| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao-Yu Hsu, Wei-Ting Yang, Ju-Hwa Lin, Chien-Hsing Lu, Kai-Cheng Hu, Tsuo-Hung Lan, Chia-Che Chan. Sertindole, an Antipsychotic Drug, Curbs the STAT3/BCL-xL Axis to Elicit Human Bladder Cancer Cell Apoptosis In Vitro. International journal of molecular sciences. vol 24. issue 14. 2023-07-29. PMID:37511611. |
moreover, bladder cancer cells overexpressing bcl-xl were refractory to sertindole's proapoptotic action, arguing that sertindole represses stat3 to downregulate bcl-xl, culminating in the induction of apoptosis. |
2023-07-29 |
2023-08-14 |
human |
| Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Yuanyuan Gao, Jiawei Chen, Lili Xie, Chaoyue Chen, Yangyang Guo, Yongheng Ba. STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage. International immunopharmacology. vol 123. 2023-07-29. PMID:37515849. |
the effects of combined application of gemcitabine and stat3 inhibition on the proliferation, apoptosis, migration, and invasion of pc cells (pccs) were investigated. |
2023-07-29 |
2023-08-14 |
Not clear |
| Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Yuanyuan Gao, Jiawei Chen, Lili Xie, Chaoyue Chen, Yangyang Guo, Yongheng Ba. STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage. International immunopharmacology. vol 123. 2023-07-29. PMID:37515849. |
stat3 inhibition enhanced mitochondrial-dependent apoptosis in gemcitabine-treated pccs, but did not induce autophagy and ferroptosis. |
2023-07-29 |
2023-08-14 |
Not clear |
| Kai-Di Wang, Miao-Lin Zhu, Cheng-Jiao Qin, Rui-Fang Dong, Cheng-Mei Xiao, Qing Lin, Rong-Yuan Wei, Xiao-Yu He, Xin Zang, Ling-Yi Kong, Yuan-Zheng Xi. Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the SSBP1 promoter region. British journal of pharmacology. 2023-07-28. PMID:37501645. |
sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of stat3 to the ssbp1 promoter region. |
2023-07-28 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. Correction to: PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2023-07-26. PMID:37491607. |
correction to: ppdpf promotes lung adenocarcinoma progression via inhibiting apoptosis and nk cell-mediated cytotoxicity through stat3. |
2023-07-26 |
2023-08-14 |
Not clear |
| Wenqiong Ma, Zexiu Wu, Mazaher Maghsoudloo, Iqra Ijaz, Marzieh Dehghan Shasaltaneh, Yuqin Zhang, Qiao Weng, Junjiang Fu, Saber Imani, Qing Lian We. Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways. PloS one. vol 18. issue 7. 2023-07-12. PMID:37432950. |
furthermore, in vitro, knockdown of dmkn inhibited the cell proliferation, migration, invasion, and apoptosis of mm cancer cells by the activation of erk/mapk signaling pathways and regulator of stat3 in downstream molecular. |
2023-07-12 |
2023-08-14 |
human |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating stat1 and stat3. |
2023-07-03 |
2023-08-14 |
mouse |
| Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yan. Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3. Archives of toxicology. 2023-07-03. PMID:37395757. |
in conclusion, our results indicate that apelin-13 could be a potential otoprotective agent to prevent cisplatin-induced ototoxicity by inhibiting apoptosis, ros production, tnf-α and il-6 expression, and regulating phosphorylation of stat1 and stat3 transcription factors. |
2023-07-03 |
2023-08-14 |
mouse |
| Chao Zhang, Hong-Ying Yang, Long Gao, Ming-Zhen Bai, Wen-Kang Fu, Chong-Fei Huang, Ning-Ning Mi, Hai-Dong Ma, Ya-Wen Lu, Ning-Zu Jiang, Liang Tian, Teng Cai, Yan-Yan Lin, Xing-Xing Zheng, Kun Gao, Jian-Jun Chen, Wen-Bo Men. Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma. Frontiers in pharmacology. vol 14. 2023-07-03. PMID:37397486. |
lanatoside c decelerates proliferation and induces apoptosis through inhibition of stat3 and ros-mediated mitochondrial membrane potential transformation in cholangiocarcinoma. |
2023-07-03 |
2023-08-14 |
Not clear |
| Mehrdad Hashemi, Sahar Abbaszadeh, Mohsen Rashidi, Nafisesadat Amini, Kasra Talebi Anaraki, Motahhar Motahhary, Ensi Khalilipouya, Abdorrahma Harif Nashtifani, Sasan Shafiei, Marzieh Ramezani Farani, Noushin Nabavi, Shokooh Salimimoghadam, Amir Reza Aref, Rasoul Raesi, Afshin Taheriazam, Maliheh Entezari, Wenliang Zh. STAT3 as a newly emerging target in colorectal cancer therapy: Tumorigenesis, therapy response, and pharmacological/nanoplatform strategies. Environmental research. 2023-06-22. PMID:37348629. |
