| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengjun Zhou, You Zhou, Zhengxuan Huang, Ming Wang, Jie Jiang, Min Yan, Wei Xiang, Shenjie Li, Yang Yu, Ligang Chen, Jie Zhou, Wei Don. Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice. International immunopharmacology. vol 118. 2023-04-02. PMID:37004346. |
in this study, we found that notopterol inhibited growth and increased apoptosis of glioma via inhibiting stat3 activity. |
2023-04-02 |
2023-08-14 |
mouse |
| Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Zishun Zhan, Yisu Li, Shiqi Pan, Jishi Liu, Juan Tan. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochemical pharmacology. 2023-04-01. PMID:37003346. |
here, we found that lyn protected against renal tubular injury in cecal ligation and puncture (clp) induced aki mouse model by inhibition of signal transducer and activator of transcription 3 (stat3) phosphorylation and cell apoptosis. |
2023-04-01 |
2023-08-14 |
mouse |
| Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Zishun Zhan, Yisu Li, Shiqi Pan, Jishi Liu, Juan Tan. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochemical pharmacology. 2023-04-01. PMID:37003346. |
moreover, lyn agonist mlr-1023 pretreatment improved renal function, inhibited stat3 phosphorylation and decreased cell apoptosis. |
2023-04-01 |
2023-08-14 |
mouse |
| Wei Wei, Juanhong Wang, Pu Huang, Siqi Gou, Daihua Yu, Lei Zon. Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation. Immunogenetics. 2023-03-18. PMID:36933092. |
tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through stat3 activation. |
2023-03-18 |
2023-08-14 |
human |
| Wei Wei, Juanhong Wang, Pu Huang, Siqi Gou, Daihua Yu, Lei Zon. Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation. Immunogenetics. 2023-03-18. PMID:36933092. |
in the present study, we investigated whether tnf-α has a role in proliferation and apoptosis of colorectal cancer cells through stat3 activation. |
2023-03-18 |
2023-08-14 |
human |
| Wenliang Gong, Xinyu Li, Yuliang Feng, Ming Ji, Dianjun Zhang, Binjie Chen, Siman Wang, Xiafang Wu, Lulu Cui, Baoman Li, Maosheng Xi. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. Journal of psychiatric research. vol 161. 2023-03-18. PMID:36933445. |
additionally, leptin attenuated neuronal apoptosis by increasing the phosphorylation of signal transducer and activator of transcription 3 (stat3), which further elevated the expression of ucp2 and inhibited the mitochondrial production of ros induced by ptsd, thus reducing neuronal apoptosis and ameliorating ptsd-related behaviors. |
2023-03-18 |
2023-08-14 |
mouse |
| Mehrdokht Sadrkhanloo, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Rasoul Raesi, Motahhar Motahhary, Sam Saghari, Laleh Sharifi, Saied Bokaie, Sepideh Mirzaei, Maliheh Entezari, Amir Reza Aref, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Kiavash Hushmand. STAT3 signaling in prostate cancer progression and therapy resistance: An oncogenic pathway with diverse functions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2023-03-14. PMID:36916439. |
induction of stat3 signaling increases glycolysis and proliferation of prostate cancer cells and prevents apoptosis. |
2023-03-14 |
2023-08-14 |
Not clear |
| Jing Zhang, Yang Li, Ji-Guo Wang, Jing-Yu Feng, Guo-Dong Huang, Chang-Guo Lu. Dihydroartemisinin Affects STAT3/DDA1 Signaling Pathway and Reverses Breast Cancer Resistance to Cisplatin. The American journal of Chinese medicine. 2023-03-09. PMID:36891981. |
dha treatment repressed proliferation and induced apoptosis of ddp-resistant cells by suppressing stat3 phosphorylation; the inhibition ability was positively proportional to the dha concentration. |
2023-03-09 |
2023-08-14 |
Not clear |
| Jing Zhang, Yang Li, Ji-Guo Wang, Jing-Yu Feng, Guo-Dong Huang, Chang-Guo Lu. Dihydroartemisinin Affects STAT3/DDA1 Signaling Pathway and Reverses Breast Cancer Resistance to Cisplatin. The American journal of Chinese medicine. 2023-03-09. PMID:36891981. |
furthermore, knockdown of stat3 restrained proliferation and induced apoptosis and g0/g1 cell cycle arrest of ddp-resistant cells by targeting dda1. |
2023-03-09 |
2023-08-14 |
Not clear |
| Guanghua Xiong, Hongmei Hu, Haiyan Zhang, Jun'e Zhang, Zigang Cao, Huiqiang Lu, Xinjun Lia. Cyhalofop-butyl exposure induces the severe hepatotoxicity and immunotoxicity in zebrafish embryos. Fish & shellfish immunology. 2023-02-26. PMID:36842639. |
moreover, cyb induced zebrafish liver injury and increased hepatocyte apoptosis, which increased the protein expression levels of bax, tlr4, nf-kb p65 and stat3 in zebrafish. |
2023-02-26 |
2023-08-14 |
cat |
| Juan Huang, Chunhua Lv, Baoyu Zhao, Zhongqian Ji, Zhenran Ga. SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K/AKT signaling pathways. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-02-14. PMID:36785765. |
in conclusion, scara5 inhibited the proliferation and emt and induced the apoptosis of oscc cells through the inhibition of stat3 and pi3k/akt signaling pathways, thereby exerting a tumor suppressor effect. |
2023-02-14 |
2023-08-14 |
human |
