06-21 |
2023-08-12 |
human |
| J Plümpe, N P Malek, C T Bock, T Rakemann, M P Manns, C Trautwei. NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration. American journal of physiology. Gastrointestinal and liver physiology. vol 278. issue 1. 2000-06-16. PMID:10644576. |
tumor necrosis factor (tnf)-alpha is a potent inducer of apoptotic cell death in various tissues, whereas the transcription factor nuclear factor (nf)-kappab is essential to protect against tnf-alpha-induced apoptosis. |
2000-06-16 |
2023-08-12 |
mouse |
| A Nasir, H S Arora, H E Kaise. Apoptosis and pathogenesis of viral hepatitis C--an update. In vivo (Athens, Greece). vol 14. issue 1. 2000-06-16. PMID:10757089. |
possible inducers of apoptosis in hepatitis c include cytokines, especially tumor necrosis factor-alpha (tnf-alpha), released by inflammatory cells, and acting through tnf and other cytokine receptors. |
2000-06-16 |
2023-08-12 |
Not clear |
| K M Kurrelmeyer, L H Michael, G Baumgarten, G E Taffet, J J Peschon, N Sivasubramanian, M L Entman, D L Man. Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 10. 2000-06-13. PMID:10779546. |
these data suggest that tnf signaling gives rise to one or more cytoprotective signals that prevent and/or delay the development of cardiac myocyte apoptosis after acute ischemic injury. |
2000-06-13 |
2023-08-12 |
mouse |
| M Kawanish. The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells: the role of LMP1 C-terminal activation regions 1 and 2. Virology. vol 270. issue 2. 2000-06-13. PMID:10792984. |
the epstein-barr virus latent membrane protein 1 (lmp1) enhances tnf alpha-induced apoptosis of intestine 407 epithelial cells: the role of lmp1 c-terminal activation regions 1 and 2. |
2000-06-13 |
2023-08-12 |
Not clear |
| M Kawanish. The Epstein-Barr virus latent membrane protein 1 (LMP1) enhances TNF alpha-induced apoptosis of intestine 407 epithelial cells: the role of LMP1 C-terminal activation regions 1 and 2. Virology. vol 270. issue 2. 2000-06-13. PMID:10792984. |
in contrast, the present study showed that the expression of lmp1 induced high susceptibility to tumor necrosis factor alpha (tnfalpha)-induced apoptosis in intestine 407 epithelial cells, without affecting expression of tnf receptors i and ii. |
2000-06-13 |
2023-08-12 |
Not clear |
| M E Burow, C B Weldon, L I Melnik, B N Duong, B M Collins-Burow, B S Beckman, J A McLachla. PI3-K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochemical and biophysical research communications. vol 271. issue 2. 2000-06-13. PMID:10799299. |
we found that in mcf-7 breast carcinoma cells, pi3k and akt suppressed a dose-dependent induction of apoptosis by tumor necrosis factor alpha (tnf). |
2000-06-13 |
2023-08-12 |
Not clear |
| M D Josephs, F R Bahjat, K Fukuzuka, R Ksontini, C C Solorzano, C K Edwards, C L Tannahill, S L MacKay, E M Copeland, L L Moldawe. Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 5. 2000-06-08. PMID:10801287. |
tumor necrosis factor (tnf)-alpha and fas ligand (fasl) are trimeric proteins that induce apoptosis through similar caspase-dependent pathways. |
2000-06-08 |
2023-08-12 |
mouse |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
all-trans-retinoic acid upregulates tnf receptors and potentiates tnf-induced activation of nuclear factors-kappab, activated protein-1 and apoptosis in human lung cancer cells. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
the increase in tnf receptors sensitized h596 cells to tnf-induced activation of nf-kappab, ap-1 and apoptosis. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-kappaB, activated protein-1 and apoptosis in human lung cancer cells. Oncogene. vol 19. issue 17. 2000-06-08. PMID:10815802. |
overall our results indicate that atra induces the tnf receptors in human lung cancer cells, which sensitizes them to tnf-induced signaling leading to activation of nf-kappab, ap-1 and apoptosis. |
2000-06-08 |
2023-08-12 |
human |
| S K Manna, B B Aggarwa. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799874. |
hiv-tat protein, like tnf, activates a wide variety of cellular responses, including nf-kappa b, ap-1, c-jun n-terminal kinase (jnk), and apoptosis. |
2000-06-07 |
2023-08-12 |
Not clear |
| S K Manna, B B Aggarwa. Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 164. issue 10. 2000-06-07. PMID:10799874. |
overall, our results demonstrate that p56lck plays a critical role in the activation of nf-kappa b, ap-1, jnk, and apoptosis by hiv-tat protein but has minimal or no role in activation of these responses by tnf. |
2000-06-07 |
2023-08-12 |
Not clear |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
the effects of polyunsaturated fatty acids and vitamin e on tumor necrosis factor (tnf)-induced apoptosis of human monocytic u937 cells was explored to assess to what extent these nutrients could attenuate apoptosis. |
2000-06-07 |
2023-08-12 |
human |
| M Yano, E Kishida, M Iwasaki, S Kojo, Y Masuzaw. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. The Journal of nutrition. vol 130. issue 5. 2000-06-07. PMID:10801904. |
eicosapentaenoic acid slightly but significantly reduced the proportion of apoptotic cells only when apoptosis was induced by tnf without cycloheximide (chi). |
2000-06-07 |
2023-08-12 |
human |