| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina Manni, Maria Pesavento, Zaira Spinello, Lara Saggin, Arash Arjomand, Anna Fregnani, Laura Quotti Tubi, Greta Scapinello, Carmela Gurrieri, Gianpietro Semenzato, Livio Trentin, Francesco Piazz. Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity in mantle cell lymphoma. Frontiers in cell and developmental biology. vol 10. 2022-08-29. PMID:36035991. |
ck2 promotes cancer cell growth and clonal expansion, sustaining pivotal survival signaling cascades, such as the ones dependent on akt, nf-κb, stat3 and others, counteracting apoptosis through a "non-oncogene" addiction mechanism. |
2022-08-29 |
2023-08-14 |
Not clear |
| Li Pan, Xiang Chen, Feyruz Virgilia Rassool, Chenglong Li, Jiayuh Li. LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009550. |
lll12b, a novel small-molecule stat3 inhibitor, induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer cells. |
2022-08-26 |
2023-08-14 |
mouse |
| Li Pan, Xiang Chen, Feyruz Virgilia Rassool, Chenglong Li, Jiayuh Li. LLL12B, a Novel Small-Molecule STAT3 Inhibitor, Induces Apoptosis and Suppresses Cell Migration and Tumor Growth in Triple-Negative Breast Cancer Cells. Biomedicines. vol 10. issue 8. 2022-08-26. PMID:36009550. |
in addition, targeting stat3 with lll12b induced apoptosis, reduced colony formation ability, and inhibited cell migration in tnbc cells. |
2022-08-26 |
2023-08-14 |
mouse |
| Wenjing Xiang, Wanchen Qi, Huayu Li, Jia Sun, Chao Dong, Haojie Ou, Bing Li. Palbociclib Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells via RB-Independent STAT3 Phosphorylation. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005200. |
palbociclib induces the apoptosis of lung squamous cell carcinoma cells via rb-independent stat3 phosphorylation. |
2022-08-25 |
2023-08-14 |
human |
| Wenjing Xiang, Wanchen Qi, Huayu Li, Jia Sun, Chao Dong, Haojie Ou, Bing Li. Palbociclib Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells via RB-Independent STAT3 Phosphorylation. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005200. |
we found that palbociclib induced lusc cell apoptosis through inhibition of src tyrosine kinase/signal transducers and activators of transcription 3 (stat3). |
2022-08-25 |
2023-08-14 |
human |
| Ji Di, Bo Jiang, Hao Shang, Xin Yang, Chengwu Zhang, Xiali Shi, Yan Cha. Study on the Mechanism of Action of STAT3 in the Drug Resistance of Gastric Cancer Cells. Contrast media & molecular imaging. vol 2022. 2022-08-22. PMID:35992548. |
this research detected the expression of stat3 in gastric cancer tissues and adjacent tissues by western blot and immunohistochemical experiments and conducted corresponding basic experiments to explore the role of stat3 in inhibiting the proliferation of cisplatin-resistant gastric cancer cells and promoting their apoptosis, including the construction of cisplatin-resistant gastric cancer cell line, the knock-out stat3 in drug-resistant gastric cancer cells by crispr-cas9, and the comparison of the proliferation and apoptosis of drug-resistant cells and drug-resistant cells stat3(-). |
2022-08-22 |
2023-08-14 |
Not clear |
| Cheng-Chen Zhang, Ting Wu, Li Guan, Yu-Jue Wang, Rui-Qin Yao, Dian-Shuai Gao, Feng L. Effects of STAT3 Inhibitor BP-1-102 on The Proliferation, Invasiveness, Apoptosis and Neurosphere Formation of Glioma Cells in Vitro. Cell biochemistry and biophysics. 2022-08-22. PMID:35994220. |
effects of stat3 inhibitor bp-1-102 on the proliferation, invasiveness, apoptosis and neurosphere formation of glioma cells in vitro. |
2022-08-22 |
2023-08-14 |
Not clear |
| Xueyao Wang, Rui Hu, Zhenwei Song, Huajun Zhao, Zhaoyi Pan, Yujie Feng, Yating Yu, Qiuju Han, Jian Zhan. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity. Cancer letters. 2022-08-18. PMID:35981569. |
sorafenib combined with stat3 knockdown triggers er stress-induced hcc apoptosis and cgas-sting-mediated anti-tumor immunity. |
2022-08-18 |
2023-08-14 |
Not clear |
| Xueyao Wang, Rui Hu, Zhenwei Song, Huajun Zhao, Zhaoyi Pan, Yujie Feng, Yating Yu, Qiuju Han, Jian Zhan. Sorafenib combined with STAT3 knockdown triggers ER stress-induced HCC apoptosis and cGAS-STING-mediated anti-tumor immunity. Cancer letters. 2022-08-18. PMID:35981569. |
our studies demonstrated that stat3 knockdown promoted sorafenib-induced er stress-induced apoptosis. |
2022-08-18 |
2023-08-14 |
Not clear |
| Cairu Liu, Haiqin Feng, Lihong Song, Shuirui Li, Yiping Wu, Liping Yan. Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. Oncology reports. vol 48. issue 4. 2022-08-03. PMID:35920185. |
