| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zsuzsanna S Nagy, Hallgeir Rui, Stanislaw M Stepkowski, James Karras, Robert A Kirke. A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 8. 2007-02-06. PMID:17015686. |
depletion of stat3 protein expression reduced tumor cell viability with protracted kinetics (72-96 h), while tunel assays demonstrated cell death occurred via apoptosis. |
2007-02-06 |
2023-08-12 |
human |
| Xiangde Li. STAT3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure. Biochemical and biophysical research communications. vol 353. issue 1. 2007-02-06. PMID:17173857. |
stat3 activation inhibits human bronchial epithelial cell apoptosis in response to cigarette smoke exposure. |
2007-02-06 |
2023-08-12 |
human |
| Sylvane Desrivières, Christian Kunz, Itamar Barash, Vida Vafaizadeh, Corina Borghouts, Bernd Grone. The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition. Journal of mammary gland biology and neoplasia. vol 11. issue 1. 2007-01-30. PMID:16947086. |
in the mammary gland, stat5-induced genes contribute mainly to the prolactin dependent lobulo-alveolar development, whereas stat3 induced genes control apoptosis during involution. |
2007-01-30 |
2023-08-12 |
mouse |
| Yang Lu, Satoru Fukuyama, Ryoko Yoshida, Takashi Kobayashi, Kazuko Saeki, Hiroshi Shiraishi, Akihiko Yoshimura, Giichi Takaes. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17028185. |
exogenous expression of the dominant negative form of stat3 but not stat1 suppressed lif-induced apoptosis of socs3(-/-) mefs, indicating that stat3 plays a critical role in apoptosis induction. |
2007-01-30 |
2023-08-12 |
Not clear |
| Yang Lu, Satoru Fukuyama, Ryoko Yoshida, Takashi Kobayashi, Kazuko Saeki, Hiroshi Shiraishi, Akihiko Yoshimura, Giichi Takaes. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. The Journal of biological chemistry. vol 281. issue 48. 2007-01-30. PMID:17028185. |
furthermore, we found that some of the stat3 target genes related to apoptosis and proliferation, such as bcl-2 and cyclin d1, were repressed upon lif treatment in socs3(-/-) cells. |
2007-01-30 |
2023-08-12 |
Not clear |
| H Yamashita, M Nishio, Y Ando, Z Zhang, M Hamaguchi, K Mita, S Kobayashi, Y Fujii, H Iwas. Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. Endocrine-related cancer. vol 13. issue 3. 2007-01-08. PMID:16954437. |
constitutively activated signal transducers and activators of transcription (stats), in particular stat3 and stat5, have been demonstrated to directly contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis in various cancers. |
2007-01-08 |
2023-08-12 |
human |
| H Yamashita, M Nishio, Y Ando, Z Zhang, M Hamaguchi, K Mita, S Kobayashi, Y Fujii, H Iwas. Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. Endocrine-related cancer. vol 13. issue 3. 2007-01-08. PMID:16954437. |
stat3 is essential in mammary gland epithelial cell apoptosis and involution, whereas stat5 is well established as a key factor in mammary epithelial cell growth and differentiation. |
2007-01-08 |
2023-08-12 |
human |
| Dennis C Otero, Valeria Poli, Michael David, Robert C Ricker. Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 10. 2007-01-05. PMID:17082570. |
cutting edge: inherent and acquired resistance to radiation-induced apoptosis in b cells: a pivotal role for stat3. |
2007-01-05 |
2023-08-12 |
mouse |
| Daniel G Rosen, Imelda Mercado-Uribe, Gong Yang, Robert C Bast, Hesham M Amin, Raymond Lai, Jinsong Li. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. vol 107. issue 11. 2006-12-19. PMID:17063503. |
signal transducer and activator of transcription 3 (stat3), which is a latent transcription factor that participates in the transcriptional activation of apoptosis and cell cycle progression, has been implicated as an oncogene in several neoplastic diseases. |
2006-12-19 |
2023-08-12 |
Not clear |
| Daniel G Rosen, Imelda Mercado-Uribe, Gong Yang, Robert C Bast, Hesham M Amin, Raymond Lai, Jinsong Li. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. vol 107. issue 11. 2006-12-19. PMID:17063503. |
the objectives of the current study were to examine the effect of stat3 activation on the phenotypic transformation of an immortalized, nontumorigenic ovarian epithelial cell line and to evaluate the expression of tyrosine-activated stat3 (pstat3) in tissue microarrays from 303 ovarian carcinomas to determine its prognostic relevance and to correlate its expression with several upstream oncogenes of stat3 and with the oncogenes involved in apoptosis and proliferation. |
