| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeppe Falsig, Markus Latta, Marcel Leis. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. Journal of neurochemistry. vol 88. issue 1. 2004-01-29. PMID:14675162. |
two other death-inducing ligands, tnf and tnf-related apoptosis-inducing ligand (trail) did not induce apoptosis in reactive astrocytes. |
2004-01-29 |
2023-08-12 |
Not clear |
| Jeppe Falsig, Markus Latta, Marcel Leis. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. Journal of neurochemistry. vol 88. issue 1. 2004-01-29. PMID:14675162. |
in contrast, p38 kinase activity was identified as an important controller of both the inflammatory reaction and apoptosis both in astrocytes stimulated with ccm and in glia exposed to tnf and il-1 only. |
2004-01-29 |
2023-08-12 |
Not clear |
| Julien Guergnon, Marie Chaussepied, Paul Sopp, Regina Lizundia, Marie-Françoise Moreau, Brigitte Blumen, Dirk Werling, Christopher J Howard, Gordon Langsle. A tumour necrosis factor alpha autocrine loop contributes to proliferation and nuclear factor-kappaB activation of Theileria parva-transformed B cells. Cellular microbiology. vol 5. issue 10. 2004-01-23. PMID:12969376. |
interestingly, both pharmacological inhibition of tnf synthesis and neutralizing anti-tnf antibodies lead to a reduction in proliferation and a 50% drop in nf-kappab activation, without inducing apoptosis. |
2004-01-23 |
2023-08-12 |
cattle |
| O Nyormoi, L Mills, M Bar-El. An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. Cell death and differentiation. vol 10. issue 5. 2004-01-22. PMID:12728254. |
an mmp-2/mmp-9 inhibitor, 5a, enhances apoptosis induced by ligands of the tnf receptor superfamily in cancer cells. |
2004-01-22 |
2023-08-12 |
mouse |
| O Nyormoi, L Mills, M Bar-El. An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. Cell death and differentiation. vol 10. issue 5. 2004-01-22. PMID:12728254. |
facs analysis showed that 5a interacted synergistically with ligands of the tnf receptor superfamily, including tnfalpha and tnf receptor-like apoptosis-inducing ligand (trail), and with a fas-cross-linking antibody (ch11), uv, paclitaxel, thapsigargin, and staurosporin, to induce apoptosis in a cell-type-specific manner. |
2004-01-22 |
2023-08-12 |
mouse |
| Ulrike Böer, Alexandra Fennekohl, Gerhard P Püsche. Sensitization by interleukin-6 of rat hepatocytes to tumor necrosis factor alpha-induced apoptosis. Journal of hepatology. vol 38. issue 6. 2004-01-22. PMID:12763364. |
tumor necrosis factor (tnf) elicits hepatocyte apoptosis in toxic liver injury and is also central in hepatocyte proliferation after partial hepatectomy. |
2004-01-22 |
2023-08-12 |
mouse |
| Yuka Miyasaka, Nobuyuki Enomoto, Masayuki Kurosaki, Naoya Sakamoto, Nobuhiko Kanazawa, Takahiro Kohashi, Eri Ueda, Shinya Maekawa, Hideki Watanabe, Namiki Izumi, Chifumi Sato, Mamoru Watanab. Hepatitis C virus nonstructural protein 5A inhibits tumor necrosis factor-alpha-mediated apoptosis in Huh7 cells. The Journal of infectious diseases. vol 188. issue 10. 2004-01-22. PMID:14624380. |
to analyze the influence of hepatitis c virus nonstructural protein 5a (ns5a) on apoptosis, we established huh7 cells that stably express ns5a, and induced apoptosis using tumor necrosis factor (tnf)-alpha. |
2004-01-22 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Shishir Shishodia, Kazuhiro Ashikawa, Alok C Bhart. The role of TNF and its family members in inflammation and cancer: lessons from gene deletion. Current drug targets. Inflammation and allergy. vol 1. issue 4. 2004-01-16. PMID:14561180. |
all the cytokines of the tnf superfamily mediate their effects through the activation of the transcription factor nf-kappab, c-jun n-terminal kinase, apoptosis, and proliferation. |
2004-01-16 |
2023-08-12 |
Not clear |
| Yun Dai, Paul Dent, Steven Gran. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645670. |
coadministration of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) or tnf-alpha substantially increased mek inhibitors (e.g., pd184352 or u0126)/ucn-01-induced mitochondrial dysfunction, activation of procaspase-8 and bid, and apoptosis in bcl-2- and bcl-xl-overexpressing cells but not in those in which the extrinsic pathway was interrupted. |
2004-01-16 |
2023-08-12 |
human |
| Kye Young Lee, Jae Seuk Park, Young Koo Jee, Glenn D Rose. Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation. Experimental & molecular medicine. vol 34. issue 6. 2004-01-14. PMID:12526088. |
tnf-related apoptosis-inducing ligand (trail/apo- 2l), a newly identified member of the tnf family promotes apoptosis by binding to the transmembrane receptors (trail-r1/dr4 and trail-r2/dr5). |
2004-01-14 |
2023-08-12 |
human |
