| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
upregulation of tumor suppressor pias3 by honokiol promotes tumor cell apoptosis via selective inhibition of stat3 tyrosine 705 phosphorylation. |
2023-12-11 |
2023-12-17 |
mouse |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
then sirna constructs specific for pias3, pias3 overexpression plasmid and the mutation of the stat3 tyr705 residue were used to confirm the mechanism of honokiol-induced apoptosis. |
2023-12-11 |
2023-12-17 |
mouse |
| Yue Fei, Xiaoyan Zhang, Xiaohui Wang, Yifei Sun, Jin He, Xia Liu, Zheng Song, Lanfang Li, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xianming Liu, Huilai Zhang, Xianhuo Wan. Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation. Journal of natural medicines. 2023-12-11. PMID:38082192. |
pias3 knockdown and overexpression in tumor cells altered stat3 activation and associated dna binding activity through the control of tyr705 phosphorylation via pias3-stat3 complex formation, ultimately shaping honokiol-induced tumor cell apoptosis. |
2023-12-11 |
2023-12-17 |
mouse |
| Sara Molenda, Agata Sikorska, Anna Florczak, Patryk Lorenc, Hanna Dams-Kozlowsk. Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer-Drug Carriers Matter. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067351. |
the constitutive activation of stat3 in cancer affects processes such as cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. |
2023-12-09 |
2023-12-17 |
Not clear |
| Zhifang Tang, Jingyuan Li, Chuan L. Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation. Biochemical genetics. 2023-12-09. PMID:38070024. |
results from the recovery assay showed that the re-activation of stat3 signaling by overexpressing fbxo2 or stat3 counteracted the alleviating effect of rbm47 downregulation on il-1β-induced inflammation, apoptosis, and ecm degradation. |
2023-12-09 |
2023-12-17 |
Not clear |
| Songxian Zhu, Jingjing Guo, Li Yu, Jun Liu, Jixiang Chen, Jinxin Xin, Yuqiang Zhang, Jie Luo, Chao Dua. Synergistic effect of cryptotanshinone and temozolomide treatment against human glioblastoma cells. Scientific reports. vol 13. issue 1. 2023-12-09. PMID:38071213. |
furthermore, cell viability, dna damage, apoptosis rate, and signal transducer and activator of transcription 3 (stat3) protein were measured using cytotoxic assay, comet assay, flow cytometry, and western blotting analysis, respectively. |
2023-12-09 |
2023-12-17 |
human |
| Zhengchen Jiang, Wanzhen Li, Shuna Yu, Xuyang Wang, Hongxin Jiang, Chen Bai, Ming Li, Fangfang Chu, Jiying Jiang, Xiaomin M. IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3. The international journal of biochemistry & cell biology. 2023-11-30. PMID:38036287. |
il-22 relieves hepatic ischemia-reperfusion injury by inhibiting mitochondrial apoptosis based on the activation of stat3. |
2023-11-30 |
2023-12-10 |
Not clear |
| Zhengchen Jiang, Wanzhen Li, Shuna Yu, Xuyang Wang, Hongxin Jiang, Chen Bai, Ming Li, Fangfang Chu, Jiying Jiang, Xiaomin M. IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3. The international journal of biochemistry & cell biology. 2023-11-30. PMID:38036287. |
this study aimed to explore the change of il-22 and il-22 receptor 1 (il-22r1) axis in hiri and its role in mitochondrial apoptosis associated with stat3 activation. |
2023-11-30 |
2023-12-10 |
Not clear |
| Jinxiang Liu, Dan Fei, Jie Xing, Juan D. Retraction notice to "MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3" [Biomed. Pharmacother. 96 (2017) 173-181]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023-11-26. PMID:38008610. |
retraction notice to "microrna-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing stat3" [biomed. |
2023-11-26 |
2023-11-28 |
Not clear |
| Chao Liang, Ying Bai, Rui Miao, Xuelian Yang, Lu Gao, Yafeng Liu, Jiawei Zhou, Jianqiang Guo, Dong Hu, Jing W. Celastrol as a candidate drug for silicosis: From bioinformatics and network pharmacology to experimental validation. International immunopharmacology. vol 125. issue Pt B. 2023-11-10. PMID:37948856. |
in vitro, celastrol suppressed cs-induced cytokine expression, apoptosis of macrophages and activation of stat3 and erk1/2 signals. |
2023-11-10 |
2023-11-20 |
mouse |
| J Arévalo, I Campoy, M Durán, S Nemours, A Areny, M Vall-Palomar, C Martínez, G Cantero-Recasens, A Mesegue. STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness. Scientific reports. vol 13. issue 1. 2023-11-09. PMID:37945711. |
