| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cindy Y F Yau, Jeffery J Wheeler, Kymberley L Sutton, David W Hedle. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer research. vol 65. issue 4. 2005-04-04. PMID:15735038. |
inhibition of integrin-linked kinase by a selective small molecule inhibitor, qlt0254, inhibits the pi3k/pkb/mtor, stat3, and fkhr pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. |
2005-04-04 |
2023-08-12 |
mouse |
| Sichuan Xi, William E Gooding, Jennifer Rubin Grandi. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592503. |
several approaches have been used to block stat3 in cancer cells resulting in reduced proliferation and apoptosis. |
2005-03-02 |
2023-08-12 |
Not clear |
| Sichuan Xi, William E Gooding, Jennifer Rubin Grandi. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592503. |
blockade of stat3 with the stat3 decoy also induced apoptosis and decreased proliferation, an effect that was augmented when the stat3 decoy was combined with cisplatin, both in vitro and in vivo. |
2005-03-02 |
2023-08-12 |
Not clear |
| C Brender, P Lovato, V H Sommer, A Woetmann, A-M Mathiesen, C Geisler, M Wasik, N Ødu. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha. Leukemia. vol 19. issue 2. 2005-02-22. PMID:15618960. |
we show that (i) socs-3 expression in tumour cells is equal to or higher than in cytokine-stimulated nonmalignant t cells, (ii) socs-3 is not mutated in ctcl, (iii) overexpression of socs-3 blocks ifnalpha-mediated growth inhibition without affecting stat3 activation, growth, and apoptosis, and (iv) inhibition of socs-3 by a dominant negative stat3 (stat3d) increases the ifnalpha-mediated growth inhibition. |
2005-02-22 |
2023-08-12 |
Not clear |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Martin Fuchs, Karol Kaminski, Arnd Schaefer, Bernhard Schieffer, Anja Hillmer, Andreas Schmiedl, Zhaoping Ding, Edith Podewski, Eva Podewski, Valeria Poli, Michael D Schneider, Rainer Schulz, Joon-Keun Park, Kai C Wollert, Helmut Drexle. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circulation research. vol 95. issue 2. 2005-02-08. PMID:15192020. |
the transcription factor signal transducer and activator of transcription 3 (stat3) participates in a wide variety of physiological processes and directs seemingly contradictory responses such as proliferation and apoptosis. |
2005-02-08 |
2023-08-12 |
mouse |
| A Stephano. Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury. Journal of cellular and molecular medicine. vol 8. issue 4. 2005-01-31. PMID:15601580. |
for example, stat-1 has been shown to induced apoptosis, whilst stat3 is able protect cardiac myocytes following ischaemia/reperfusion (i/r) injury. |
2005-01-31 |
2023-08-12 |
Not clear |
| Manik Chatterjee, Thorsten Stühmer, Pia Herrmann, Kurt Bommert, Bernd Dörken, Ralf C Bargo. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood. vol 104. issue 12. 2004-12-30. PMID:15297310. |
the interleukin-6 receptor (il-6r)/signal transducer and activator of transcription 3 (stat3) pathway contributes to the pathogenesis of multiple myeloma (mm) and protects mm cells from apoptosis. |
2004-12-30 |
2023-08-12 |
Not clear |
| Amie S Corbin, Ian J Griswold, Paul La Rosée, Kevin W H Yee, Michael C Heinrich, Corinne L Reimer, Brian J Druker, Michael W N Deininge. Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970. Blood. vol 104. issue 12. 2004-12-30. PMID:15304388. |
mln518 additionally targets active site mutant cell lines, inhibiting cell proliferation, kit, and signal transducer and activator of transcription-3 (stat3) phosphorylation and inducing apoptosis at concentrations that may be clinically achievable. |
2004-12-30 |
2023-08-12 |
Not clear |
| Christian Liedtke, Christian Trautwei. A protective role of Stat3 in Fas mediated apoptosis of the liver. Journal of hepatology. vol 40. issue 5. 2004-12-15. PMID:15094244. |
a protective role of stat3 in fas mediated apoptosis of the liver. |
2004-12-15 |
2023-08-12 |
Not clear |
| H Siavash, N G Nikitakis, J J Sau. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. British journal of cancer. vol 91. issue 6. 2004-11-26. PMID:15316561. |
