| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiwei Zhang, Bo Li, Shuqin Wu, Yuxin Yang, Binkang Wu, Qi Lai, Fuchong Lai, Fengbo Mo, Yufei Zhong, Song Wang, Runsheng Guo, Bin Zhan. Bergenin protects against osteoarthritis by inhibiting STAT3, NF-κB and Jun pathways and suppressing osteoclastogenesis. Scientific reports. vol 14. issue 1. 2024-08-31. PMID:39217193. |
ber suppressed il-1β-induced chondrocyte apoptosis and extracellular matrix catabolism by inhibiting the stat3, nf-κb and jun signalling pathway in vitro. |
2024-08-31 |
2024-09-04 |
mouse |
| Samarpana Chakraborty, Claudia Morganti, Bianca Rivera Pena, Hui Zhang, Divij Verma, Kimberly Zaldana, Nadege Gitego, Feiyang Ma, Srinivas Aluri, Kith Pradhan, Shanisha Gordon, Ioannis Mantzaris, Mendel Goldfinger, Eric Feldman, Kira Gritsman, Yang Shi, Stefan Hubner, Yi Hua Qiu, Brandon D Brown, Anna Skwarska, Amit Verma, Marina Konopleva, Yoko Tabe, Evripidis Gavathiotis, Simona Colla, Jared Gollob, Joyoti Dey, Steven M Kornblau, Sergei B Koralov, Keisuke Ito, Aditi Shastr. A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211137. |
we have previously demonstrated that the transcription factor stat3 is upregulated in aml hematopoietic stem and progenitor cells (hspcs) and can be effectively targeted to induce apoptosis of these aberrant cells. |
2024-08-30 |
2024-09-04 |
Not clear |
| Samarpana Chakraborty, Claudia Morganti, Bianca Rivera Pena, Hui Zhang, Divij Verma, Kimberly Zaldana, Nadege Gitego, Feiyang Ma, Srinivas Aluri, Kith Pradhan, Shanisha Gordon, Ioannis Mantzaris, Mendel Goldfinger, Eric Feldman, Kira Gritsman, Yang Shi, Stefan Hubner, Yi Hua Qiu, Brandon D Brown, Anna Skwarska, Amit Verma, Marina Konopleva, Yoko Tabe, Evripidis Gavathiotis, Simona Colla, Jared Gollob, Joyoti Dey, Steven M Kornblau, Sergei B Koralov, Keisuke Ito, Aditi Shastr. A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia. bioRxiv : the preprint server for biology. 2024-08-30. PMID:39211137. |
treatment with the stat3 degrader induced apoptosis in parental and ven-res aml cell lines and decreased mitochondrial depolarisation, and thereby dependency on mcl1 in ven-res aml cell line, as observed by bh3 profiling assay. |
2024-08-30 |
2024-09-04 |
Not clear |
| Muhammad Farooq Rai, Xin Duan, Mingming Yan, Robert H Brophy, Lei Ca. Loss of periostin function impairs ligament fibroblast activity and facilitates ROS-mediated cellular senescence. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 16. 2024-08-20. PMID:39162681. |
moreover, periostin deficiency triggered apoptosis through stat3 |
2024-08-20 |
2024-08-22 |
Not clear |
| Xiyue Wen, Jinyue H. Targeting STAT3 signaling pathway in the treatment of Alzheimer's disease with compounds from natural products. International immunopharmacology. vol 141. 2024-08-20. PMID:39163684. |
stat3, a multifunctional transcription factor, is involved in various cellular processes including inflammation, cell growth, and apoptosis. |
2024-08-20 |
2024-08-23 |
Not clear |
| Dongmei Qin, Chang Han, Yuefeng Gao, Hong Li, Liping Zh. Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism. Scientific reports. vol 14. issue 1. 2024-08-20. PMID:39164375. |
we found that lactucin induced apoptosis in hsc-t6 cells, and inhibition of nuclear translocation of stat3 and p-stat3. |
2024-08-20 |
2024-08-23 |
mouse |
| Hualong Mo, JieYing Liu, Zhengxi Su, Deng-Gao Zhao, Yan-Yan Ma, Kun Zhang, Qi Wang, Chun Fu, Yao Wang, Meiwan Chen, Burong H. Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy. European journal of medicinal chemistry. vol 277. 2024-08-15. PMID:39146833. |
compound 18 is identified as a highly potent dual signal transducer and activator of transcription 3 (stat3)/histone deacetylases (hdac) inhibitor and induces autophagy and apoptosis. |
2024-08-15 |
2024-08-18 |
Not clear |
| Jinxia Wu, Ailu Feng, Chunyang Liu, Wenxiu Zhou, Kexue Li, Yan Liu, Yue Shi, Joseph Adu-Amankwaah, Hongli Yu, Xiuhua Pan, Hong Su. Genistein alleviates doxorubicin-induced cardiomyocyte autophagy and apoptosis via ERK/STAT3/c-Myc signaling pathway in rat model. Phytotherapy research : PTR. vol 38. issue 8. 2024-08-13. PMID:38818771. |
gen inhibited extracellular signal-regulated kinase1/2 (erk1/2)'s phosphorylation, increased the protein levels of stat3 and c-myc, and decreased the autophagy and apoptosis of cardiomyocytes. |
2024-08-13 |
2024-08-16 |
rat |
| Taha Monadi, Zahra Mohajer, Afsaneh Soltani, Mohammad Amin Khazeei Tabari, Azadeh Manayi, Mohammad Azadbakh. The influence of apigenin on cellular responses to radiation: From protection to sensitization. BioFactors (Oxford, England). 2024-08-12. PMID:39134426. |
it inhibits radiation-induced mammalian target of rapamycin activation, vascular endothelial growth factor (vegf), matrix metalloproteinase-2 (mmp), and stat3 expression, while promoting ampk, autophagy, and apoptosis, suggesting potential in cancer prevention. |
2024-08-12 |
2024-08-16 |
Not clear |
| Taha Monadi, Zahra Mohajer, Afsaneh Soltani, Mohammad Amin Khazeei Tabari, Azadeh Manayi, Mohammad Azadbakh. The influence of apigenin on cellular responses to radiation: From protection to sensitization. BioFactors (Oxford, England). 2024-08-12. PMID:39134426. |
as a radiosensitizer, apigenin inhibits tumor growth by inducing apoptosis, suppressing vegf-c, tumor necrosis factor alpha, and stat3, reducing mmp-2/9 activity, and inhibiting cancer cell glucose uptake. |
2024-08-12 |
2024-08-16 |
Not clear |
| Lujuan Pan, Zongshuai Qin, Qinghong Zhou, Pin Zheng, Hua Li, Xihan Zhou, Yueqiu Qi. Unlocking the Therapeutic Potential: Harnessing miR-125a-5p To Enhance Autophagy and Apoptosis in Pancreatic Cancer through Targeting STAT3. Journal of Cancer. vol 15. issue 15. 2024-08-12. PMID:39132168. |
unlocking the therapeutic potential: harnessing mir-125a-5p to enhance autophagy and apoptosis in pancreatic cancer through targeting stat3. |
2024-08-12 |
2024-08-14 |
Not clear |
| Orit Uziel, Lian Lipshtein, Zinab Sarsor, Einat Beery, Shaked Bogen, Meir Lahav, Alon Regev, Vitali Kliminski, Roded Sharan, Asia Gervits, Lorenzo Federico Signorini, Shai Shimony, Pia Raanani, Uri Rozovsk. Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells. Biomedicines. vol 12. issue 7. 2024-07-27. PMID:39061955. |
after 15 min, stat3 became phosphorylated, and there was a 40% decrease in apoptosis rate, indicating that il-6 activated the stat3-dependent anti-apoptotic pathway. |
2024-07-27 |
2024-07-29 |
Not clear |
| Yizi Li, Manlin Tian, Jaceline Gislaine Pires Sanches, Qingqing Zhang, Li Hou, Jun Zhan. Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000312. |
sorcin inhibits mitochondrial apoptosis by interacting with stat3 via nf-κb pathway. |
2024-07-13 |
2024-07-15 |
Not clear |
| Yizi Li, Manlin Tian, Jaceline Gislaine Pires Sanches, Qingqing Zhang, Li Hou, Jun Zhan. Sorcin Inhibits Mitochondrial Apoptosis by Interacting with STAT3 via NF-κB Pathway. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000312. |
sri interacting with stat3 inhibits apoptosis by the nf-κb pathway and further contributes to the proliferation in hcc, which offers a novel clue and a new potential therapeutic target for hcc. |
2024-07-13 |
2024-07-15 |
Not clear |
| Misaki Kabasawa, Masateru Furuta, Yuuka Ibayashi, Kaori Kanemaru, Haruki Kohatsu, Fumiyo Kuramochi, Kenji Yamatoya, Kazuya Nakata, Yoshikazu Nakamura, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Ryoko Takasawa, Susumu Kobayashi, Fumio Sugawara, Masahiko Ikekita, Kouji Kuramoch. Plakevulin a induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorganic & medicinal chemistry letters. 2024-07-12. PMID:38996938. |
plakevulin a induces apoptosis and suppresses il-6-induced stat3 activation in hl60 cells. |
2024-07-12 |
2024-07-15 |
human |
| Xianglei Fu, Yanbin Shi, Zili Gu, Hengchang Zang, Lian Li, Qingjie Wang, Yongjun Wang, Xiaogang Zhao, Hang Wu, Shengnan Qiu, Yankun Zhang, Jiamin Zhou, Xiangqin Chen, Hua Shen, Guimei Li. Immunotherapeutic hydrogel for co-delivery of STAT3 siRNA liposomes and lidocaine hydrochloride for postoperative comprehensive management of NSCLC in a single application. Asian journal of pharmaceutical sciences. vol 19. issue 3. 2024-07-06. PMID:38966285. |
once applied, msls strongly downregulated stat3 expression in the tumor microenvironment, resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the m1-like phenotype. |
2024-07-06 |
2024-07-08 |
mouse |
| Huize Zhang, Yong Li, Yi Li. An updated review of the pharmacological effects and potential mechanisms of hederagenin and its derivatives. Frontiers in pharmacology. vol 15. 2024-07-04. PMID:38962311. |
previous studies have confirmed that hg and its derivatives combat cancer by exerting cytotoxicity, inhibiting proliferation, inducing apoptosis, modulating autophagy, and reversing chemotherapy resistance in cancer cells, and the action targets involved mainly include stat3, aurora b, kif7, pi3k/akt, nf-κb, nrf2/are, drp1, and p-gp. |
2024-07-04 |
2024-07-10 |
Not clear |
| Manoj Kumar Baniya, Eun-Hee Kim, Kyung-Soo Chu. Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells. Frontiers in pharmacology. vol 15. 2024-06-28. PMID:38939837. |
terfenadine, a histamine h1 receptor antagonist, induces apoptosis by suppressing stat3 signaling in human colorectal cancer hct116 cells. |
2024-06-28 |
2024-06-30 |
human |
| Jianyu Lv, Yuchen Fu, Yu Ga, Chao Han, Yimeng Fan, Yuanyuan Wei, Sijia Hao, Zhihui Ha. Lianweng Granules Alleviate Intestinal Barrier Damage via the IL-6/STAT3/PI3K/AKT Signaling Pathway with Dampness-Heat Syndrome Diarrhea. Antioxidants (Basel, Switzerland). vol 13. issue 6. 2024-06-27. PMID:38929100. |
lwg targeted stat3 to inhibit inflammation, oxidative stress, and apoptosis in the colon, thereby restoring the intestinal barrier function to some extent and exerting a therapeutic effect on dhsd. |
2024-06-27 |
2024-06-29 |
mouse |
| Chuqing Li, Xia Liu, Jiali Li, Jia Lai, Jingyao Su, Bing Zhu, Buyun Gao, Yinghua Li, Mingqi Zha. Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway. Nutrients. vol 16. issue 12. 2024-06-27. PMID:38931321. |
conclusions: selenomethionine improved the regulation of ros-mediated apoptosis by modulating the expression of jak1/2, stat3, and bcl-xl, which led to the inhibition of apoptosis. |
2024-06-27 |
2024-06-29 |
human |