| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Waleed Khalaf, Caroline Maina, Joseph Byers, William Harve. Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested. Leukemia research. vol 26. issue 2. 2002-03-27. PMID:11755467. |
we suggest that ifn decreases apoptosis by mechanisms involving enhanced il-6 and bcl-2 levels, decreased tnf alpha and the down regulation of apoptotic oncogenes, including c-myc. |
2002-03-27 |
2023-08-12 |
Not clear |
| C Guiet, E Silvestri, E De Smaele, G Franzoso, P Vit. c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis. Cell death and differentiation. vol 9. issue 2. 2002-03-27. PMID:11840164. |
for the past 20 years, it has been known that preparations of tumor necrosis factor alpha (tnf) fail to induce apoptosis due to cytoprotective responses that render cells resistant to its cytotoxic activity. |
2002-03-27 |
2023-08-12 |
Not clear |
| Sang-Youel Park, Timothy R Billiar, Dai-Wu Seo. IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis. Biochemical and biophysical research communications. vol 291. issue 2. 2002-03-19. PMID:11846395. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a type ii transmembrane cytokine molecule of tnf family and a potent inducer of apoptosis. |
2002-03-19 |
2023-08-12 |
Not clear |
| Faina Vikhanskaya, Carla Falugi, Piera Valente, Patrizia Russ. Human papillomavirus type 16 E6-enhanced susceptibility to apoptosis induced by TNF in A2780 human ovarian cancer cell line. International journal of cancer. vol 97. issue 6. 2002-03-15. PMID:11857347. |
human papillomavirus type 16 e6-enhanced susceptibility to apoptosis induced by tnf in a2780 human ovarian cancer cell line. |
2002-03-15 |
2023-08-12 |
human |
| Faina Vikhanskaya, Carla Falugi, Piera Valente, Patrizia Russ. Human papillomavirus type 16 E6-enhanced susceptibility to apoptosis induced by TNF in A2780 human ovarian cancer cell line. International journal of cancer. vol 97. issue 6. 2002-03-15. PMID:11857347. |
the major induction of massive apoptosis induced by tnf is not p53- and p21(waf-1)-dependent but it is principally related to nf-kappab inhibition in a2780/e6 cells. |
2002-03-15 |
2023-08-12 |
human |
| T J Zuzak, D F Steinhoff, L N Sutton, P C Phillips, A Eggert, M A Grotze. Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma. European journal of cancer (Oxford, England : 1990). vol 38. issue 1. 2002-03-07. PMID:11750844. |
upon binding of tumour necrosis factor (tnf)-related apoptosis inducing ligand (trail), the agonistic trail receptors dr4 and dr5 activate caspase-8 leading to apoptosis. |
2002-03-07 |
2023-08-12 |
Not clear |
| A Oberholzer, C Oberholzer, F R Bahjat, C K Edwards, L L Moldawe. Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality. Journal of endotoxin research. vol 7. issue 5. 2002-03-07. PMID:11753206. |
the studies confirm an essential role for tnf-alpha and p55 tnf receptor signaling in the hepatocyte apoptosis and lethality associated with lipopolysaccharide and d-galactosamine administration. |
2002-03-07 |
2023-08-12 |
mouse |
| Delphine Javelaud, Marie-France Poupon, Juana Wietzerbin, Françoise Besanço. Inhibition of constitutive NF-kappa B activity suppresses tumorigenicity of Ewing sarcoma EW7 cells. International journal of cancer. vol 98. issue 2. 2002-03-07. PMID:11857407. |
it causes, however, a remarkable loss of their ability to generate tumors in nude mice that correlates with both a decrease in extracellular matrix (ecm) protein secretion and an acquisition of sensitivity to murine tumor necrosis factor alpha (tnf alpha)-induced apoptosis. |
2002-03-07 |
2023-08-12 |
mouse |
| M K Sharie. Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis. European journal of neurology. vol 9. issue 1. 2002-03-06. PMID:11784376. |
human cd137 (ila/4-1bb), a member of the tumour necrosis factor (tnf) receptor family, regulates the activation and proliferation of immune cells, and may induce apoptosis (programmed cell death) of activated lymphocytes. |
2002-03-06 |
2023-08-12 |
human |
| Ganwei Lu, Bratislav M Janjic, Jelena Janjic, Theresa L Whiteside, Walter J Storkus, Nikola L Vujanovi. Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 4. 2002-03-04. PMID:11823516. |
we determine that human immature dcs express on their cell surface four different cytotoxic tnf family ligands: tnf, lymphotoxin-alpha(1)beta(2), fas ligand, and tnf-related apoptosis inducing ligand; while cancer cells express the corresponding death receptors. |
2002-03-04 |
2023-08-12 |
human |
