| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hesham M Amin, Timothy J McDonnell, Yupo Ma, Quan Lin, Yasushi Fujio, Keita Kunisada, Vasiliki Leventaki, Pamela Das, George Z Rassidakis, Cathy Cutler, L Jeffrey Medeiros, Raymond La. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene. vol 23. issue 32. 2004-08-23. PMID:15184887. |
these results support the concept that stat3 activation is pathogenetically important in alcl cells by deregulating the expression of multiple target proteins that are involved in the control of apoptosis and cell cycle progression. |
2004-08-23 |
2023-08-12 |
Not clear |
| A V Ivanova, S V Ivanov, X Zhang, V N Ivanov, O A Timofeeva, M I Lerma. STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. Journal of molecular biology. vol 340. issue 4. 2004-08-03. PMID:15223310. |
thus, for the first time, we identify stra13 as a stat3 partner and provide a consistent line of evidence for stra13 involvement into regulation of apoptosis via the stat pathways. |
2004-08-03 |
2023-08-12 |
Not clear |
| V H Sommer, O J Clemmensen, O Nielsen, M Wasik, P Lovato, C Brender, K W Eriksen, A Woetmann, C G Kaestel, M H Nissen, C Ropke, S Skov, N Ødu. In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3. Leukemia. vol 18. issue 7. 2004-07-23. PMID:15141228. |
moreover, stat3 protects tumor cells from apoptosis in vitro. |
2004-07-23 |
2023-08-12 |
Not clear |
| Li Li, Doreen Hooi, Siri Ram Chhabra, David Pritchard, Peter E Sha. Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15064716. |
bacterial n-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of stat3. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
the aim of the present study was to clarify the role of stat3 signaling in apoptosis and cellular proliferation in gastric cancer. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
here we reported that stat3 was constitutively activated in various human gastric cancer cells and its inhibition by ectopic dominant-negative stat3 or janus kinase inhibitor, tyrphostin ag490, induced apoptosis. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
furthermore, stat3 inhibition markedly decreased survivin expression, and forced expression of survivin rescued ags cells from apoptosis induced by stat3 inhibition. |
2004-07-16 |
2023-08-12 |
human |
| Huang Shao, Xuejun Xu, Mary-Ann A Mastrangelo, Naijie Jing, Richard G Cook, Glen B Legge, David J Tweard. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14966128. |
stat3 is an src homology (sh)2-containing protein constitutively activated in a wide variety of human cancers following its recruitment to yxxq-containing motifs, which results in resistance to apoptosis. |
2004-06-10 |
2023-08-12 |
human |
| Liza Konnikova, Maciej Kotecki, Mathew M Kruger, Brent H Cochra. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC cancer. vol 3. 2004-06-08. PMID:13678425. |
knockdown of stat3 expression by rnai induces apoptosis in astrocytoma cells. |
2004-06-08 |
2023-08-12 |
human |
| Liza Konnikova, Maciej Kotecki, Mathew M Kruger, Brent H Cochra. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC cancer. vol 3. 2004-06-08. PMID:13678425. |
stat3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas. |
2004-06-08 |
2023-08-12 |
human |
| Alok C Bharti, Shishir Shishodia, James M Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B Aggarwa. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. vol 103. issue 8. 2004-05-27. PMID:15070700. |
nuclear factor-kappab and stat3 are constitutively active in cd138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Alok C Bharti, Shishir Shishodia, James M Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B Aggarwa. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood. vol 103. issue 8. 2004-05-27. PMID:15070700. |
