| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
our conclusion is supported (i) by sirna-mediated depletion of stat3 in trps1-deficient chondrocytes, which normalized the expression of cyclin d1 and bcl2, (ii) by overexpression of trps1 in atdc5 chondrocytes, which diminished stat3 levels and increased proliferation and apoptosis, and (iii) by mutational analysis of the gata-binding sites in the stat3 gene, which revealed that their integrity is critical for the direct association with trps1 and for trps1-mediated repression of stat3. |
2008-01-23 |
2023-08-12 |
mouse |
| Lena Thyrell, Velmurugesan Arulampalam, Linn Hjortsberg, Marianne Farnebo, Dan Grandér, Katja Pokrovskaja Tam. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Experimental cell research. vol 313. issue 19. 2008-01-02. PMID:17880940. |
ectopic expression of a form of stat3, stat3c, rescued u266-1984 cells from ifnalpha-induced apoptosis. |
2008-01-02 |
2023-08-12 |
Not clear |
| Lena Thyrell, Velmurugesan Arulampalam, Linn Hjortsberg, Marianne Farnebo, Dan Grandér, Katja Pokrovskaja Tam. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Experimental cell research. vol 313. issue 19. 2008-01-02. PMID:17880940. |
thus our data demonstrated that ifnalpha is able to interfere with il-6 signaling by inhibiting stat3 activity and that the abrogation of stat3 activity accounts for the ability of ifnalpha to induce apoptosis in myeloma cells. |
2008-01-02 |
2023-08-12 |
Not clear |
| Michele S Redell, Anna Tsimelzon, Susan G Hilsenbeck, David J Tweard. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. Journal of leukocyte biology. vol 82. issue 4. 2007-12-18. PMID:17634277. |
comparison of gene expression profiles of g-csf-stimulated, stat3alpha-overexpressing 32d cells with those of cells with normal stat3alpha expression revealed novel stat3 gene targets, which may contribute to neutrophil expansion and improved survival, most notably slc28a2, a purine nucleoside transporter, which is critical for maintenance of intracellular nucleotide levels and prevention of apoptosis, and gpr65, an acid-sensing, g protein-coupled receptor with pro-oncogenic and antiapoptotic functions. |
2007-12-18 |
2023-08-12 |
mouse |
| Mariko Kusaba, Kazuhiko Nakao, Takashi Goto, Daisuke Nishimura, Hiroshi Kawashimo, Hidetaka Shibata, Yasuhide Motoyoshi, Naota Taura, Tatsuki Ichikawa, Keisuke Hamasaki, Katsumi Eguch. Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis. Journal of hepatology. vol 47. issue 4. 2007-12-06. PMID:17602782. |
abrogation of constitutive stat3 activity sensitizes human hepatoma cells to trail-mediated apoptosis. |
2007-12-06 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
egf-induced apoptosis in a431 cells is dependent on stat1, but not on stat3. |
2007-11-28 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
the knockdown of stat3 did not alter cell growth or apoptosis. |
2007-11-28 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
taken together, our experiments prove the essential role of tyrosine phosphorylated stat1, but not of stat3, in egf-induced apoptosis in a431 cells. |
2007-11-28 |
2023-08-12 |
human |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
lbh589 selectively depleted proteins important in signaling cascades in cell lines harboring egfr kinase mutations, such as egfr, stat3, and akt, and these cells underwent apoptosis following exposure to lbh589. |
2007-11-27 |
2023-08-12 |
human |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
tgf-beta1-induced apoptosis and emt were associated with the activation of protein kinase a (pka) and signal transducers and activators of transcription 3 (stat3). |
2007-11-26 |
2023-08-12 |
Not clear |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
inhibition of pka by specific pka inhibitor h89 or by pka inhibitor peptide blocked stat3 activation and suppressed tgf-beta1-induced apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
furthermore, overexpression of a phosphorylation-deficient form of stat3, but not wild-type stat3, produced an inhibitory effect on tgf-beta1-induced apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
