| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
finally, an adenoviral vector expressing a dominant-negative stat3 isoform results in loss of stat3 dna-binding activity, apoptosis, and reduced cellular viability. |
2003-08-01 |
2023-08-12 |
human |
| Virote Sriuranpong, Jong In Park, Panomwat Amornphimoltham, Vyomesh Patel, Barry D Nelkin, J Silvio Gutkin. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer research. vol 63. issue 11. 2003-07-31. PMID:12782602. |
treatment with a specific inhibitor of janus kinase, ag490, in hnscc cells led to a reduction of active stat3 and caused significant growth retardation and apoptosis. |
2003-07-31 |
2023-08-12 |
Not clear |
| Steve Alas, Benjamin Bonavid. Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 1. 2003-07-17. PMID:12538484. |
inhibition of constitutive stat3 activity sensitizes resistant non-hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. |
2003-07-17 |
2023-08-12 |
Not clear |
| Chiharu Kawamura, Masahiro Kizaki, Yasuo Iked. Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells. Leukemia & lymphoma. vol 43. issue 3. 2003-07-11. PMID:12002771. |
further analysis showed that bmp-2 induced down-regulation of bcl-x(l) through the inactivation of stat3, resulting in the induction of apoptosis in myeloma cells. |
2003-07-11 |
2023-08-12 |
human |
| Vladimir N Ivanov, Anindita Bhoumik, Ze'ev Rona. Death receptors and melanoma resistance to apoptosis. Oncogene. vol 22. issue 20. 2003-07-07. PMID:12789291. |
changes at genomic, transcriptional and post-translational levels of g-proteins and protein kinases (ras, b-raf) and their transcription factor effectors (c-jun, atf2, stat3 and nf-kappab) affects tnf, fas and trail receptors, which play important roles in acquiring melanoma's resistance to apoptosis. |
2003-07-07 |
2023-08-12 |
Not clear |
| Rozita Bagheri-Yarmand, Ratna K Vadlamudi, Rakesh Kuma. Activating transcription factor 4 overexpression inhibits proliferation and differentiation of mammary epithelium resulting in impaired lactation and accelerated involution. The Journal of biological chemistry. vol 278. issue 19. 2003-06-30. PMID:12611881. |
mammary glands from atf4-transgenic mice also showed significant nuclear translocation of activated stat3 and up-regulation of one of its target genes, insulin-like growth factor-binding protein-5, which is thought to facilitate apoptosis by sequestering insulin-like growth factor. |
2003-06-30 |
2023-08-12 |
mouse |
| Juan F García, Francisca I Camacho, Manuel Morente, Máximo Fraga, Carlos Montalbán, Tomás Alvaro, Carmen Bellas, Angel Castaño, Ana Díez, Teresa Flores, Carmen Martin, Miguel A Martinez, Francisco Mazorra, Javier Menárguez, Maria J Mestre, Manuela Mollejo, Ana I Sáez, Lydia Sánchez, Miguel A Piri. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood. vol 101. issue 2. 2003-04-08. PMID:12393683. |
a multiparametric analysis identified proteins associated with increased growth fraction (hdm2, p53, p21, rb, cyclins a, b1, d3, and e, cdk2, cdk6, skp2, bcl-x(l), survivin, stat1, and stat3), and proteins associated with apoptosis (nf-kappab, stat1, and rb). |
2003-04-08 |
2023-08-12 |
Not clear |
| Keiko Yamauchi-Takihar. Gp130-mediated pathway and left ventricular remodeling. Journal of cardiac failure. vol 8. issue 6 Suppl. 2003-04-08. PMID:12555148. |
in this review, stat3 is highlighted as a regulator of antiogenic factors, and together with bclxl and mnsod, promotes cardiac myocyte survival by prevention of apoptosis and restoration of energy deprivation. |
2003-04-08 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
inhibition of stat3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
here we show that inhibition of signal transducer and activator of transcription-3 (stat3) leads to apoptosis in pel cells. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
although stat3 activation is known to induce expression of bcl-2 family proteins, pel cell apoptosis was independent of bcl-2, bcl-x(l), or mcl-1 protein expression. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
instead, stat3 inhibition induced transcriptional repression of survivin, a recently identified inhibitor of apoptosis. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
forced overexpression of survivin rescued vg-1 cells from apoptosis induced by stat3 inhibition. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
our findings suggest that activated stat3 signaling directly contributes to malignant progression of pel by preventing apoptosis, acting through the prosurvival protein survivin. |
2003-03-13 |
2023-08-12 |
Not clear |
| Carolina Schere-Levy, Valeria Buggiano, Ana Quaglino, Albana Gattelli, Maria Cecilia Cirio, Isabel Piazzon, Silvia Vanzulli, Edith C Kordo. Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution. Experimental cell research. vol 282. issue 1. 2003-01-08. PMID:12490192. |
it has been shown that stat3 is the main factor in signaling the initiation of apoptosis, but the mechanism of its activation remains unclear. |
2003-01-08 |
2023-08-12 |
mouse |
| Carolina Schere-Levy, Valeria Buggiano, Ana Quaglino, Albana Gattelli, Maria Cecilia Cirio, Isabel Piazzon, Silvia Vanzulli, Edith C Kordo. Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution. Experimental cell research. vol 282. issue 1. 2003-01-08. PMID:12490192. |
our results also show that lif-induced mammary epithelium apoptosis could be mediated, at least partially, by stat3 activation. |
2003-01-08 |
2023-08-12 |
mouse |
| N G Nikitakis, H Siavash, C Hebert, M A Reynolds, A W Hamburger, J J Sau. 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. British journal of cancer. vol 87. issue 12. 2003-01-07. PMID:12454768. |
15-pgj2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of stat3 in human oral scca cells. |
2003-01-07 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
inhibition of constitutively active stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. |
2003-01-06 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
stat3, a latent transcription factor being activated by aberrant cytokine or growth factor signaling, acts as a suppressor of apoptosis in a number of cancer cells. |
2003-01-06 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
janus kinase inhibitor ag490 inhibits stat3 activation with a concomitant reduction in steady-state levels of bcl-x(l), bcl-2 and mcl-1 proteins and induces apoptosis in u251 cells as revealed by poly (adp-ribose) polymerase cleavage and annexin-v staining. |
2003-01-06 |
2023-08-12 |
human |