we recently showed that treatment with 15d-pgj(2) induces apoptosis accompanied by downregulation of the oncogenic signal transducer and activator of transcription 3 (stat3) signalling in human oral squamous cell carcinoma (scc) cells. |
2004-11-26 |
2023-08-12 |
human |
| H Siavash, N G Nikitakis, J J Sau. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. British journal of cancer. vol 91. issue 6. 2004-11-26. PMID:15316561. |
targeting of jak signalling using a specific jak inhibitor also abolished stat3 phosphorylation and resulted in apoptosis in oral scc cells. |
2004-11-26 |
2023-08-12 |
human |
| H Siavash, N G Nikitakis, J J Sau. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. British journal of cancer. vol 91. issue 6. 2004-11-26. PMID:15316561. |
our findings provide the first evidence for 15d-pgj(2)-mediated downregulation of constitutive and il-6-induced jak signalling in cancer and support that jak inhibition and suppression of egfr-independent stat3 activation by 15d-pgj(2) represent a promising approach for induction of apoptosis in oral scc cells. |
2004-11-26 |
2023-08-12 |
human |
| David R Hodge, Weihua Xiao, Li Hua Wang, Dapei Li, William L Farra. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726660. |
despite the presence of activated stat3 and stat5a, apoptosis is induced upon exposure to micromolar levels of dexamethasone, and il-6 or igf-1 is still required to rescue the cells. |
2004-11-19 |
2023-08-12 |
Not clear |
| David R Hodge, Weihua Xiao, Li Hua Wang, Dapei Li, William L Farra. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726660. |
however, ectopic expression of activated stat3 results in partial rescue from apoptosis of cells treated with fas ligand. |
2004-11-19 |
2023-08-12 |
Not clear |
| James Turkson, Joon S Kim, Shumin Zhang, Jing Yuan, Mei Huang, Matthew Glenn, Eric Haura, Said Sebti, Andrew D Hamilton, Richard Jov. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular cancer therapeutics. vol 3. issue 3. 2004-11-09. PMID:15026546. |
moreover, iss 610 induces cell growth inhibition and apoptosis of src-transformed fibroblasts that contain persistently active stat3. |
2004-11-09 |
2023-08-12 |
mouse |
| Beverly E Barton, James G Karras, Thomas F Murphy, Arnold Barton, Hosea F-S Huan. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Molecular cancer therapeutics. vol 3. issue 1. 2004-11-04. PMID:14749471. |
signal transducer and activator of transcription 3 (stat3) activation in prostate cancer: direct stat3 inhibition induces apoptosis in prostate cancer lines. |
2004-11-04 |
2023-08-12 |
Not clear |
| Beverly E Barton, James G Karras, Thomas F Murphy, Arnold Barton, Hosea F-S Huan. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Molecular cancer therapeutics. vol 3. issue 1. 2004-11-04. PMID:14749471. |
both induction of apoptosis and reduction in intracellular stat3 protein were observed following treatment with antisense stat3 oligonucleotides, while transfection of a dn-stat3 plasmid into both prostate cancer cell lines resulted in loss of viability and onset of apoptosis. |
2004-11-04 |
2023-08-12 |
Not clear |
| Naijie Jing, Yidong Li, Weijun Xiong, Wei Sha, Ling Jing, David J Tweard. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer research. vol 64. issue 18. 2004-11-04. PMID:15374974. |
thus, gq-odn targeting stat3 induces tumor cell apoptosis when delivered into tumor xenografts and represents a novel class of chemotherapeutic agents that holds promise for the systemic treatment of many forms of metastatic cancer. |
2004-11-04 |
2023-08-12 |
mouse |
| Kerstin Nagel-Wolfrum, Claudia Buerger, Ilka Wittig, Karin Butz, Felix Hoppe-Seyler, Bernd Grone. The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Molecular cancer research : MCR. vol 2. issue 3. 2004-10-22. PMID:15037656. |
the interaction of specific peptide aptamers with the dna binding domain and the dimerization domain of the transcription factor stat3 inhibits transactivation and induces apoptosis in tumor cells. |
2004-10-22 |
2023-08-12 |
human |
| Nicole Schick, Edward J Oakeley, Nancy E Hynes, Ali Badach. TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. The Journal of biological chemistry. vol 279. issue 37. 2004-10-19. PMID:15229229. |
enhanced and prolonged stat3 activity led to cell cycle arrest and apoptosis. |
2004-10-19 |
2023-08-12 |
Not clear |