| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naoko Sumita, Toshinori Bito, Koichi Nakajima, Chikako Nishigor. Stat3 activation is required for cell proliferation and tumorigenesis but not for cell viability in cutaneous squamous cell carcinoma cell lines. Experimental dermatology. vol 15. issue 4. 2006-07-19. PMID:16512876. |
introduction of stat3 sirna into scc cells led to inhibition of growth and changes in morphology but did not induce apoptosis. |
2006-07-19 |
2023-08-12 |
mouse |
| Naoko Sumita, Toshinori Bito, Koichi Nakajima, Chikako Nishigor. Stat3 activation is required for cell proliferation and tumorigenesis but not for cell viability in cutaneous squamous cell carcinoma cell lines. Experimental dermatology. vol 15. issue 4. 2006-07-19. PMID:16512876. |
these findings demonstrate that stat3 plays a critical role in the tumorigenesis, but not in the cell survival, of scc cells and suggest that additional pro-apoptotic signals are necessary for the induction of apoptosis. |
2006-07-19 |
2023-08-12 |
mouse |
| Kathrin Zitzmann, Stephan Brand, Sebastian Baehs, Burkhard Göke, Jennifer Meinecke, Gerald Spöttl, Heinrich Meyer, Christoph J Auernhamme. Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells. Biochemical and biophysical research communications. vol 344. issue 4. 2006-07-19. PMID:16650825. |
similar to ifn-alpha, incubation of bon1 cells with il-28a (10 ng/ml) and il-29 (10 ng/ml) induced phosphorylation of stat1, stat2, and stat3, significantly decreased cell numbers in a proliferation assay, and induced apoptosis as demonstrated by poly(adp-ribose) polymerase (parp)-cleavage, caspase-3-cleavage, and dna-fragmentation. |
2006-07-19 |
2023-08-12 |
human |
| Akihiko Yoshimur. Signal transduction of inflammatory cytokines and tumor development. Cancer science. vol 97. issue 6. 2006-07-13. PMID:16734720. |
one function of nf-kappab and stat3 in tumor cells is the promotion of cell growth and cell survival through the induction of target genes, whose products promote cell division and inhibit apoptosis. |
2006-07-13 |
2023-08-12 |
Not clear |
| Jae Ho Lee, Dorothea Schütte, Gerald Wulf, Laszlo Füzesi, Heinz-Joachim Radzun, Stephan Schweyer, Wolfgang Engel, Karim Nayerni. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Human molecular genetics. vol 15. issue 2. 2006-07-12. PMID:16377660. |
gene silencing of piwil2 with its small interference rna suppressed stat3 and bcl-x(l) expression and induced apoptosis. |
2006-07-12 |
2023-08-12 |
mouse |
| Naijie Jing, David J Tweard. Targeting Stat3 in cancer therapy. Anti-cancer drugs. vol 16. issue 6. 2006-07-06. PMID:15930886. |
stat3 is constitutively activated in many human cancers where it functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors (e.g. |
2006-07-06 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Hironori Koga, Takato Ueno, Takafumi Yoshida, Michiko Maeyama, Takuji Torimura, Hirohisa Yano, Masamichi Kojiro, Michio Sat. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer research. vol 66. issue 9. 2006-07-05. PMID:16651438. |
these data suggested that luteolin targeted stat3 through dual pathways-the ubiquitin-dependent degradation in tyr(705)-phosphorylated stat3 and the gradual down-regulation in ser(727)-phosphorylated stat3 through inactivation of cdk5, thereby triggering apoptosis via up-regulation in fas/cd95. |
2006-07-05 |
2023-08-12 |
mouse |
| Peng Fang, Vivian Hwa, Ron G Rosenfel. Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16427044. |
interferon-gamma-induced dephosphorylation of stat3 and apoptosis are dependent on the mtor pathway. |
2006-06-08 |
2023-08-12 |
human |
| Peng Fang, Vivian Hwa, Ron G Rosenfel. Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16427044. |
strikingly, ifn-gamma-induced apoptosis and growth inhibition of m12 cells were associated with persistent suppression of the constitutive tyrosine-phosphorylated stat3 (py-stat3). |