| N Mitsiades, C S Mitsiades, V Poulaki, K C Anderson, S P Treo. Concepts in the use of TRAIL/Apo2L: an emerging biotherapy for myeloma and other neoplasias. Expert opinion on investigational drugs. vol 10. issue 8. 2002-03-01. PMID:11772267. |
tnf-related apoptosis inducing ligand/apo2 ligand (trail/apo2l) is a member of the tnf superfamily of death ligands that selectively induces apoptosis in tumour cells of diverse origins. |
2002-03-01 |
2023-08-12 |
mouse |
| N Mitsiades, C S Mitsiades, V Poulaki, K C Anderson, S P Treo. Concepts in the use of TRAIL/Apo2L: an emerging biotherapy for myeloma and other neoplasias. Expert opinion on investigational drugs. vol 10. issue 8. 2002-03-01. PMID:11772267. |
importantly, trail/apo2l-induced apoptosis was unaffected by il-6, a potent growth and survival factor for mm cells which, as we and others have previously shown, blocks various pro-apoptotic signals including fas ligand, which like trail/apo2l is also a member of the tnf family of ligands. |
2002-03-01 |
2023-08-12 |
mouse |
| Jan Dörr, Ingo Bechmann, Sonia Waiczies, Orhan Aktas, Henning Walczak, Peter H Krammer, Robert Nitsch, Frauke Zip. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 4. 2002-02-26. PMID:11844843. |
apoptosis mediated by members of the tumor necrosis factor (tnf)-nerve growth factor superfamily plays a crucial role in the interaction of the nervous and the immune system. |
2002-02-26 |
2023-08-12 |
human |
| Ilana Kronfeld, Gila Kazimirsky, Erwin W Gelfand, Chaya Brodi. NGF rescues human B lymphocytes from anti-IgM induced apoptosis by activation of PKCzeta. European journal of immunology. vol 32. issue 1. 2002-02-25. PMID:11754354. |
the low-affinity ngfr, p75, shares structural homology with the b cell antigen, cd40, tumor necrosis factor (tnf) receptor and fas antigen (apo-1), which play a role in cell apoptosis. |
2002-02-25 |
2023-08-12 |
human |
| Alexander R Moise, Jason R Grant, Timothy Z Vitalis, Wilfred A Jefferie. Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release. Journal of virology. vol 76. issue 4. 2002-02-22. PMID:11799152. |
in addition, e3-6.7k protected cells against apoptosis induced through fas, tnf receptor, and trail receptors. |
2002-02-22 |
2023-08-12 |
human |
| W Gao, Y Pu, K Q Luo, D C Chan. Temporal relationship between cytochrome c release and mitochondrial swelling during UV-induced apoptosis in living HeLa cells. Journal of cell science. vol 114. issue Pt 15. 2002-02-21. PMID:11683418. |
in addition, we found evidence that cytochrome c was also released before mitochondrial swelling in apoptosis induced by other cell death-inducing treatments, including tumor necrosis factor (tnf) and actinomycin d. |
2002-02-21 |
2023-08-12 |
Not clear |
| M E Burow, C B Weldon, Y Tang, J A McLachlan, B S Beckma. Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. The Journal of steroid biochemistry and molecular biology. vol 78. issue 5. 2002-02-21. PMID:11738551. |
the role of bcl-2 in mcf-7 cell survival was confirmed by stable overexpression of bcl-2 which resulted in suppression of apoptosis induced by doxorubicin (dox), paclitaxel (tax) and tnf as compared to vector-control cells. |
2002-02-21 |
2023-08-12 |
Not clear |
| M E Burow, C B Weldon, Y Tang, J A McLachlan, B S Beckma. Oestrogen-mediated suppression of tumour necrosis factor alpha-induced apoptosis in MCF-7 cells: subversion of Bcl-2 by anti-oestrogens. The Journal of steroid biochemistry and molecular biology. vol 78. issue 5. 2002-02-21. PMID:11738551. |
the pure anti-oestrogen ici 182,780 in combination with tnf, dox or tax potentiated apoptosis in vector-transfected cells. |
2002-02-21 |
2023-08-12 |
Not clear |
| S Chen, A Fribley, C Y Wan. Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitor. Journal of dental research. vol 81. issue 2. 2002-02-21. PMID:11827262. |
the stress-responsive transcription factor nuclear factor kappa b (nf-kappab), which has been found to be associated with scc development, plays an essential role in the suppression of tumor necrosis factor (tnf)-mediated apoptosis. |
2002-02-21 |
2023-08-12 |
Not clear |
| J Zamorano, A L Mora, M Boothby, A D Keega. NF-kappa B activation plays an important role in the IL-4-induced protection from apoptosis. International immunology. vol 13. issue 12. 2002-02-14. PMID:11717189. |
to determine the contribution of co-stimulatory signals to the regulation of apoptosis by il-4, we first analyzed whether tumor necrosis factor (tnf)-alpha, which has been shown to inhibit the activation of irs-1 by insulin, could modify il-4 signaling and protection from apoptosis. |
2002-02-14 |
2023-08-12 |
mouse |