| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tin Lap Lee, Jason Yeh, Carter Van Waes, Zhong Che. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Molecular cancer therapeutics. vol 5. issue 1. 2006-03-10. PMID:16432158. |
pharmacologic inhibitors of jak and mek and expression of socs-1 following demethylation or transient transfection inhibited stat3 activation and cell proliferation and induced cell apoptosis in corresponding cell lines. |
2006-03-10 |
2023-08-12 |
human |
| Joo Eun Jung, Hyun Gyu Lee, Ik Hyun Cho, Doo Hyun Chung, Sun-Hee Yoon, Young Mok Yang, Jung Weon Lee, Seongwon Choi, Jong-Wan Park, Sang-Kyu Ye, Myung-Hee Chun. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 10. 2006-03-06. PMID:15919761. |
therefore, these findings provide compelling evidence that a causal relationship exists between stat3 activation and hif-1-dependent angiogenesis and suggest that therapeutic modalities designed to disrupt stat3 signaling hold considerable promise for the blocking tumor growth and enhancing apoptosis of cancer cells and tissues. |
2006-03-06 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
the aim of the present study was to clarify the role of stat3 signalling in the protection of polyamine-depleted intestinal epithelial cells against tnf-alpha (tumour necrosis factor-alpha)-induced apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
inhibition of stat3 activation by ag490 or cell-membrane-permeant inhibitory peptide (ppylktk; where py represents phospho-tyr) increased the sensitivity of polyamine-depleted cells to apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
these results suggest that activation of stat3 in response to polyamine depletion increases the transcription and subsequent expression of anti-apoptotic bcl-2 and iap family proteins and thereby promotes survival of cells against tnf-alpha-induced apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Qingde Zhou, Salomon Ama. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infection and immunity. vol 74. issue 2. 2006-02-22. PMID:16428770. |
the expression of proteins involved in gene transcription (e.g., monocyte enhancer factor 2d [mef2d], signal transducer and activator of transcription 1 [stat1], stat3, stat6, and il enhancer binding factors [ilf3]), of protein kinases (e.g., mitogen-activated protein kinase 3 [mapk3], map3k8, double-stranded rna-activated protein kinase [prkr], and map2k4), and of proteins involved in immune responses (e.g., tnf super family member 6 [tnfsf6] and interferon-induced protein with tetratricopeptide repeat 4 [ifit4]), apoptosis (e.g., genes associated with retinoid interferon-induced mortality 19 [grim19]), and other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and ras-associated protein rab27a) was found to be modulated differentially by p. gingivalis, lps, and fima. |
2006-02-22 |
2023-08-12 |
human |
| Michal Marzec, Monika Kasprzycka, Andrzej Ptasznik, Pawel Wlodarski, Qian Zhang, Niels Odum, Mariusz A Wasi. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16170336. |
inhibition of alk enzymatic activity in t-cell lymphoma cells induces apoptosis and suppresses proliferation and stat3 phosphorylation independently of jak3. |
2006-02-16 |
2023-08-12 |
Not clear |
| Michal Marzec, Monika Kasprzycka, Andrzej Ptasznik, Pawel Wlodarski, Qian Zhang, Niels Odum, Mariusz A Wasi. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16170336. |
the inhibition of npm/alk activity resulted in malignant t cells in suppression of their growth, induction of apoptosis and inhibition of tyrosine phosphorylation of stat3, the key effector of the npm/alk-induced oncogenesis. |
2006-02-16 |
2023-08-12 |
Not clear |
| Tanya Gritsko, Ann Williams, James Turkson, Satoshi Kaneko, Tammy Bowman, Mei Huang, Sangkil Nam, Ibrahim Eweis, Nils Diaz, Daniel Sullivan, Sean Yoder, Steve Enkemann, Steven Eschrich, Ji-Hyun Lee, Craig A Beam, Jin Cheng, Susan Minton, Carlos A Muro-Cacho, Richard Jov. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397018. |
persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. |
2006-02-09 |
2023-08-12 |
human |
| Tanya Gritsko, Ann Williams, James Turkson, Satoshi Kaneko, Tammy Bowman, Mei Huang, Sangkil Nam, Ibrahim Eweis, Nils Diaz, Daniel Sullivan, Sean Yoder, Steve Enkemann, Steven Eschrich, Ji-Hyun Lee, Craig A Beam, Jin Cheng, Susan Minton, Carlos A Muro-Cacho, Richard Jov. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397018. |
to gain a better understanding of the role of constitutive stat3 signaling in breast cancer progression, we evaluated the expression profile of potential stat3-regulated genes that may confer resistance to apoptosis. |
