| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
the importance of bcl2 and stat3 on il-6-induced macrophage-differentiation and apoptosis was studied with 1a9-m cells expressing human bcl2 or a dominant-negative form of stat3, respectively. |
1999-03-11 |
2023-08-12 |
human |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
a dominant-negative form of stat3 inhibited both macrophage-differentiation and apoptosis induced by il-6. |
1999-03-11 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
constitutive activation of stat3 signaling confers resistance to apoptosis in human u266 myeloma cells. |
1999-03-03 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
blocking il-6 receptor signaling from janus kinases to the stat3 protein inhibits bcl-xl expression and induces apoptosis, demonstrating that stat3 signaling is essential for the survival of myeloma tumor cells. |
1999-03-03 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
these findings provide evidence that constitutively activated stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. |
1999-03-03 |
2023-08-12 |
human |
| K Takeda, T Kaisho, N Yoshida, J Takeda, T Kishimoto, S Akir. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 9. 1998-11-18. PMID:9794394. |
stat3 activation is responsible for il-6-dependent t cell proliferation through preventing apoptosis: generation and characterization of t cell-specific stat3-deficient mice. |
1998-11-18 |
2023-08-12 |
mouse |
| K Takeda, T Kaisho, N Yoshida, J Takeda, T Kishimoto, S Akir. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 9. 1998-11-18. PMID:9794394. |
these results demonstrate that stat3 activation is involved in il-6-dependent t cell proliferation through prevention of apoptosis independently of bcl-2. |
1998-11-18 |
2023-08-12 |
mouse |
| S Zushi, Y Shinomura, T Kiyohara, Y Miyazaki, S Kondo, M Sugimachi, Y Higashimoto, S Kanayama, Y Matsuzaw. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. International journal of cancer. vol 78. issue 3. 1998-10-28. PMID:9766567. |
we also show that disruption of the stat3 pathway by introduction of a dominant-negative stat3 mutant abolishes the apoptosis resistance against uvc and mmc treatment observed in iec-ras cells without affecting proliferation. |
1998-10-28 |
2023-08-12 |
Not clear |
| T Naka, M Narazaki, M Hirata, T Matsumoto, S Minamoto, A Aono, N Nishimoto, T Kajita, T Taga, K Yoshizaki, S Akira, T Kishimot. Structure and function of a new STAT-induced STAT inhibitor. Nature. vol 387. issue 6636. 1997-07-17. PMID:9202127. |
forced overexpression of ssi-1 complementary dna interfered with il-6- and lif-mediated apoptosis and macrophage differentiation of m1 cells, as well as il-6 induced tyrosine-phosphorylation of a receptor glycoprotein component, gp130, and of stat3. |
1997-07-17 |
2023-08-12 |
Not clear |