| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H W Zhao, S Y Hu, M W Barger, J K H Ma, V Castranova, J Y C M. Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2. Journal of toxicology and environmental health. Part A. vol 67. issue 17. 2004-09-30. PMID:15371238. |
the present study was carried out to study the time dependence of apoptotic signaling pathways and the potential roles of tnf receptors in blm-induced am apoptosis. |
2004-09-30 |
2023-08-12 |
rat |
| H W Zhao, S Y Hu, M W Barger, J K H Ma, V Castranova, J Y C M. Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2. Journal of toxicology and environmental health. Part A. vol 67. issue 17. 2004-09-30. PMID:15371238. |
the release of cytochrome c from mitochrondria, the activation of caspase-3, -8, and -9, the cleavage of nuclear poly(adp-ribose) polymerase (parp), and the expression of tnf receptors (tnf-r1/p55 and tnf-r2/p75), tnf-r-associated factor 2 (traf2), and cellular inhibitor of apoptosis 1 (c-iap1) were determined by immunoblotting. |
2004-09-30 |
2023-08-12 |
rat |
| Jeppe Falsig, Peter Pörzgen, Julie Lotharius, Marcel Leis. Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 4. 2004-09-28. PMID:15294995. |
quantitative transcript profiling of 17 inflammation-linked genes revealed a specific modulation pattern of astrocyte activation by mlk inhibition, for instance, characterized by up-regulation of the anti-stress factors inhibitor of apoptosis protein-2 and activated transcription factor 4, no effect on manganese superoxide dismutase and caspase-11, and down-regulation of major inflammatory players like tnf, gm-csf, urokinase-type plasminogen activator, and il-6. |
2004-09-28 |
2023-08-12 |
Not clear |
| Gretchen M Argast, Jean S Campbell, John T Brooling, Nelson Faust. Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication. The Journal of biological chemistry. vol 279. issue 33. 2004-09-24. PMID:15199050. |
tumor necrosis factor (tnf) has multiple biological effects such as participating in inflammation, apoptosis, and cell proliferation, but the mechanisms of its effects on epithelial cell proliferation have not been examined in detail. |
2004-09-24 |
2023-08-12 |
Not clear |
| Laurie E Kilpatrick, Shuang Sun, Helen M Korcha. Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. American journal of physiology. Cell physiology. vol 287. issue 3. 2004-09-23. PMID:15115707. |
tnf is implicated in the attenuation of neutrophil constitutive apoptosis during sepsis. |
2004-09-23 |
2023-08-12 |
Not clear |
| Laurie E Kilpatrick, Shuang Sun, Helen M Korcha. Selective regulation by delta-PKC and PI 3-kinase in the assembly of the antiapoptotic TNFR-1 signaling complex in neutrophils. American journal of physiology. Cell physiology. vol 287. issue 3. 2004-09-23. PMID:15115707. |
both kinases associate with tnfr-1 in response to tnf and are required for tnfr-1 serine phosphorylation, nf-kappab activation, and inhibition of apoptosis. |
2004-09-23 |
2023-08-12 |
Not clear |
| Karen Heyninck, Sofie Van Huffel, Marja Kreike, Rudi Beyaer. Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20. Methods in molecular biology (Clifton, N.J.). vol 282. 2004-09-21. PMID:15105568. |
the latter is an inducible cellular inhibitor of tumor necrosis factor (tnf)-induced apoptosis and nuclear factor (nf)-kappab-dependent gene expression. |
2004-09-21 |
2023-08-12 |
Not clear |
| Franco Silvestris, Paola Cafforio, Nicola Calvani, Franco Dammacc. Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells. British journal of haematology. vol 126. issue 4. 2004-09-20. PMID:15287939. |
circulating tumour necrosis factor (tnf)-alpha, interferon-gamma, interleukin (il)-1beta, and il-6 levels were higher in myeloma patients with overt bone disease, whose osteoblasts constitutively overexpressed fas, dr4/dr5 complex as receptors to tnf-related apoptosis inducing ligand, intercellular adhesion molecule-1 (icam-1), and monocyte chemotactic protein-1 (mcp-1). |
2004-09-20 |
2023-08-12 |
Not clear |
| Tomohiro Banno, Alix Gazel, Miroslav Blumenber. Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15145954. |
we found that tnf alpha regulates not only immune and inflammatory responses but also tissue remodeling, cell motility, cell cycle, and apoptosis. |
2004-09-10 |
2023-08-12 |
human |
| David Engel, Ronald Peshock, Robert C Armstong, Natarajan Sivasubramanian, Douglas L Man. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15317679. |
cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted tnf overexpression. |
2004-09-10 |
2023-08-12 |
mouse |
| David Engel, Ronald Peshock, Robert C Armstong, Natarajan Sivasubramanian, Douglas L Man. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15317679. |
