| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James Turkson, Shumin Zhang, Linda B Mora, Audrey Burns, Said Sebti, Richard Jov. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. The Journal of biological chemistry. vol 280. issue 38. 2005-11-28. PMID:16046414. |
in human and mouse tumor cell lines with constitutively active stat3, is3 295 selectively attenuated stat3 signaling, thereby inducing cell growth arrest at g0/g1 phase and apoptosis. |
2005-11-28 |
2023-08-12 |
mouse |
| Peter Stärkel, Christine De Saeger, Isabelle Leclercq, Alastair Strain, Yves Horsman. Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis. Journal of hepatology. vol 43. issue 4. 2005-11-28. PMID:16098628. |
in vitro and animal data suggest that alcohol and hepatitis c virus (hcv) proteins might interfere with stat3 signaling, a potential regulator of liver cell apoptosis and proliferation. |
2005-11-28 |
2023-08-12 |
human |
| Anette Weber, Ulrich R Hengge, Walter Bardenheuer, Iris Tischoff, Florian Sommerer, Annett Markwarth, Andreas Dietz, Christian Wittekind, Andrea Tannapfe. SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Oncogene. vol 24. issue 44. 2005-11-15. PMID:16007169. |
overexpression of wild-type socs-3 in carcinoma cells with methylated socs-3 resulted in the induction of apoptosis and growth suppression as well as downregulation of stat3, bcl-2 as well as bcl-xl. |
2005-11-15 |
2023-08-12 |
Not clear |
| Shahab Uddin, Azhar R Hussain, Pulicat S Manogaran, Khaled Al-Hussein, Leonidas C Platanias, Marina I Gutierrez, Kishor G Bhati. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene. vol 24. issue 47. 2005-11-15. PMID:16044161. |
altogether, our findings suggest a novel function for curcumin, acting as a suppressor of jak-1 and stat3 activation in pel cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis. |
2005-11-15 |
2023-08-12 |
Not clear |
| Stefania Militi, Caterina Chiapparino, Ugo Testa, Paolo Carminati, Rita De Santis, Ottaviano Serlupi-Crescenz. Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells. Cytokine. vol 31. issue 4. 2005-11-07. PMID:16009564. |
however, this inhibition is associated with marginal induction of apoptosis and with minor decrease of cell proliferation, contrary to the effect of the jak kinase inhibitor ag490, which down-regulates both proliferation and stat3 activation. |
2005-11-07 |
2023-08-12 |
Not clear |
| Stefania Militi, Caterina Chiapparino, Ugo Testa, Paolo Carminati, Rita De Santis, Ottaviano Serlupi-Crescenz. Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells. Cytokine. vol 31. issue 4. 2005-11-07. PMID:16009564. |
inhibition of stat3 activation is therefore not sufficient to prevent proliferation and to induce apoptosis in these cells. |
2005-11-07 |
2023-08-12 |
Not clear |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
role of stat3 and nfkappab signaling in the serum factor-induced apoptosis in ak-5 cells. |
2005-11-01 |
2023-08-12 |
rat |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
our results demonstrate downregulation of a transcription factor, stat3, as a critical regulator of sf-induced apoptosis in bc-8 cells. |
2005-11-01 |
2023-08-12 |
rat |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
sf induced apoptosis in bc-8 cells mediated through downregulation of stat3 and elevated nfkappab activity is abrogated by treatment with mapk inhibitors-pd98059 and sb203580. |
2005-11-01 |
2023-08-12 |
rat |
| Li-fang Gao, De-qi Xu, Lian-ji Wen, Xing-yi Zhang, Yue-ting Shao, Xue-jian Zha. Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells. Acta pharmacologica Sinica. vol 26. issue 3. 2005-10-25. PMID:15715937. |
inhibition of stat3 expression by sirna suppresses growth and induces apoptosis in laryngeal cancer cells. |
2005-10-25 |
2023-08-12 |
human |
| Li-fang Gao, De-qi Xu, Lian-ji Wen, Xing-yi Zhang, Yue-ting Shao, Xue-jian Zha. Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells. Acta pharmacologica Sinica. vol 26. issue 3. 2005-10-25. PMID:15715937. |
to determine the inhibitory effect of the synthetic stat3 sirna on the expression of stat3 gene in human laryngeal cancer cell lines hep2 and to investigate the effect of stat3 sirna on growth and apoptosis in hep2 cells. |
2005-10-25 |
2023-08-12 |
human |