2006-02-09 |
2023-08-12 |
human |
| Nills Diaz, Susan Minton, Charles Cox, Tammy Bowman, Tanya Gritsko, Roy Garcia, Ibrahim Eweis, Marek Wloch, Sandy Livingston, Ed Seijo, Alan Cantor, Ji-Hyun Lee, Craig A Beam, Daniel Sullivan, Richard Jove, Carlos A Muro-Cach. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397019. |
constitutive activation of signal transducer and activator of transcription 3 (stat3) protein has been observed in a wide variety of tumors, including breast cancer, and contributes to oncogenesis at least in part by prevention of apoptosis. |
2006-02-09 |
2023-08-12 |
Not clear |
| Eric B Haura, Zhong Zheng, Lanxi Song, Alan Cantor, Gerold Beple. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 23. 2006-01-24. PMID:16322287. |
we evaluated stat3 activation in early stage non-small cell lung cancers (nsclc) and how this relates to upstream epidermal growth factor receptor (egfr) activation, tumor apoptosis, and prognosis. |
2006-01-24 |
2023-08-12 |
Not clear |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
transcript levels of the genes encoding leptin receptor (lepr), signal transducer and activator of transcription (stat3), bcl2 associated x-protein (bax), and baculoviral inhibitor of apoptosis protein repeat-containing 4 (birc4, also known as xiap), were determined by reverse transcriptase-quantitative polymerase chain reaction analysis of expanded and hatched blastocysts. |
2006-01-23 |
2023-08-12 |
cattle |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
in conclusion, leptin improved the ability of the oocyte to sustain embryonic development and had long-term effects on blastocyst apoptosis and transcript abundance of lepr, stat3, and apoptosis-associated genes. |
2006-01-23 |
2023-08-12 |
cattle |
| Wangrong Wen, Shengting Chen, Yan Cao, Yonghua Zhu, Yukiyo Yamamot. HIV-1 infection initiates changes in the expression of a wide array of genes in U937 promonocytes and HUT78 T cells. Virus research. vol 113. issue 1. 2005-12-27. PMID:15885842. |
these genes encode a host of proteins with divergent functions in a variety of cellular processes including apoptosis (fas, fas ligand, pin, hsp90beta, bcl-2, bcl-x), cell signal transduction (ras, rgs1, irf-1, stat3), receptor-mediated signaling transduction (cd71, cd69, cd3delta), cell cycle and growth (c-myc, cytokines, kinase), transcriptional regulation (ews, creb-2), and chemotaxis (beta-chemokines, rantes), supporting the general effects of hiv-1 infection on cells of different origin. |
2005-12-27 |
2023-08-12 |
human |
| Adina Vultur, Rozanne Arulanandam, James Turkson, Guilian Niu, Richard Jove, Leda Rapti. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15917293. |
inhibition of src activity led to stat3 down-regulation as well as apoptosis of sparsely growing, tag-transformed cells. |
2005-12-12 |
2023-08-12 |
Not clear |
| Adina Vultur, Rozanne Arulanandam, James Turkson, Guilian Niu, Richard Jove, Leda Rapti. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15917293. |
direct stat3 inhibition on the other hand induced apoptosis very effectively in confluent cells, which could have significant therapeutic implications. |
2005-12-12 |
2023-08-12 |
Not clear |
| Sheng-Hua Wu, Chao Lu, Ling Dong, Guo-Ping Zhou, Zha-Guang He, Zi-Qing Che. High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. Prostaglandins, leukotrienes, and essential fatty acids. vol 73. issue 2. 2005-12-05. PMID:15936930. |
rat renal interstitial fibroblasts (nrk-49f cells) were exposed to lxa4 in 5% fcs for 24 h. lxa4 at 0.1 and 1 microm induced 9.83% and 33.82% apoptosis of the cells, respectively, upregulated the expression of calpain 10 and smac, the levels of [ca2+]i and activity of caspase-3, and downregulated the activity of stat3 and threonine phosphorylated akt1. |
2005-12-05 |
2023-08-12 |
rat |
| Mrinal K Ghosh, Pankaj Sharma, Phyllis C Harbor, Shaik O Rahaman, S Jaharul Haqu. PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. vol 24. issue 49. 2005-12-01. PMID:16007122. |
blockade of egfr activation inhibited the activation of both akt and stat3 in u87 and d54 gbm cells and induced spontaneous apoptosis, which were associated with reduction in the steady-state level of mcl-1. |
2005-12-01 |
2023-08-12 |
Not clear |
| James Turkson, Shumin Zhang, Linda B Mora, Audrey Burns, Said Sebti, Richard Jov. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. The Journal of biological chemistry. vol 280. issue 38. 2005-11-28. PMID:16046414. |
a novel platinum compound inhibits constitutive stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. |
2005-11-28 |
2023-08-12 |
mouse |