| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charles Thompson, Devin Gary, Mark Mattson, Alex Mackenzie, George S Robertso. Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors. Brain research. Molecular brain research. vol 123. issue 1-2. 2004-08-03. PMID:15046874. |
we report here that systemic administration of kainic acid rapidly elevates expression of mrna encoding neuronal apoptosis inhibitor protein (naip) in the hippocampus and that this increase does not occur in mice that lack tnf receptors. |
2004-08-03 |
2023-08-12 |
mouse |
| Charles Thompson, Devin Gary, Mark Mattson, Alex Mackenzie, George S Robertso. Kainic acid-induced naip expression in the hippocampus is blocked in mice lacking TNF receptors. Brain research. Molecular brain research. vol 123. issue 1-2. 2004-08-03. PMID:15046874. |
given that naip overexpression can reduce neuronal injury by blocking apoptosis, our findings suggest that induction of the naip gene may contribute to the neuroprotective properties of tnf. |
2004-08-03 |
2023-08-12 |
mouse |
| Ahter D Sanlioglu, Cigdem Aydin, Hakan Bozcuk, Ender Terzioglu, Salih Sanliogl. Fundamental principals of tumor necrosis factor-alpha gene therapy approach and implications for patients with lung carcinoma. Lung cancer (Amsterdam, Netherlands). vol 44. issue 2. 2004-08-03. PMID:15084385. |
since resistance to tumor necrosis factor (tnf)-alpha-mediated apoptosis represented an obstacle for the treatment of patients with lung carcinoma in the earlier attempts, an extensive research was recently initiated to understand molecular mechanism of tnf-alpha signaling. |
2004-08-03 |
2023-08-12 |
Not clear |
| Andrew Thorbur. Death receptor-induced cell killing. Cellular signalling. vol 16. issue 2. 2004-08-02. PMID:14636884. |
apoptosis pathways activated by death receptors of the tumour necrosis factor (tnf) family such as fas, tnfr1, or the trail receptors dr4 and dr5 are implicated in diverse diseases. |
2004-08-02 |
2023-08-12 |
Not clear |
| Kazumi Kajiwara, Atsuhiro Saito, Shin-ichi Ogata, Masao Tanihar. Synthetic peptides corresponding to ligand-binding region of death receptors, DR5, Fas, and TNFR, specifically inhibit cell death mediated by the death ligands, respectively. Biochimica et biophysica acta. vol 1699. issue 1-2. 2004-07-27. PMID:15158720. |
apoptosis is mediated by soluble factors, which belong to the tnf superfamily, such as tnf-alpha, fasl, and trail. |
2004-07-27 |
2023-08-12 |
Not clear |
| Ping Yang, Brian S McKay, Janice B Allen, Glenn J Jaff. Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. Investigative ophthalmology & visual science. vol 45. issue 7. 2004-07-27. PMID:15223828. |
in many cell types, tumor necrosis factor (tnf)-alpha-induced apoptosis is prevented by production of tnf-alpha-induced antiapoptotic protein, a process mediated by nuclear transcription factor (nf)-kappa b. tnf-alpha is widely expressed in proliferative vitreoretinopathy (pvr) membranes and is present in the vitreous of eyes with pvr. |
2004-07-27 |
2023-08-12 |
human |
| Yasunari Takada, Fadlo R Khuri, Bharat B Aggarwa. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. The Journal of biological chemistry. vol 279. issue 25. 2004-07-23. PMID:15090542. |
the tnf-induced nf-kappab-regulated gene products cyclin d1, cox-2, mmp-9, survivin, iap1, iap2, xiap, bcl-2, bfl-1/a1, traf1, and flip were all down-regulated by sch 66336, which potentiated apoptosis induced by tnf and doxorubicin. |
2004-07-23 |
2023-08-12 |
Not clear |
| Anjana Bhardwaj, Bharat B Aggarwa. Receptor-mediated choreography of life and death. Journal of clinical immunology. vol 23. issue 5. 2004-07-20. PMID:14601641. |
the apoptosis induced by tnf, and other members of the family, for example, fasl, vegi, and trail is mediated through death receptors. |
2004-07-20 |
2023-08-12 |
Not clear |
| Ireneusz Całkosiński, Marek Cegielski, Piotr Dziegiel, Robert Skalik, Jacek Majd. Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy. Folia morphologica. vol 63. issue 2. 2004-07-20. PMID:15232782. |
the secreted proinflammatory interleukins il-1, il-6 and tnf in the course of experimentally-induced pleurisy can be the cause of pathological changes in the ultrastructure of cardiac muscle and of apoptosis. |
2004-07-20 |
2023-08-12 |
rat |
| T J Kemp, J-S Kim, S A Crist, T S Griffit. Induction of necrotic tumor cell death by TRAIL/Apo-2L. Apoptosis : an international journal on programmed cell death. vol 8. issue 6. 2004-07-19. PMID:14739604. |
in contrast, apoptosis was induced in tramp-c2 using tnf, as measured by the criteria listed above, as was renca by mtrail/apo-2l. |
2004-07-19 |
2023-08-12 |
Not clear |