the results indicate that pka is an upstream regulator for tgf-beta1-induced stat3 activation and plays an important role in tgf-beta1-mediated apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |
| Andreas Herrmann, Michael Vogt, Martin Mönnigmann, Thomas Clahsen, Ulrike Sommer, Serge Haan, Valeria Poli, Peter C Heinrich, Gerhard Müller-Newe. Nucleocytoplasmic shuttling of persistently activated STAT3. Journal of cell science. vol 120. issue Pt 18. 2007-11-21. PMID:17726064. |
inhibition of exportin-1-mediated nuclear export slowed down nucleocytoplasmic shuttling of v-src-activated stat3 resulting in reduced tyrosine phosphorylation, decreased induction of stat3 target genes and increased apoptosis. |
2007-11-21 |
2023-08-12 |
Not clear |
| Aurélie Cabrespine, Jacques-Olivier Bay, Pierre Verrelle, Laurent More. [Interleukin-6 implication in prostate cancer]. Bulletin du cancer. vol 94. issue 7 Suppl. 2007-11-08. PMID:17845991. |
il-6 seems to be implicated in androgen receptor activation in lack of steroid ligand, apoptosis decrease and increase of invasive capacity and angiogenesis via three major signaling pathways: mapk, stat3 and pi3k-akt. |
2007-11-08 |
2023-08-12 |
Not clear |
| H M Yu, J L Zhi, Y Cui, E H Tang, S N Sun, J Q Feng, P X Che. Role of the JAK-STAT pathway in protection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC12 cells. Apoptosis : an international journal on programmed cell death. vol 11. issue 6. 2007-11-01. PMID:16547593. |
it was shown that (1) preconditioning with 100 micromol/l h(2)o(2) can markedly protect pc12 cells against apoptosis and cytotoxicity induced by 300 micromol/l h(2)o(2); (2) the expression and tyrosine phosphorylation of jak2, not jak1 were rapidly increased at 5 min after h(2)o(2) preconditioning; (3) the expression of stat1 and stat3 were significantly increased at 15 min after h(2)o(2) preconditioning, and the ptyr-stat1 and ptyr-stat3 were markedly increased at 60 min after h(2)o(2) preconditioning; (4) pretreatment with the jak inhibitor ag-490 (10 micromol/l) 20 min before h(2)o(2) preconditioning blocked not only the activation of jak2, stat1 and stat3, but also the cytoprotection of h(2)o(2) preconditioning against apoptosis and cytotoxicity induced by oxidative stress. |
2007-11-01 |
2023-08-12 |
Not clear |
| M A Scheper, N G Nikitakis, J J Sau. Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer. International journal of oral and maxillofacial surgery. vol 36. issue 7. 2007-10-11. PMID:17566705. |
the importance of constitutive stat3 activation in tumourigenesis was confirmed by sirna inhibition of stat3, resulting in cell growth inhibition and apoptosis, via a downregulation of survivin mrna and protein expression. |
2007-10-11 |
2023-08-12 |
Not clear |
| Chapla Agarwal, Alpna Tyagi, Manjinder Kaur, Rajesh Agarwa. Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells. Carcinogenesis. vol 28. issue 7. 2007-10-04. PMID:17341659. |
given a critical role of stat3 activation in pca, our results showed that silibinin inhibits constitutively active stat3 and induces apoptosis in du145 cells, and thus might have potential significance in therapeutic intervention of this deadly malignancy. |
2007-10-04 |
2023-08-12 |
human |
| A Pardanani, J Hood, T Lasho, R L Levine, M B Martin, G Noronha, C Finke, C C Mak, R Mesa, H Zhu, R Soll, D G Gilliland, A Teffer. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia. vol 21. issue 8. 2007-09-25. PMID:17541402. |
in a human jak2v617f-expressing acute myeloid leukemia cell line, tg101209-induced cell cycle arrest and apoptosis, and inhibited phosphorylation of jak2v617f, stat5 and stat3. |
2007-09-25 |
2023-08-12 |
mouse |
| Xiao Tang Yu, Shi Neng Zhu, Zu De Xu, Xi Qi Hu, Teng Fang Zhu, Jie Qing Chen, Shi Lun L. Roles of EGFR-Stat3 signal pathway in carcinogenesis of experimental hepatoma in rats. Journal of cancer research and clinical oncology. vol 133. issue 3. 2007-09-20. PMID:17031671. |
tgfalpha-egfr autocrine ring formation may lead to the activation of stat3 and in turn, promote proliferation and regulate the transcription of genes regulating cell apoptosis and cell cycle. |
2007-09-20 |
2023-08-12 |
rat |