| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E A Blinova, V S Nikiforov, A I Kotikova, M A Yanishevskaya, A V Akleye. [Methylation Status of Apoptosis Genes and Intensity of Apoptotic Death of Peripheral Blood Lymphocytes in Persons Chronically Exposed to Radiation]. Molekuliarnaia biologiia. vol 56. issue 6. 2022-12-07. PMID:36475490. |
here, the methylation level of cpg islands of the promoter regions of apoptosis genes (bcl2, atm, mdm2, cdkn1a, stat3, and nfkb1), and also its influence on apoptosis of peripheral blood lymphocytes in chronically exposed persons were studied. |
2022-12-07 |
2023-08-14 |
human |
| Yuzhou Xue, Minghao Luo, Xiankang Hu, Xiang Li, Jian Shen, Wenyan Zhu, Longxiang Huang, Yu Hu, Yongzheng Guo, Lin Liu, Lingbang Wang, Suxin Lu. Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling. Communications biology. vol 5. issue 1. 2022-12-01. PMID:36456628. |
il-1β promots the adhesion, inflammation, and apoptosis of macrophage-like vsmcs in a stat3 dependent manner. |
2022-12-01 |
2023-08-14 |
human |
| Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikaw. Sunitinib promotes apoptosis via p38 MAPK activation and STAT3 downregulation in oral keratinocytes. Oral diseases. 2022-11-30. PMID:36447393. |
sunitinib promotes apoptosis via p38 mapk activation and stat3 downregulation in oral keratinocytes. |
2022-11-30 |
2023-08-14 |
Not clear |
| Guanghua Tang, Linyue Pan, Zhixiang Wang, Hua Zhu, Yong Yang, Zijian Wang, Hongqin Yue, Yuhua Shi, Dichen Wu, Zhilong Jiang, Danbin Jian. Knockdown of membrane-bound complement regulatory proteins suppresses colon cancer growth in mice through inducing tumor cell apoptosis. International immunopharmacology. vol 114. 2022-11-29. PMID:36446233. |
in addition, stat3, stat6, and p38 mapk inhibitors, including c188-9, as1517499 and sb203580 effectively reduced the expression of cd46 in the treated colon cells, associated with increased cell apoptosis and ldh release. |
2022-11-29 |
2023-08-14 |
mouse |
| Yongmei Zhao, Mao Ding, Feng Yan, Jie Yin, Wenjuan Shi, Nan Yang, Haiping Zhao, Yalan Fang, Yuyou Huang, Yangmin Zheng, Xueqi Yang, Wei Li, Xunming Ji, Yumin Lu. Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury. CNS neuroscience & therapeutics. 2022-11-24. PMID:36419252. |
in the present study, we investigated the role of janus-activated kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway and cell cycle arrest, and their relationship with neuronal apoptosis following ripc. |
2022-11-24 |
2023-08-14 |
rat |
| Joaquim Carreras, Giovanna Roncador, Rifat Hamoud. Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels. Cancers. vol 14. issue 21. 2022-11-11. PMID:36358737. |
oncogenes and tumor suppressor genes were highlighted (myc, bcl2, and tp53), along with immune microenvironment markers of tumor-associated macrophages (m2-like tams), t-cells and regulatory t lymphocytes (tregs) (cd68, cd163, marco, csf1r, csf1, pd-l1/cd274, sirpa, cd85a/lilrb3, cd47, il10, tnfrsf14/hvem, tnfaip8, ikaros, stat3, nfkb, mapk, pd-1/pdcd1, btla, and foxp3), apoptosis (bcl2, casp3, casp8, parp, and pathway-related mdm2, e2f1, cdk6, myb, and lmo2), and metabolism (eno3, gga3). |
2022-11-11 |
2023-08-14 |
Not clear |
| Jing Wang, Qiwen Man, Niannian Zhong, Hanqi Wang, Chenxi Zhang, Suran Li, Linlin Bu, Bing Li. ENO1 Binds to ApoC3 and Impairs the Proliferation of T Cells via IL-8/STAT3 Pathway in OSCC. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361568. |
