| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Mitsiades, V Poulaki, C S Mitsiades, K C Anderso. Induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug. Expert opinion on investigational drugs. vol 10. issue 6. 2002-02-14. PMID:11772236. |
in particular, synthetic mmpis may directly induce apoptosis of cancer cells via their inhibitory effect on the shedding of fas ligand (fasl), a transmembrane member of the tnf superfamily that kills susceptible cells through its receptor, fas. |
2002-02-14 |
2023-08-12 |
human |
| Christine Odoux, Andreas Albers, Andrew A Amoscato, Michael T Lotze, Michael K K Won. TRAIL, FasL and a blocking anti-DR5 antibody augment paclitaxel-induced apoptosis in human non-small-cell lung cancer. International journal of cancer. vol 97. issue 4. 2002-02-12. PMID:11802207. |
fas and trail receptors (dr4 and dr5) are tnf family members and act as death signal transduction proteins in the apoptosis cascade. |
2002-02-12 |
2023-08-12 |
human |
| H U Simo. Evidence for a pro-apoptotic function of CD137 in granulocytes. Swiss medical weekly. vol 131. issue 31-32. 2002-02-08. PMID:11641968. |
besides survival factors, granulocyte apoptosis is also regulated by death factors, which belong to the tumor necrosis factor (tnf)/nerve growth factor (ngf) superfamily. |
2002-02-08 |
2023-08-12 |
Not clear |
| J J Wu, X Chen, X C Cao, M S Baker, D B Kaufma. Cytokine-induced metabolic dysfunction of MIN6 beta cells is nitric oxide independent. The Journal of surgical research. vol 101. issue 2. 2002-02-07. PMID:11735275. |
we tested the in vitro effects of interleukin (il)-1 beta, tumor necrosis factor (tnf)alpha, and interferon (ifn)gamma on glucose-stimulated insulin release in the min6 beta-cell line and correlated metabolic dysfunction with no production and rates of apoptosis. |
2002-02-07 |
2023-08-12 |
Not clear |
| T Tsutamoto, A Wada, K Maeda, N Mabuchi, M Hayashi, T Tsutsui, M Ohnishi, M Fujii, T Matsumoto, T Yamamoto, T Takayama, M Kinoshit. Relationship between plasma levels of cardiac natriuretic peptides and soluble Fas: plasma soluble Fas as a prognostic predictor in patients with congestive heart failure. Journal of cardiac failure. vol 7. issue 4. 2002-02-07. PMID:11782855. |
cardiac natriuretic peptides may induce apoptosis in myocytes; however, the relationship between plasma levels of cardiac natriuretic peptides and those of soluble fas (sfas) and tumor necrosis factor (tnf)-alpha remains unknown in patients with congestive heart failure (chf). |
2002-02-07 |
2023-08-12 |
Not clear |
| Nina Beate Liabakk, Anders Sundan, Sverre Torp, Pål Aukrust, Stig S Frøland, Terje Espevi. Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA. Journal of immunological methods. vol 259. issue 1-2. 2002-02-01. PMID:11730847. |
two monoclonal antibodies against tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail), designated vi10e and iii6f, have been generated. |
2002-02-01 |
2023-08-12 |
human |
| E A Dearstyne, N I Kerkvlie. Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced decrease in anti-CD3-activated CD4(+) T cells: the roles of apoptosis, Fas, and TNF. Toxicology. vol 170. issue 1-2. 2002-01-31. PMID:11750091. |
mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)-induced decrease in anti-cd3-activated cd4(+) t cells: the roles of apoptosis, fas, and tnf. |
2002-01-31 |
2023-08-12 |
mouse |
| Isabelle Daigle, Shida Yousefi, Marco Colonna, Douglas R Green, Hans-Uwe Simo. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nature medicine. vol 8. issue 1. 2002-01-30. PMID:11786908. |
death domain-containing receptors of the tumor necrosis factor (tnf)/nerve growth factor (ngf) family can induce apoptosis upon activation in many cellular systems. |
2002-01-30 |
2023-08-12 |
Not clear |
| T Yamauchi, T Kadowak. [The molecular mechanisms by which PPAR gamma/RXR inhibitors improve insulin resistance]. Nihon rinsho. Japanese journal of clinical medicine. vol 59. issue 11. 2002-01-25. PMID:11712415. |
moreover, ppar gamma/rxr inhibitors decrease lipogenesis in wat, while tzd stimulate adipocyte differentiation and apoptosis, thereby both preventing adipocyte hypertrophy, which is associated with alleviation of insulin resistance presumably due to decreases in ffa, and tnf alpha, and upregulation of adiponectin. |
2002-01-25 |
2023-08-12 |
Not clear |
| S O Kim, J Ha. Pan-caspase inhibitor zVAD enhances cell death in RAW246.7 macrophages. Journal of endotoxin research. vol 7. issue 4. 2002-01-24. PMID:11717584. |
however, unlike l929 cells, in which the cell death by tnf is known to be necrosis, raw246.7 cells manifested features of apoptosis such as chromatin condensation and nuclear fragmentation. |
2002-01-24 |
