| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosane de Oliveira Duarte Achcar, Philip T Cagle, Jaishree Jagirda. Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas: possible role for chemotherapeutic intervention. Archives of pathology & laboratory medicine. vol 131. issue 9. 2007-09-20. PMID:17824789. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in diverse human cancers and plays a critical role in tumor cell survival, proliferation, migration, invasion, angiogenesis, and inhibition of apoptosis. |
2007-09-20 |
2023-08-12 |
human |
| Priya Weerasinghe, Gabriela E Garcia, Qiqing Zhu, Ping Yuan, Lili Feng, Li Mao, Naijie Jin. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. International journal of oncology. vol 31. issue 1. 2007-09-14. PMID:17549413. |
results show that gq-odn t40214 and t40231 significantly suppress the growth of nsclc tumors in nude mice by selectively inhibiting the activation of stat3 and its downstream proteins bcl-2, bcl-xl, mcl-1, survivin, vegf, cyclin d1 and c-myc; thereby, promoting apoptosis and reducing angiogenesis and cell proliferation. |
2007-09-14 |
2023-08-12 |
mouse |
| C-L Chen, F-C Hsieh, J C Lieblein, J Brown, C Chan, J A Wallace, G Cheng, B M Hall, J Li. Stat3 activation in human endometrial and cervical cancers. British journal of cancer. vol 96. issue 4. 2007-09-13. PMID:17311011. |
expression of a dominant-negative stat3 mutant using adenovirus-mediated gene transfer inhibited cell growth and induced apoptosis in hela and siha cervical cancer cell lines expressing elevated levels of stat3 phosphorylation. |
2007-09-13 |
2023-08-12 |
mouse |
| C-L Chen, F-C Hsieh, J C Lieblein, J Brown, C Chan, J A Wallace, G Cheng, B M Hall, J Li. Stat3 activation in human endometrial and cervical cancers. British journal of cancer. vol 96. issue 4. 2007-09-13. PMID:17311011. |
further, a jak/stat3 small molecular inhibitor, jsi-124, induced apoptosis more selectively in hela and siha cancer cell lines than ishikawa cell line without elevated levels of stat3 phosphorylation. |
2007-09-13 |
2023-08-12 |
mouse |
| Hiroyuki Mori, Takashi Shichita, Qingsheng Yu, Ryoko Yoshida, Masayuki Hashimoto, Fuyuki Okamoto, Takahiro Torisu, Mako Nakaya, Takashi Kobayashi, Giichi Takaesu, Akihiko Yoshimur. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochemical and biophysical research communications. vol 359. issue 4. 2007-08-23. PMID:17562326. |
the islets from cko mice demonstrated hyperactivation of stat3 and higher induction of bcl-xl than did islets from wt mice, and socs3-deficient beta-cells were more resistant to apoptosis induced by stz in vitro than were wt beta-cells. |
2007-08-23 |
2023-08-12 |
mouse |
| Xulong Zhang, Jian Zhang, Haiming Wei, Zhigang Tia. STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncology reports. vol 17. issue 6. 2007-08-17. PMID:17487394. |
in this study, it was noted that stat3 was overactivated in human lung cancer cells, and stat3-decoy odn, which was high-efficiently transfected into nucleus of cancer cells, significantly inhibited the proliferation of pg cells by inducing apoptosis or cell cycle arrest. |
2007-08-17 |
2023-08-12 |
human |
| Gertraud W Robinson, Margit Pacher-Zavisin, Bing Mei Zhu, Akihiko Yoshimura, Lothar Hennighause. Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 3. 2007-08-01. PMID:17205581. |
thus, socs3 serves as a modulator of stat3 activity to ensure controlled proliferation and apoptosis in pregnancy and involution, respectively. |
2007-08-01 |
2023-08-12 |
Not clear |
| O Kosmider, N Denis, P Dubreuil, F Moreau-Gacheli. Semaxinib (SU5416) as a therapeutic agent targeting oncogenic Kit mutants resistant to imatinib mesylate. Oncogene. vol 26. issue 26. 2007-07-09. PMID:17173066. |
using these cells in vitro, we demonstrate that the tyrosine kinase inhibitor su5416 (semaxinib) induces growth arrest and apoptosis independent of the mutation type by inhibiting the functions of kit, including kit autophosphorylation and activation of akt, erk1/erk2 and stat3 downstream signaling pathways. |
2007-07-09 |
2023-08-12 |
mouse |