mechanistically, oscc cells activated the stat3 signaling pathway on jurkat t cells through il-8 secretion, promoted apoptosis, and inhibited the proliferation of jurkat t cells. |
2022-11-11 |
2023-08-14 |
Not clear |
| Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Y. Niraparib-induced STAT3 inhibition increases its antitumor effects. Frontiers in oncology. vol 12. 2022-11-03. PMID:36324587. |
moreover, niraparib regulates the expression of several stat3 downstream genes involved in apoptosis. |
2022-11-03 |
2023-08-14 |
Not clear |
| Qianqian Zhao, Adrian Kohut, Yi-Jia Li, Antons Martincuks, Theresa Austria, Chunyan Zhang, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Xuan Thuy Phan, Laleh Melstrom, Lorna Rodriguez-Rodriguez, Hua Y. Niraparib-induced STAT3 inhibition increases its antitumor effects. Frontiers in oncology. vol 12. 2022-11-03. PMID:36324587. |
overexpression of a constitutively activated stat3 mutant rescues niraparib-induced cancer cell apoptosis. |
2022-11-03 |
2023-08-14 |
Not clear |
| Rajina Shakya, Gyu Hwan Park, Sang Hoon Joo, Jung-Hyun Shim, Joon-Seok Cho. Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling. Biomolecules & therapeutics. vol 30. issue 6. 2022-10-28. PMID:36305293. |
western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of jak2 and stat3 by hydroxyzine treatment. |
2022-10-28 |
2023-08-14 |
human |
| Xin Li, Wenkai Jiang, Shi Dong, Wancheng Li, Weixiong Zhu, Wence Zho. STAT3 Inhibitors: A Novel Insight for Anticancer Therapy of Pancreatic Cancer. Biomolecules. vol 12. issue 10. 2022-10-27. PMID:36291659. |
among them, stat3 is involved in cell proliferation, differentiation, apoptosis, and inflammatory responses. |
2022-10-27 |
2023-08-14 |
Not clear |
| Katja Seipel, Yvo Brügger, Harpreet Mandhair, Ulrike Bacher, Thomas Pabs. Rationale for Combining the BCL2 Inhibitor Venetoclax with the PI3K Inhibitor Bimiralisib in the Treatment of IDH2- and FLT3-Mutated Acute Myeloid Leukemia. International journal of molecular sciences. vol 23. issue 20. 2022-10-27. PMID:36293442. |
in this study, the bcl-xl inhibitor a1331852, mcl1-inhibitor s63845, dual pi3k-mtor inhibitor bimiralisib (pqr309), bmi-1 inhibitor unesbulin (ptc596), mek-inhibitor trametinib (gsk1120212), and stat3 inhibitor c-188-9 were assessed as single agents and in combination with venetoclax, for their ability to induce apoptosis and cell death in leukemic cells grown in the absence or presence of bone marrow stroma. |
2022-10-27 |
2023-08-14 |
Not clear |
| Feng Guan, Youming Ding, Yikang He, Lu Li, Xinyu Yang, Changhua Wang, Mingbai H. Involvement of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in diallyl trisulfide-induced cytotoxicity in hepatocellular carcinoma cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 26. issue 6. 2022-10-27. PMID:36302621. |
compared with wild-type appl1, overexpression of appl1 k63r mutant dramatically increased cell apoptosis and mitigated cell survival, along with a reduction of phosphorylation of stat3, akt, and erk1/2. |
2022-10-27 |
2023-08-14 |
human |
| Yueh-Shan Weng, I-Tsang Chiang, Jai-Jen Tsai, Yu-Chang Liu, Fei-Ting Hs. Lenvatinib Synergistically Promotes Radiation Therapy in Hepatocellular Carcinoma by Inhibiting Src/STAT3/NF-κB-Mediated Epithelial-Mesenchymal Transition and Metastasis. International journal of radiation oncology, biology, physics. 2022-10-17. PMID:36245124. |
