| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marion MacFarlan. TRAIL-induced signalling and apoptosis. Toxicology letters. vol 139. issue 2-3. 2003-05-07. PMID:12628743. |
a more recently identified member of the tnf ligand family is tnf-related apoptosis-inducing ligand (trail), apo-2l, which induces apoptosis in a number of tumour cell lines, yet is relatively non-toxic to normal cells. |
2003-05-07 |
2023-08-12 |
human |
| Zhong-Wei Xu, Jörg Kleeff, Helmut Friess, Markus W Büchler, Marc Solio. Synergistic cytotoxic effect of TRAIL and gemcitabine in pancreatic cancer cells. Anticancer research. vol 23. issue 1A. 2003-05-01. PMID:12680221. |
tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a novel member of the tnf family and triggers apoptosis in a variety of malignant cells. |
2003-05-01 |
2023-08-12 |
Not clear |
| H Wajant, K Pfizenmaier, P Scheuric. TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis : an international journal on programmed cell death. vol 7. issue 5. 2003-04-30. PMID:12207178. |
tnf-related apoptosis-inducing ligand (trail/apo-2l) is a typical member of the tnf ligand family that induces apoptosis by activating the death receptors trail-r1 and trail-r2. |
2003-04-30 |
2023-08-12 |
human |
| Windy Irawaty, Thomas W H Kay, Helen E Thoma. Transmembrane TNF and IFNgamma induce caspase-independent death of primary mouse pancreatic beta cells. Autoimmunity. vol 35. issue 6. 2003-04-30. PMID:12568116. |
we conclude that the role of tnf in the development of type 1 diabetes is likely to be the activation of gene expression and not apoptosis. |
2003-04-30 |
2023-08-12 |
mouse |
| Anwu Zhou, Shane Scoggin, Richard B Gaynor, Noelle Sevilir William. Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interference. Oncogene. vol 22. issue 13. 2003-04-23. PMID:12673210. |
tumor necrosis factor alpha (tnf alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. |
2003-04-23 |
2023-08-12 |
human |
| Tom Vanden Berghe, Michael Kalai, Geert van Loo, Wim Declercq, Peter Vandenabeel. Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. The Journal of biological chemistry. vol 278. issue 8. 2003-04-22. PMID:12441346. |
inhibition of hsp90, a chaperone for many kinases, by geldanamycin or radicicol shifted the response of l929sa cells to tnf from necrosis to apoptosis. |
2003-04-22 |
2023-08-12 |
Not clear |
| Olivier Meye. [Anti-SSA/Ro and anti-SSB/La antibodies. What's new?]. Annales de medecine interne. vol 153. issue 8. 2003-04-22. PMID:12610426. |
these hyrnps (h=human) can be found on the cytoplasmic membrane or in small blebs during apoptosis after various stimuli such as uvb, 17-beta-estradiol, viral infection, tnf alpha and other cellular apoptosis inducing molecules. |
2003-04-22 |
2023-08-12 |
Not clear |
| Masaya Shigeno, Kazuhiko Nakao, Tatsuki Ichikawa, Kasumi Suzuki, Atsushi Kawakami, Seigou Abiru, Seiji Miyazoe, Yuichi Nakagawa, Hiroki Ishikawa, Keisuke Hamasaki, Keisuke Nakata, Nobuko Ishii, Katsumi Eguch. Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation. Oncogene. vol 22. issue 11. 2003-04-22. PMID:12642868. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail), a member of the tnf superfamily, induces apoptosis in a variety of cancer cells with little or no effect on normal cells. |
2003-04-22 |
2023-08-12 |
human |
| Mary Lynn Bajt, Ye-Shih Ho, Steven L Vonderfecht, Hartmut Jaeschk. Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice. Antioxidants & redox signaling. vol 4. issue 5. 2003-04-17. PMID:12470500. |
reactive oxygen as modulator of tnf and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice. |
2003-04-17 |
2023-08-12 |
mouse |
| Mary Lynn Bajt, Ye-Shih Ho, Steven L Vonderfecht, Hartmut Jaeschk. Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice. Antioxidants & redox signaling. vol 4. issue 5. 2003-04-17. PMID:12470500. |
reactive oxygen species (ros) can directly induce or enhance tumor necrosis factor (tnf)-mediated apoptosis in a number of different cell lines. |
2003-04-17 |
2023-08-12 |
mouse |
| Mary Lynn Bajt, Ye-Shih Ho, Steven L Vonderfecht, Hartmut Jaeschk. Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice. Antioxidants & redox signaling. vol 4. issue 5. 2003-04-17. PMID:12470500. |
to test the relevance of intracellular ros in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the tnf or fas receptor in wild-type and glutathione peroxidase-1 (gpx1-/-)-deficient mice (129sv/b6 background). |
2003-04-17 |
2023-08-12 |
mouse |
| Mahmoud R Hussein, Anna K Haemel, Gary S Woo. Apoptosis and melanoma: molecular mechanisms. The Journal of pathology. vol 199. issue 3. 2003-04-14. PMID:12579529. |