| Peter Szodoray, Stig Jellestad, Britt Nakken, Johan G Brun, Roland Jonsso. Programmed cell death in rheumatoid arthritis peripheral blood T-cell subpopulations determined by laser scanning cytometry. Laboratory investigation; a journal of technical methods and pathology. vol 83. issue 12. 2004-01-14. PMID:14691302. |
freshly separated peripheral blood lymphocytes were stained for apoptosis markers (cd95, bax, bcl-2, tnf receptor) and for an activation marker (cd45-ro), and the apoptosis frequency of cells bearing these markers were assessed by the terminal-deoxynucleotidyl transferase-mediated dutp digoxigenin nick end labeling method and nuclear condensation analysis with laser scanning cytometry. |
2004-01-14 |
2023-08-12 |
Not clear |
| D K Giri, P Pantazis, B B Aggarwa. Cellular resistance to vincristine suppresses NF-kappa B activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis. Apoptosis : an international journal on programmed cell death. vol 4. issue 4. 2004-01-14. PMID:14692400. |
in this report, we investigated the effect of tnf on activation of nf-kappa b, c-jun n-terminal kinase (jnk), and apoptosis in vincristine-resistant human histiocytic lymphoma u937-vr cells. |
2004-01-14 |
2023-08-12 |
human |
| D K Giri, P Pantazis, B B Aggarwa. Cellular resistance to vincristine suppresses NF-kappa B activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis. Apoptosis : an international journal on programmed cell death. vol 4. issue 4. 2004-01-14. PMID:14692400. |
when examined for apoptosis, vincristine resistance suppressed the cytotoxic effects and caspase-3 activation by tnf. |
2004-01-14 |
2023-08-12 |
human |
| Rosa Bernardi, Pier Paolo Pandolf. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. vol 22. issue 56. 2004-01-09. PMID:14663483. |
as a result, pml(-/-) mice and cells are protected from apoptosis triggered by a number of stimuli such as ionizing radiation, interferon, ceramide, fas and tnf. |
2004-01-09 |
2023-08-12 |
mouse |
| P Clarke, K L Tyle. Reovirus-induced apoptosis: A minireview. Apoptosis : an international journal on programmed cell death. vol 8. issue 2. 2004-01-08. PMID:12766474. |
in epithelial cells, reovirus-induced apoptosis involves the release of tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) from infected cells and the activation of trail-associated death receptors (drs) dr4 and dr5. |
2004-01-08 |
2023-08-12 |
Not clear |
| Sun-Mi Park, Hae-Young Park, Tae H Le. Functional effects of TNF-alpha on a human follicular dendritic cell line: persistent NF-kappa B activation and sensitization for Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 8. 2004-01-06. PMID:14530313. |
as a result, antiapoptotic genes including tnfr-associated factors 1 and 2, and cellular inhibitor of apoptosis proteins 1 and 2 were persistently induced by tnf, leading to the protection against tnf-mediated cell death. |
2004-01-06 |
2023-08-12 |
human |
| Sun-Mi Park, Hae-Young Park, Tae H Le. Functional effects of TNF-alpha on a human follicular dendritic cell line: persistent NF-kappa B activation and sensitization for Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 8. 2004-01-06. PMID:14530313. |
however, tnf pretreatment enhanced fas-mediated apoptosis by up-regulating surface fas expression in an nf-kappab-dependent pathway. |
2004-01-06 |
2023-08-12 |
human |
| Sun-Mi Park, Hae-Young Park, Tae H Le. Functional effects of TNF-alpha on a human follicular dendritic cell line: persistent NF-kappa B activation and sensitization for Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 8. 2004-01-06. PMID:14530313. |
however, our in vitro results suggest that fdcs proliferate in response to tnf, and die by fas-mediated apoptosis whose susceptibility is enhanced by tnf, representing a mode of action for tnf in the maintenance of fdc networks by regulating the survival or death of fdc. |
2004-01-06 |
2023-08-12 |
human |
| E Ucur, J Mattern, T Wenger, S Okouoyo, A Schroth, K-M Debatin, I Her. Induction of apoptosis in experimental human B cell lymphomas by conditional TRAIL-expressing T cells. British journal of cancer. vol 89. issue 11. 2004-01-06. PMID:14647152. |
in the present study, we demonstrate the utility of a non-tumour-forming t-cell line for the inducible gene transfer of tumour necrosis factor (tnf)-related apoptosis-inducing ligand (apo2l/trail), which has been shown to selectively induce apoptosis in malignant but not in normal cells. |
2004-01-06 |
2023-08-12 |
mouse |
| A Lamberti, M F Romano, V Agosti, C Garbi, S C Sun, H M Bond, P Bonelli, M C Turco, S Venut. Regulation of cell survival in CD95-induced T cell apoptosis: role of NF-kappa B/Rel transcription factors. Apoptosis : an international journal on programmed cell death. vol 4. issue 3. 2004-01-05. PMID:14634280. |
the activity of nf-kappa b/rel transcription factors can inhibit the apoptosis induced by tnf, uv or cancer therapy drugs in a number of cell types, including human t lymphocytes. |
2004-01-05 |
2023-08-12 |
human |