2006-12-19 |
2023-08-12 |
Not clear |
| Aikaterini Anagnostopoulou, Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S Kim, Matthew Glenn, Andrew D Hamilton, Leda Rapti. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer letters. vol 242. issue 1. 2006-12-08. PMID:16377083. |
the results demonstrate that stat3 downregulation in vsrc transformed nih3t3 cells or in breast cancer lines harboring activated src induces apoptosis, which is evident at all densities but is more pronounced at post-confluence. |
2006-12-08 |
2023-08-12 |
Not clear |
| Aikaterini Anagnostopoulou, Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S Kim, Matthew Glenn, Andrew D Hamilton, Leda Rapti. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer letters. vol 242. issue 1. 2006-12-08. PMID:16377083. |
in normal cells on the other hand, stat3 inhibition at post-confluence caused apoptosis while in sparsely growing cells it induced merely a growth retardation. |
2006-12-08 |
2023-08-12 |
Not clear |
| Mark F McCarty, Keith I Bloc. Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy. Integrative cancer therapies. vol 5. issue 3. 2006-12-07. PMID:16880431. |
ultimately, more complex adjuvant regimens can be envisioned in which salicylates are used in conjunction with other nf-kappa antagonists and/or agents that target other mediators of down-regulated apoptosis in cancer, such as stat3; coadministration of salicylate and organic selenium may have intriguing potential in this regard. |
2006-12-07 |
2023-08-12 |
mouse |
| R A Mesa, A Tefferi, T S Lasho, D Loegering, R F McClure, H L Powell, N T Dai, D P Steensma, S H Kaufman. Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia. Leukemia. vol 20. issue 10. 2006-11-07. PMID:16871275. |
these results suggest that mutant jak2 contributes to mmm pathogenesis by constitutively phosphorylating stat3 and diminishing myeloid cell apoptosis. |
2006-11-07 |
2023-08-12 |
Not clear |
| Ashish Bhattacharjee, Bo Xu, David A Frank, Gerald M Feldman, Martha K Cathcar. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 6. 2006-10-24. PMID:16951338. |
furthermore, by transfecting monocytes with stat3 containing mutations in tyr705 or ser727 or with wild-type stat3, we demonstrated that both stat3 tyrosine and serine phosphorylations are required for optimal binding of stat3 with dna and maximal expression of 15-lipoxygenase, an important regulator of inflammation and apoptosis. |
2006-10-24 |
2023-08-12 |
human |
| Gu-Sheng Tang, Jian-Ming Cai, Jin Ni, Ying-Song Xiang, Jian-Guo Cui, Dan Zhu, Jun-Rui Don. [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16]. Ai zheng = Aizheng = Chinese journal of cancer. vol 25. issue 3. 2006-10-20. PMID:16536977. |
[effects of stat3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line b16]. |
2006-10-20 |
2023-08-12 |
mouse |
| Gu-Sheng Tang, Jian-Ming Cai, Jin Ni, Ying-Song Xiang, Jian-Guo Cui, Dan Zhu, Jun-Rui Don. [Effects of STAT3 antisense oligodeoxynucleotides on apoptosis and proliferation of mouse melanoma cell line B16]. Ai zheng = Aizheng = Chinese journal of cancer. vol 25. issue 3. 2006-10-20. PMID:16536977. |
this study was to observe the activation of stat3 protein in mouse melanoma cell line b16, human liver cancer cell lines smmc-7721 and hepg-2, human lung cancer cell line a549, and human cervical cancer cell line hela, and to investigate the effects of stat3 antisense oligodeoxynucleotides (asodn) on proliferation and apoptosis of b16 cells. |
2006-10-20 |
2023-08-12 |
mouse |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
integrin beta3-mediated src activation regulates apoptosis in iec-6 cells via akt and stat3. |
2006-08-25 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
the depletion of polyamines rapidly activates nf-kappab (nuclear factor kappab) and stat3 (signal transducer and activator of transcription 3), which is responsible for the observed decrease in apoptosis. |
2006-08-25 |
2023-08-12 |
Not clear |
| Yohei Matsuzaki, Yan Xu, Machiko Ikegami, Valérie Besnard, Kwon-Sik Park, William M Hull, Susan E Wert, Jeffrey A Whitset. Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 1. 2006-08-09. PMID:16785550. |
rna microarray analysis of type ii epithelial cells isolated from stat3(deltadelta) mice demonstrated significant changes in expression of numerous genes, including those genes regulating apoptosis, supporting the concept that the susceptibility of stat3-deficient mice to adenovirus was related to the role of stat3 in the regulation of cell survival. |
2006-08-09 |
2023-08-12 |
mouse |