the signal transducer and activator of transcription 3 (stat3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (y705) or serine 727 (s727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. |
2023-11-09 |
2023-11-20 |
human |
| Zhizhuan Guo, Wenwen Zhong, Zhengshou Zo. miR-98-5p Prevents Hippocampal Neurons from Oxidative Stress and Apoptosis by Targeting STAT3 in Epilepsy in vitro. Neuropsychiatric disease and treatment. vol 19. 2023-11-06. PMID:37928166. |
mir-98-5p prevents hippocampal neurons from oxidative stress and apoptosis by targeting stat3 in epilepsy in vitro. |
2023-11-06 |
2023-11-08 |
Not clear |
| Po-Chang Shih, Miyako Naganuma, Genichiro Tsuji, Yosuke Demizu, Mikihiko Nait. Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. Bioorganic & medicinal chemistry. vol 95. 2023-11-03. PMID:37922656. |
a double-stranded decoy oligonucleotide specific to stat3 was conjugated to e3 binders (pomalidomide, vh032, and lcl161) to generate protac molecules that recruited different e3 ubiquitin ligases cereblon (crbn), von hippel-lindau (vhl), and inhibitor of apoptosis protein (iap), respectively. |
2023-11-03 |
2023-11-08 |
Not clear |
| Linyan Xu, Jun Jiao, Mengdi Liu, Yuanyuan Qin, Meng Zhang, Dongmei Yan, Kailin Xu, Wei San. A Combination of CPI-0610 and SAHA Induces Apoptosis through STAT3 and p38 Signalling Pathways in Diffuse Large B-cell Lymphoma Cells. Current medicinal chemistry. 2023-11-02. PMID:37916635. |
a combination of cpi-0610 and saha induces apoptosis through stat3 and p38 signalling pathways in diffuse large b-cell lymphoma cells. |
2023-11-02 |
2023-11-08 |
Not clear |
| Rajina Shakya, Mi Ran Byun, Sang Hoon Joo, Kyung-Soo Chun, Joon-Seok Cho. Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling. Biomolecules & therapeutics. vol 31. issue 6. 2023-10-30. PMID:37899746. |
immunoblot analysis showed that domperidone-induced apoptosis occurred through the down-regulation of the phosphorylation of jak2 and stat3. |
2023-10-30 |
2023-11-08 |
human |
| Min Hee Yang, Gautam Sethi, Akshay Ravish, Arun Kumar Mohan, Vijay Pandey, Peter E Lobie, Shreeja Basappa, Basappa Basappa, Kwang Seok Ah. Discovery of imidazopyridine-pyrazoline-hybrid structure as SHP-1 agonist that suppresses phospho-STAT3 signaling in human breast cancer cells. Chemico-biological interactions. 2023-10-25. PMID:37879592. |
further, silencing of shp-1 gene reversed the dip-induced attenuation of stat3 activation and apoptosis. |
2023-10-25 |
2023-11-08 |
human |
| Shuaishuai Huang, Minyi Sun, Yu Ren, Ting Luo, Xue Wang, Guobin Weng, Dong Ce. Solamargine induces apoptosis of human renal carcinoma cells via downregulating phosphorylated STAT3 expression. Oncology letters. vol 26. issue 5. 2023-10-20. PMID:37854861. |
solamargine induces apoptosis of human renal carcinoma cells via downregulating phosphorylated stat3 expression. |
2023-10-20 |
2023-11-08 |
human |
| Qiang Gu, Ying-Bin Xiao, Yong Wan. Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells. Journal of physiology and biochemistry. 2023-10-19. PMID:37856074. |
in the study, we investigated the effect of socs3 on the p65 and stat3 signaling pathways and further examined the potential molecular mechanism involved in regulating apoptosis. |
2023-10-19 |
2023-11-08 |
Not clear |
| Bingge Zhang, Huali Wan, Maimaitijian Maierwufu, Qian Liu, Ting Li, Ye He, Xin Wang, Gongping Liu, Xiaoyue Hong, Qiong Fen. STAT3 ameliorates truncated tau-induced cognitive deficits. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843229. |
evidence suggests that signal transduction and activator of transcription-3 (stat3) is associated with modulating synaptic plasticity, cell apoptosis, and cognitive function. |
2023-10-16 |
2023-11-08 |
mouse |
| Xin-Yue Zhao, Ying-Ying Tian, Chuang Liu, Yi-Lin Li, Ying-Nan Lyu, Shang-Yue Yu, Shi-Qiu Tian, Hai-Luan Pei, Ze-Ping Zuo, Zhi-Bin Wan. [Morin induces autophagy and apoptosis in hepatocellular carcinoma cells through Akt/mTOR/STAT3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 16. 2023-10-06. PMID:37802874. |
this study investigated the effect and mechanism of morin in inducing autophagy and apoptosis in hepatocellular carcinoma cells through the protein kinase b(akt)/mammalian target of rapamycin(mtor)/signal transducer and activator of transcription protein 3(stat3) pathway. |
2023-10-06 |
2023-10-15 |
human |