| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V N Ivanov, A Bhoumik, M Krasilnikov, R Raz, L B Owen-Schaub, D Levy, C M Horvath, Z Rona. Cooperation between STAT3 and c-jun suppresses Fas transcription. Molecular cell. vol 7. issue 3. 2001-08-30. PMID:11463377. |
the expression of dominant negative stat3 or c-jun in melanoma cells efficiently increased fas expression and sensitized cells to fasl-induced apoptosis. |
2001-08-30 |
2023-08-12 |
mouse |
| B Groner, L Hennighause. Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium. Breast cancer research : BCR. vol 2. issue 3. 2001-08-02. PMID:11250703. |
stat3 activation seems to be a driving force in the induction of apoptosis early in the involution period. |
2001-08-02 |
2023-08-12 |
mouse |
| J Turkson, R Jov. STAT proteins: novel molecular targets for cancer drug discovery. Oncogene. vol 19. issue 56. 2001-07-26. PMID:11426647. |
block of constitutive stat3 signaling results in growth inhibition and apoptosis of stat3-positive tumor cells in vitro and in vivo. |
2001-07-26 |
2023-08-12 |
human |
| R Garcia, T L Bowman, G Niu, H Yu, S Minton, C A Muro-Cacho, C E Cox, R Falcone, R Fairclough, S Parsons, A Laudano, A Gazit, A Levitzki, A Kraker, R Jov. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene. vol 20. issue 20. 2001-07-05. PMID:11420660. |
in addition, transfection of a dominant-negative form of stat3 leads to growth inhibition involving apoptosis of breast cancer cells. |
2001-07-05 |
2023-08-12 |
human |
| J Zhang, B Shen, Y Li, Y Su. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leukemia research. vol 25. issue 6. 2001-06-28. PMID:11337018. |
interleukin-6 (il-6), a pleiotropic cytokine, induces a robust and sustained activation of stat3 in m1 acute myeloid leukemia cells, which in turn undergo growth arrest, terminal differentiation and apoptosis in response to il-6. |
2001-06-28 |
2023-08-12 |
Not clear |
| J Zhang, B Shen, Y Li, Y Su. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leukemia research. vol 25. issue 6. 2001-06-28. PMID:11337018. |
on the other hand, stat3 antisense cdna augmented il-6-induced apoptosis of m1 cells, which was supported by the cell cycle assay, dna fragmentation assay and detection of the p17 active fragment of caspase 3. |
2001-06-28 |
2023-08-12 |
Not clear |
| H Yoshikawa, K Matsubara, G S Qian, P Jackson, J D Groopman, J E Manning, C C Harris, J G Herma. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature genetics. vol 28. issue 1. 2001-05-31. PMID:11326271. |
this growth suppression was caused by apoptosis and was reproduced by ag490, a specific, chemical jak2 inhibitor that reversed constitutive phosphorylation of stat3 in socs-1 inactivated cells. |
2001-05-31 |
2023-08-12 |
human |
| K W Eriksen, K Kaltoft, G Mikkelsen, M Nielsen, Q Zhang, C Geisler, M H Nissen, C Röpke, M A Wasik, N Odu. Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells. Leukemia. vol 15. issue 5. 2001-05-31. PMID:11368440. |
we show that (1) stat3 (a transcription factor known to regulate il-2ralpha transcription) is constitutively tyrosine-phosphorylated in ss tumor cells, but not in non-malignant t cells; (2) stat3 binds constitutively to a stat-binding sequence in the promotor of the il-2ralpha gene; (3) the janus kinase inhibitor, tyrphostine ag490, inhibits stat3 activation, stat3 dna binding, and il-2ralpha mrna and protein expression in parallel; and (4) tyrphostine ag490 inhibits il-2 driven mitogenesis and triggers apoptosis in ss tumor cells. |
2001-05-31 |
2023-08-12 |
Not clear |
| G Niu, K H Shain, M Huang, R Ravi, A Bedi, W S Dalton, R Jove, H Y. Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. Cancer research. vol 61. issue 8. 2001-05-10. PMID:11309279. |
