| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Poulaki, C S Mitsiades, N Mitsiade. The role of Fas and FasL as mediators of anticancer chemotherapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 4. issue 4. 2002-05-29. PMID:11991678. |
fas ligand (fasl) is a member of the tnf superfamily that induces apoptosis in susceptible cells upon cross-linking of its own receptor, fas (apo-1/cd95). |
2002-05-29 |
2023-08-12 |
Not clear |
| J Held, K Schulze-Osthof. Potential and caveats of TRAIL in cancer therapy. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. vol 4. issue 4. 2002-05-29. PMID:11991679. |
tnf-related apoptosis-inducing ligand (trail) is a recently identified cytokine of the tnf superfamily that induces apoptosis in tumor cells upon binding to different receptors. |
2002-05-29 |
2023-08-12 |
Not clear |
| K L Tyler, P Clarke, R L DeBiasi, D Kominsky, G J Poggiol. Reoviruses and the host cell. Trends in microbiology. vol 9. issue 11. 2002-05-13. PMID:11825717. |
reovirus-induced apoptosis involves members of the tumor necrosis factor (tnf) superfamily of death receptors and is associated with activation of both death receptor- and mitochondrial-associated caspases. |
2002-05-13 |
2023-08-12 |
Not clear |
| Asok Mukhopadhyay, Shishir Shishodia, Xin-Yuan Fu, Bharat B Aggarwa. Lack of requirement of STAT1 for activation of nuclear factor-kappaB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-alpha. Journal of cellular biochemistry. vol 84. issue 4. 2002-05-10. PMID:11835405. |
tumor necrosis factor (tnf) is one of the most potent activators of nuclear transcription factor nf-kappab, c-jun n-terminal protein kinase (jnk), and apoptosis in a wide variety of cells. |
2002-05-10 |
2023-08-12 |
Not clear |
| S Airenne, H-M Surcel, J Tuukkanen, M Leinonen, P Saikk. Chlamydia pneumoniae inhibits apoptosis in human epithelial and monocyte cell lines. Scandinavian journal of immunology. vol 55. issue 4. 2002-05-08. PMID:11967121. |
when aiming to study the impact of c. pneumoniae infection on host cell apoptosis, we found that epithelial infected (hl) cells and macrophages (u937-line) were resistant to staurosporine and tumour necrosis factor (tnf)-alpha-induced physiological apoptosis 48, 72 or 120 h post-infection, as determined by flow cytometry, dna fragmentation assay and fluorescence microscopy. |
2002-05-08 |
2023-08-12 |
human |
| Maria-Emily R Gapuzan, Pavel V Yufit, Thomas D Gilmor. Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype. Oncogene. vol 21. issue 16. 2002-05-08. PMID:11971183. |
immortalized embryonic fibroblasts established from rela knockout mice have previously been shown to be more sensitive to apoptosis induced by tumor necrosis factor (tnf) than are control fibroblasts. |
2002-05-08 |
2023-08-12 |
mouse |
| Ya-Chien Yang, Tsuey-Ying Hsu, Rong-Hwa Lin, Ih-Jen Su, Jen-Yang Chen, Czau-Siung Yan. Resistance to tumor necrosis factor-alpha-induced apoptosis in human T-lymphotropic virus type I-infected T cell lines. AIDS research and human retroviruses. vol 18. issue 3. 2002-04-30. PMID:11839155. |
in addition, signals that induce apoptosis in t cells can result from interaction of tumor necrosis factor (tnf)-alpha with tnf receptors (tnfrs). |
2002-04-30 |
2023-08-12 |
human |
| Raweewan Hoontrakoon, Hong Wei Chu, Shyra J Gardai, Sally E Wenzel, Patrick McDonald, Valerie A Fadok, Peter M Henson, Donna L Bratto. Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. American journal of respiratory cell and molecular biology. vol 26. issue 4. 2002-04-30. PMID:11919076. |
here we demonstrate that interleukin (il)-15, in the presence or absence of tumor necrosis factor (tnf)-alpha, reduces spontaneous apoptosis in freshly isolated human eosinophils. |
2002-04-30 |
2023-08-12 |
human |
| L Fang, J Fang, C Q Che. TNF receptor-associated factor-2 binding site is involved in TNFR75-dependent enhancement of TNFR55-induced cell death. Cell research. vol 11. issue 3. 2002-04-29. PMID:11642407. |
tnf recepter-55 is the main mediator of tnf-induced apoptosis. |
2002-04-29 |
2023-08-12 |
human |
| William G Brodbeck, Mathew S Shive, Erica Colton, Nicholas P Ziats, James M Anderso. Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. The Journal of laboratory and clinical medicine. vol 139. issue 2. 2002-04-18. PMID:11919547. |