| Fu-Chuan Hsieh, Gong Cheng, Jiayuh Li. Evaluation of potential Stat3-regulated genes in human breast cancer. Biochemical and biophysical research communications. vol 335. issue 2. 2005-10-14. PMID:16081048. |
our results also indicate that elevated levels of stat3 phosphorylation were significantly associated with increased expression of potential downstream targets of stat3 which include apoptosis inhibitors (survivin, mcl-1, hsp27, adrenomedullin, and bcl-xl), cell-cycle regulators (c-fos, mek5, and c-myc), and inducer of tumor angiogenesis (vegf, cox-2, mmp-2, mmp-10, and mmp-1) in invasive breast cancer tissues. |
2005-10-14 |
2023-08-12 |
mouse |
| Raymond Lai, George Z Rassidakis, Quan Lin, Coralyn Atwell, L Jeffrey Medeiros, Hesham M Ami. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Human pathology. vol 36. issue 9. 2005-10-13. PMID:16153455. |
in previous studies of anaplastic large cell lymphoma (alcl), we showed that inhibition of jak3 down-regulates activated/phosphorylated stat3 (pstat3), decreases anaplastic lymphoma kinase (alk) enzymatic activity, and induces cell-cycle arrest and apoptosis in alk-positive alcl. |
2005-10-13 |
2023-08-12 |
Not clear |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Helmut Drexle. Many good reasons to have STAT3 in the heart. Pharmacology & therapeutics. vol 107. issue 1. 2005-10-05. PMID:15963355. |
the transcription factor signal transducer and activator of transcription 3 (stat3) participates in a wide variety of physiological processes and directs seemingly contradictory responses, such as proliferation and apoptosis. |
2005-10-05 |
2023-08-12 |
mouse |
| M Amit-Vazina, S Shishodia, D Harris, Q Van, M Wang, D Weber, R Alexanian, M Talpaz, B B Aggarwal, Z Estro. Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. British journal of cancer. vol 93. issue 1. 2005-09-26. PMID:15970928. |
atiprimod blocks stat3 phosphorylation and induces apoptosis in multiple myeloma cells. |
2005-09-26 |
2023-08-12 |
Not clear |
| Guilian Niu, Kenneth L Wright, Yihong Ma, Gabriela M Wright, Mei Huang, Rosalyn Irby, Jon Briggs, James Karras, W Douglas Cress, Drew Pardoll, Richard Jove, Jiangdong Chen, Hua Y. Role of Stat3 in regulating p53 expression and function. Molecular and cellular biology. vol 25. issue 17. 2005-09-22. PMID:16107692. |
furthermore, blocking stat3 in cancer cells up-regulates expression of p53, leading to p53-mediated tumor cell apoptosis. |
2005-09-22 |
2023-08-12 |
Not clear |
| Yang Yang, Takayuki Ikezoe, Tamotsu Takeuchi, Yoshihiro Adachi, Yuji Ohtsuki, Seisho Takeuchi, H Phillip Koeffler, Hirokuni Taguch. HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling. Cancer science. vol 96. issue 7. 2005-09-21. PMID:16053514. |
hiv-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer lncap cells in vitro and in vivo in conjunction with blockade of androgen receptor stat3 and akt signaling. |
2005-09-21 |
2023-08-12 |
mouse |
| Lina Y Dimberg, Anna I Dimberg, Karolina Ivarsson, Thomas Strömberg, Anders Osterborg, Kenneth Nilsson, Fredrik Oberg, Helena Jernberg Wiklun. Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. Blood. vol 106. issue 4. 2005-09-19. PMID:15860671. |
in addition, ifn treatment attenuated the interleukin 6 (il-6)-dependent activation of signal transducer and activator of transcription 3 (stat3), interfering with a known survival pathway in mm that has previously been linked with resistance to fas-mediated apoptosis. |
2005-09-19 |
2023-08-12 |
Not clear |
| Lina Y Dimberg, Anna I Dimberg, Karolina Ivarsson, Thomas Strömberg, Anders Osterborg, Kenneth Nilsson, Fredrik Oberg, Helena Jernberg Wiklun. Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. Blood. vol 106. issue 4. 2005-09-19. PMID:15860671. |
taken together, our results show that ifn-induced up-regulation of fas sensitizes mm cells to fas-mediated apoptosis and suggest that attenuation of stat3 activation may be a potentially important event in this process. |
2005-09-19 |
2023-08-12 |
Not clear |
| Erina Sakamoto, Fumihiko Hato, Takayuki Kato, Chikahiko Sakamoto, Mika Akahori, Masayuki Hino, Seiichi Kitagaw. Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15845643. |
type i and type ii interferons delay human neutrophil apoptosis via activation of stat3 and up-regulation of cellular inhibitor of apoptosis 2. |
2005-09-08 |
2023-08-12 |
human |