the biological and malignant characteristics of crc cells contribute to low survival rates in patients, as the upregulation of stat3 prevents apoptosis and promotes pro-survival autophagy, thereby accelerating tumorigenesis. |
2023-06-22 |
2023-08-14 |
human |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑hodgkin lymphoma cells through inhibition of the stat3 pathway. |
2023-06-16 |
2023-08-14 |
Not clear |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
further studies revealed that signal transducer and activator of transcription 3 (stat3) contributed to ferroptosis induced by art and sor in nhl cells, and genetic inhibition of stat3 promoted art/sor‑induced ferroptosis and apoptosis, concomitantly reducing the expression levels of glutathione peroxidase 4 and myeloid cell leukemia‑1. |
2023-06-16 |
2023-08-14 |
Not clear |
| Yingying Chen, Huan Tao, Fujue Wang, Pengqiang Wu, Jie Gao, Xue Zhang, Zhengcang He, Zhencang Zhou, Yongqian Ji. Artesunate synergistically promotes sorafenib‑induced apoptosis and ferroptosis in non‑Hodgkin lymphoma cells through inhibition of the STAT3 pathway. Oncology reports. vol 50. issue 1. 2023-06-16. PMID:37326033. |
collectively, these findings indicated that art acted synergistically with sor to inhibit cell viability, and to induce apoptosis and ferroptosis through regulating the stat3 pathway in nhl. |
2023-06-16 |
2023-08-14 |
Not clear |
| Lintong Men, Junyi Guo, Yu Cao, Bingyu Huang, Qian Wang, Shengqi Huo, Moran Wang, Dewei Peng, Lulu Peng, Wei Shi, Sheng Li, Li Lin, Jiagao L. IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. Free radical biology & medicine. 2023-06-12. PMID:37307935. |
inhibiting il-6/gp130 pathway by bazedoxifene and inhibiting stat3 by stattic both reversed isoproterenol-induced stat3-y705 phosphorylation, ros production, perk activation, ire1α activation, and cardiomyocytes apoptosis in vitro. |
2023-06-12 |
2023-08-14 |
mouse |
| Moli Wu, Danyang Song, Hui Li, Nisar Ahmad, Hong Xu, Xiaobo Yang, Qian Wang, Xiaoxin Cheng, Sa Deng, Xiaohong Sh. Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298405. |
the combined use of res and tmz downregulated stat3 activity and stat3-regulated gene products, thus inhibited cell proliferation and migration, as well as induced apoptosis, accompanied by increased levels of its negative regulators: pias3, shp1, shp2, and socs3. |
2023-06-11 |
2023-08-14 |
Not clear |
| Che-Jui Yang, Zhao-Lin Tan, Jr-Di Yang, Fei-Ting Hsu, Chih-Hung Chian. Fluoxetine inactivates STAT3/NF-κB signaling and promotes sensitivity to cisplatin in bladder cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 164. 2023-06-05. PMID:37276643. |
in summary, the induction of apoptosis and the inhibition of invasion triggered by fluoxetine are associated with the inactivation of stat3 and nf-κb. |
2023-06-05 |
2023-08-14 |
mouse |
| P Kurowska, K Gazdzik, A Jasinska, E Mlyczynska, D Wachowska, A Ra. Resistin as a new player in the regulation of porcine corpus luteum luteolysis: in vitro effect on proliferation/viability, apoptosis and autophagy. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 1. 2023-05-28. PMID:37245230. |
thus, the aim of the present study was to examine the in vitro effect of resistin on the proliferation/viability, apoptosis and autophagy of porcine luteal cells as well as the involvement of mitogen-activated kinase (map3/1), protein kinase b (akt) and signal transducer and activator of transcription 3 (stat3) in these processes. |
2023-05-28 |
2023-08-14 |
Not clear |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
the expression levels of proteins regulating cell apoptosis, cell cycle, and the signal transducer and activator of transcription 3 (stat3) signaling pathways were examined using western blotting analysis. |
2023-05-27 |
2023-08-14 |
human |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
furthermore, lica induced an increase in ros levels, a reduction in mitochondrial membrane potential, and apoptosis accompanied by an increase in cleaved caspases and cytoplasmic cytochrome c. additionally, lica caused a dramatic decrease in stat3 protein levels, but not mrna levels, in skov3 cells. |
2023-05-27 |
2023-08-14 |
human |
| Zhenyan Hou, Songwen Lin, Tingting Du, Mingjin Wang, Weida Wang, Shen You, Nina Xue, Yichen Liu, Ming Ji, Heng Xu, Xiaoguang Che. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242532. |
as a characterized tubulin inhibitor, s-72 typically inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing stat3 signaling. |
2023-05-27 |
2023-08-14 |
Not clear |