here, we provide evidence that blocking stat3 signaling in b16 cells results in release of soluble factors that are capable of inducing apoptosis and cell cycle arrest of nontransfected b16 cells. |
2001-05-10 |
2023-08-12 |
Not clear |
| Y Shen, G Devgan, J E Darnell, J F Bromber. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11171987. |
constitutively activated stat3 protects fibroblasts from serum withdrawal and uv-induced apoptosis and antagonizes the proapoptotic effects of activated stat1. |
2001-04-19 |
2023-08-12 |
Not clear |
| Y Shen, G Devgan, J E Darnell, J F Bromber. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11171987. |
in contrast, activated stat3 can protect cells from apoptosis. |
2001-04-19 |
2023-08-12 |
Not clear |
| Y Shen, G Devgan, J E Darnell, J F Bromber. Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11171987. |
also, to examine the potential opposing roles in apoptosis of stat1 and stat3, we studied the cervical carcinoma-derived cell line, me180, which undergoes stat1-dependent, ifn gamma-induced apoptosis. |
2001-04-19 |
2023-08-12 |
Not clear |
| B Gao, X Shen, G Kunos, Q Meng, I D Goldberg, E M Rosen, S Fa. Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells. FEBS letters. vol 488. issue 3. 2001-03-29. PMID:11163768. |
blocking stat3 activation using antisense oligonucleotides significantly inhibited cell proliferation and triggered apoptosis in du-145 cells with enhanced expression of brca1. |
2001-03-29 |
2023-08-12 |
human |
| P K Epling-Burnette, J H Liu, R Catlett-Falcone, J Turkson, M Oshiro, R Kothapalli, Y Li, J M Wang, H F Yang-Yen, J Karras, R Jove, T P Loughra. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. The Journal of clinical investigation. vol 107. issue 3. 2001-03-08. PMID:11160159. |
inhibition of stat3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased mcl-1 expression. |
2001-03-08 |
2023-08-12 |
Not clear |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
the role of stat3 in apoptosis and mammary gland involution. |
2000-12-01 |
2023-08-12 |
mouse |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
involution of the mouse mammary gland is characterised by extensive apoptosis of the epithelial cells and the activation of stat3. |
2000-12-01 |
2023-08-12 |
mouse |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
to clarify the role of stat3 in mammary epithelial apoptosis, we have generated a conditional knockout using the lox/cre recombination system. |
2000-12-01 |
2023-08-12 |
mouse |
| R S Chapman, P Lourenco, E Tonner, D Flint, S Selbert, K Takeda, S Akira, A R Clarke, C J Watso. The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3. Advances in experimental medicine and biology. vol 480. 2000-12-01. PMID:10959419. |
mammary glands from crosses of transgenic mice expressing cre recombinase under the control of the beta-lactoglobulin milk protein gene promoter with mice harbouring one floxed stat3 allele and one null stat3 allele, showed a decrease in epithelial apoptosis and a dramatic delay of the involution process upon forced weaning. |
2000-12-01 |
2023-08-12 |
mouse |
| C Kawamura, M Kizaki, K Yamato, H Uchida, Y Fukuchi, Y Hattori, T Koseki, T Nishihara, Y Iked. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood. vol 96. issue 6. 2000-10-04. PMID:10979940. |
bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of stat3. |
2000-10-04 |
2023-08-12 |
human |
| R Craig, A Larkin, A M Mingo, D J Thuerauf, C Andrews, P M McDonough, C C Glembotsk. p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10781614. |
while tnf-alpha was relatively ineffective, il-6 activated myocardial cell stat3 by about 8-fold, indicating a probable role for this transcription factor in il-6-mediated protection from apoptosis. |
2000-09-07 |
2023-08-12 |
rat |