because of the central role of the nuclear transcription factors nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription 3 (stat3) in chemoresistance, cell survival, and proliferation, we investigated whether mm cells derived from patients express activated nf-kappab and stat3 and if their suppression induces apoptosis. |
2004-05-27 |
2023-08-12 |
Not clear |
| Grazyna Adamus, Brad Sugden, Sharon Shiraga, Adrian M Timmers, William W Hauswirt. Anti-apoptotic effects of CNTF gene transfer on photoreceptor degeneration in experimental antibody-induced retinopathy. Journal of autoimmunity. vol 21. issue 2. 2004-05-07. PMID:12935781. |
the present study shows that an aav-mediated delivery of cntf may protect photoreceptors from antibody-induced cell death through the activation of stat3 and the suppression of caspase 3 activity, a key caspase leading to apoptosis. |
2004-05-07 |
2023-08-12 |
human |
| Xiang-Tao Ma, Shan Wang, Ying-Jiang Ye, Ru-Yu Du, Zhi-Rong Cu. [Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma]. Ai zheng = Aizheng = Chinese journal of cancer. vol 22. issue 11. 2004-02-17. PMID:14613639. |
signal transducers and activators of transcription 3 (stat3) pathway can be activated by cytokines and growth factors, and activation of stat3 is involved in modulating cell proliferation, differentiation, and apoptosis. |
2004-02-17 |
2023-08-12 |
human |
| Biao He, Liang You, Kazutsugu Uematsu, Keling Zang, Zhidong Xu, Amie Y Lee, Joseph F Costello, Frank McCormick, David M Jablon. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 24. 2004-02-02. PMID:14617776. |
restoration of socs-3 in lung cancer cells where socs-3 was methylation-silenced resulted in the down-regulation of active stat3, induction of apoptosis, and growth suppression. |
2004-02-02 |
2023-08-12 |
human |
| Mainak Majumder, Robert Steele, Asish K Ghosh, Xiao Yan Zhou, Larry Thornburg, Ranjit Ray, Nancy J Phillips, Ratna B Ra. Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice. FEBS letters. vol 555. issue 3. 2004-01-23. PMID:14675768. |
hcv ns5a protein possesses many intriguing properties, including sequestration of p53 in the cytoplasm, downregulation of p21 protein, activation of stat3, and inhibition of tumor necrosis factor-alpha-mediated apoptosis. |
2004-01-23 |
2023-08-12 |
mouse |
| Naijie Jing, Yidong Li, Xuejun Xu, Wei Sha, Ping Li, Lili Feng, David J Tweard. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA and cell biology. vol 22. issue 11. 2004-01-05. PMID:14659041. |
genetic approaches that disrupt stat3 activity result in inhibition of cancer cell growth and enhanced cell apoptosis supporting the development of novel drugs targeting stat3 for cancer therapy. |
2004-01-05 |
2023-08-12 |
human |
| Valentina Calò, Manuela Migliavacca, Viviana Bazan, Marcella Macaluso, Maria Buscemi, Nicola Gebbia, Antonio Russ. STAT proteins: from normal control of cellular events to tumorigenesis. Journal of cellular physiology. vol 197. issue 2. 2003-11-10. PMID:14502555. |
on the other hand, stat3 and 5 are considered as oncogenes, since they bring about the activation of cyclin d1, c-myc, and bcl-xl expression, and are involved in promoting cell-cycle progression, cellular transformation, and in preventing apoptosis. |
2003-11-10 |
2023-08-12 |
human |
| Michelle M Fung, Forest Rohwer, Kathleen L McGuir. IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells. Cellular signalling. vol 15. issue 6. 2003-10-03. PMID:12681450. |
analysis of the effects of these inhibitors on cell cycle progression and apoptosis strongly suggests that pi3k-mediated events, which includes stat3 activation, are involved in il-2-mediated cell proliferation but not cell survival. |
2003-10-03 |
2023-08-12 |
human |
| Rei Shibata, Hisashi Kai, Yukihiko Seki, Seiya Kato, Yoshihiro Wada, Yasushi Hanakawa, Koji Hashimoto, Akihiko Yoshimura, Tsutomu Imaizum. Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. Human gene therapy. vol 14. issue 7. 2003-10-02. PMID:12814098. |
inhibition of stat3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells. |
2003-10-02 |
2023-08-12 |
rat |