| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniel G Rosen, Imelda Mercado-Uribe, Gong Yang, Robert C Bast, Hesham M Amin, Raymond Lai, Jinsong Li. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. vol 107. issue 11. 2006-12-19. PMID:17063503. |
the objectives of the current study were to examine the effect of stat3 activation on the phenotypic transformation of an immortalized, nontumorigenic ovarian epithelial cell line and to evaluate the expression of tyrosine-activated stat3 (pstat3) in tissue microarrays from 303 ovarian carcinomas to determine its prognostic relevance and to correlate its expression with several upstream oncogenes of stat3 and with the oncogenes involved in apoptosis and proliferation. |
2006-12-19 |
2023-08-12 |
Not clear |
| Aikaterini Anagnostopoulou, Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S Kim, Matthew Glenn, Andrew D Hamilton, Leda Rapti. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer letters. vol 242. issue 1. 2006-12-08. PMID:16377083. |
the results demonstrate that stat3 downregulation in vsrc transformed nih3t3 cells or in breast cancer lines harboring activated src induces apoptosis, which is evident at all densities but is more pronounced at post-confluence. |
2006-12-08 |
2023-08-12 |
Not clear |
| Aikaterini Anagnostopoulou, Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S Kim, Matthew Glenn, Andrew D Hamilton, Leda Rapti. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer letters. vol 242. issue 1. 2006-12-08. PMID:16377083. |
in normal cells on the other hand, stat3 inhibition at post-confluence caused apoptosis while in sparsely growing cells it induced merely a growth retardation. |
2006-12-08 |
2023-08-12 |
Not clear |
| Mark F McCarty, Keith I Bloc. Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy. Integrative cancer therapies. vol 5. issue 3. 2006-12-07. PMID:16880431. |
ultimately, more complex adjuvant regimens can be envisioned in which salicylates are used in conjunction with other nf-kappa antagonists and/or agents that target other mediators of down-regulated apoptosis in cancer, such as stat3; coadministration of salicylate and organic selenium may have intriguing potential in this regard. |
2006-12-07 |
2023-08-12 |
mouse |
| R A Mesa, A Tefferi, T S Lasho, D Loegering, R F McClure, H L Powell, N T Dai, D P Steensma, S H Kaufman. Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia. Leukemia. vol 20. issue 10. 2006-11-07. PMID:16871275. |
these results suggest that mutant jak2 contributes to mmm pathogenesis by constitutively phosphorylating stat3 and diminishing myeloid cell apoptosis. |
2006-11-07 |
2023-08-12 |
Not clear |
| Ashish Bhattacharjee, Bo Xu, David A Frank, Gerald M Feldman, Martha K Cathcar. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 6. 2006-10-24. PMID:16951338. |
furthermore, by transfecting monocytes with stat3 containing mutations in tyr705 or ser727 or with wild-type stat3, we demonstrated that both stat3 tyrosine and serine phosphorylations are required for optimal binding of stat3 with dna and maximal expression of 15-lipoxygenase, an important regulator of inflammation and apoptosis. |
2006-10-24 |
2023-08-12 |
human |
| Gu-Sheng Tang, Jian-Ming Cai, Jin Ni, Ying-Song Xiang, Jian-Guo Cui, Dan Zhu, Jun-Rui Don. [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16]. Ai zheng = Aizheng = Chinese journal of cancer. vol 25. issue 3. 2006-10-20. PMID:16536977. |
[effects of stat3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line b16]. |
2006-10-20 |
2023-08-12 |
mouse |
| Gu-Sheng Tang, Jian-Ming Cai, Jin Ni, Ying-Song Xiang, Jian-Guo Cui, Dan Zhu, Jun-Rui Don. [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16]. Ai zheng = Aizheng = Chinese journal of cancer. vol 25. issue 3. 2006-10-20. PMID:16536977. |
this study was to observe the activation of stat3 protein in mouse melanoma cell line b16, human liver cancer cell lines smmc-7721 and hepg-2, human lung cancer cell line a549, and human cervical cancer cell line hela, and to investigate the effects of stat3 antisense oligodeoxynucleotides (asodn) on proliferation and apoptosis of b16 cells. |
2006-10-20 |
2023-08-12 |
