| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gwendolyn S Kerby, Vincent Cottin, Frank J Accurso, Fukun Hoffmann, Edward D Chan, Valerie A Fadok, David W H Riche. Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 283. issue 1. 2002-07-19. PMID:12060576. |
in this study, we evaluated the role of nacl and the ensuing hyperosmolar effect on tumor necrosis factor (tnf)-alpha signaling and apoptosis in macrophages. |
2002-07-19 |
2023-08-12 |
mouse |
| Deepta Bhattacharya, Eric C Logue, Sonia Bakkour, James DeGregori, William C Sh. Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 13. 2002-07-19. PMID:12084928. |
three of the genes, rela, cellular flice-like inhibitory protein (c-flip), and a dominant-negative mutant of tnf receptor 1 arising through cpr afforded strong protection against apoptosis. |
2002-07-19 |
2023-08-12 |
Not clear |
| Laurie E Kilpatrick, Julia Y Lee, Kathleen M Haines, Donald E Campbell, Kathleen E Sullivan, Helen M Korcha. A role for PKC-delta and PI 3-kinase in TNF-alpha-mediated antiapoptotic signaling in the human neutrophil. American journal of physiology. Cell physiology. vol 283. issue 1. 2002-07-16. PMID:12055072. |
the proinflammatory cytokine tumor necrosis factor (tnf)-alpha has been implicated in the attenuation of neutrophil spontaneous apoptosis during sepsis. |
2002-07-16 |
2023-08-12 |
human |
| Zhiguo Liu, Yun Liu, Yihui Hong, Lisa Rapp, Elliot J Androphy, Jason J Che. Bovine papillomavirus type 1 E6-induced sensitization to apoptosis is distinct from its transforming activity. Virology. vol 295. issue 2. 2002-07-12. PMID:12033781. |
we have previously shown that c127 cells expressing bpv-1 e6 exhibited increased tumor necrosis factor alpha (tnf)-mediated apoptosis. |
2002-07-12 |
2023-08-12 |
cattle |
| Guoqing Chen, David V Goedde. TNF-R1 signaling: a beautiful pathway. Science (New York, N.Y.). vol 296. issue 5573. 2002-07-05. PMID:12040173. |
tumor necrosis factor (tnf) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. |
2002-07-05 |
2023-08-12 |
human |
| Hiroshi Okano, Katsuya Shiraki, Hidekazu Inoue, Takenari Yamanaka, Masatoshi Deguchi, Kazushi Sugimoto, Takahisa Sakai, Shigeru Ohmori, Katsuhiko Fujikawa, Kazumoto Murata, Takeshi Nakan. Peroxisome proliferator-activated receptor gamma augments tumor necrosis factor family-induced apoptosis in hepatocellular carcinoma. Anti-cancer drugs. vol 13. issue 1. 2002-07-02. PMID:11914642. |
this apoptosis induction by ppargamma is increased by co-stimulation with tumor necrosis factor (tnf)-alpha-related apoptosis-inducing ligand (trail), a member of the tnf family. |
2002-07-02 |
2023-08-12 |
Not clear |
| Betty Lamothe, Bharat B Aggarwa. Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 22. issue 2. 2002-06-27. PMID:11911810. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is one of the latest members of the tnf superfamily known to induce apoptosis in a wide variety of tumor cells. |
2002-06-27 |
2023-08-12 |
human |
| Yves Chicheportiche, Rachel Chicheportiche, Irene Sizing, Jeff Thompson, Christopher B Benjamin, Christine Ambrose, Jean-Michel Daye. Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies. Arthritis research. vol 4. issue 2. 2002-06-20. PMID:11879548. |
human tumour necrosis factor (tnf)-like weak inducer of apoptosis (htweak) and two anti-htweak mabs were tested for their ability to elicit or block inflammatory responses in cultured human dermal fibroblasts and synoviocytes. |
2002-06-20 |
2023-08-12 |
human |
| Jan D Lünemann, Sonia Waiczies, Stefan Ehrlich, Uwe Wendling, Bibiane Seeger, Thomas Kamradt, Frauke Zip. Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells. Journal of immunology (Baltimore, Md. : 1950). vol 168. issue 10. 2002-06-19. PMID:11994437. |
tnf-related apoptosis-inducing ligand (trail), a member of the tnf superfamily, induces apoptosis in susceptible cells, which can be both malignant and nontransformed. |
2002-06-19 |
2023-08-12 |
human |
| Anne Janin, Christophe Deschaumes, Marjan Daneshpouy, Jérôme Estaquier, Juliette Micic-Polianski, Premavathy Rajagopalan-Levasseur, Khadija Akarid, Nicolas Mounier, Eliane Gluckman, Gérard Socié, Jean Claude Ameise. CD95 engagement induces disseminated endothelial cell apoptosis in vivo: immunopathologic implications. Blood. vol 99. issue 8. 2002-06-17. PMID:11929785. |
another member of the tumor necrosis factor (tnf)/cd95l family, tnf-alpha, induces disseminated vascular endothelial cell apoptosis, which precedes apoptosis of other cell types and lethal multiorgan failure. |
2002-06-17 |
2023-08-12 |
mouse |
| L Cartee, R Smith, Y Dai, M Rahmani, R Rosato, J Almenara, P Dent, S Gran. Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Molecular pharmacology. vol 61. issue 6. 2002-06-17. PMID:12021392. |