| Ruiqiong Ran, Aigang Lu, Lu Zhang, Yang Tang, Hongyan Zhu, Huichun Xu, Yuxin Feng, Chun Han, Guoping Zhou, Alan C Rigby, Frank R Shar. Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes & development. vol 18. issue 12. 2004-07-19. PMID:15198984. |
although tnf may or may not be sufficient to trigger apoptosis on its own, tnf-triggered apoptosis was initiated or made worse when hsp70 expression increased to high levels to disrupt nf-kappa b signaling. |
2004-07-19 |
2023-08-12 |
Not clear |
| Takahiro Shimizu, Tomohiro Numata, Yasunobu Okad. A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 17. 2004-07-16. PMID:15096609. |
here, we demonstrate that in human epithelia hela cells both mitochondrion- and death receptor-mediated apoptosis inducers [staurosporine and fas ligand or tumor necrosis factor (tnf)-alpha] rapidly activate cl(-) currents that show properties phenotypical of volume-sensitive outwardly rectifying cl(-) channel currents, including outward rectification, voltage-dependent inactivation gating at large positive potentials, inhibition by osmotic shrinkage, sensitivity to classic cl(-) channel blockers, and dependence on cytosolic atp. |
2004-07-16 |
2023-08-12 |
human |
| Tomoyuki Kawakita, Katsuya Shiraki, Yutaka Yamanaka, Yumi Yamaguchi, Yukiko Saitou, Naoyuki Enokimura, Norihiko Yamamoto, Hiroshi Okano, Kazushi Sugimoto, Kazumoto Murata, Takeshi Nakan. Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis. Biochemical and biophysical research communications. vol 318. issue 3. 2004-07-16. PMID:15144899. |
tnf-like weak inducer of apoptosis (tweak) is a member of the tnf family whose transcripts are expressed in various human tissues. |
2004-07-16 |
2023-08-12 |
human |
| Harald Wajan. Death receptors. Essays in biochemistry. vol 39. 2004-07-15. PMID:14585074. |
death receptors [fas/apo-1/cd95, tnf-r1 [tumour necrosis factor (tnf) receptor 1], dr3 [death receptor 3], trail-r1 [tnf-related apoptosis-inducing ligand receptor 1], trail-r2, dr6, p75-ngfr [p75-nerve growth factor receptor], edar [ectodermal dysplasia receptor]] form a subgroup of the tnf-r superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain. |
2004-07-15 |
2023-08-12 |
mouse |
| Robert F Schwabe, Hiroshi Uchinami, Ting Qian, Brydon L Bennett, John J Lemasters, David A Brenne. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 6. 2004-07-15. PMID:14766793. |
the c-jun nh2-terminal kinase (jnk) is involved in the regulation of cell death, but its role in tumor necrosis factor (tnf)-alpha- and fas-mediated apoptosis in primary cells is not well defined. |
2004-07-15 |
2023-08-12 |
mouse |
| Stefan Bauer, Nicole Adrian, Barbara Williamson, Con Panousis, Natalie Fadle, Joanna Smerd, Ilknur Fettah, Andrew M Scott, Michael Pfreundschuh, Christoph Renne. Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 6. 2004-07-13. PMID:15004201. |
amplification of tnf-related pathways by mimicking the membrane-integrated tnf signaling was detectable in various systems, such as apoptosis induction or tissue factor production. |
2004-07-13 |
2023-08-12 |
mouse |
| Ivel De Freitas, Máximo Fernández-Somoza, Eva Essenfeld-Sekler, José E Cardie. Serum levels of the apoptosis-associated molecules, tumor necrosis factor-alpha/tumor necrosis factor type-I receptor and Fas/FasL, in sepsis. Chest. vol 125. issue 6. 2004-07-13. PMID:15189947. |
the objective of the present study was to examine the levels of molecules associated with apoptosis belonging to the tumor necrosis factor (tnf)-alpha/tnf type-i receptor (tnfri) and fas ligand (fasl)/fas receptor (fas) pathways in patients with sepsis. |
2004-07-13 |
2023-08-12 |
Not clear |
| Katsunori Fujii, Erinn Hoag Goldman, Hae Ryoun Park, Lixin Zhang, Jing Chen, Haian F. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene. vol 23. issue 29. 2004-07-12. PMID:15094778. |
apoptosis signal-regulating kinase 1 (ask1) is a serine/threonine kinase that mediates cell stress signaling initiated by diverse stimuli, such as h(2)o(2) and tnf alpha. |
2004-07-12 |
2023-08-12 |
Not clear |
| Jörn Sträter, Peter Mölle. TRAIL and viral infection. Vitamins and hormones. vol 67. 2004-07-07. PMID:15110181. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is a member of the tnf family that can induce apoptosis when binding to either of two receptors bearing an intracellular death domain. |
2004-07-07 |
2023-08-12 |
Not clear |
| Simone Fulda, Klaus-Michael Debati. Modulation of TRAIL signaling for cancer therapy. Vitamins and hormones. vol 67. 2004-07-07. PMID:15110182. |
tumor necrosis factor-related apoptosis-inducing ligans (trail) is a member of the tumor necrosis factor (tnf) superfamily that induces apoptosis upon binding to its receptors. |
2004-07-07 |
2023-08-12 |
Not clear |