| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xijun Guo, Leping He, Weifeng Xu, Wanrong Wang, Xiaoli Feng, Yuanfeng Fu, Xiaofan Zhang, Ren-Bo Ding, Xingzhu Qi, Jiaolin Bao, Sulan Lu. αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis. Marine drugs. vol 22. issue 6. 2024-06-26. PMID:38921563. |
αo-conotoxin gexiva[1,2] suppresses in vivo tumor growth of triple-negative breast cancer by inhibiting akt-mtor, stat3 and nf-κb signaling mediated proliferation and inducing apoptosis. |
2024-06-26 |
2024-06-29 |
Not clear |
| Toshimichi Onuma, Meshach Asare-Werehene, Yuko Fujita, Yoshio Yoshida, Benjamin K Tsan. Plasma Gelsolin Inhibits Natural Killer Cell Function and Confers Chemoresistance in Epithelial Ovarian Cancer. Cells. vol 13. issue 11. 2024-06-19. PMID:38891037. |
the immunoregulatory effects of pgsn on nk cells were assessed using apoptosis assay, cytokine secretion, immune checkpoint-receptor expression, and phosphorylation of stat3. |
2024-06-19 |
2024-06-21 |
Not clear |
| Shuwen Kuang, Jiajun Zhang, Ning Huang, Jing Zhang, Bo Chen, Liming Wang, Mei Li. The cumulative antitumor effects of regorafenib and radiotherapy in hepatocellular carcinoma. Molecular carcinogenesis. 2024-06-05. PMID:38837427. |
in this study, we explored whether regorafenib and rt exert a synergetic effect on the treatment of hcc. the antitumor effect and mechanisms of the combination of regorafenib and rt were verified in a xenograft mouse model in vivo and in hcc cells in vitro. the combination treatment significantly inhibited cell proliferation and promoted apoptosis both in vitro and in vivo. pdgfrl, a potential target of regorafenib, was increased after cumulative treatment in hcc cells, and pdgfrl suppressed hcc cell proliferation and promoted apoptosis by inhibiting stat3 pathway activation. |
2024-06-05 |
2024-06-08 |
mouse |
| Na-Na Yin, Xin Chen, Ying-Yin Sun, Lei Yang, Ya-Fei Zhang, Xue-Ni Niu, Heng Song, Cheng Huang, Jun L. PSTPIP2 protects against alcoholic liver injury and invokes STAT3-mediated suppression of apoptosis. Biochemical pharmacology. 2024-06-02. PMID:38824967. |
in conclusion, our findings provide compelling evidence that pstpip2 has a regulatory role in hepatocyte apoptosis via the stat3 pathway in ali, suggesting pstpip2 as a promising therapeutic target for ali. |
2024-06-02 |
2024-06-05 |
mouse |
| Kun Zhao, Qi Zhao, Xinzhi Dai, Xue Wen, Xing Luo, Yi Duan, Zhihui Yang, Qiong Da. Alantolactone enhances the sensitivity of melanoma to MAPK pathway inhibitors by targeting inhibition of STAT3 activation and down-regulating stem cell markers. Cancer cell international. vol 24. issue 1. 2024-06-01. PMID:38822350. |
our results confirmed that alantolactone suppressed cell proliferation and promoted apoptosis by inhibiting stat3 feedback activation induced by mapki and downregulating the expression of downstream oct4 and sox2. |
2024-06-01 |
2024-06-02 |
Not clear |
| Kirti S Prabhu, Serah Jessy, Shilpa Kuttikrishnan, Farina Mujeeb, Zahwa Mariyam, Ummu Habeeba, Nuha Ahmad, Ajaz A Bhat, Shahab Uddi. Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794148. |
ps modulates several key cellular processes, including apoptosis, autophagy, cell migration and invasion, angiogenesis, and resistance to chemotherapy, targeting crucial signaling pathways such as those involving nf-κb, p53, and stat3, among others. |
2024-05-25 |
2024-05-27 |
human |
