| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinhai Gu, Gang Li, Tao Sun, Yuhang Su, Xulong Zhang, Jie Shen, Zhigang Tian, Jian Zhan. Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells. Journal of neuro-oncology. vol 89. issue 1. 2008-10-20. PMID:18415045. |
the stat3 decoy odn treatment specifically blocked stat3 signaling and subsequently inhibited u251 and a172 cell proliferation by inducing apoptosis and cell-cycle arrest. |
2008-10-20 |
2023-08-12 |
human |
| Björn Lamprecht, Stephan Kreher, Ioannis Anagnostopoulos, Korinna Jöhrens, Giovanni Monteleone, Franziska Jundt, Harald Stein, Martin Janz, Bernd Dörken, Stephan Matha. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood. vol 112. issue 8. 2008-10-16. PMID:18684866. |
we demonstrate that il-21 activates stat3 in hrs cells, up-regulates stat3 target genes, and protects hrs cells from cd95 death receptor-induced apoptosis. |
2008-10-16 |
2023-08-12 |
Not clear |
| R Novosyadlyy, N Kurshan, D Lann, A Vijayakumar, S Yakar, D LeRoit. Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell death and differentiation. vol 15. issue 8. 2008-10-14. PMID:18437163. |
application of signal transduction inhibitors of mek (u1026), pi3k (ly294002 and wortmannin), jnk (sp600125), p38 (sb203580), protein kinases a and c (h-89 and staurosporine) and stat3 (stattic) does not prevent igf-i-mediated protection from er stress-induced apoptosis. |
2008-10-14 |
2023-08-12 |
human |
| Daisuke Iizuka, Aki Ogura, Mikinori Kuwabara, Osamu Inanam. Purvalanol A induces apoptosis and downregulation of antiapoptotic proteins through abrogation of phosphorylation of JAK2/STAT3 and RNA polymerase II. Anti-cancer drugs. vol 19. issue 6. 2008-10-14. PMID:18525315. |
to clarify the mechanisms of purvalanol a in the induction of apoptosis, we investigated whether purvalanol a influenced the rna synthesis and expression of rna polymerase ii and signal transducer and activator of transcription 3 (stat3). |
2008-10-14 |
2023-08-12 |
Not clear |
| Maria L Jaramillo, Myriam Banville, Catherine Collins, Beatrice Paul-Roc, Lucie Bourget, Maureen O'Connor-McCour. Differential sensitivity of A549 non-small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors. Cancer biology & therapy. vol 7. issue 4. 2008-10-06. PMID:18296914. |
we found that the limited ability of 225 mab to inhibit mapk, pi3k and stat3 phosphorylation correlated with its inability to promote anchorage independent apoptosis, but did not correlate with its ability to inhibit motility. |
2008-10-06 |
2023-08-12 |
Not clear |
| Pawel Gaj, Michal Mikula, Lucjan S Wyrwicz, Jaroslaw Regula, Jerzy Ostrowsk. Barrett's esophagus associates with a variant of IL23R gene. Acta biochimica Polonica. vol 55. issue 2. 2008-09-30. PMID:18560602. |
the il23/il23r pathway may modulate stat3 transcriptional activity which is an essential regulator not only of immune-mediated inflammation, but also of inflammatory-associated apoptosis resistance. |
2008-09-30 |
2023-08-12 |
Not clear |
| Yanjie Lu, Jin Zhou, Chaoqian Xu, Huixian Lin, Jiening Xiao, Zhiguo Wang, Baofeng Yan. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 4. 2008-09-29. PMID:18441519. |
we identified a population of cells bearing higher resistance to apoptosis and found that the cells that survived from apoptotic insults had markedly higher levels of akt and stat3. |
2008-09-29 |
2023-08-12 |
rat |
| Priya Weerasinghe, Yifei Li, Yongli Guan, Ruiwen Zhang, David J Tweardy, Naijie Jin. T40214/PEI complex: a potent therapeutics for prostate cancer that targets STAT3 signaling. The Prostate. vol 68. issue 13. 2008-09-05. PMID:18615483. |
stat3 has become a very important molecular target for pc therapy since it upregulates the oncogenes encoding apoptosis inhibitors, cell cycle regulators, and inducers of angiogenesis. |
2008-09-05 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
previously, we reported that single-stranded oligonucleotides containing consensus stat3 binding sequences (13410 and 13411) were more effective for inducing apoptosis in prostate cancer cells than antisense stat3 oligonucleotides. |
2008-08-22 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