blocking experiments and evaluation of shedding of soluble tnf receptor type i (tnf-ri) demonstrated that endogenous tnf-alpha production is responsible for spontaneous apoptosis of biomaterial-adherent cells and that il-4 inhibits this apoptosis by increasing levels of shedding of soluble tnf-ri. |
2002-04-18 |
2023-08-12 |
Not clear |
| Mainak Majumder, Asish K Ghosh, Robert Steele, Xiao Yan Zhou, Nancy J Phillips, Ranjit Ray, Ratna B Ra. Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. Virology. vol 294. issue 1. 2002-04-17. PMID:11886269. |
intraperitoneal injection of recombinant tnf induced hepatic injury and apoptosis in normal mice. |
2002-04-17 |
2023-08-12 |
mouse |
| Mainak Majumder, Asish K Ghosh, Robert Steele, Xiao Yan Zhou, Nancy J Phillips, Ranjit Ray, Ratna B Ra. Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. Virology. vol 294. issue 1. 2002-04-17. PMID:11886269. |
in contrast, transgenic mice expressing ns5a protein were protected against hepatic apoptosis after injection of tnf. |
2002-04-17 |
2023-08-12 |
mouse |
| Hailing Liu, Chau R Lo, Mark J Czaj. NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology (Baltimore, Md.). vol 35. issue 4. 2002-04-17. PMID:11915022. |
hepatocyte resistance to tumor necrosis factor alpha (tnf)-induced apoptosis is dependent on activation of the transcription factor nuclear factor kappab (nf-kappab). |
2002-04-17 |
2023-08-12 |
rat |
| Pu Xia, Lijun Wang, Paul A B Moretti, Nathaniel Albanese, Fugui Chai, Stuart M Pitson, Richard J D'Andrea, Jennifer R Gamble, Mathew A Vada. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11777919. |
in addition, by using a kinase inactive dominant-negative sphk and a mutant sphk that lacks traf2-binding motif we show that the interaction of traf2 with sphk and subsequent activation of sphk are critical for prevention of apoptosis during tnf stimulation. |
2002-04-15 |
2023-08-12 |
Not clear |
| José E Cardier, Connie L Erickson-Mille. Fas (CD95)- and tumor necrosis factor-mediated apoptosis in liver endothelial cells: role of caspase-3 and the p38 MAPK. Microvascular research. vol 63. issue 1. 2002-04-12. PMID:11749068. |
recently, we showed that tnf enhances the susceptibility of endothelial cells from murine liver sinusoids (lec) to fas-mediated apoptosis, suggesting that signals transduced by fas and tnf receptors may synergistically increase intracellular death signals in these cells. |
2002-04-12 |
2023-08-12 |
Not clear |
| José E Cardier, Connie L Erickson-Mille. Fas (CD95)- and tumor necrosis factor-mediated apoptosis in liver endothelial cells: role of caspase-3 and the p38 MAPK. Microvascular research. vol 63. issue 1. 2002-04-12. PMID:11749068. |
in this work we evaluated whether caspase-3 and p38 are involved in lec apoptosis induced by fas and tnf. |
2002-04-12 |
2023-08-12 |
Not clear |
| R K Srivastav. TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia (New York, N.Y.). vol 3. issue 6. 2002-04-02. PMID:11774036. |
tnf-related apoptosis-inducing ligand (trail/apo-2l) is a member of the tnf family that promotes apoptosis by binding to the transmembrane receptors trail-r1/dr4 and trail-r2/dr5. |
2002-04-02 |
2023-08-12 |
human |
| Makoto Kamachi, Atsushi Kawakami, Satoshi Yamasaki, Ayumi Hida, Tomoki Nakashima, Hideki Nakamura, Hiroaki Ida, Masako Furuyama, Koto Nakashima, Kazutaka Shibatomi, Taiichiro Miyashita, Kiyoshi Migita, Katsumi Eguch. Regulation of apoptotic cell death by cytokines in a human salivary gland cell line: distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor alpha and interferon gamma. The Journal of laboratory and clinical medicine. vol 139. issue 1. 2002-04-02. PMID:11873240. |
we examined the mechanisms of apoptosis in a human salivary gland (hsg) cell line induced by tumor necrosis factor (tnf) alpha and interferon (ifn) gamma. |
2002-04-02 |
2023-08-12 |
human |
| Waleed Khalaf, Caroline Maina, Joseph Byers, William Harve. Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested. Leukemia research. vol 26. issue 2. 2002-03-27. PMID:11755467. |
ifn enhances differentiation in eskol, decreases tnf alpha levels, decreases apoptosis, increases il-6 levels, and down regulates the expression of several oncogenes. |
2002-03-27 |
2023-08-12 |
Not clear |
| Waleed Khalaf, Caroline Maina, Joseph Byers, William Harve. Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested. Leukemia research. vol 26. issue 2. 2002-03-27. PMID:11755467. |
vesnarinone (ves), a tnf alpha repressor, lowers tnf-alpha and decreases apoptosis in the same cell line. |
2002-03-27 |
2023-08-12 |
Not clear |