| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana M Gamero, Ramesh Potla, Joanna Wegrzyn, Magdelena Szelag, Andrea E Edling, Kazuya Shimoda, Daniel C Link, Jozef Dulak, Darren P Baker, Yoshinari Tanabe, Jason M Grayson, Andrew C Larne. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16601124. |
in contrast to ifnbeta-stimulated tyrosine phosphorylation of stat1 and stat2, stat3 tyrosine phosphorylation is defective in tyk2(-/-) pro-b cells, suggesting that this stat family member is required for apoptosis. |
2006-08-01 |
2023-08-12 |
mouse |
| Ana M Gamero, Ramesh Potla, Joanna Wegrzyn, Magdelena Szelag, Andrea E Edling, Kazuya Shimoda, Daniel C Link, Jozef Dulak, Darren P Baker, Yoshinari Tanabe, Jason M Grayson, Andrew C Larne. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. The Journal of biological chemistry. vol 281. issue 24. 2006-08-01. PMID:16601124. |
these results demonstrate an important role of tyk2-mediated tyrosine phosphorylation of stat3 in the ability of ifnbeta to stimulate apoptosis of primary pro-b cells. |
2006-08-01 |
2023-08-12 |
mouse |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
in vivo studies have shown that stat5 contributes to prolactin-dependent lobuloalveolar development and lactation whereas stat3 mediates lif-dependent epithelial apoptosis during postlactational involution. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
thus, using conditionally active stat3- or stat5a-gyraseb fusion proteins, we observed that enforced and specific dimerization of stat3 induced apoptosis whereas stat5 induced differentiation of mammary epithelial cells. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
furthermore, stat5 attenuated apoptosis mediated by lif, the physiological inducer of stat3. |
2006-07-31 |
2023-08-12 |
Not clear |
| Richard W E Clarkson, Marion P Boland, Ekaterini A Kritikou, Jennifer M Lee, Tom C Freeman, Paul G Tiffen, Christine J Watso. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Molecular endocrinology (Baltimore, Md.). vol 20. issue 3. 2006-07-31. PMID:16293640. |
these data illustrate that specific activation of stat3 and stat5 alone is sufficient to induce and suppress apoptosis, respectively, and that these transcription factors elicit their actions by inducing distinct subsets of target genes in mammary epithelial cells. |
2006-07-31 |
2023-08-12 |
Not clear |
| Lanxi Song, Mark Morris, Tapan Bagui, Francis Y Lee, Richard Jove, Eric B Haur. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740687. |
the induction of apoptosis in these egfr-mutant cell lines corresponds to down-regulation of activated akt and stat3 survival proteins. |
2006-07-27 |
2023-08-12 |
human |
| Markus J Riemenschneider, Rebecca A Betensky, Saskia M Pasedag, David N Loui. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer research. vol 66. issue 11. 2006-07-27. PMID:16740698. |
mtor activation results in subsequent activation of s6k and stat3, as well as suppression (i.e., phosphorylation) of 4e-bp1, leading to cell cycle progression and inhibition of apoptosis. |
2006-07-27 |
2023-08-12 |
human |
| Deeba N Syed, Arshi Malik, Naghma Hadi, Sami Sarfaraz, Farrukh Afaq, Hasan Mukhta. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochemistry and photobiology. vol 82. issue 2. 2006-07-20. PMID:16613491. |
signal transducers and activators of transcription 3 (stat3), protein kinase b/akt and map kinases (mapks), which are activated by a variety of factors, modulate cell proliferation, apoptosis and other biological activities. |
2006-07-20 |
2023-08-12 |
human |
| Naoko Sumita, Toshinori Bito, Koichi Nakajima, Chikako Nishigor. Stat3 activation is required for cell proliferation and tumorigenesis but not for cell viability in cutaneous squamous cell carcinoma cell lines. Experimental dermatology. vol 15. issue 4. 2006-07-19. PMID:16512876. |
introduction of stat3 sirna into scc cells led to inhibition of growth and changes in morphology but did not induce apoptosis. |
2006-07-19 |
2023-08-12 |
mouse |