to determine whether progressive cardiac myocyte apoptosis contributes to the transition from a hypertrophic to a dilated cardiac phenotype that is observed in transgenic myosin heavy chain secreted tnf (mhcstnf) mice with cardiac restricted overexpression of tumor necrosis factor (tnf), we assessed cardiac myocyte apoptosis (using a dna ligase technique) in mhcstnf mice and littermate control mice in relation to serial changes in lv structure, which was assessed using mri. |
2004-09-10 |
2023-08-12 |
mouse |
| Sharmila Shankar, Thiyam Ramsing Singh, Rakesh K Srivastav. Ionizing radiation enhances the therapeutic potential of TRAIL in prostate cancer in vitro and in vivo: Intracellular mechanisms. The Prostate. vol 61. issue 1. 2004-09-09. PMID:15287092. |
we assessed the influence of sequential treatment of ionizing radiation followed by tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) on intracellular mechanisms of apoptosis of prostate tumor cells in vitro and in vivo. |
2004-09-09 |
2023-08-12 |
Not clear |
| b' Nicole Fehrenbacher, Mads Gyrd-Hansen, Birgit Poulsen, Ute Felbor, Tuula Kallunki, Marianne Boes, Ekkehard Weber, Marcel Leist, Marja J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. Sensitization to the lysosomal cell death pathway upon immortalization and transformation. Cancer research. vol 64. issue 15. 2004-09-09. PMID:15289336.' |
this effect was specific for cysteine cathepsins, because also lack of cathepsin l (a lysosomal cysteine protease), but not that of cathepsin d (a lysosomal aspartyl protease) or caspase-3 (the major executioner protease in classic apoptosis) inhibited the immortalization-associated sensitization of mefs to tnf. |
2004-09-09 |
2023-08-12 |
Not clear |
| Anike Joswig, Heinz-Dieter Gabriel, Mark Kibschull, Elke Winterhage. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12801416. |
in order to investigate pathways of apoptosis in mouse uterine epithelium and decidua during early pregnancy (day 4.5-7.0 post coitum), we have investigated different proteins such as tnfalpha, tnf receptor1, fas ligand, fas receptor1, bax and bcl2 as well as caspase-9 and caspase-3 using immunohistochemistry. |
2004-09-08 |
2023-08-12 |
mouse |
| Anike Joswig, Heinz-Dieter Gabriel, Mark Kibschull, Elke Winterhage. Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12801416. |
taken together, the apoptotic degeneration of the uterine epithelium seems to be mediated by tnf receptor1 followed by caspase-3, whereas the very moderate regression of the decidua did not show the investigated death receptor, but bax and blc2 instead and in addition caspase-9, which indicates a different regulation for epithelial versus decidual apoptosis. |
2004-09-08 |
2023-08-12 |
mouse |
| Victoria P Werth, Muhammad Bashir, Wei Zhan. Photosensitivity in rheumatic diseases. The journal of investigative dermatology. Symposium proceedings. vol 9. issue 1. 2004-09-03. PMID:14870987. |
the current genetic data suggest that increased keratinocyte apopotosis can result from increased amounts of tnf-alpha that induce apoptosis due to a ultraviolet light-sensitive tnf promoter polymorphism or to decreased clearance of apototic cells due to polymorphisms associated with decreased serum levels of collectins such as c1q and mannose-binding lectin. |
2004-09-03 |
2023-08-12 |
Not clear |
| Yasunari Takada, Bharat B Aggarwa. TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 2. 2004-08-27. PMID:15240695. |
tnf activates syk protein tyrosine kinase leading to tnf-induced mapk activation, nf-kappab activation, and apoptosis. |
2004-08-27 |
2023-08-12 |
Not clear |
| Lian Duan, Masaru Aoyagi, Masashi Tamaki, Yoshikazu Yoshino, Takashi Morimoto, Hiroaki Wakimoto, Yasuhiko Nagasaka, Kimiyoshi Hirakawa, Kikuo Ohno, Kiyotaka Yamamot. Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor alpha. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 1 Pt 1. 2004-08-19. PMID:14734475. |
tumor necrosis factor (tnf)-alpha elicits two opposing effects, the induction of apoptosis and the transcription of antiapoptotic genes. |
2004-08-19 |
2023-08-12 |
Not clear |
| N Dietrich, J Thastrup, C Holmberg, M Gyrd-Hansen, N Fehrenbacher, U Lademann, M Lerdrup, T Herdegen, M Jäättelä, T Kallunk. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways. Cell death and differentiation. vol 11. issue 3. 2004-08-16. PMID:14685158. |
recent studies strongly suggest an active involvement of the c-jun n-terminal kinase (jnk) signaling pathway in tumor necrosis factor (tnf)-induced apoptosis. |
2004-08-16 |
2023-08-12 |
mouse |
| Sunghoon Kim, Junghee Kang, Jingbo Qiao, Robert P Thomas, B Mark Evers, Dai H Chun. Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. Journal of pediatric surgery. vol 39. issue 4. 2004-08-10. PMID:15065019. |
the purpose of this study was to determine whether the phosphatidylinositol 3-kinase (pi3k)/akt pathway can alter the expression of survivin and facilitate tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-mediated apoptosis in neuroblastoma cells. |
2004-08-10 |
2023-08-12 |
Not clear |