| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carrie J Riendeau, Hardy Kornfel. THP-1 cell apoptosis in response to Mycobacterial infection. Infection and immunity. vol 71. issue 1. 2003-02-10. PMID:12496173. |
interference with tnf death signaling may be a virulence mechanism that allows m. tuberculosis to circumvent innate defenses leading to apoptosis of infected host cells. |
2003-02-10 |
2023-08-12 |
human |
| Eduardo Moreno, Minhong Yan, Konrad Basle. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Current biology : CB. vol 12. issue 14. 2003-01-30. PMID:12176339. |
evolution of tnf signaling mechanisms: jnk-dependent apoptosis triggered by eiger, the drosophila homolog of the tnf superfamily. |
2003-01-30 |
2023-08-12 |
human |
| Eduardo Moreno, Minhong Yan, Konrad Basle. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Current biology : CB. vol 12. issue 14. 2003-01-30. PMID:12176339. |
like a subset of mammalian tnf proteins, eiger is a potent inducer of apoptosis. |
2003-01-30 |
2023-08-12 |
human |
| Raja Goswami, John Kilkus, Bobbie Scurlock, Glyn Dawso. CrmA protects against apoptosis and ceramide formation in PC12 cells. Neurochemical research. vol 27. issue 7-8. 2003-01-30. PMID:12374208. |
thus in pc12 pheochromocytoma cells, ceramide appears to amplify the death signal and there appears to be a sequence of events: tnf; tradd, pro-caspase 8, caspase 8, sphingomyelinase, ceramide, caspase 3, apoptosis. |
2003-01-30 |
2023-08-12 |
Not clear |
| Zuhal Ergonul, Alisa K Hughes, Donald E Koha. Induction of apoptosis of human brain microvascular endothelial cells by shiga toxin 1. The Journal of infectious diseases. vol 187. issue 1. 2003-01-30. PMID:12508161. |
hbecs were exposed to tumor necrosis factor (tnf)-alpha, with and without stx-1, and cell survival, (125)i-stx1 binding, globotriaosylceramide content, cell necrosis, and cell apoptosis levels were determined. |
2003-01-30 |
2023-08-12 |
human |
| Zuhal Ergonul, Alisa K Hughes, Donald E Koha. Induction of apoptosis of human brain microvascular endothelial cells by shiga toxin 1. The Journal of infectious diseases. vol 187. issue 1. 2003-01-30. PMID:12508161. |
tnf greatly increased stx-1 cytotoxicity, primarily through induction of apoptosis, in hbec. |
2003-01-30 |
2023-08-12 |
human |
| Paulo Lin, Jason A Bush, K-John J Cheung, Gang L. Tissue-specific regulation of Fas/APO-1/CD95 expression by p53. International journal of oncology. vol 21. issue 2. 2003-01-27. PMID:12118319. |
the regulation of fas/apo-1(cd95), an important member of the tumor necrosis factor (tnf) superfamily involved in membrane-mediated apoptosis, has been a subject of recent research. |
2003-01-27 |
2023-08-12 |
mouse |
| Alison F Littlejohn, Steven J Tucker, Ahmed A A Mohamed, Stephen McKay, Matt J Helms, Peter Vandenabeele, David J MacEwa. Modulation by caspases of tumor necrosis factor-stimulated c-Jun N-terminal kinase activation but not nuclear factor-kappaB signaling. Biochemical pharmacology. vol 65. issue 1. 2003-01-27. PMID:12473383. |
tnf can also induce apoptosis within cells due to its ability to recruit procaspase-8 to tnfr1, which in turn induces the caspase proteolytic cascade. |
2003-01-27 |
2023-08-12 |
human |
| Marcus Schuchmann, Eugene E Varfolomeev, Frank Hermann, Felix Rueckert, Dennis Strand, Heinz Koehler, Susanne Strand, Ansgar W Lohse, David Wallach, Peter R Gall. Dominant negative MORT1/FADD rescues mice from CD95 and TNF-induced liver failure. Hepatology (Baltimore, Md.). vol 37. issue 1. 2003-01-23. PMID:12500197. |
it became clear that receptor-mediated apoptosis is of specific interest in this context, and cd95 and cd120a, both members of the tumor necrosis factor (tnf) receptor superfamily, are the most prominent cell death receptors involved. |
2003-01-23 |
2023-08-12 |
mouse |
| Michael J Pinkoski, Nathalie M Droin, Douglas R Gree. Tumor necrosis factor alpha up-regulates non-lymphoid Fas-ligand following superantigen-induced peripheral lymphocyte activation. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12196549. |
members of the tumor necrosis factor (tnf) and tnf receptor families play important roles in inducing apoptosis and mediating the inflammatory response. |
2003-01-17 |
2023-08-12 |
mouse |
| Kohei Ando, Yoshikazu Higami, Tomoshi Tsuchiya, Takashi Kanematsu, Isao Shimokaw. Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver. Microscopy research and technique. vol 59. issue 4. 2003-01-16. PMID:12424791. |
