| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victor J Wroblewski, Derrick R Witcher, Gerald W Becker, Kelly A Davis, Shenshen Dou, Radmila Micanovic, Christy M Newton, Timothy W Noblitt, John M Richardson, Ho Yeong Song, John E Hal. Decoy receptor 3 (DcR3) is proteolytically processed to a metabolic fragment having differential activities against Fas ligand and LIGHT. Biochemical pharmacology. vol 65. issue 4. 2003-03-10. PMID:12566095. |
fas ligand (fasl) and fas receptor are members of the tumor necrosis factor (tnf) receptor and ligand family that play an important role in regulating apoptosis in normal physiology. |
2003-03-10 |
2023-08-12 |
mouse |
| Dong-Myung Kim, Sun-Young Koo, Kiwan Jeon, Min Hyung Kim, Jinho Lee, Chang Yong Hong, ShinWu Jeon. Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. Cancer research. vol 63. issue 3. 2003-03-07. PMID:12566305. |
rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (tnf)-alpha or tnf-related apoptosis-inducing ligand in human cancer cell lines. |
2003-03-07 |
2023-08-12 |
human |
| Dong-Myung Kim, Sun-Young Koo, Kiwan Jeon, Min Hyung Kim, Jinho Lee, Chang Yong Hong, ShinWu Jeon. Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines. Cancer research. vol 63. issue 3. 2003-03-07. PMID:12566305. |
we found that the combination treatment of flavopiridol (100-500 nm) with tumor necrosis factor (tnf)-alpha (10 ng/ml) induced a rapid and eminent apoptosis, 20 +/- 5% in 6-h treatment, in a human non-small cell lung carcinoma cell line, a549, as determined by the increase of sub-g(1) fraction in flow cytometry. |
2003-03-07 |
2023-08-12 |
human |
| Masafumi Nakayama, Kazumi Ishidoh, Yuko Kojima, Norihiro Harada, Eiki Kominami, Ko Okumura, Hideo Yagit. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 1. 2003-03-05. PMID:12496418. |
tweak, a tnf family member, is produced by ifn-gamma-stimulated monocytes and induces multiple pathways of cell death, including caspase-dependent apoptosis, cathepsin b-dependent necrosis, and endogenous tnf-alpha-mediated cell death, in a cell type-specific manner. |
2003-03-05 |
2023-08-12 |
Not clear |
| Ville Hietakangas, Minna Poukkula, Kaisa M Heiskanen, Jarkko T Karvinen, Lea Sistonen, John E Eriksso. Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP. Molecular and cellular biology. vol 23. issue 4. 2003-03-05. PMID:12556488. |
to better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied death receptor responses during erythroid differentiation of k562 erythroleukemia cells, which normally are highly resistant to tumor necrosis factor (tnf) alpha-, fasl-, and trail-induced apoptosis. |
2003-03-05 |
2023-08-12 |
Not clear |
| Yonglian Sun, Helen M Chen, Sumit K Subudhi, Jonathan Chen, Rima Koka, Lieping Chen, Yang-Xin F. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nature medicine. vol 8. issue 12. 2003-03-04. PMID:12426559. |
humans and mice deficient in fas, a tumor necrosis factor (tnf)-receptor family member, cannot induce apoptosis of autoreactive cells, and consequently develop progressive lymphoproliferative disorders and lupus-like autoimmune diseases. |
2003-03-04 |
2023-08-12 |
mouse |
| Yonglian Sun, Helen M Chen, Sumit K Subudhi, Jonathan Chen, Rima Koka, Lieping Chen, Yang-Xin F. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nature medicine. vol 8. issue 12. 2003-03-04. PMID:12426559. |
notably, 2a treatment rapidly augments ifn-gamma production, and induces the depletion of autoreactive b cells and abnormal double-negative t cells, possibly by increasing their apoptosis through fas- and tnf receptor-independent mechanisms. |
2003-03-04 |
2023-08-12 |
mouse |
| X C Wei, X L Lin, X J Wan. [TNF-related apoptosis inducing ligand and its research progress on cancer treatment]. Sheng li ke xue jin zhan [Progress in physiology]. vol 32. issue 1. 2003-03-04. PMID:12545771. |
trail (tnf-related apoptosis inducing ligand) belongs to the tumor necrosis factor (tnf) cytokine family, can induce apoptosis in a wide variety of tumor cell lines. |
2003-03-04 |
2023-08-12 |
Not clear |
| Suparna A Sarkar, Raghubir P Sharm. Expression of selected apoptosis related genes, MIF, IGIF and TNF alpha, during retinoic acid-induced neural differentiation in murine embryonic stem cells. Cell structure and function. vol 27. issue 2. 2003-02-27. PMID:12207051. |
expression of selected apoptosis related genes, mif, igif and tnf alpha, during retinoic acid-induced neural differentiation in murine embryonic stem cells. |
2003-02-27 |
2023-08-12 |
Not clear |
| Suparna A Sarkar, Raghubir P Sharm. Expression of selected apoptosis related genes, MIF, IGIF and TNF alpha, during retinoic acid-induced neural differentiation in murine embryonic stem cells. Cell structure and function. vol 27. issue 2. 2003-02-27. PMID:12207051. |
the function of tnf alpha, igif/il-18 and mif in all-trans-retinoic acid-treated cells during es differentiation and apoptosis is still speculatory. |
2003-02-27 |
2023-08-12 |
Not clear |
