| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura Pedranzini, Andrea Leitch, Jacqueline Bromber. Stat3 is required for the development of skin cancer. The Journal of clinical investigation. vol 114. issue 5. 2004-10-14. PMID:15343379. |
inhibition of activated stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of stat3 into immortalized human breast epithelial cells and rodent fibroblasts results in cellular transformation. |
2004-10-14 |
2023-08-12 |
mouse |
| Nalin J Patel, Anne Hansen, Albert L Merati, Joseph E Kerschne. STAT3 activation in recurrent respiratory papillomatosis. Archives of otolaryngology--head & neck surgery. vol 130. issue 9. 2004-10-06. PMID:15381590. |
the activation of signal transducer and activator of transduction (stat) protein is thought to lead to the genesis of neoplasia by promoting cellular growth and preventing apoptosis, and by immune system modulation; stat3 protein has also been implicated in tumor survival and propagation in recurrent respiratory papillomatosis (rrp). |
2004-10-06 |
2023-08-12 |
Not clear |
| Hongwei Gao, Ren-Feng Guo, Cecilia L Speyer, Jayne Reuben, Thomas A Neff, L Marco Hoesel, Niels C Riedemann, Shannon D McClintock, J Vidya Sarma, Nico Van Rooijen, Firas S Zetoune, Peter A War. Stat3 activation in acute lung injury. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187153. |
stat3 plays diverse roles in biological processes including cell proliferation, survival, apoptosis, and inflammation. |
2004-09-16 |
2023-08-12 |
rat |
| Shuo Dong, Sai-Juan Chen, David J Tweard. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leukemia & lymphoma. vol 44. issue 12. 2004-09-09. PMID:14959844. |
constitutive stat3 activation has been observed in a number of hematopoietic and non-hematopoietic malignancies where it contributes to apoptosis resistance. |
2004-09-09 |
2023-08-12 |
Not clear |
| Shuo Dong, Sai-Juan Chen, David J Tweard. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leukemia & lymphoma. vol 44. issue 12. 2004-09-09. PMID:14959844. |
these findings support the hypothesis that apoptosis resistance in apl may be mediated through the effects of apl fusion proteins on stat3 signaling and suggest that targeting of stat3 may be a useful adjunctive treatment strategy in apl. |
2004-09-09 |
2023-08-12 |
Not clear |
| Soo Ok Lee, Wei Lou, Candace S Johnson, Donald L Trump, Allen C Ga. Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. The Prostate. vol 60. issue 3. 2004-09-03. PMID:15176047. |
interleukin-6 protects lncap cells from apoptosis induced by androgen deprivation through the stat3 pathway. |
2004-09-03 |
2023-08-12 |
Not clear |
| Huamin Wang, Hua Wang, Wei Zhang, Helen J Huang, Warren S L Liao, Gregory N Fulle. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 8. 2004-09-02. PMID:15184909. |
as downstream targets of the pten and egfr signaling pathways, akt, nfkappab, and signal transducer and activator of transcription-3 (stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis. |
2004-09-02 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
rna interference targeting stat3 inhibits growth and induces apoptosis of human prostate cancer cells. |
2004-08-31 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
previous studies demonstrated that constitutively activated stat3 plays an important role in the development and progression of prostate cancer by promoting cell proliferation and protecting against apoptosis. |
2004-08-31 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
the stat3 sirna does not inhibit the proliferation nor induces apoptosis of stat3-inactive human prostate cancer cells. |
2004-08-31 |
2023-08-12 |
human |
| Hesham M Amin, Timothy J McDonnell, Yupo Ma, Quan Lin, Yasushi Fujio, Keita Kunisada, Vasiliki Leventaki, Pamela Das, George Z Rassidakis, Cathy Cutler, L Jeffrey Medeiros, Raymond La. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene. vol 23. issue 32. 2004-08-23. PMID:15184887. |
selective inhibition of stat3 induces apoptosis and g(1) cell cycle arrest in alk-positive anaplastic large cell lymphoma. |
2004-08-23 |
2023-08-12 |
Not clear |
| Hesham M Amin, Timothy J McDonnell, Yupo Ma, Quan Lin, Yasushi Fujio, Keita Kunisada, Vasiliki Leventaki, Pamela Das, George Z Rassidakis, Cathy Cutler, L Jeffrey Medeiros, Raymond La. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene. vol 23. issue 32. 2004-08-23. PMID:15184887. |
these results support the concept that stat3 activation is pathogenetically important in alcl cells by deregulating the expression of multiple target proteins that are involved in the control of apoptosis and cell cycle progression. |
2004-08-23 |
2023-08-12 |
Not clear |
| A V Ivanova, S V Ivanov, X Zhang, V N Ivanov, O A Timofeeva, M I Lerma. STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. Journal of molecular biology. vol 340. issue 4. 2004-08-03. PMID:15223310. |
thus, for the first time, we identify stra13 as a stat3 partner and provide a consistent line of evidence for stra13 involvement into regulation of apoptosis via the stat pathways. |
2004-08-03 |
2023-08-12 |
Not clear |
| V H Sommer, O J Clemmensen, O Nielsen, M Wasik, P Lovato, C Brender, K W Eriksen, A Woetmann, C G Kaestel, M H Nissen, C Ropke, S Skov, N Ødu. In vivo activation of STAT3 in cutaneous T-cell lymphoma. Evidence for an antiapoptotic function of STAT3. Leukemia. vol 18. issue 7. 2004-07-23. PMID:15141228. |
moreover, stat3 protects tumor cells from apoptosis in vitro. |
2004-07-23 |
2023-08-12 |
Not clear |
| Li Li, Doreen Hooi, Siri Ram Chhabra, David Pritchard, Peter E Sha. Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15064716. |
bacterial n-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of stat3. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
the aim of the present study was to clarify the role of stat3 signaling in apoptosis and cellular proliferation in gastric cancer. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
here we reported that stat3 was constitutively activated in various human gastric cancer cells and its inhibition by ectopic dominant-negative stat3 or janus kinase inhibitor, tyrphostin ag490, induced apoptosis. |
2004-07-16 |
2023-08-12 |
human |
| Naoki Kanda, Hiroshi Seno, Yoshitaka Konda, Hiroyuki Marusawa, Masashi Kanai, Toshio Nakajima, Tomoko Kawashima, Apichart Nanakin, Tateo Sawabu, Yoshito Uenoyama, Akira Sekikawa, Mayumi Kawada, Katsumasa Suzuki, Takahisa Kayahara, Hirokazu Fukui, Mitsutaka Sawada, Tsutomu Chib. STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. Oncogene. vol 23. issue 28. 2004-07-16. PMID:15077160. |
furthermore, stat3 inhibition markedly decreased survivin expression, and forced expression of survivin rescued ags cells from apoptosis induced by stat3 inhibition. |
2004-07-16 |
2023-08-12 |
human |
| Huang Shao, Xuejun Xu, Mary-Ann A Mastrangelo, Naijie Jing, Richard G Cook, Glen B Legge, David J Tweard. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14966128. |
stat3 is an src homology (sh)2-containing protein constitutively activated in a wide variety of human cancers following its recruitment to yxxq-containing motifs, which results in resistance to apoptosis. |
2004-06-10 |
2023-08-12 |
human |
| Liza Konnikova, Maciej Kotecki, Mathew M Kruger, Brent H Cochra. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC cancer. vol 3. 2004-06-08. PMID:13678425. |
knockdown of stat3 expression by rnai induces apoptosis in astrocytoma cells. |
2004-06-08 |
2023-08-12 |
human |