| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fu-Chuan Hsieh, Gong Cheng, Jiayuh Li. Evaluation of potential Stat3-regulated genes in human breast cancer. Biochemical and biophysical research communications. vol 335. issue 2. 2005-10-14. PMID:16081048. |
our results also indicate that elevated levels of stat3 phosphorylation were significantly associated with increased expression of potential downstream targets of stat3 which include apoptosis inhibitors (survivin, mcl-1, hsp27, adrenomedullin, and bcl-xl), cell-cycle regulators (c-fos, mek5, and c-myc), and inducer of tumor angiogenesis (vegf, cox-2, mmp-2, mmp-10, and mmp-1) in invasive breast cancer tissues. |
2005-10-14 |
2023-08-12 |
mouse |
| Raymond Lai, George Z Rassidakis, Quan Lin, Coralyn Atwell, L Jeffrey Medeiros, Hesham M Ami. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Human pathology. vol 36. issue 9. 2005-10-13. PMID:16153455. |
in previous studies of anaplastic large cell lymphoma (alcl), we showed that inhibition of jak3 down-regulates activated/phosphorylated stat3 (pstat3), decreases anaplastic lymphoma kinase (alk) enzymatic activity, and induces cell-cycle arrest and apoptosis in alk-positive alcl. |
2005-10-13 |
2023-08-12 |
Not clear |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Helmut Drexle. Many good reasons to have STAT3 in the heart. Pharmacology & therapeutics. vol 107. issue 1. 2005-10-05. PMID:15963355. |
the transcription factor signal transducer and activator of transcription 3 (stat3) participates in a wide variety of physiological processes and directs seemingly contradictory responses, such as proliferation and apoptosis. |
2005-10-05 |
2023-08-12 |
mouse |
| M Amit-Vazina, S Shishodia, D Harris, Q Van, M Wang, D Weber, R Alexanian, M Talpaz, B B Aggarwal, Z Estro. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. British journal of cancer. vol 93. issue 1. 2005-09-26. PMID:15970928. |
atiprimod blocks stat3 phosphorylation and induces apoptosis in multiple myeloma cells. |
2005-09-26 |
2023-08-12 |
Not clear |
| Guilian Niu, Kenneth L Wright, Yihong Ma, Gabriela M Wright, Mei Huang, Rosalyn Irby, Jon Briggs, James Karras, W Douglas Cress, Drew Pardoll, Richard Jove, Jiangdong Chen, Hua Y. Role of Stat3 in regulating p53 expression and function. Molecular and cellular biology. vol 25. issue 17. 2005-09-22. PMID:16107692. |
furthermore, blocking stat3 in cancer cells up-regulates expression of p53, leading to p53-mediated tumor cell apoptosis. |
2005-09-22 |
2023-08-12 |
Not clear |
| Yang Yang, Takayuki Ikezoe, Tamotsu Takeuchi, Yoshihiro Adachi, Yuji Ohtsuki, Seisho Takeuchi, H Phillip Koeffler, Hirokuni Taguch. HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling. Cancer science. vol 96. issue 7. 2005-09-21. PMID:16053514. |
hiv-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer lncap cells in vitro and in vivo in conjunction with blockade of androgen receptor stat3 and akt signaling. |
2005-09-21 |
2023-08-12 |
mouse |
| Lina Y Dimberg, Anna I Dimberg, Karolina Ivarsson, Thomas Strömberg, Anders Osterborg, Kenneth Nilsson, Fredrik Oberg, Helena Jernberg Wiklun. Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. Blood. vol 106. issue 4. 2005-09-19. PMID:15860671. |
in addition, ifn treatment attenuated the interleukin 6 (il-6)-dependent activation of signal transducer and activator of transcription 3 (stat3), interfering with a known survival pathway in mm that has previously been linked with resistance to fas-mediated apoptosis. |
2005-09-19 |
2023-08-12 |
Not clear |
| Lina Y Dimberg, Anna I Dimberg, Karolina Ivarsson, Thomas Strömberg, Anders Osterborg, Kenneth Nilsson, Fredrik Oberg, Helena Jernberg Wiklun. Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. Blood. vol 106. issue 4. 2005-09-19. PMID:15860671. |
taken together, our results show that ifn-induced up-regulation of fas sensitizes mm cells to fas-mediated apoptosis and suggest that attenuation of stat3 activation may be a potentially important event in this process. |
2005-09-19 |
2023-08-12 |
Not clear |
| Erina Sakamoto, Fumihiko Hato, Takayuki Kato, Chikahiko Sakamoto, Mika Akahori, Masayuki Hino, Seiichi Kitagaw. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845643. |
type i and type ii interferons delay human neutrophil apoptosis via activation of stat3 and up-regulation of cellular inhibitor of apoptosis 2. |
2005-09-08 |
2023-08-12 |
human |
| Erina Sakamoto, Fumihiko Hato, Takayuki Kato, Chikahiko Sakamoto, Mika Akahori, Masayuki Hino, Seiichi Kitagaw. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845643. |