here, we report that authentic stat3 binding sequences, identified from published literature, were more effective for inducing apoptosis in prostate cancer cells and pancreatic cancer cells than was oligonucleotide 13410. |
2008-08-22 |
2023-08-12 |
Not clear |
| H Dan Lewis, Ashley Winter, Thomas F Murphy, Snehlata Tripathi, Virendra N Pandey, Beverly E Barto. STAT3 inhibition in prostate and pancreatic cancer lines by STAT3 binding sequence oligonucleotides: differential activity between 5' and 3' ends. Molecular cancer therapeutics. vol 7. issue 6. 2008-08-22. PMID:18566225. |
we conclude that truncating the 5' end left intact enough of the canonical stat3 binding site for effective hybridization to the genome, whereas truncation of the 3' end, which is outside the canonical binding site, may have affected binding of required cofactors essential for stat3 activity, thereby reducing the capacity of this modified oligonucleotide to induce apoptosis. |
2008-08-22 |
2023-08-12 |
Not clear |
| Wenwen Ren, Yanhong Duan, Yang Yang, Yonghua Ji, Fuxue Che. Down-regulation of Stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. Neurological research. vol 30. issue 3. 2008-08-01. PMID:17716392. |
down-regulation of stat3 induces apoptosis of human glioma cell: a potential method to treat brain cancer. |
2008-08-01 |
2023-08-12 |
human |
| Feng Huang, Xiaoyun Tong, Liangqing Fu, Ronghua Zhan. Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell line in vitro and in vivo. Acta biochimica et biophysica Sinica. vol 40. issue 6. 2008-07-21. PMID:18535750. |
in addition, stat3 knockdown inhibited anchorage-independent growth and induced apoptosis in caov3 cells, and decreased tumor growth in nude mice implanted with ovarian cancer cells. |
2008-07-21 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
pre-treatment of rats with a selective inhibitor of stat3, t40214, reduced the il-6-mediated increase in cardiac stat3 activity, blocked successful resuscitation by il-6 and reversed il-6-mediated protection from cardiac apoptosis. |
2008-07-15 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
the hearts of mice deficient in the naturally occurring dominant negative isoform of stat3, stat3beta, were completely resistant to hs-induced apoptosis. |
2008-07-15 |
2023-08-12 |
mouse |
| Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweard. Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PloS one. vol 3. issue 2. 2008-07-15. PMID:18270592. |
thus, cardiac dysfunction, cardiomyocyte apoptosis and induction of apoptosis pathway genes are important components of hcc; il-6 administration prevented hcc by blocking cardiomyocyte apoptosis and induction of apoptosis pathway genes via stat3 and warrants further study as a resuscitation adjuvant for prevention of hcc and death in trauma patients. |
2008-07-15 |
2023-08-12 |
mouse |
| Marloes S van Kester, Jacoba J Out-Luiting, Peter A von dem Borne, Rein Willemze, Cornelis P Tensen, Maarten H Vermee. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells. The Journal of investigative dermatology. vol 128. issue 7. 2008-06-24. PMID:18200050. |
cucurbitacin i inhibits stat3 and induces apoptosis in sézary cells. |
2008-06-24 |
2023-08-12 |
Not clear |
| Amanda L Boehm, Malabika Sen, Raja Seethala, William E Gooding, Maria Freilino, Silvia Man Yan Wong, Shaomeng Wang, Daniel E Johnson, Jennifer Rubin Grandi. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Molecular pharmacology. vol 73. issue 6. 2008-06-10. PMID:18326051. |
the triple combination of erlotinib, stat3 decoy, and gossypol further enhanced cell growth inhibition and apoptosis in vitro, and it down-regulated signaling molecules further downstream of the egfr-stat3 signaling pathway, such as cyclin d1. |
2008-06-10 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active nf-kappab and stat3 pathways in hodgkin's lymphoma cells. |
2008-06-02 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
therefore, the current goal in hl treatment is to find new therapies that specifically target the deregulated signaling cascades, such as nf-kappab and stat3, which cause hodgkin and reed-sternberg (h-rs) cell proliferation and resistance of apoptosis. |
2008-06-02 |
2023-08-12 |
Not clear |