mouse |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
integrin beta3-mediated src activation regulates apoptosis in iec-6 cells via akt and stat3. |
2006-08-25 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
the depletion of polyamines rapidly activates nf-kappab (nuclear factor kappab) and stat3 (signal transducer and activator of transcription 3), which is responsible for the observed decrease in apoptosis. |
2006-08-25 |
2023-08-12 |
Not clear |
| Yohei Matsuzaki, Yan Xu, Machiko Ikegami, Valérie Besnard, Kwon-Sik Park, William M Hull, Susan E Wert, Jeffrey A Whitset. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 1. 2006-08-09. PMID:16785550. |
rna microarray analysis of type ii epithelial cells isolated from stat3(deltadelta) mice demonstrated significant changes in expression of numerous genes, including those genes regulating apoptosis, supporting the concept that the susceptibility of stat3-deficient mice to adenovirus was related to the role of stat3 in the regulation of cell survival. |
2006-08-09 |
2023-08-12 |
mouse |
| Ana M Gamero, Ramesh Potla, Joanna Wegrzyn, Magdelena Szelag, Andrea E Edling, Kazuya Shimoda, Daniel C Link, Jozef Dulak, Darren P Baker, Yoshinari Tanabe, Jason M Grayson, Andrew C Larne. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16601124. |
in contrast to ifnbeta-stimulated tyrosine phosphorylation of stat1 and stat2, stat3 tyrosine phosphorylation is defective in tyk2(-/-) pro-b cells, suggesting that this stat family member is required for apoptosis. |
2006-08-01 |
2023-08-12 |
mouse |
| Ana M Gamero, Ramesh Potla, Joanna Wegrzyn, Magdelena Szelag, Andrea E Edling, Kazuya Shimoda, Daniel C Link, Jozef Dulak, Darren P Baker, Yoshinari Tanabe, Jason M Grayson, Andrew C Larne. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16601124. |
these results demonstrate an important role of tyk2-mediated tyrosine phosphorylation of stat3 in the ability of ifnbeta to stimulate apoptosis of primary pro-b cells. |
2006-08-01 |
2023-08-12 |
mouse |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
in vivo studies have shown that stat5 contributes to prolactin-dependent lobuloalveolar development and lactation whereas stat3 mediates lif-dependent epithelial apoptosis during postlactational involution. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
thus, using conditionally active stat3- or stat5a-gyraseb fusion proteins, we observed that enforced and specific dimerization of stat3 induced apoptosis whereas stat5 induced differentiation of mammary epithelial cells. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
furthermore, stat5 attenuated apoptosis mediated by lif, the physiological inducer of stat3. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
these data illustrate that specific activation of stat3 and stat5 alone is sufficient to induce and suppress apoptosis, respectively, and that these transcription factors elicit their actions by inducing distinct subsets of target genes in mammary epithelial cells. |
2006-07-31 |
2023-08-12 |
Not clear |
| Lanxi Song, Mark Morris, Tapan Bagui, Francis Y Lee, Richard Jove, Eric B Haur. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740687. |
the induction of apoptosis in these egfr-mutant cell lines corresponds to down-regulation of activated akt and stat3 survival proteins. |
2006-07-27 |
2023-08-12 |
human |
| Markus J Riemenschneider, Rebecca A Betensky, Saskia M Pasedag, David N Loui. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740698. |
mtor activation results in subsequent activation of s6k and stat3, as well as suppression (i.e., phosphorylation) of 4e-bp1, leading to cell cycle progression and inhibition of apoptosis. |
2006-07-27 |
2023-08-12 |
human |
| Deeba N Syed, Arshi Malik, Naghma Hadi, Sami Sarfaraz, Farrukh Afaq, Hasan Mukhta. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochemistry and photobiology. vol 82. issue 2. 2006-07-20. PMID:16613491. |
signal transducers and activators of transcription 3 (stat3), protein kinase b/akt and map kinases (mapks), which are activated by a variety of factors, modulate cell proliferation, apoptosis and other biological activities. |
2006-07-20 |
2023-08-12 |
human |