2006-06-08 |
2023-08-12 |
human |
| Rebecca J Leeman, Vivian Wai Yan Lui, Jennifer Rubin Grandi. STAT3 as a therapeutic target in head and neck cancer. Expert opinion on biological therapy. vol 6. issue 3. 2006-06-06. PMID:16503733. |
in hnscc, stat3 alters the cell cycle, prevents apoptosis, and mediates the proliferation and survival of tumour cells. |
2006-06-06 |
2023-08-12 |
Not clear |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
resveratrol inhibits src and stat3 signaling and induces the apoptosis of malignant cells containing activated stat3 protein. |
2006-05-26 |
2023-08-12 |
mouse |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
analyses of resveratrol-treated malignant cells harboring constitutively-active stat3 reveal irreversible cell cycle arrest of v-src-transformed mouse fibroblasts (nih3t3/v-src), human breast (mda-mb-231), pancreatic (panc-1), and prostate carcinoma (du145) cell lines at the g0-g1 phase or at the s phase of human breast cancer (mda-mb-468) and pancreatic cancer (colo-357) cells, and loss of viability due to apoptosis. |
2006-05-26 |
2023-08-12 |
mouse |
| Soon-Tae Lee, Kon Chu, Dong-In Sinn, Keun-Hwa Jung, Eun-Hee Kim, Se-Jeong Kim, Jeong-Min Kim, Song-Yi Ko, Manho Kim, Jae-Kyu Ro. Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage. Journal of neurochemistry. vol 96. issue 6. 2006-05-10. PMID:16539688. |
these data suggests that epo treatment in ich induces better functional recovery with reducing perihematomal inflammation and apoptosis, coupled with activations of enos, stat3 and erk. |
2006-05-10 |
2023-08-12 |
human |
| Kathrine Abell, Christine J Watso. The Jak/Stat pathway: a novel way to regulate PI3K activity. Cell cycle (Georgetown, Tex.). vol 4. issue 7. 2006-05-04. PMID:15970662. |
stat3 is essential for the induction of apoptosis and, in the absence of stat3 or lif, expression of the p55alpha and p50alpha subunits is abrogated. |
2006-05-04 |
2023-08-12 |
mouse |
| Naijie Jing, Qiqing Zhu, Ping Yuan, Yidong Li, Li Mao, David J Tweard. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Molecular cancer therapeutics. vol 5. issue 2. 2006-05-04. PMID:16505101. |
signal transducer and activator of transcription 3 (stat3) is a critical mediator of oncogenic signaling activated frequently in many types of human cancer where it contributes to tumor cell growth and resistance to apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| James V Alvarez, Heidi Greulich, William R Sellers, Matthew Meyerson, David A Fran. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer research. vol 66. issue 6. 2006-05-03. PMID:16540667. |
inhibiting stat3 function increases apoptosis of these cells, suggesting that stat3 is necessary for their survival. |
2006-05-03 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
cd40 mediated human cholangiocyte apoptosis requires jak2 dependent activation of stat3 in addition to activation of jnk1/2 and erk1/2. |
2006-04-18 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
because stat3 has been implicated in liver regeneration we investigated this signalling pathway during cd40 mediated cholangiocyte apoptosis. |
2006-04-18 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
in conclusion, induction of cd40-mediated cholangiocyte apoptosis requires jak2-mediated phosphorylation of stat3 as well as sustained jnk1/2, erk1/2 activation. |
2006-04-18 |
2023-08-12 |
human |
| Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, William L Farra. Nuclear receptors as negative modulators of STAT3 in multiple myeloma. Cell cycle (Georgetown, Tex.). vol 4. issue 2. 2006-03-31. PMID:15655377. |
particularly, stat3 activated by il-6 has a key role in preventing apoptosis and stimulating growth of multiple myeloma cells. |
2006-03-31 |
2023-08-12 |
Not clear |