however, u937 cells ectopically expressing crma, dominant-negative caspase-8, or dominant-negative fas-associated death domain that were highly resistant to tumor necrosis factor (tnf)/cycloheximide-induced lethality displayed significant, albeit incomplete, resistance to pma/fp-induced apoptosis after 24 h. furthermore, coadministration of tnf soluble receptor significantly attenuated pma/fp-induced apoptosis in u937 (p < 0.02) and hl-60 (p < 0.03) cells at 24 h. pma/fp coadministration also triggered substantial increases in tnfalpha mrna and protein secretion compared with the effects of pma administered alone. |
2002-06-17 |
2023-08-12 |
human |
| L Cartee, R Smith, Y Dai, M Rahmani, R Rosato, J Almenara, P Dent, S Gran. Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways. Molecular pharmacology. vol 61. issue 6. 2002-06-17. PMID:12021392. |
taken together, these results suggest that coadministration of pma with fp in myeloid leukemia cells initially triggers mitochondrial damage, an event followed by the pkc-dependent induction and release of tnfalpha, supporting a model in which the synergistic induction of leukemic cell apoptosis by this drug combination proceeds via both mitochondrial- and tnf receptor-related apoptotic pathways. |
2002-06-17 |
2023-08-12 |
human |
| Xiaotang Hu, Matthew Bryington, Ariana B Fisher, Xiaomei Liang, Xiaohong Zhang, Dongming Cui, Indrani Datta, Kenneth S Zuckerma. Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest. The Journal of biological chemistry. vol 277. issue 19. 2002-06-13. PMID:11864973. |
in this study, we found that tnf induced g(1) arrest of tf-1 and mv4-11 cells while simultaneously causing apoptosis. |
2002-06-13 |
2023-08-12 |
Not clear |
| Terrance A Stadheim, Nanjoo Suh, Neema Ganju, Michael B Sporn, Alan Eastma. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. The Journal of biological chemistry. vol 277. issue 19. 2002-06-13. PMID:11880365. |
hence, tnf induces apoptosis in the presence of inhibitors of protein or rna synthesis. |
2002-06-13 |
2023-08-12 |
human |
| Terrance A Stadheim, Nanjoo Suh, Neema Ganju, Michael B Sporn, Alan Eastma. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. The Journal of biological chemistry. vol 277. issue 19. 2002-06-13. PMID:11880365. |
cddo in combination with tnf caused a dramatic increase in apoptosis in ml-1 leukemia cells that was associated with activation of caspase-8, cleavage of bid, translocation of bax, cytochrome c release, and caspase-3 activation. |
2002-06-13 |
2023-08-12 |
human |
| E P K Mensah-Brown, S Stosic Grujicic, D Maksimovic, A Jasima, A Shahin, M L Luki. Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes. Molecular immunology. vol 38. issue 12-13. 2002-06-11. PMID:12009572. |
our data are compatible with the notion that interferon-gamma (ifn-gamma)/tumor necrosis factor (tnf)/nitric oxide (no)-induced apoptosis of beta-cells in experimental diabetes is attenuated by ptx. |
2002-06-11 |
2023-08-12 |
mouse |
| M Seve, F Chimienti, A Favie. [Role of intracellular zinc in programmed cell death]. Pathologie-biologie. vol 50. issue 3. 2002-06-10. PMID:11980336. |
zinc addition in cell culture medium prevents the apparition of morphological and biochemical signs induced by intracellular zinc chelation, but also by other apoptosis inducers like etoposide or tumour necrosis factor alpha (tnf alpha). |
2002-06-10 |
2023-08-12 |
Not clear |
| Vladimir L Gabai, Katsuhide Mabuchi, Dick D Mosser, Michael Y Sherma. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Molecular and cellular biology. vol 22. issue 10. 2002-06-04. PMID:11971973. |
here we investigated the mechanism of hsp72-mediated protection from tumor necrosis factor (tnf)-induced apoptosis of primary culture of imr90 human fibroblasts. |
2002-06-04 |
2023-08-12 |
mouse |
| Vladimir L Gabai, Katsuhide Mabuchi, Dick D Mosser, Michael Y Sherma. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Molecular and cellular biology. vol 22. issue 10. 2002-06-04. PMID:11971973. |
hsp72 temporarily blocked apoptosis in response to tnf and permanently protected cells from heat shock. |
2002-06-04 |
2023-08-12 |
mouse |
| Keiko Aota, Masayuki Azuma, Tetsuya Tamatani, Tsuyoshi Yamashita, Yuki Ashida, Mitsunobu Sat. Stable inhibition of NF-kappa B in salivary gland cells does not enhance sensitivity to TNF-alpha-induced apoptosis due to upregulation of TRAF-1 expression. Experimental cell research. vol 276. issue 1. 2002-05-31. PMID:11978013. |
thus, to investigate the molecular mechanism involved in the unresponsiveness of these cell clones to tnf-alpha-induced apoptosis, we examined the effect of tnf-alpha on the expression of antiapoptotic proteins, including tnf receptor-associated factor (traf)-1, traf-2, cellular inhibitor of apoptosis protein (ciap)-1, and ciap-2. |
2002-05-31 |
2023-08-12 |
Not clear |