this study suggested that lenvatinib may incapacitate hepatocellular carcinoma (hcc) to radiation treatment by abrogating radiation-induced src/signal transducer and the activator of transcription 3 signaling (stat3)/nuclear factor-κb (nf-κb) to escalate radiation-induced extrinsic and intrinsic apoptosis. |
2022-10-17 |
2023-08-14 |
Not clear |
| Jun-Kui Li, Hai-Tao Sun, Xiao-Li Jiang, Yi-Fei Chen, Zhu Zhang, Ying Wang, Wen-Qing Chen, Zhang Zhang, Stephen Cho Wing Sze, Pei-Li Zhu, Ken Kin Lam Yun. Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36233191. |
polyphyllin ii induces protective autophagy and apoptosis via inhibiting pi3k/akt/mtor and stat3 signaling in colorectal cancer cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Tingting Kong, Zhenxue He, Shuying Wang, Chunxin Jiang, Fei Zhu, Jingjing Gao, Liu Li, Yanping Wang, Qing Xie, Yunsen L. Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells. Biochemical pharmacology. vol 205. 2022-10-10. PMID:36210604. |
diterpenoid dga induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of stat3 in glioma cells. |
2022-10-10 |
2023-08-14 |
mouse |
| Tingting Kong, Zhenxue He, Shuying Wang, Chunxin Jiang, Fei Zhu, Jingjing Gao, Liu Li, Yanping Wang, Qing Xie, Yunsen L. Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells. Biochemical pharmacology. vol 205. 2022-10-10. PMID:36210604. |
moreover, western blotting showed dga inhibited the signal transducers and activators of transcription 3 (stat3) signaling pathway by reducing the phosphorylation of stat3 and its upstream kinases, which also promoted the apoptosis of glioma cells. |
2022-10-10 |
2023-08-14 |
mouse |
| Min Zhou, Ping Zhang, Mengting Da, Rui Yang, Yulian Ma, Jiuda Zhao, Tao Ma, Jiazeng Xia, Guoshuang Shen, Yu Chen, Daozhen Che. A pan-cancer analysis of the expression of STAT family genes in tumors and their relationship to the tumor microenvironment. Frontiers in oncology. vol 12. 2022-09-30. PMID:36176415. |
the signal transducer and activator of transcription (stat) protein family, a group of seven members (stat1, stat2, stat3, stat4, stat5a, stat5b, and stat6), has been widely used to investigate numerous biological functions including cell proliferation, differentiation, apoptosis, and immune regulation. |
2022-09-30 |
2023-08-14 |
Not clear |
| Shuzhen Liu, Dongmei Yu, Peng Wei, Jiansheng Cai, Min Xu, Haoyu He, Xu Tang, Chuntao Nong, Yi Wei, Xia Xu, Xiaoting Mo, Zhiyong Zhang, Jian Qi. JAK2/STAT3 Signaling Pathway and Klotho Gene in Cadmium-induced Neurotoxicity In Vitro and In Vivo. Biological trace element research. 2022-09-27. PMID:36166115. |
in comparison with the high-dose cd exposure group, after adding tyrphostin ag490 (ag490), the apoptosis rate of pc12 cells increased, whereas the phosphorylation levels of jak2 and stat3 in the cells decreased significantly (p < 0.05). |
2022-09-27 |
2023-08-14 |
rat |
| Xuqing Li, Li Wang, Xinwang Ying, Yujun Zheng, Qianqian Tan, Xiaolan Yu, Jiahong Gong, Ming Li, Xiaofeng Deng, Guanhu Yang, Shengcun Li, Songhe Jian. Electroacupuncture pre-treatment alleviates sepsis-induced cardiac inflammation and dysfunction by inhibiting the calpain-2/STAT3 pathway. Frontiers in physiology. vol 13. 2022-09-26. PMID:36160853. |
additionally, inhibition of calpain-2 expression using the corresponding sirna decreased the phosphorylation of stat3,pro-inflammatory factors and apoptosis in lipopolysaccharide- treated cardiomyocytes, confirming that calpain-2 activated p-stat3 participate in septic cardiomyopathy. |
2022-09-26 |
2023-08-14 |
mouse |