| Tingting Xua. Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling. Journal of physiological investigation. vol 67. issue 1. 2024-05-23. PMID:38780271. |
of note, the stat3 activator partially reversed the effects of trim11 depletion on the proliferation, apoptosis, and glycolysis in escc cells. |
2024-05-23 |
2024-05-27 |
human |
| Zhen Tian, Haoran Gao, Wenjun Xia, Zhaohui Lo. S1PR3 suppresses the inflammatory response and extracellular matrix degradation in human nucleus pulposus cells. Experimental and therapeutic medicine. vol 27. issue 6. 2024-05-18. PMID:38756905. |
in conclusion, stat3 overexpression suppressed viability injury, the inflammatory response and the level of apoptosis and alleviated ecm protein deposition in hnpcs through the tlr2/stat3 and tlr2/mapk pathways, which may offer a promising candidate for the amelioration of intervertebral disc degeneration. |
2024-05-18 |
2024-05-27 |
human |
| Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Le Mai Huong, Kwang Seok Ah. Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP-1 expression, and the STAT3 pathway. IUBMB life. 2024-05-06. PMID:38708996. |
kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ros production, shp-1 expression, and the stat3 pathway. |
2024-05-06 |
2024-05-08 |
Not clear |
| Hirotaka Fuchizawa, Kiyohiro Ando, Noriko Motoi, Toshihiko Iizuka, Masaharu Inoue, Kouki Mitani, Yuta Sano, Hisanori Takenobu, Masayuki Haruta, Ritsuko Onuki, Yoh Matsuoka, Takehiko Kamijo, Yukio Kageyam. STAT3 Contributes a Favorable Response to Pembrolizumab Through IFN-γ-induced Apoptosis in Urothelial Cancer. Anticancer research. vol 44. issue 5. 2024-04-27. PMID:38677727. |
stat3 contributes a favorable response to pembrolizumab through ifn-γ-induced apoptosis in urothelial cancer. |
2024-04-27 |
2024-04-30 |
Not clear |
| Rokeya Akter, Rackhyun Park, Soo Kyung Lee, Eun Ju Han, Kyu-Sang Park, Junsoo Park, Mee-Yon Ch. Upregulation of EMR1 (ADGRE1) by Tumor-Associated Macrophages Promotes Colon Cancer Progression by Activating the JAK2/STAT1,3 Signaling Pathway in Tumor Cells. International journal of molecular sciences. vol 25. issue 8. 2024-04-27. PMID:38673975. |
jak2/stat3 inhibition decreased the levels of emr1, jak2, stat1, and stat3, significantly impeded the proliferation, migration, and mobility of cells, and increased the apoptosis of emr1 |
2024-04-27 |
2024-04-29 |
Not clear |
| Juan Liu, Ye Huang, Zhong Li. [Curcumin Combined with Thalidomide Inhibits Proliferation of KG-1 Cells and Its Related Mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 32. issue 2. 2024-04-25. PMID:38660846. |
to investigate the effects of curcumin combined with thalidomide on the proliferation and apoptosis of acute myeloid leukemia kg-1 cells, and its correlation with b-cell lymphoma-xl (bcl-xl), signal transducer and activator of transcription 3 (stat3). |
2024-04-25 |
2024-04-28 |
Not clear |
| Bashir Ahmad, Chuan Tian, Ji-Xin Tang, John Sieh Dumbuya, Wen Li, Jun L. Anticancer activities of natural abietic acid. Frontiers in pharmacology. vol 15. 2024-04-18. PMID:38633616. |
these natural products have complex structures due to which they work against cancer through different molecular pathways, stat3, nf-kb, pi3k/akt/mtor, cell cycle arrest, mitochondrial dependent pathway, extrinsic apoptosis pathway, autophagy, mitophagy and ferroptosis. |
2024-04-18 |
2024-04-20 |
Not clear |