relative cell viability and apoptosis, as well as the mrna and protein levels of pi3k, akt, jak1 and stat3 were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2022-07-29. PMID:35906391. |
ppdpf promotes lung adenocarcinoma progression via inhibiting apoptosis and nk cell-mediated cytotoxicity through stat3. |
2022-07-29 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2022-07-29. PMID:35906391. |
activated stat3 promoted bmpr2 transcription, which further inhibited apoptosis. |
2022-07-29 |
2023-08-14 |
Not clear |
| Sunanda Singh, Genoveva Murillo, Justin Richner, Samara P Singh, Erica Berleth, Vijay Kumar, Rajendra Mehta, Vijay Ramiya, Ashutosh S Pariha. A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35886918. |
stat3 and kras regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. |
2022-07-27 |
2023-08-14 |
human |
| Pen-An Liao, Pei-Yi Chu, Zhao-Lin Tan, Fei-Ting Hsu, Yang-Cheng Lee, Hsing-Ju W. STAT3 Inactivation and Induction of Apoptosis Associate With Fluoxetine-inhibited Epithelial-mesenchymal Transition and Growth of Triple-negative Breast Cancer Anticancer research. vol 42. issue 8. 2022-07-27. PMID:35896246. |
stat3 inactivation and induction of apoptosis associate with fluoxetine-inhibited epithelial-mesenchymal transition and growth of triple-negative breast cancer breast cancer (bc) is the most common cancer and second leading cause of death in women worldwide. |
2022-07-27 |
2023-08-14 |
Not clear |
| Agnieszka Witalisz-Siepracka, Klara Klein, Bernhard Zdársky, Dagmar Stoibe. The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance. Frontiers in immunology. vol 13. 2022-07-22. PMID:35865518. |
in cancer, stat3 is mainly described as a tumor promoter driving tumor cell proliferation, resistance to apoptosis, angiogenesis and metastasis and aberrant activation of stat3 is associated with poor prognosis. |
2022-07-22 |
2023-08-14 |
Not clear |
| Jing Yang, Lingling Wang, Xiaoqing Guan, Jiang-Jiang Qi. Inhibiting STAT3 Signaling Pathway by Natural Products for Cancer Prevention and Therapy: In Vitro and In Vivo Activity and Mechanisms of Action. Pharmacological research. 2022-07-22. PMID:35868477. |
signal transducer and activator of transcription 3 (stat3) plays a critical role in signal transmission from the plasma membrane to the nucleus, regulating the expression of genes involved in essential cell functions and controlling the processes of cell cycle progression and apoptosis. |
2022-07-22 |
2023-08-14 |
Not clear |
| Yibin Xu, Yulin Huang, Siyu Zhang, Lijin Guo, Ruiquan Wu, Xiang Fang, Xiaolan Chen, Haiping Xu, Qinghua Ni. CircDCLRE1C Regulated Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Regulating miR-214b-3p/STAT3 Pathway in Macrophages. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743265. |
in conclusion, our study showed that circdclre1c could aggravate lps-induced inflammation and apoptosis through competitive adsorption of mir-214b-3p, thereby increasing the expression of stat3. |
2022-06-24 |
2023-08-14 |
chicken |
| Rajappa S Kenchappa, Athanassios Dovas, Michael G Argenziano, Christian T Meyer, Lauren E Stopfer, Matei A Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Vito Quaranta, Peter Sims, Peter Canoll, Steven S Rosenfel. Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma. Cell reports. vol 39. issue 12. 2022-06-22. PMID:35732128. |
while resistance to kif11 inhibitors in other cell types is due to mechanisms that prevent these drugs from disrupting mitosis, we find that in glioblastoma (gbm), resistance to the kif11 inhibitor ispinesib works instead through suppression of apoptosis driven by activation of stat3. |
2022-06-22 |
2023-08-14 |
mouse |
| Lucia T Angulo-Sanchez, Damian López-Peña, Heriberto Torres-Moreno, Aldo Gutiérrez, Rigoberto Gaitán-Hernández, Martín Esqued. Biosynthesis, Gene Expression, and Pharmacological Properties of Triterpenoids of Ganoderma Species (Agaricomycetes): A Review. International journal of medicinal mushrooms. vol 24. issue 6. 2022-06-13. PMID:35695634. |
the effect of gas against cancer cells has been associated with their capability to inhibit specific targets such as stat3, to induce apoptosis and cell cycle blockage, and to increase natural killer cell activity. |
2022-06-13 |
2023-08-14 |
Not clear |
| Huang Hong, Weilan Cao, Quanpeng Wang, Changbao Liu, Chongjie Huan. Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer. Medical oncology (Northwood, London, England). vol 39. issue 5. 2022-05-22. PMID:35599281. |
notably, pre-treatment of nac, a ros scavenger, reversed apoptosis induced by combined treatment of ap and cisplatin, while relieving the activation of endoplasmic reticulum stress as well as stat3 inhibition. |
2022-05-22 |
2023-08-13 |
Not clear |