| X G Li, Y Zhang, B L Che. [Expression of different receptors of the apoptosis inducing gene TRAIL in human ovarian tumors]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 5. 2003-02-25. PMID:12212122. |
reverse transcriptase polymerase chain reaction (rt-pcr) was applied to assay mrna expression of trail(the tnf related apoptosis inducing ligand) receptors (dr5, dcr1, and dcr2) in 3 cases of normal ovarian tissues, 6 cases of ovarian benign tumors, and 16 cases of ovarian cancers. |
2003-02-25 |
2023-08-12 |
human |
| Germán Gallardo, Félix López-Blanco, Carlos M Ruiz de Galarreta, Luisa F Fanju. HMGCoA reductase inhibition partially mediates tumor necrosis factor alpha-induced apoptosis in human U-937 and HL-60 cells. Biochemical and biophysical research communications. vol 300. issue 2. 2003-02-25. PMID:12504097. |
the addition of mevalonate to both u-937 and hl-60 cells could also partially prevent tnf alpha and ceramide-induced apoptosis. |
2003-02-25 |
2023-08-12 |
human |
| Germán Gallardo, Félix López-Blanco, Carlos M Ruiz de Galarreta, Luisa F Fanju. HMGCoA reductase inhibition partially mediates tumor necrosis factor alpha-induced apoptosis in human U-937 and HL-60 cells. Biochemical and biophysical research communications. vol 300. issue 2. 2003-02-25. PMID:12504097. |
these results support the hypothesis that the inhibition of hmgcoa reductase expression and the subsequent decrease in prenylation of proteins such as p21(ras) are part of the mechanism by which tnf alpha induces apoptosis in these cells. |
2003-02-25 |
2023-08-12 |
human |
| Katerina Akassoglou, Eleni Douni, Jan Bauer, Hans Lassmann, George Kollias, Lesley Prober. Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 2. 2003-02-24. PMID:12522266. |
we have shown previously that human transmembrane tnf (tmtnf)p55tnfr signaling in transgenic mice triggers oligodendrocyte apoptosis, endothelial cell activation, parenchymal inflammation, and primary demyelinating lesions similar to those of acute multiple sclerosis. |
2003-02-24 |
2023-08-12 |
mouse |
| Marek Los, Christof J Burek, Christopher Stroh, Konrad Benedyk, Hubert Hug, Andrzej Mackiewic. Anticancer drugs of tomorrow: apoptotic pathways as targets for drug design. Drug discovery today. vol 8. issue 2. 2003-02-21. PMID:12565009. |
components of this signaling network, which include ligands, such as cd95, tumor necrosis factor (tnf) and tnf-related apoptosis-inducing ligand, as well as downstream molecules, such as caspases, bcl-2 family members, and inhibitor-of-apoptosis proteins, which trigger and regulate apoptosis, are crucial targets for conventional drug development and gene therapy of cancer and other diseases. |
2003-02-21 |
2023-08-12 |
Not clear |
| Marco Tafani, Joshua A Cohn, Natalie O Karpinich, Ronald J Rothman, Matteo A Russo, John L Farbe. Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12393866. |
apoptosis induced by tumor necrosis factor-alpha (tnf) lowered ph(i), an effect also accompanied by bax translocation, cytochrome c release, and cell killing. |
2003-02-12 |
2023-08-12 |
Not clear |
| Koichi Saeki, Norihiko Kobayashi, Yuko Inazawa, Hong Zhang, Hideki Nishitoh, Hidenori Ichijo, Kumiko Saeki, Mamoru Isemura, Akira Yu. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. The Biochemical journal. vol 368. issue Pt 3. 2003-02-10. PMID:12206715. |
we investigated intracellular signalling pathways for apoptosis induced by epigallocatechin-3-gallate (egcg) as compared with those induced by a toxic chemical substance (etoposide, vp16) or the death receptor ligand [tumour necrosis factor (tnf)]. |
2003-02-10 |
2023-08-12 |
human |
| Koichi Saeki, Norihiko Kobayashi, Yuko Inazawa, Hong Zhang, Hideki Nishitoh, Hidenori Ichijo, Kumiko Saeki, Mamoru Isemura, Akira Yu. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. The Biochemical journal. vol 368. issue Pt 3. 2003-02-10. PMID:12206715. |
in u937 cells, the apoptosis and activation of caspases-3 and -9 induced by egcg but not vp16 and tnf were inhibited with sb203580, a specific inhibitor of p38, while those induced by egcg and vp16 but not tnf were inhibited with sb202190, a rather broad inhibitor of jnk and p38. |
2003-02-10 |
2023-08-12 |
human |
| Koichi Saeki, Norihiko Kobayashi, Yuko Inazawa, Hong Zhang, Hideki Nishitoh, Hidenori Ichijo, Kumiko Saeki, Mamoru Isemura, Akira Yu. Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis. The Biochemical journal. vol 368. issue Pt 3. 2003-02-10. PMID:12206715. |
n -acetyl-l-cysteine (nac) almost completely abolished apoptosis induced by egcg under conditions in which the apoptosis induced by vp16 or tnf was not affected. |
2003-02-10 |
2023-08-12 |
human |
| Carrie J Riendeau, Hardy Kornfel. THP-1 cell apoptosis in response to Mycobacterial infection. Infection and immunity. vol 71. issue 1. 2003-02-10. PMID:12496173. |
consistent with the behavior of alveolar macrophages, attenuated m. tuberculosis h37ra and mycobacterium bovis bcg strongly induce thp-1 apoptosis, which requires endogenous tnf. |
2003-02-10 |
2023-08-12 |
human |