| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tudor M Baetu, John Hiscot. On the TRAIL to apoptosis. Cytokine & growth factor reviews. vol 13. issue 3. 2003-01-13. PMID:12486874. |
unlike other members of the tnf ligand family, tnf-related apoptosis-inducing ligand (trail) preferentially induces apoptosis in tumor cell lines, but not in normal cells, suggesting that trail could potentially represent a powerful cancer therapeutic. |
2003-01-13 |
2023-08-12 |
Not clear |
| Young-Soo Kim, Robert F Schwabe, Ting Qian, John J Lemasters, David A Brenne. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology (Baltimore, Md.). vol 36. issue 6. 2003-01-08. PMID:12447876. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis in a wide range of malignant cells. |
2003-01-08 |
2023-08-12 |
human |
| Carl G Feng, Marika C Kullberg, Dragana Jankovic, Allen W Cheever, Patricia Caspar, Robert L Coffman, Alan She. Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis. Infection and immunity. vol 70. issue 12. 2003-01-07. PMID:12438341. |
in contrast, mycobacterium-induced macrophage apoptosis as well as production of tnf, nitric oxide, and il-12p40 were strongly inhibited in hu10tg mice. |
2003-01-07 |
2023-08-12 |
mouse |
| Anja Krippner-Heidenreich, Fabian Tübing, Susanne Bryde, Sylvia Willi, Gudrun Zimmermann, Peter Scheuric. Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12215450. |
the membrane form of tnf, but not its soluble form, was capable of inducing apoptosis as well as activation of c-jun n-terminal kinase and nf-kappab via the tnfr2-derived chimera. |
2003-01-02 |
2023-08-12 |
Not clear |
| Amit K Garg, Bharat B Aggarwa. Reactive oxygen intermediates in TNF signaling. Molecular immunology. vol 39. issue 9. 2002-12-31. PMID:12431383. |
tumor necrosis factor (tnf) is arguably the most potent inducer of several intracellular signals, including apoptosis, cell differentiation, and gene transcription. |
2002-12-31 |
2023-08-12 |
Not clear |
| Marek Los, Malgorzata Mozoluk, Davide Ferrari, Anna Stepczynska, Christopher Stroh, Andrea Renz, Zdenko Herceg, Zhao-Qi Wang, Klaus Schulze-Osthof. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Molecular biology of the cell. vol 13. issue 3. 2002-12-30. PMID:11907276. |
we recently showed that in l929 cells cd95 ligation induces apoptosis, whereas tnf elicits necrosis. |
2002-12-30 |
2023-08-12 |
Not clear |
| Jérôme Dellacasagrande, Eric Ghigo, Didier Raoult, Christian Capo, Jean-Louis Meg. IFN-gamma-induced apoptosis and microbicidal activity in monocytes harboring the intracellular bacterium Coxiella burnetii require membrane TNF and homotypic cell adherence. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 11. 2002-12-24. PMID:12444137. |
ifn-gamma-induced apoptosis and microbicidal activity in monocytes harboring the intracellular bacterium coxiella burnetii require membrane tnf and homotypic cell adherence. |
2002-12-24 |
2023-08-12 |
Not clear |
| Jérôme Dellacasagrande, Eric Ghigo, Didier Raoult, Christian Capo, Jean-Louis Meg. IFN-gamma-induced apoptosis and microbicidal activity in monocytes harboring the intracellular bacterium Coxiella burnetii require membrane TNF and homotypic cell adherence. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 11. 2002-12-24. PMID:12444137. |
thus, adherence via cd54/beta(2) integrins together with membrane tnf are required to eliminate c. burnetii-infected cells through cell contact-dependent apoptosis. |
2002-12-24 |
2023-08-12 |
Not clear |
| Zhaoyu Jin, David T Dicker, Wafik S El-Deir. Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL. Cell cycle (Georgetown, Tex.). vol 1. issue 1. 2002-12-23. PMID:12429913. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) preferentially induces apoptosis in tumor cells over normal cells. |
2002-12-23 |
2023-08-12 |
human |
| Liarisa A Shchepina, Olga Y Pletjushkina, Armine V Avetisyan, Liora E Bakeeva, Elena K Fetisova, Denis S Izyumov, Valeria B Saprunova, Mikhail Y Vyssokikh, Boris V Chernyak, Vladimir P Skulache. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. vol 21. issue 53. 2002-12-23. PMID:12444550. |