2023-08-12 |
Not clear |
| M L Kayton, S K Libutt. Endothelial monocyte activating polypeptide II (EMAP II) enhances the effect of TNF on tumor-associated vasculature. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 1. 2002-01-22. PMID:11527006. |
these include induction of endothelial cell apoptosis and upregulation of tnf receptor i (tnfr1). |
2002-01-22 |
2023-08-12 |
Not clear |
| F S Zetoune, A R Murthy, Z Shao, T Hlaing, M G Zeidler, Y Li, C Vincen. A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. Cytokine. vol 15. issue 6. 2002-01-22. PMID:11594795. |
a20, a tnf inducible gene, inhibits tnf-mediated apoptosis as well as nf-kappa b induced by this cytokine. |
2002-01-22 |
2023-08-12 |
Not clear |
| G Tang, J Yang, Y Minemoto, A Li. Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis. Molecular cell. vol 8. issue 5. 2002-01-22. PMID:11741536. |
we report here that ikappab kinase (ikk) beta was specifically proteolyzed by caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (tnf)-alpha-induced apoptosis. |
2002-01-22 |
2023-08-12 |
Not clear |
| M Ahmed, I Dusanter-Fourt, A Dugray, L Dubrez, S Novault, M L Bonnet, S Gisselbrecht, B Varet, E Solary, W Vainchenker, A G Turha. BCR-ABL fails to inhibit apoptosis in U937 myelomonocytic cells expressing a carboxyl-terminal truncated STAT5. Leukemia & lymphoma. vol 42. issue 3. 2002-01-16. PMID:11699409. |
in addition to serum deprivation and etoposide, bcr-abl-expressing clones were not protected from apoptosis induced by tnf, ceramide-c2 and fas-cross-linking. |
2002-01-16 |
2023-08-12 |
Not clear |
| Y Yasuoka, Y Naomoto, T Yamatsuji, M Takaoka, M Kimura, H Uetsuka, N Matsubara, T Fujiwara, M Gunduz, N Tanaka, M Hais. Combination of tumor necrosis factor alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell lung cancer cell line. Experimental cell research. vol 271. issue 2. 2002-01-11. PMID:11716533. |
the c-myc oncogene is known to be involved in apoptosis induced by tnf. |
2002-01-11 |
2023-08-12 |
human |
| Tara L Garvey, John Bertin, Richard M Siegel, G H Wang, Michael J Lenardo, Jeffrey I Cohe. Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. Journal of virology. vol 76. issue 2. 2002-01-11. PMID:11752160. |
molluscum contagiosum virus (mcv), a member of the human poxvirus family, encodes the mc159 protein that inhibits fas-, tumor necrosis factor (tnf)-, and tnf-related apoptosis-inducing ligant (trail)-induced apoptosis. |
2002-01-11 |
2023-08-12 |
human |
| Tara L Garvey, John Bertin, Richard M Siegel, G H Wang, Michael J Lenardo, Jeffrey I Cohe. Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function. Journal of virology. vol 76. issue 2. 2002-01-11. PMID:11752160. |
amino acid substitutions in the rxdl motif located in the alpha6 region of either ded resulted in loss of protection from apoptosis induced by fas, tnf, and trail and abolished the ability of mc159 to block death effector filament formation. |
2002-01-11 |
2023-08-12 |
human |
| M D Southall, J S Isenberg, H Nakshatri, Q Yi, Y Pei, D F Spandau, J B Traver. The platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (TNF) alpha and TNF-related apoptosis-inducing ligand-induced apoptosis through an NF-kappa B-dependent process. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11571293. |
the platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (tnf) alpha and tnf-related apoptosis-inducing ligand-induced apoptosis through an nf-kappa b-dependent process. |
2002-01-10 |
2023-08-12 |
human |
| M D Southall, J S Isenberg, H Nakshatri, Q Yi, Y Pei, D F Spandau, J B Traver. The platelet-activating factor receptor protects epidermal cells from tumor necrosis factor (TNF) alpha and TNF-related apoptosis-inducing ligand-induced apoptosis through an NF-kappa B-dependent process. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11571293. |
using a model system created by retroviral transduction of the paf receptor (paf-r) into the paf-r-negative human epidermal cell line kb and the paf-r-expressing keratinocyte cell line hacat, we now demonstrate that activation of the epidermal paf-r results in protection from apoptosis induced by tumor necrosis factor (tnf) alpha or tnf-related apoptosis-inducing ligand. |
2002-01-10 |
2023-08-12 |
human |
| D Bernard, C Slomianny, B Vandenbunder, C Abbadi. cRel induces mitochondrial alterations in correlation with proliferation arrest. Free radical biology & medicine. vol 31. issue 8. 2002-01-10. PMID:11595379. |
we have previously shown that overexpressing crel, a transcription factor of the rel/nf-kappa b family, concomitantly inhibits proliferation of hela cells and makes them resistant against tnf alpha-induced apoptosis. |
2002-01-10 |
2023-08-12 |
Not clear |