| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tin Lap Lee, Jason Yeh, Jay Friedman, Bin Yan, Xinping Yang, Ning T Yeh, Carter Van Waes, Zhong Che. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. International journal of cancer. vol 122. issue 9. 2008-03-18. PMID:18172861. |
over-expression of p53 together with inhibition of nf-kappab or stat3 induced greater increase in the bax/bcl-xl ratio and apoptosis than modulation of these transcription factors individually. |
2008-03-18 |
2023-08-12 |
Not clear |
| Ana Quaglino, Carolina Schere-Levy, Leonardo Romorini, Roberto P Meiss, Edith C Kordo. Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling. Breast cancer research : BCR. vol 9. issue 5. 2008-03-11. PMID:17925034. |
it has been demonstrated that leukemia inhibitory factor (lif) induces epithelium apoptosis through stat3 activation during mouse mammary gland involution. |
2008-03-11 |
2023-08-12 |
mouse |
| Akiko Onishi, Qianming Chen, Joseph O Humtsoe, Randall H Krame. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Experimental cell research. vol 314. issue 2. 2008-03-05. PMID:17961551. |
in squamous cell carcinoma of the head and neck (hnscc), stat3 signaling has been shown to inhibit apoptosis and induce a more aggressive phenotype through the activation of specific signaling pathways. |
2008-03-05 |
2023-08-12 |
Not clear |
| Qiang Cui, Wei Jiang, Yingxin Wang, Chen Lv, Jingjing Luo, Wei Zhang, Fang Lin, Yuexiang Yin, Rong Cai, Ping Wei, Cheng Qia. Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 47. issue 1. 2008-03-04. PMID:17935223. |
the constitutive activation of signal transducer and activator of transcription 3 (stat3) participates in carcinogenesis through up-regulation of genes encoding apoptosis inhibitors and cell cycle regulators, such as bcl-xl, cyclins d1 and d2, and c-myc. |
2008-03-04 |
2023-08-12 |
Not clear |
| Stephanie Kreis, Georg A Munz, Serge Haan, Peter C Heinrich, Iris Behrman. Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular cancer research : MCR. vol 5. issue 12. 2008-03-04. PMID:18171991. |
although stat3 activation was completely blocked with jak inhibitor i and to a lesser extent with the common jak inhibitor ag490, only the latter compound markedly decreased proliferation and induced apoptosis. |
2008-03-04 |
2023-08-12 |
Not clear |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in various cancers and plays a crucial role in oncogensis, including the activation of genes encoding apoptosis inhibitors and cell-cycle regulators. |
2008-02-11 |
2023-08-12 |
human |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
jak inhibitor ag490 inhibited activation of stat3 and markedly reduced cell viability without significant apoptosis. |
2008-02-11 |
2023-08-12 |
human |
| Olga A Timofeeva, Vadim Gaponenko, Stephen J Lockett, Sergey G Tarasov, Sheng Jiang, Christopher J Michejda, Alan O Perantoni, Nadya I Tarasov. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS chemical biology. vol 2. issue 12. 2008-01-31. PMID:18154267. |
activated stat3 may participate in oncogenesis by stimulating cell proliferation and resisting apoptosis, as well as promoting tumor angiogenesis, invasion, and migration. |
2008-01-31 |
2023-08-12 |
Not clear |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
trps1 regulates proliferation and apoptosis of chondrocytes through stat3 signaling. |
2008-01-23 |
2023-08-12 |
mouse |
| Hiroki Suemoto, Yasuteru Muragaki, Katsuhiro Nishioka, Misako Sato, Akira Ooshima, Shunji Itoh, Ikuji Hatamura, Michitaka Ozaki, Attila Braun, Erika Gustafsson, Reinhard Fässle. Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling. Developmental biology. vol 312. issue 2. 2008-01-23. PMID:17997399. |
