| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annayya R Aroor, Shivendra D Shukl. MAP kinase signaling in diverse effects of ethanol. Life sciences. vol 74. issue 19. 2004-04-02. PMID:15027449. |
apoptosis caused by chronic ethanol treatment may be due to ethanol potentiation of tnf induced activation of p38 mapk. |
2004-04-02 |
2023-08-12 |
Not clear |
| W Van Molle, C Liber. Bilirubin release induced by tumor necrosis factor in combination with galactosamine is toxic to mice. Cytokine. vol 23. issue 3. 2004-03-30. PMID:12906872. |
application of tumor necrosis factor (tnf) in combination with galactosamine (galn) in mice causes severe apoptosis of hepatocytes, resulting in complete destruction of the liver. |
2004-03-30 |
2023-08-12 |
mouse |
| Alok C Bharti, Yasunari Takada, Shishir Shishodia, Bharat B Aggarwa. Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism. The Journal of biological chemistry. vol 279. issue 7. 2004-03-30. PMID:14645259. |
most members of the tnf superfamily suppress cell proliferation and induce apoptosis, but whether rankl does so is not known. |
2004-03-30 |
2023-08-12 |
Not clear |
| L-M Ching, S Zwain, B C Bagule. Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. British journal of cancer. vol 90. issue 4. 2004-03-26. PMID:14970872. |
apoptosis was significantly lower in colon 38 tumours of mice, with a targeted disruption in the tnf gene (tnf(-/-)), or in the tnf receptor 1 gene (tnfr(-/-)), as compared with that in wild-type mice. |
2004-03-26 |
2023-08-12 |
mouse |
| Marc E Van Eden, Marshall P Byrd, Kyle W Sherrill, Richard E Lloy. Translation of cellular inhibitor of apoptosis protein 1 (c-IAP1) mRNA is IRES mediated and regulated during cell stress. RNA (New York, N.Y.). vol 10. issue 3. 2004-03-24. PMID:14970392. |
cellular inhibitor of apoptosis protein 1 (c-iap1) can regulate apoptosis through its interaction with downstream tnf receptor effectors (traf1 and traf2), by binding to and inhibiting certain caspases, and by controlling the levels of specific proapoptotic stimuli (e.g., smac/diablo) within the cell. |
2004-03-24 |
2023-08-12 |
rabbit |
| E G E de Vries, T Timmer, N H Mulder, C M M van Geelen, W T A van der Graaf, D C J Spierings, M N de Hooge, J A Gietema, S de Jon. Modulation of death receptor pathways in oncology. Drugs of today (Barcelona, Spain : 1998). vol 39 Suppl C. 2004-03-23. PMID:14988748. |
the death receptor ligands tumor necrosis factor (tnf), fasl and tnf-related apoptosis-inducing ligand (trail) might be interesting candidates as they are able to induce apoptosis by binding to their cell membrane receptors. |
2004-03-23 |
2023-08-12 |
mouse |
| Juan Shi, Dexian Zheng, Kwan Man, Sheung-tat Fan, Ruian X. TRAIL: a potential agent for cancer therapy. Current molecular medicine. vol 3. issue 8. 2004-03-19. PMID:14682494. |
tnf-related apoptosis inducing ligand (trail/apo-2l) is a typical member of the tnf ligand family that induces apoptosis through activating the death receptors. |
2004-03-19 |
2023-08-12 |
Not clear |
| V Jurisic, V Bumbasirevic, G Konjevic, B Djuricic, I Spuzi. TNF-alpha induces changes in LDH isotype profile following triggering of apoptosis in PBL of non-Hodgkin's lymphomas. Annals of hematology. vol 83. issue 2. 2004-03-18. PMID:14586559. |
based on the possibility of tumor necrosis factor (tnf)-alpha to perform multiple and opposite biologic effects, we simultaneously investigated in vitro its effects on intracellular lactate dehydrogenase (ldh)-h and ldh-m isoenzyme activity and morphological characteristics following induction of apoptosis in peripheral blood mononuclear cells (pbmc) of non-hodgkin's lymphoma patients (nhl) prior to and after the end of applied chemotherapy. |
2004-03-18 |
2023-08-12 |
Not clear |
| Yusuke Gotoh, Kumiko Oishi, Hideki Shibata, Akiko Yamagiwa, Takayuki Isagawa, Tamako Nishimura, Emiko Goyama, Mikiko Takahashi, Hideyuki Mukai, Yoshitaka On. Protein kinase PKN1 associates with TRAF2 and is involved in TRAF2-NF-kappaB signaling pathway. Biochemical and biophysical research communications. vol 314. issue 3. 2004-03-17. PMID:14741690. |