some of these molecules are of potential therapeutic use, such as: (1) p53, which influences resistance to chemotherapy; (2) mcl-1 and bcl-x(l), which can override apoptosis; (3) trail, which has selective fatal effects on tumour cells; (4) nf-(k)b, which when downregulated sensitizes cells to trail and tnf; (5) the pitslre kinases, whose alteration appears to result in fas resistance; (6) interferons, which sensitize cells to other factors; and (7) survivin and other iaps that inhibit apoptosis. |
2003-04-14 |
2023-08-12 |
Not clear |
| Min Xia, Cunshuan Xu, Shengdong Ji, Shaobai Xu. Shedding of Fas ectodomain that affects apoptosis of hepatocytes occurring in regenerative liver. Journal of gastroenterology. vol 37. issue 12. 2003-04-11. PMID:12522536. |
on the basis of comprehending several membrane proteins undergoing ectodomain shedding, including tumor necrosis factor (tnf) alpha receptors, we want to know if fas (cd95/apo-1), which belongs to the tnf receptor (tnfr) superfamily and transduces signals resulting in apoptosis upon binding of fas ligand (l) or agonistic anti-fas antibody, is shed on its ectodomain during liver regeneration |
2003-04-11 |
2023-08-12 |
Not clear |
| Wendelina J M Mackus, Susanne M A Lens, René H Medema, Mark J Kwakkenbos, Ludo M Evers, Marinus H J van Oers, René A W van Lier, Eric Elderin. Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation. International immunology. vol 14. issue 9. 2003-04-02. PMID:12202395. |
using the burkitt lymphoma cell line ramos as a model, we studied the commitment to apoptosis following growth arrest, as well as how triggering of cd40 or addition of tumor necrosis factor (tnf)-alpha can interfere to block cell death. |
2003-04-02 |
2023-08-12 |
Not clear |
| Seong G Kim, Kelly A Soltysiak, Zhan-Guo Gao, Tong-Shin Chang, Eunju Chung, Kenneth A Jacobso. Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors. Biochemical pharmacology. vol 65. issue 6. 2003-04-02. PMID:12623123. |
even a brief (10-min) incubation with udp protected the cells against tnf alpha-induced apoptosis. |
2003-04-02 |
2023-08-12 |
human |
| R Sharma, F O Al-Nasser, S D Anke. The importance of tumor necrosis factor and lipoproteins in the pathogenesis of chronic heart failure. Heart failure monitor. vol 2. issue 2. 2003-04-02. PMID:12634890. |
furthermore, tnf can cause skeletal muscle wasting and apoptosis, and, therefore, may be important in the development of cardiac cachexia. |
2003-04-02 |
2023-08-12 |
Not clear |
| Debajit K Biswas, Katherine J Martin, Cliona McAlister, Antonio P Cruz, Edgard Graner, Sun-chun Dai, Arthur B Parde. Apoptosis caused by chemotherapeutic inhibition of nuclear factor-kappaB activation. Cancer research. vol 63. issue 2. 2003-03-13. PMID:12543776. |
these included: up-regulation of proapoptotic genes of the tumor necrosis factor (tnf) pathway, death-associated protein (dap) kinase, p53, and p21/waf1; and down-regulation of inhibitors of apoptosis: inhibitor of apoptosis(iap)-1 and x-iap, tnf receptor-associated factor (traf)-2, and factors ox40 and 4-1bb. |
2003-03-13 |
2023-08-12 |
mouse |
| Hongtao Fan, Curla S Walters, Georgia M Dunston, Robert Tacke. IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation. Cytokine. vol 19. issue 3. 2003-03-12. PMID:12242079. |
furthermore, il-12 induced apoptosis was associated with caspase-3, caspase-2, caspase-7, dna fragmentation factor 45 (dff45) and fas associated death domain (fadd) whereas tnf receptor associated death domain (tradd) and receptor interacting protein (rip) were not. |
2003-03-12 |
2023-08-12 |
human |
| Juan José Lasarte, Pablo Sarobe, Patricia Boya, Noelia Casares, Laura Arribillaga, Ascensión López-Díaz de Cerio, Marta Gorraiz, Francisco Borrás-Cuesta, Jesús Priet. A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage. Hepatology (Baltimore, Md.). vol 37. issue 2. 2003-03-12. PMID:12540797. |
radce1 also causes a reduction in serum transaminase levels and inhibits hepatocellular apoptosis in mice given tumor necrosis factor (tnf)-alpha plus d-galactosamine. |
2003-03-12 |
2023-08-12 |
mouse |
| Catherine Emmanuel, Eugene Foo, Heather J Medbury, Janice Matthews, Alfio Comis, Hans Zoellne. Synergistic induction of apoptosis in human endothelial cells by tumour necrosis factor-alpha and transforming growth factor-beta. Cytokine. vol 18. issue 5. 2003-03-11. PMID:12161098. |
tumour necrosis factor (tnf)-alpha and transforming growth factor (tgf)-beta are also reported to induce endothelial apoptosis. |
2003-03-11 |
2023-08-12 |
human |