| Xuejiao Li, Hua Peng, Jianshu Kang, Xiaomei Sun, Jian Li. IL-1β induced down-regulation of miR-146a-5p promoted pyroptosis and apoptosis of corneal epithelial cell in dry eye disease through targeting STAT3. BMC ophthalmology. vol 24. issue 1. 2024-03-30. PMID:38553670. |
il-1β induced down-regulation of mir-146a-5p promoted pyroptosis and apoptosis of corneal epithelial cell in dry eye disease through targeting stat3. |
2024-03-30 |
2024-04-01 |
Not clear |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
sts pretreatment inhibited lps-stimulated pro-inflammatory cytokine secretion, reduced stat3 pathway related-proteins and apoptosis, increased mir-125b-5p and proopiomelanocortin expression, and enhanced microglia transformation from m1 to m2 phenotype in bv-2 cells. |
2024-03-29 |
2024-04-01 |
rat |
| Xiaofan Gu, Shanshan Lu, Meng Fan, Shuang Xu, Guangyu Lin, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhan. Compound Z526 alleviates chemotherapy-induced cachectic muscle loss by ameliorating oxidative stress-driven protein metabolic imbalance and apoptosis. European journal of pharmacology. 2024-03-29. PMID:38552940. |
the pharmacological effects of z526 were based on its potency in reducing oxidative stress in cachectic myocytes and muscle tissues, which inhibited the activation of nf-κb and stat3 to decrease atrogin-1-mediated protein degradation, activated the akt/mtor signaling pathway to promote protein synthesis, regulated bcl-2/bax ratio to reduce caspase-3-triggered apoptosis. |
2024-03-29 |
2024-04-01 |
mouse |
| Anqi Fan, Mengxiang Gao, Xuhuan Tang, Mengya Jiao, Chenchen Wang, Yingying Wei, Quan Gong, Jixin Zhon. HMGB1/RAGE axis in tumor development: unraveling its significance. Frontiers in oncology. vol 14. 2024-03-26. PMID:38529373. |
this axis is instrumental in tumor progression, promoting tumor cell proliferation, autophagy, metastasis, and angiogenesis while inhibiting apoptosis, through pivotal signaling pathways, including mapk, nf-κb, pi3k/akt, erk, and stat3. |
2024-03-26 |
2024-03-28 |
Not clear |
| Jiang Cao, Xiao Yu, Jingcheng Liu, Jiaju Fu, Binyu Wang, Chaoqin Wu, Sheng Zhang, Hongtao Chen, Zi Wang, Yinyang Xu, Tao Sui, Jie Chang, Xiaojian Ca. Ruxolitinib improves the inflammatory microenvironment, restores glutamate homeostasis, and promotes functional recovery after spinal cord injury. Neural regeneration research. vol 19. issue 11. 2024-03-25. PMID:38526286. |
additionally, in glutamate-induced excitotoxicity astrocytes, ruxolitinib restored eaat2 expression and increased glutamate uptake by inhibiting the activation of stat3, thereby reducing glutamate-induced neurotoxicity, calcium influx, oxidative stress, and cell apoptosis, and increasing the complexity of dendritic branching. |
2024-03-25 |
2024-03-27 |
mouse |
| Zhipan Liang, Qiuyun Chen, Liuying Pan, Xiaowei She, Tengfei Che. Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer. Journal of thoracic disease. vol 16. issue 2. 2024-03-20. PMID:38505087. |
mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated stat3 signaling downregulation in non-small cell lung cancer. |
2024-03-20 |
2024-03-23 |
Not clear |
| Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahman. Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules. Molecules (Basel, Switzerland). vol 29. issue 5. 2024-03-13. PMID:38474604. |
the studies have confirmed that luteolin can inhibit cancer-cell survival and proliferation, angiogenesis, invasion, metastasis, mtor/pi3k/akt, stat3, wnt/β-catenin, and cell-cycle arrest, and induce apoptosis. |
2024-03-13 |
2024-03-15 |
Not clear |