| Jiaqi Wu, Danrui Xiao, Kaiwen Yu, Kudureti Shalamu, Ben He, Min Zhan. The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy. Acta biochimica et biophysica Sinica. 2023-02-14. PMID:36786072. |
our results demonstrate that mots-c treatment reduces the mrna levels of inflammatory cytokines ( il-1β, il-4, il-6, and tnfα) in cardiomyocytes and the levels of circulating myocardial injury markers, such as ck-mb and tnt, alleviates cardiomyocyte mitochondrial dysfunction and oxidative stress, reduces cardiomyocyte apoptosis, activates cardioprotection-related signaling pathways, including ampk, akt, and erk, and inhibits the inflammation-related signaling pathways jnk and stat3. |
2023-02-14 |
2023-08-14 |
Not clear |
| Young Song, Joseph Leem, Mehul Dhanani, M Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O Harrington, H Kirk Hammond, David M Roth, Hemal H Pate. Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models. PloS one. vol 18. issue 2. 2023-02-13. PMID:36780477. |
apoptosis and necrosis were increased in cells incubated with dauno-hf plasma for 24 h. down-regulation of voltage-dependent anion-selective channel (vdac)-1, translocase of outer membrane 20 (tom20), and mitochondrial fission factor (mff) in cells exposed to dauno-hf plasma and mitochondrial signal transducer and activator of transcription 3 (stat3) and mff in cells exposed to mi-hf plasma were observed. |
2023-02-13 |
2023-08-14 |
mouse |
| Hanwen Yang, Pengpeng Zhang, Qiang Wang, Ke Cheng, Yujun Zha. The research development of STAT3 in hepatic ischemia-reperfusion injury. Frontiers in immunology. vol 14. 2023-02-10. PMID:36761734. |
stat3 influences the mitochondria through multiple pathways and is also involved in apoptosis and other forms of programmed cell death. |
2023-02-10 |
2023-08-14 |
Not clear |
| Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen, Peng Ca. Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer. Journal of nanobiotechnology. vol 21. issue 1. 2023-02-05. PMID:36740689. |
intriguingly, the systemic administration of stat3/ekevs significantly suppressed subcutaneous pc9-gr4-azd1 tumor xenografts in nude mice by stat3 mediated apoptosis. |
2023-02-05 |
2023-08-14 |
mouse |
| Xueying Wang, Jiling Feng, Rong Wu, Jiaqi Tan, Qing Huang, Yeelin Phang, Li Zhang, Wenwei Fu, Hongxi Xu, Changwu Zhen. Garcinol and its analogues: Synthesis, cytotoxic activity and mechanistic investigation. Bioorganic chemistry. vol 133. 2023-02-02. PMID:36731298. |
cambogin and 21' were shown to have a greater capacity to cause apoptosis in pancreatic cancer bxpc3 cells, and the suppression of bxpc3 cells by 21' might be attributed to the target of stat3 signaling. |
2023-02-02 |
2023-08-14 |
Not clear |
| Chunxiao Li, Yu Xu, Tengjiao Gao, Shunyao Zhang, Zhe Lin, Shaobo Gu, Yi Fang, Xin Yuan, Siyi Yu, Qi Jiang, Zhongze Lou, Xiuming Zhang, Jie Zhang, Qiaoyan Wu, Mengli Gu, Xiaoyun Ding, Jing Sun, Yi Che. Ruxolitinib Alleviates Inflammation, Apoptosis, and Intestinal Barrier Leakage in Ulcerative Colitis via STAT3. Inflammatory bowel diseases. 2023-02-01. PMID:36721335. |
ruxolitinib alleviates inflammation, apoptosis, and intestinal barrier leakage in ulcerative colitis via stat3. |
2023-02-01 |
2023-08-14 |
Not clear |
| Yumeng Jiang, Zhuangzhuang Li, Qiang Ma, Wenqi Dong, Qingxiu Yao, Dongzhen Y. Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway. Biochemical pharmacology. 2023-01-31. PMID:36720354. |
inhibition of the stat3 signaling pathway with the inhibitor s3i-201 or sirna disrupted the protective effects of aucubin on cisplatin-induced apoptosis. |
2023-01-31 |
2023-08-14 |
mouse |
| Mustafa M M Elbakry, Nermeen M ElBakary, Sanaa A Hagag, Eman H A Hemid. Pomegranate Peel Extract Sensitizes Hepatocellular Carcinoma Cells to Ionizing Radiation, Induces Apoptosis and Inhibits MAPK, JAK/STAT3, β-Catenin/NOTCH, and SOCS3 Signaling. Integrative cancer therapies. vol 22. 2023-01-30. PMID:36710483. |
as a key player in tumor proliferation, and inflammatory cascade induction, the down-regulation of stat3 following treatment of irradiated and non-irradiated hepg2 cells with ppe as recorded in the present work resulted in reduction of tumor growth, via modulating inflammatory response manifested by (down-regulation of tlr4 expression and nfkb level), suppressing survival markers expressed by reduction of jak, notch1, β-catenin, socs3, and enhancing apoptosis (induction of tumor ppar-γ and caspase-3) followed by changes in redox tone (expressed by increase in nrf-2, sod and catalase activities, and decrease in mda concentration). |
2023-01-30 |
2023-08-14 |
Not clear |
| Wei Sun, Nai-Dan Zhang, Tong Zhang, Yan-Nan Li, Hui Xue, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Ying Wang, Cheng-Hao Ji. Cyanidin-3-O-Glucoside Induces the Apoptosis of Human Gastric Cancer MKN-45 Cells through ROS-Mediated Signaling Pathways. Molecules (Basel, Switzerland). vol 28. issue 2. 2023-01-21. PMID:36677726. |
in conclusion, c3g caused mkn-45 cells to undergo apoptosis; arrested the cell cycle in the g2/m phase; hindered cell migration; and activated the mapk, stat3, and nf-κb signaling pathways, by inducing an increase in ros levels. |
2023-01-21 |
2023-08-14 |
human |