| Khandaker Siddiquee, Shumin Zhang, Wayne C Guida, Michelle A Blaskovich, Benjamin Greedy, Harshani R Lawrence, M L Richard Yip, Richard Jove, Mark M McLaughlin, Nicholas J Lawrence, Said M Sebti, James Turkso. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 18. 2007-06-20. PMID:17463090. |
furthermore, s3i-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated stat3. |
2007-06-20 |
2023-08-12 |
human |
| Khandaker Siddiquee, Shumin Zhang, Wayne C Guida, Michelle A Blaskovich, Benjamin Greedy, Harshani R Lawrence, M L Richard Yip, Richard Jove, Mark M McLaughlin, Nicholas J Lawrence, Said M Sebti, James Turkso. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 18. 2007-06-20. PMID:17463090. |
constitutively dimerized and active stat3c and stat3 sh2 domain rescue tumor cells from s3i-201-induced apoptosis. |
2007-06-20 |
2023-08-12 |
human |
| Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L Madden, Michael Andreef. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483332. |
in vitro, after treatment of 4t1 cells with 500 nmol/l cddo-me for 2 h, we found (a) inactivation of stat3, (b) inactivation of src and akt, (c) 4-fold reduction of c-myc mrna levels, (d) accumulation of cells in g(2)-m cell cycle phase, (e) abrogation of invasive growth of 4t1 cells, and (f) lack of apoptosis induction. |
2007-06-18 |
2023-08-12 |
mouse |
| A Iwamaru, S Szymanski, E Iwado, H Aoki, T Yokoyama, I Fokt, K Hess, C Conrad, T Madden, R Sawaya, S Kondo, W Priebe, Y Kond. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17043651. |
a novel inhibitor of the stat3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. |
2007-05-31 |
2023-08-12 |
mouse |
| A Iwamaru, S Szymanski, E Iwado, H Aoki, T Yokoyama, I Fokt, K Hess, C Conrad, T Madden, R Sawaya, S Kondo, W Priebe, Y Kond. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17043651. |
a selective inhibitor of stat3 phosphorylation, ag490, has been shown to inhibit growth and induce apoptosis in some cancer cell types. |
2007-05-31 |
2023-08-12 |
mouse |
| Daniela Baus, Edith Pfitzne. Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells. International journal of cancer. vol 118. issue 6. 2007-05-29. PMID:16206268. |
specific downregulation of stat3 by sirna expression decreased cell proliferation and induced apoptosis. |
2007-05-29 |
2023-08-12 |
Not clear |
| Natalia Cuesta, Quan M Nhu, Enrique Zudaire, Swamy Polumuri, Frank Cuttitta, Stefanie N Voge. IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 6. 2007-05-22. PMID:17339457. |
using microarray gene expression profiling of liver rna samples derived from irf-2(+/+) and irf-2(-/-) mice treated with saline or lps, we identified >40 genes that were significantly down-regulated in irf-2(-/-) mice, including stat3, which has been reported to regulate apoptosis. |
2007-05-22 |
2023-08-12 |
mouse |
| Natalia Cuesta, Quan M Nhu, Enrique Zudaire, Swamy Polumuri, Frank Cuttitta, Stefanie N Voge. IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 6. 2007-05-22. PMID:17339457. |
pharmacologic inhibition of stat3 and caspase-1 abolished gliotoxin-induced apoptosis in irf-2(-/-) macrophages. |
2007-05-22 |
2023-08-12 |
mouse |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor stat3 and promotes apoptosis in neoplastic b-cells and b-cell precursors exposed to oxidative stress. |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
the present study examined whether btk mediates apoptosis during oxidative stress by interfering with the anti-apoptotic function of signal transducer and activator of transcription 3 (stat3). |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
similarly, while the btk-positive nalm-6 human leukaemic b-cell precursor cell line showed no stat3 activation after pv treatment and was exquisitely sensitive to pv-induced apoptosis, pv failed to induce apoptosis in btk-deficient ramos-1 human lymphoma b-cells that showed a robust stat3 response. |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
these results provide unprecedented biochemical and genetic evidence for a unique mode of cross-talk that occurs between btk and stat3 pathways during oxidative stress, whereby btk may trigger apoptosis via negative regulation of the anti-apoptotic stat3 activity. |
2007-04-24 |
2023-08-12 |
human |