traf2 is one of the major mediators of tnf receptor superfamily transducing tnf signal to various functional targets, including activation of nf-kappab, jnk, and apoptosis. |
2004-03-17 |
2023-08-12 |
Not clear |
| Anna Zganiacz, Michael Santosuosso, Jun Wang, Tony Yang, Lihao Chen, Maria Anzulovic, Scott Alexander, Brigitte Gicquel, Yonghong Wan, Jonathan Bramson, Mark Inman, Zhou Xin. TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. The Journal of clinical investigation. vol 113. issue 3. 2004-03-16. PMID:14755337. |
we found that tnf-alpha-deficient (tnf(-/-)) mice quickly succumbed to respiratory failure following lung infection with replication-competent mycobacteria, because of apoptosis and necrosis of granuloma and lung structure. |
2004-03-16 |
2023-08-12 |
mouse |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
numerous studies have shown that proinflammatory cytokines may regulate endothelial cells (ec) apoptosis mediated by members of the tumor necrosis factor (tnf) family, such as tnf-alpha and fas. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
in this study we hypothesized that il-18 may regulate the susceptibility of liver endothelial cells (lec) to apoptosis induced by tnf and fas. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
il-18 increased the susceptibility of lec to undergo apoptosis mediated by tnf but not by fas. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
since tnf-induced apoptosis is mediated by the type i tnf receptor (tnfri), we investigated up-regulation of this receptor in il-18-treated lec. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
partial blocking of lec apoptosis induced by il-18 and tnf was observed when the cells were pretreated with the broad-spectrum inhibitor of caspases z-vad-fmk, suggesting involvement of the caspase pathway in apoptosis induced by these cytokines in these cells. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
our results show that il-18 differentially regulates apoptosis mediated by the death-inducing factors, tnf and fas. |
2004-03-12 |
2023-08-12 |
Not clear |
| Eliana Mariño, José E Cardie. Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-alpha and Fas (CD95). Cytokine. vol 22. issue 5. 2004-03-12. PMID:12842762. |
to our knowledge, this is the first report that il-18 may regulate endothelial cell apoptosis mediated by tnf. |
2004-03-12 |
2023-08-12 |
Not clear |
| Yong J Lee, Jae J Song, Jin H Kim, Hyeong-Reh Choi Kim, Young K Son. Low extracellular pH augments TRAIL-induced apoptotic death through the mitochondria-mediated caspase signal transduction pathway. Experimental cell research. vol 293. issue 1. 2004-03-11. PMID:14729063. |
tumor necrosis factor-related apoptosis inducing ligand (trail/apo-2l), a member of the tumor necrosis factor (tnf) gene family, is considered as one of the most promising cancer therapeutic agents due to its ability to selectively kill tumor cells. |
2004-03-11 |
2023-08-12 |
human |
| Takami Fukui, Kouji Matsui, Hiroki Kato, Hiroshi Takao, Yasuyuki Sugiyama, Katsuyuki Kunieda, Shigetoyo Saj. Significance of apoptosis induced by tumor necrosis factor-alpha and/or interferon-gamma against human gastric cancer cell lines and the role of the p53 gene. Surgery today. vol 33. issue 11. 2004-03-10. PMID:14605957. |
the expression of the p53 gene in target cells plays an important role in the induction of apoptosis by tumor necrosis factor (tnf)-alpha and interferon (ifn)-gamma. |
2004-03-10 |
2023-08-12 |
human |
| Kazuhiko Tsuruya, Toshiharu Ninomiya, Masanori Tokumoto, Makoto Hirakawa, Kohsuke Masutani, Masatomo Taniguchi, Kyoichi Fukuda, Hidetoshi Kanai, Kenji Kishihara, Hideki Hirakata, Mitsuo Iid. Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney international. vol 63. issue 1. 2004-03-02. PMID:12472770. |
tumor necrosis factor (tnf) receptor family members, such as fas and tnf receptor 1 (tnfr1), are thought to induce apoptosis in a variety of cells and organs. |
2004-03-02 |
2023-08-12 |
Not clear |