we have recently demonstrated that granulocyte-colony stimulating factor (g-csf) delays human neutrophil apoptosis via up-regulation of cellular inhibitor of apoptosis 2 (ciap2), which is dependent on activation of janus kinase 2 (jak2) and signal transducer and activator of transcription 3 (stat3). |
2005-09-08 |
2023-08-12 |
human |
| Shigetoshi Sano, Keith Syson Chan, Masahiro Kira, Ken Kataoka, Satoshi Takagi, Masahito Tarutani, Satoshi Itami, Kaoru Kiguchi, Masayuki Yokoi, Kaoru Sugasawa, Toshio Mori, Fumio Hanaoka, Junji Takeda, John DiGiovann. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994947. |
uvb irradiation of signal transducer and activator of transcription 3 (stat3)-deficient keratinocytes resulted in a high incidence of apoptosis compared with controls. |
2005-09-07 |
2023-08-12 |
mouse |
| Shigetoshi Sano, Keith Syson Chan, Masahiro Kira, Ken Kataoka, Satoshi Takagi, Masahito Tarutani, Satoshi Itami, Kaoru Kiguchi, Masayuki Yokoi, Kaoru Sugasawa, Toshio Mori, Fumio Hanaoka, Junji Takeda, John DiGiovann. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer research. vol 65. issue 13. 2005-09-07. PMID:15994947. |
conversely, forced expression of stat3 desensitized keratinocytes to uvb-induced apoptosis. |
2005-09-07 |
2023-08-12 |
mouse |
| Toru Yamashita, Kazunobu Sawamoto, Shigeaki Suzuki, Norihiro Suzuki, Kazuhide Adachi, Takeshi Kawase, Masahiko Mihara, Yoshiyuki Ohsugi, Koji Abe, Hideyuki Okan. Blockade of interleukin-6 signaling aggravates ischemic cerebral damage in mice: possible involvement of Stat3 activation in the protection of neurons. Journal of neurochemistry. vol 94. issue 2. 2005-09-07. PMID:15998296. |
these results suggest that endogenous il-6 plays a critical role in preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia and that its role may be mediated by stat3 activation. |
2005-09-07 |
2023-08-12 |
mouse |
| E Puxeddu, J A Knauf, M A Sartor, N Mitsutake, E P Smith, M Medvedovic, C R Tomlinson, S Moretti, J A Fagi. RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response. Endocrine-related cancer. vol 12. issue 2. 2005-08-22. PMID:15947106. |
functional clustering of genes with greater than or less than 1.75-fold expression change (86 genes) revealed ret/ptc3-induced regulation of genes with key functions in apoptosis (ripk3, tdga), cell-cell signaling (cdh6, fn1), cell cycle (il24), immune and inflammation response (cxcl10, scya2, il6, gbp2, oas1, tap1, rt1aw2, c2ta, irf1, lmp2, psme2, prkr), metabolism (aldob, ptges, nd2, gss, gstt1), signal transduction (socs3, nf1, jak2, cpg21, dusp6, socs1, stat1, stat3, cish) and transcription (nr4a1, junb, hfh1, runx1, foxe1). |
2005-08-22 |
2023-08-12 |
Not clear |
| Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, Richard Jov. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 17. 2005-07-08. PMID:15837920. |
indirubin derivatives inhibit stat3 signaling and induce apoptosis in human cancer cells. |
2005-07-08 |
2023-08-12 |
human |
| Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, Richard Jov. Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 17. 2005-07-08. PMID:15837920. |
the antiapoptotic proteins mcl-1 and survivin, which are encoded in target genes of stat3, were down-regulated by indirubin derivatives, followed by induction of apoptosis. |
2005-07-08 |
2023-08-12 |
human |
| U Holtick, M Vockerodt, D Pinkert, N Schoof, B Stürzenhofecker, N Kussebi, K Lauber, S Wesselborg, D Löffler, F Horn, L Trümper, D Kub. STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. Leukemia. vol 19. issue 6. 2005-06-30. PMID:15912144. |
stat3 is essential for hodgkin lymphoma cell proliferation and is a target of tyrphostin ag17 which confers sensitization for apoptosis. |
2005-06-30 |
2023-08-12 |
Not clear |
| Hui Song, Renxiao Wang, Shaomeng Wang, Jiayuh Li. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 13. 2005-06-09. PMID:15781862. |
activated stat3 may participate in oncogenesis by stimulating cell proliferation, promoting tumor angiogenesis, and resisting apoptosis. |
2005-06-09 |
2023-08-12 |
human |
| James R Matthews, Alan R Clark. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene. vol 24. issue 19. 2005-05-31. PMID:15735683. |
previous studies have demonstrated a proapoptotic role for the transcription factor stat3 in involuting murine mammary epithelium, resulting in delayed involution and lower levels of apoptosis in the stat3 null gland relative to wild-type controls. |
2005-05-31 |
2023-08-12 |
Not clear |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |