| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chia-Ling Li, Han-Yu Chen, Jiin-Cherng Yen, Sheng-Jie Yu, Ting-Yu Chou, Sih-Wen Yeh, Huai-Yu Chuang, Fang-Liang Huan. Stattic suppresses p‑STAT3 and induces cell death in T‑cell acute lymphoblastic leukemia. Molecular medicine reports. vol 31. issue 2. 2024-12-13. PMID:39670305. |
the effects of stattic on cell viability, stat3 phosphorylation, apoptosis and autophagy in t‑all cell lines, and on tumor growth in a xenograft mouse model of t‑all, were assessed. |
2024-12-13 |
2024-12-22 |
mouse |
| Susheel Kumar Nethi, Siddhant Kothadiya, Brianna M White, Satyanarayana Rachagani, Rizia Bardhan, Surya K Mallapragad. Polyanhydride Copolymer-Based Niclosamide Nanoparticles for Inhibiting Triple-Negative Breast Cancer: Metabolic Responses and Synergism with Paclitaxel. ACS applied materials & interfaces. 2024-12-12. PMID:39666980. |
nic nps effectively inhibited migration, proliferation, and clonogenicity in both murine and human tnbc cells, inducing apoptosis and suppressing stat3 signaling. |
2024-12-12 |
2024-12-22 |
mouse |
| Seul-Ki Kim, Yong-Jin Kwon, Eun-Bi Seo, Hyun-Seung Lee, Jie Ohn Sohn, Hyun Mu Shin, Sung Joon Kim, Sang-Kyu Y. Neuroprotective Effects of STAT3 Inhibitor on Hydrogen Peroxide-Induced Neuronal Cell Death via the ERK/CREB Signaling Pathway. Neurochemical research. vol 50. issue 1. 2024-12-08. PMID:39648181. |
this study investigates the neuroprotective potential of stat3 inhibition in reducing oxidative stress-induced neuronal damage and apoptosis, a major factor contributing to the onset and progression of neurodegenerative diseases, including alzheimer's disease (ad). |
2024-12-08 |
2024-12-11 |
Not clear |
| Seul-Ki Kim, Yong-Jin Kwon, Eun-Bi Seo, Hyun-Seung Lee, Jie Ohn Sohn, Hyun Mu Shin, Sung Joon Kim, Sang-Kyu Y. Neuroprotective Effects of STAT3 Inhibitor on Hydrogen Peroxide-Induced Neuronal Cell Death via the ERK/CREB Signaling Pathway. Neurochemical research. vol 50. issue 1. 2024-12-08. PMID:39648181. |
our findings demonstrate that stat3 inhibitors significantly enhance cell survival and reduce apoptosis in sh-sy5y cells exposed to hydrogen peroxide. |
2024-12-08 |
2024-12-11 |
Not clear |
| Saber Imani, Sargol Aminnezhad, Moslem Alikarami, Zahra Abedi, Iman Samei Mosleh, Mazaher Maghsoudloo, Zahra Taher. Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions. Scientific reports. vol 14. issue 1. 2024-11-28. PMID:39604570. |
proviral genes are involved in the akt, wnt, and stat3 pathways, while antiviral genes impact the ap-1, nf-κb, apoptosis, and ifn pathways. |
2024-11-28 |
2024-11-30 |
Not clear |
| Min-Che Tung, Ge-Man Chang, Wen-Chyi Dai, Chen-Hsuan Hsu, Hsiang-Chun Chang, Wei-Ting Yang, Yann-Jen Ho, Chien-Hsing Lu, Yi-Hsin Chen, Chia-Che Chan. Cryptotanshinone Suppresses the STAT3/BCL-2 Pathway to Provoke Human Bladder Urothelial Carcinoma Cell Death. Environmental toxicology. 2024-11-27. PMID:39601353. |
notably, ectopic expression of a dominant-active stat3 mutant (stat3-c) or bcl-2 alleviated cts-induced apoptosis and clonogenicity inhibition, thus confirming stat3 blockade as a pivotal mechanism of cts's cytotoxic action on bladder tcc cells. |
2024-11-27 |
2024-11-29 |
human |
| Sandra Maria Barbalho, Karina Torres Pomini, Enzo Pereira de Lima, Jéssica da Silva Camarinha Oliveira, Beatriz Leme Boaro, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Rose Eli Grassi Rici, Durvanei Augusto Maria, Jesselina Francisco Dos Santos Haber, Virgínia Maria Cavallari Strozze Catharin, Patrícia Cincotto Dos Santos Bueno, Eliana de Souza Bastos Mazuqueli Pereira, Ricardo de Alvares Goulart, Lucas Fornari Laurind. Fantastic Frogs and Where to Use Them: Unveiling the Hidden Cinobufagin's Promise in Combating Lung Cancer Development and Progression Through a Systematic Review of Preclinical Evidence. Cancers. vol 16. issue 22. 2024-11-27. PMID:39594713. |
specifically, cb was found to decrease cell viability and increase apoptosis in lung cancer cells by modulating key molecular pathways, including bcl-2, bax, cleaved caspases, caveolin-1, flot2, akt, stat3, and foxo1. |
2024-11-27 |
2024-11-29 |
human |
| Yoon-Jin Lee, Changyeol Lee, Dongsic Choi, Yeji Lee, Sang-Han Le. Effect of Soy Isoflavone on Prostate Cancer Cell Apoptosis Through Inhibition of STAT3, ERK, and AKT. Current issues in molecular biology. vol 46. issue 11. 2024-11-26. PMID:39590337. |
effect of soy isoflavone on prostate cancer cell apoptosis through inhibition of stat3, erk, and akt. |
2024-11-26 |
2024-11-29 |
Not clear |
| M Malarvannan, Sujith Unnikrishnan, S Monohar, V Ravichandiran, David Pau. Design and optimization strategies of PROTACs and its Application, Comparisons to other targeted protein degradation for multiple oncology therapies. Bioorganic chemistry. vol 154. 2024-11-26. PMID:39591691. |
abbreviations: protacs, proteolysis targeting chimeras; pk, pharmacokinetic; pd, pharmacodynamic; metap-2, (methionine aminopeptidase 2); bcl6, b-cell lymphoma 6; gcn5, general control nonderepressible 5; bkt, bruton's tyrosine kinase; bet, bromodomain and extra-terminal; ar, androgen or androgen receptor; er, estrogen or estrogen receptor; fda, food and drug administration; mcrpc, metastatic castration-resistant prostate cancer; stat3, signal transducer and activator of transcription 3; fak, focal adhesion kinase; poi, protein of interest; peg, polyethylene glycol; ups, ubiquitin-proteasome system; vhl, von hippel-lindau; crbn, cereblon; mdm2, mouse double minute 2 homologue; ciap, cellular inhibitor of apoptosis; rnf, ring finger protein; brd, bromodomain; cdk, cyclin-dependent kinase; pampa, parallel artificial membrane permeability studies; bret, bioluminescence resonance energy transfer; mcl, mantle cell lymphoma; mcl-1, myeloid cell leukemia 1; bcl-x |
2024-11-26 |
2024-11-29 |
mouse |
| ZeWei Zhong, XiaoHua Huang, Qiong Lan, WeiHua Che. Up-Regulated MiR-20b-5p Mitigates Cell Inflammation and Apoptosis in Allergic Rhinitis via STAT3. The Tohoku journal of experimental medicine. 2024-11-20. PMID:39566998. |
up-regulated mir-20b-5p mitigates cell inflammation and apoptosis in allergic rhinitis via stat3. |
2024-11-20 |
2024-11-23 |
Not clear |
| Monika Dawid, Karolina Pich, Natalia Respekta-Długosz, Wiktoria Gieras, Małgorzata Opydo, Tomasz Milewicz, Pascal Froment, Joëlle Dupont, Agnieszka Ra. Visfatin exerts an anti-proliferative and pro-apoptotic effect in the human placenta cells. Biology of reproduction. 2024-11-19. PMID:39561117. |
we studied placenta cells viability, proliferation, cell cycle, proliferation/apoptotic factors and insulin receptor (insr) expression, dna fragmentation, casp3/7 activity, and phosphorylation of erk1/2, akt, ampkα, stat3 with their involvement after pharmacological inhibition in visfatin action on proliferation and apoptosis. |
2024-11-19 |
2024-11-23 |
human |
| Ye Jin Cho, Beom Seok Han, Soyeon Ko, Min Seok Park, Yun Ji Lee, Sang Eun Kim, Pureunchowon Lee, Han Gyeol Go, Shinyoung Park, Hyunho Lee, Sohee Kim, Eun-Ran Park, Kyung Hee Jung, Soon-Sun Hon. Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer. International journal of molecular medicine. vol 55. issue 1. 2024-11-14. PMID:39540370. |
the results showed that the repositioning of aripiprazole inhibits cancer cell growth by blocking the stat3 signaling pathway and effectively enhancing cisplatin‑induced apoptosis, thereby suggesting that the combination of aripiprazole and cisplatin may be a potent chemotherapeutic strategy for the treatment of pancreatic cancer. |
2024-11-14 |
2024-11-17 |
Not clear |
| Yufei Jia, Yanhong Song, Hang Xue, Xingyue Li, Yinong Zhang, Shiyue Fan, Xu Yang, Zixuan Ding, Yue Qiu, Ziyi Wu, Ping Zha. Sevoflurane Postconditioning Mitigates Neuronal Hypoxic-Ischemic Injury via Regulating Reactive Astrocytic STAT3 Protein Modification. Chemico-biological interactions. 2024-11-13. PMID:39536892. |
the inhibitory effect on astrocytes suppressed stat3 nuclear translocation, reduced astrocyte reactivity, decreased the release of the inflammatory cytokines il6 and il-1β, attenuated neuronal apoptosis following hi insult, and improved neuron viability. |
2024-11-13 |
2024-11-17 |
rat |
| Jieyu Guo, Rongyi Huang, Yan Mei, Siao Lu, Jun Gong, Long Wang, Liqiong Ding, Hongnian Wu, Dan Pan, Wu Li. Application of stress granule core element G3BP1 in various diseases: A review. International journal of biological macromolecules. vol 282. issue Pt 5. 2024-11-12. PMID:39515684. |
as a multifunctional binding protein, g3bp1 has diverse biological functions, influencing cell proliferation, differentiation, apoptosis, and rna metabolism and serving as a crucial regulator in signaling pathways such as rac1-pak1, tsc-mtorc1, nf-κb, and stat3. |
2024-11-12 |
2024-11-17 |
Not clear |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. Correction: STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. 2024-11-07. PMID:39511405. |
correction: stat3 dictates β-cell apoptosis by modulating pten in streptozocin-induced hyperglycemia. |
2024-11-07 |
2024-11-16 |
Not clear |
| Hisham Al-Ward, Wei Chen, Wenxia Gao, Chunxue Zhang, Xueyan Yang, Yao Xiong, Xinyi Wang, Rafeq Agila, Hui Xu, Yi Eve Su. Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy? Stem cell reviews and reports. 2024-11-06. PMID:39503828. |
by modulating pathways such as nf-κb, stat3, and pi3k/akt, these mirnas influence neuroinflammatory processes, reduce neuronal apoptosis, and promote tissue repair. |
2024-11-06 |
2024-11-08 |
Not clear |
| Dandan Shi, Jiejing Tao, Shuli Man, Ning Zhang, Long Ma, Lanping Guo, Luqi Huang, Wenyuan Ga. Structure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy. Biochimica et biophysica acta. Reviews on cancer. 2024-11-05. PMID:39500413. |
in contrast, the phosphorylated stat3 at serine 727 site (sp-stat3) is found on the mitochondria, affects electron respiration transport chain activity and thereby prevents tumor cell apoptosis. |
2024-11-05 |
2024-11-08 |
human |
| Caiqi Zhao, Yan Bai, Wei Wang, Gaurang M Amonkar, Hongmei Mou, Judith Olejnik, Adam J Hume, Elke Mühlberger, Nicholas W Lukacs, Rachel Fearns, Paul H Lerou, Xingbin A. Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484716. |
activation of stat3 and blockade of apoptosis rendered protection against severe rsv infection in infant bronchial epithelium. |
2024-11-01 |
2024-11-03 |
mouse |
| Raymond J Pickles, Gang Chen, Scott H Randel. Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484717. |
using precision cut lung slices (pcls) and air-liquid interface (ali) airway epithelial cell cultures, the authors showed that impaired stat3 activation in rsv-infected pediatric multiciliated cells increased cell apoptosis and viral shedding, which enhanced the spread of infection. |
2024-11-01 |
2024-11-03 |
mouse |
| Raymond J Pickles, Gang Chen, Scott H Randel. Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484717. |
bolstering stat3 activation and treatment of neonatal mice with apoptosis inhibitors suppressed virus spread, suggesting that enhancing stat3 activation may provide therapeutic benefit. |
2024-11-01 |
2024-11-03 |
mouse |