in the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis factor alpha (tnf) in hela cells can be inhibited by (i) overexpression of an oncoprotein bcl-2, (ii) cyclosporin a, an inhibitor of the mitochondrial permeability transition pore (ptp) or (iii) oligomycin, an inhibitor of h+- atp-synthase. |
2002-12-23 |
2023-08-12 |
Not clear |
| Gyu Hyun Nam, Kwan Yong Cho. Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidification. European journal of biochemistry. vol 269. issue 21. 2002-12-13. PMID:12392561. |
tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) has been known to induce tumor-specific apoptosis and to share the structural and functional characteristics with the proteins of tnf family. |
2002-12-13 |
2023-08-12 |
human |
| Martin Krönke, Sabine Adam-Klage. Role of caspases in TNF-mediated regulation of cPLA(2). FEBS letters. vol 531. issue 1. 2002-12-13. PMID:12401196. |
in this review we highlight the evidence for a caspase-mediated cleavage and inactivation of cpla(2), which seems to be an important mechanism by which tnf downregulates cpla(2) activity in cells undergoing apoptosis. |
2002-12-13 |
2023-08-12 |
Not clear |
| Fanny Baran-Marszak, Remi Fagard, Bernard Girard, Sophie Camilleri-Broët, Feng Zeng, Gilbert M Lenoir, Martine Raphaël, Jean Feuillar. Gene array identification of Epstein Barr virus-regulated cellular genes in EBV-converted Burkitt lymphoma cell lines. Laboratory investigation; a journal of technical methods and pathology. vol 82. issue 11. 2002-12-10. PMID:12429807. |
functional classification of ebv-regulated genes gave a comprehensive picture of cellular reprogramming by ebv in bl, by pointing out cellular modules such as cell cycle, apoptosis, and signal transduction pathways, including bcr and tnf receptor family and interferon pathways. |
2002-12-10 |
2023-08-12 |
Not clear |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
tnf inhibited the apoptosis by activation of akt serine/threonine kinase in the human head and neck squamous cell carcinoma. |
2002-12-09 |
2023-08-12 |
human |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
tumour necrosis factor (tnf) is known to induce apoptosis, but recently, tnf was shown to promote cell survival, a process regulated by phosphatidylinositol-3-oh kinase (pi3k) and the nfkappab pathway. |
2002-12-09 |
2023-08-12 |
human |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
in this study, we investigated the relationship between the molecules implicated in regulating tnf-induced cell survival and apoptosis induced by tnf in a human head and neck squamous cell carcinoma cell line (sas), with special reference to the akt pathway, one of the pathways related to cell survival. |
2002-12-09 |
2023-08-12 |
human |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
the apoptosis of sas cells induced by tnf was dependent on the concentration: a high concentration of tnf, but not a low concentration, induced apoptosis within 30 h. however, a low concentration of tnf in the presence of wortmannin or ly294002 induced apoptosis. |
2002-12-09 |
2023-08-12 |
human |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
furthermore, expression of the kinase-negative form of akt, ikkalpha or ikkbeta, and the undegradable mutant of ikappab, also induced apoptosis at low concentrations of tnf. |
2002-12-09 |
2023-08-12 |
human |
| Ferry Sandra, Nori-aki Matsuki, Hiroshi Takeuchi, Tetsuro Ikebe, Takashi Kanematsu, Masamichi Ohishi, Masato Hirat. TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma. Cellular signalling. vol 14. issue 9. 2002-12-09. PMID:12034358. |
when the sas cells expressed constitutively activated akt, apoptosis was not induced, even by high concentrations of tnf. |
2002-12-09 |
2023-08-12 |
human |
| Michael Bergman, Hertzel Salman, Yichayaou Beloosesky, Meir Djaldetti, Hanna Bessle. Are peripheral blood cells from patients with Alzheimer disease more sensitive to apoptotic stimuli? Alzheimer disease and associated disorders. vol 16. issue 3. 2002-12-04. PMID:12218646. |
in addition, the effect of sera from subjects in the three groups on the apoptosis, interleukin (il)-1beta, il-2, il-6, il-10, and tumor necrosis factor (tnf)alpha production by peripheral blood cells from healthy control subjects was examined. |
2002-12-04 |
2023-08-12 |
human |