| Naoko Sumita, Toshinori Bito, Koichi Nakajima, Chikako Nishigor. Stat3 activation is required for cell proliferation and tumorigenesis but not for cell viability in cutaneous squamous cell carcinoma cell lines. Experimental dermatology. vol 15. issue 4. 2006-07-19. PMID:16512876. |
these findings demonstrate that stat3 plays a critical role in the tumorigenesis, but not in the cell survival, of scc cells and suggest that additional pro-apoptotic signals are necessary for the induction of apoptosis. |
2006-07-19 |
2023-08-12 |
mouse |
| Kathrin Zitzmann, Stephan Brand, Sebastian Baehs, Burkhard Göke, Jennifer Meinecke, Gerald Spöttl, Heinrich Meyer, Christoph J Auernhamme. Novel interferon-lambdas induce antiproliferative effects in neuroendocrine tumor cells. Biochemical and biophysical research communications. vol 344. issue 4. 2006-07-19. PMID:16650825. |
similar to ifn-alpha, incubation of bon1 cells with il-28a (10 ng/ml) and il-29 (10 ng/ml) induced phosphorylation of stat1, stat2, and stat3, significantly decreased cell numbers in a proliferation assay, and induced apoptosis as demonstrated by poly(adp-ribose) polymerase (parp)-cleavage, caspase-3-cleavage, and dna-fragmentation. |
2006-07-19 |
2023-08-12 |
human |
| Akihiko Yoshimur. Signal transduction of inflammatory cytokines and tumor development. Cancer science. vol 97. issue 6. 2006-07-13. PMID:16734720. |
one function of nf-kappab and stat3 in tumor cells is the promotion of cell growth and cell survival through the induction of target genes, whose products promote cell division and inhibit apoptosis. |
2006-07-13 |
2023-08-12 |
Not clear |
| Jae Ho Lee, Dorothea Schütte, Gerald Wulf, Laszlo Füzesi, Heinz-Joachim Radzun, Stephan Schweyer, Wolfgang Engel, Karim Nayerni. Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Human molecular genetics. vol 15. issue 2. 2006-07-12. PMID:16377660. |
gene silencing of piwil2 with its small interference rna suppressed stat3 and bcl-x(l) expression and induced apoptosis. |
2006-07-12 |
2023-08-12 |
mouse |
| Naijie Jing, David J Tweard. Targeting Stat3 in cancer therapy. Anti-cancer drugs. vol 16. issue 6. 2006-07-06. PMID:15930886. |
stat3 is constitutively activated in many human cancers where it functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors (e.g. |
2006-07-06 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Hironori Koga, Takato Ueno, Takafumi Yoshida, Michiko Maeyama, Takuji Torimura, Hirohisa Yano, Masamichi Kojiro, Michio Sat. Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids. Cancer research. vol 66. issue 9. 2006-07-05. PMID:16651438. |
these data suggested that luteolin targeted stat3 through dual pathways-the ubiquitin-dependent degradation in tyr(705)-phosphorylated stat3 and the gradual down-regulation in ser(727)-phosphorylated stat3 through inactivation of cdk5, thereby triggering apoptosis via up-regulation in fas/cd95. |
2006-07-05 |
2023-08-12 |
mouse |
| Peng Fang, Vivian Hwa, Ron G Rosenfel. Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16427044. |
interferon-gamma-induced dephosphorylation of stat3 and apoptosis are dependent on the mtor pathway. |
2006-06-08 |
2023-08-12 |
human |
| Peng Fang, Vivian Hwa, Ron G Rosenfel. Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16427044. |
strikingly, ifn-gamma-induced apoptosis and growth inhibition of m12 cells were associated with persistent suppression of the constitutive tyrosine-phosphorylated stat3 (py-stat3). |
2006-06-08 |
2023-08-12 |
human |
| Rebecca J Leeman, Vivian Wai Yan Lui, Jennifer Rubin Grandi. STAT3 as a therapeutic target in head and neck cancer. Expert opinion on biological therapy. vol 6. issue 3. 2006-06-06. PMID:16503733. |
in hnscc, stat3 alters the cell cycle, prevents apoptosis, and mediates the proliferation and survival of tumour cells. |
2006-06-06 |
2023-08-12 |
Not clear |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
resveratrol inhibits src and stat3 signaling and induces the apoptosis of malignant cells containing activated stat3 protein. |
2006-05-26 |
2023-08-12 |
mouse |