to clarify the subcellular mechanisms of age-associated dysregulation of apoptosis and the effects of cr, we analyzed the expression of genes promoting apoptosis (p53, fas receptor, fas ligand, tnf receptor 1, tnfalpha, bax, tgf beta 1) and genes preventing apoptosis (bcl-2 and bcl-xl) in the livers of 3-, 6-, 15-, and 24-month-old male f344 rats that were either fed ad libitum or subjected to a 30% reduction in food intake (cr). |
2003-01-16 |
2023-08-12 |
rat |
| Kohei Ando, Yoshikazu Higami, Tomoshi Tsuchiya, Takashi Kanematsu, Isao Shimokaw. Impact of aging and life-long calorie restriction on expression of apoptosis-related genes in male F344 rat liver. Microscopy research and technique. vol 59. issue 4. 2003-01-16. PMID:12424791. |
our findings suggest that tnf ligand/tnf receptor family signaling, particularly fas receptor expression, is important in age- and cr-modulated apoptosis of hepatocytes. |
2003-01-16 |
2023-08-12 |
rat |
| F Garrouste, M Remacle-Bonnet, C Fauriat, J Marvaldi, J Luis, G Pommie. Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. Cell death and differentiation. vol 9. issue 7. 2003-01-14. PMID:12058282. |
we have previously established that insulin-like growth factor (igf)-i, -ii and insulin exert a strong protective effect against tumor necrosis factor-alpha (tnf)-induced apoptosis in interferon-gamma (ifn)-sensitized ht29-d4 human colon carcinoma cells. |
2003-01-14 |
2023-08-12 |
human |
| Noreen M Robertson, James G Zangrilli, Andrzej Steplewski, Annette Hastie, Rochelle G Lindemeyer, Maria A Planeta, Mary K Smith, Nathalie Innocent, Ali Musani, Rodolfo Pascual, Stephen Peters, Gerald Litwac. Differential expression of TRAIL and TRAIL receptors in allergic asthmatics following segmental antigen challenge: evidence for a role of TRAIL in eosinophil survival. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 10. 2003-01-14. PMID:12421985. |
trail, a member of the tnf family, induces apoptosis in most transformed cells; however, its role in health and disease remains unknown. |
2003-01-14 |
2023-08-12 |
human |
| Tudor M Baetu, John Hiscot. On the TRAIL to apoptosis. Cytokine & growth factor reviews. vol 13. issue 3. 2003-01-13. PMID:12486874. |
apoptosis in mammalian cells can be initiated through two major interrelated pathways, one involving engagement of the tnf family of death receptors, the other involving the release of cytochrome c from mitochondria. |
2003-01-13 |
2023-08-12 |
Not clear |
| Tudor M Baetu, John Hiscot. On the TRAIL to apoptosis. Cytokine & growth factor reviews. vol 13. issue 3. 2003-01-13. PMID:12486874. |
unlike other members of the tnf ligand family, tnf-related apoptosis-inducing ligand (trail) preferentially induces apoptosis in tumor cell lines, but not in normal cells, suggesting that trail could potentially represent a powerful cancer therapeutic. |
2003-01-13 |
2023-08-12 |
Not clear |
| Young-Soo Kim, Robert F Schwabe, Ting Qian, John J Lemasters, David A Brenne. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology (Baltimore, Md.). vol 36. issue 6. 2003-01-08. PMID:12447876. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis in a wide range of malignant cells. |
2003-01-08 |
2023-08-12 |
human |
| Carl G Feng, Marika C Kullberg, Dragana Jankovic, Allen W Cheever, Patricia Caspar, Robert L Coffman, Alan She. Transgenic mice expressing human interleukin-10 in the antigen-presenting cell compartment show increased susceptibility to infection with Mycobacterium avium associated with decreased macrophage effector function and apoptosis. Infection and immunity. vol 70. issue 12. 2003-01-07. PMID:12438341. |
in contrast, mycobacterium-induced macrophage apoptosis as well as production of tnf, nitric oxide, and il-12p40 were strongly inhibited in hu10tg mice. |
2003-01-07 |
2023-08-12 |
mouse |
| Anja Krippner-Heidenreich, Fabian Tübing, Susanne Bryde, Sylvia Willi, Gudrun Zimmermann, Peter Scheuric. Control of receptor-induced signaling complex formation by the kinetics of ligand/receptor interaction. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12215450. |
the membrane form of tnf, but not its soluble form, was capable of inducing apoptosis as well as activation of c-jun n-terminal kinase and nf-kappab via the tnfr2-derived chimera. |
2003-01-02 |
2023-08-12 |
Not clear |
| Amit K Garg, Bharat B Aggarwa. Reactive oxygen intermediates in TNF signaling. Molecular immunology. vol 39. issue 9. 2002-12-31. PMID:12431383. |
tumor necrosis factor (tnf) is arguably the most potent inducer of several intracellular signals, including apoptosis, cell differentiation, and gene transcription. |
2002-12-31 |
2023-08-12 |
Not clear |