our conclusion is supported (i) by sirna-mediated depletion of stat3 in trps1-deficient chondrocytes, which normalized the expression of cyclin d1 and bcl2, (ii) by overexpression of trps1 in atdc5 chondrocytes, which diminished stat3 levels and increased proliferation and apoptosis, and (iii) by mutational analysis of the gata-binding sites in the stat3 gene, which revealed that their integrity is critical for the direct association with trps1 and for trps1-mediated repression of stat3. |
2008-01-23 |
2023-08-12 |
mouse |
| Lena Thyrell, Velmurugesan Arulampalam, Linn Hjortsberg, Marianne Farnebo, Dan Grandér, Katja Pokrovskaja Tam. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Experimental cell research. vol 313. issue 19. 2008-01-02. PMID:17880940. |
ectopic expression of a form of stat3, stat3c, rescued u266-1984 cells from ifnalpha-induced apoptosis. |
2008-01-02 |
2023-08-12 |
Not clear |
| Lena Thyrell, Velmurugesan Arulampalam, Linn Hjortsberg, Marianne Farnebo, Dan Grandér, Katja Pokrovskaja Tam. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Experimental cell research. vol 313. issue 19. 2008-01-02. PMID:17880940. |
thus our data demonstrated that ifnalpha is able to interfere with il-6 signaling by inhibiting stat3 activity and that the abrogation of stat3 activity accounts for the ability of ifnalpha to induce apoptosis in myeloma cells. |
2008-01-02 |
2023-08-12 |
Not clear |
| Michele S Redell, Anna Tsimelzon, Susan G Hilsenbeck, David J Tweard. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. Journal of leukocyte biology. vol 82. issue 4. 2007-12-18. PMID:17634277. |
comparison of gene expression profiles of g-csf-stimulated, stat3alpha-overexpressing 32d cells with those of cells with normal stat3alpha expression revealed novel stat3 gene targets, which may contribute to neutrophil expansion and improved survival, most notably slc28a2, a purine nucleoside transporter, which is critical for maintenance of intracellular nucleotide levels and prevention of apoptosis, and gpr65, an acid-sensing, g protein-coupled receptor with pro-oncogenic and antiapoptotic functions. |
2007-12-18 |
2023-08-12 |
mouse |
| Mariko Kusaba, Kazuhiko Nakao, Takashi Goto, Daisuke Nishimura, Hiroshi Kawashimo, Hidetaka Shibata, Yasuhide Motoyoshi, Naota Taura, Tatsuki Ichikawa, Keisuke Hamasaki, Katsumi Eguch. Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis. Journal of hepatology. vol 47. issue 4. 2007-12-06. PMID:17602782. |
abrogation of constitutive stat3 activity sensitizes human hepatoma cells to trail-mediated apoptosis. |
2007-12-06 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
egf-induced apoptosis in a431 cells is dependent on stat1, but not on stat3. |
2007-11-28 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
the knockdown of stat3 did not alter cell growth or apoptosis. |
2007-11-28 |
2023-08-12 |
human |
| Pavel S Grudinkin, Valery V Zenin, Andrey V Kropotov, Viktoria N Dorosh, Nikolay N Nikolsk. EGF-induced apoptosis in A431 cells is dependent on STAT1, but not on STAT3. European journal of cell biology. vol 86. issue 10. 2007-11-28. PMID:17646016. |
taken together, our experiments prove the essential role of tyrosine phosphorylated stat1, but not of stat3, in egf-induced apoptosis in a431 cells. |
2007-11-28 |
2023-08-12 |
human |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
lbh589 selectively depleted proteins important in signaling cascades in cell lines harboring egfr kinase mutations, such as egfr, stat3, and akt, and these cells underwent apoptosis following exposure to lbh589. |
2007-11-27 |
2023-08-12 |
human |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
tgf-beta1-induced apoptosis and emt were associated with the activation of protein kinase a (pka) and signal transducers and activators of transcription 3 (stat3). |
2007-11-26 |
2023-08-12 |
Not clear |
| Yanan Yang, Xinchao Pan, Weiwei Lei, Jun Wang, Jian Shi, Fuqiang Li, Jianguo Son. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951175. |
inhibition of pka by specific pka inhibitor h89 or by pka inhibitor peptide blocked stat3 activation and suppressed tgf-beta1-induced apoptosis and emt. |
2007-11-26 |
2023-08-12 |
Not clear |